Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing

Authors: Atreya, Imke ¹, Atreya, Raja ¹, Bacher, Petra ^{2, 3}, Becker, Christoph ¹, Bojarski, Christian ⁴, Britzen-Laurent, Nathalie ¹, Bosch-Voskens, Caroline ¹, Chang, Hyun-Dong ⁵, Diefenbach, Andreas ⁶, Günther, Claudia ¹, Hegazy, Ahmed N. ⁴, Hildner, Kai ¹, Klose, Christoph S.N. ⁶, Koop, Kristina ¹, Krug, Susanne ⁴, Kühl, Anja A. ⁴, Leppkes, Moritz ¹, López-Posadas, Rocío ¹, Ludwig, Leif S.-H. ⁷, Neufert, Clemens ¹, Neurath, Markus ¹, Patankar, Jay V. ¹, Plattner, Christina ⁹, Prüß, Magdalena ³, Radbruch, Andreas ⁵, Romagnani, Chiara ³, Ronchi, Francesca ⁶, Sanders, Ashley ^{4, 8}, Scheffold, Alexander ², Schulzke, Jörg-Dieter ⁴, Schumann, Michael ⁴, Schürmann, Sebastian ¹, Siegmund, Britta ⁴, Stürzl, Michael ¹, Trajanoski, Zlatko ⁹, Triantafyllopoulou, Antigoni ^{5, 10}, Waldner, Maximilian ¹, Weidinger, Carl ⁴, Wirtz, Stefan ¹, Zundler, Sebastian ¹, Müller, Tanja M., Liu, Li-Juan, Wiesinger, Manuel, Neurath, Markus F., Voskens, Caroline J. ^§

Source: In Gastroenterology February 2025 168(2):389-392

Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7–Blocking Therapy in Inflammatory Bowel Disease

Authors: Atreya, Imke ¹, Atreya, Raja ¹, Bacher, Petra ^{2, 3}, Becker, Christoph ¹, Bojarski, Christian ⁴, Britzen-Laurent, Nathalie ¹, Bosch-Voskens, Caroline ¹, Chang, Hyun-Dong ⁵, Diefenbach, Andreas ⁶, Günther, Claudia ¹, Hegazy, Ahmed N. ⁴, Hildner, Kai ¹, Klose, Christoph S.N. ⁶, Koop, Kristina ¹, Krug, Susanne ⁴, Kühl, Anja A. ⁷, Leppkes, Moritz ¹, López-Posadas, Rocío ¹, Ludwig, Leif S-H. ^{8, 9}, Neufert, Clemens ¹, Neurath, Markus ¹, Patankar, Jay ¹, Prüß, Magdalena ³, Radbruch, Andreas ⁵, Romagnani, Chiara ³, Ronchi, Francesca ⁶, Sanders, Ashley ^{4, 9}, Scheffold, Alexander ², Schulzke, Jörg-Dieter ⁴, Schumann, Michael ⁴, Schürmann, Sebastian ¹, Siegmund, Britta ⁴, Stürzl, Michael ¹, Trajanoski, Zlatko ¹⁰, Triantafyllopoulou, Antigoni ^{5, 11}, Waldner, Maximilian ¹, Weidinger, Carl ⁴, Wirtz, Stefan ¹, Zundler, Sebastian ¹, Horn, Veronika ^{1, 2, ∗}, Cancino, Camila A. ^{1, 2, ∗}, Steinheuer, Lisa M. ^{3, ∗}, Obermayer, Benedikt ^{4, ∗}, Fritz, Konstantin ^{1, 2}, Nguyen, Anke L. ^{1, 5}, Juhran, Kim Susan ^{1, 2}, Plattner, Christina ⁶, Bösel, Diana ^{1, 2}, Oldenburg, Lotte ⁷, Burns, Marie ², Schulz, Axel Ronald ², Saliutina, Mariia ^{1, 2}, Mantzivi, Eleni ¹, Lissner, Donata ¹, Conrad, Thomas ^{8, 9}, Mashreghi, Mir-Farzin ^{2, 10}, Sonnenberg, Elena ¹, Haag, Lea-Maxie ¹, Beule, Dieter ⁴, Flatz, Lukas ^{12, 13}, D’Haens, Geert ⁷, Mei, Henrik E. ², Thurley, Kevin ^{2, 3, ∗}

Source: In Gastroenterology February 2025 168(2):327-343

TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice

Authors: Atreya, Imke ^h, Atreya, Raja ^h, Bacher, Petra ^{i, j}, Becker, Christoph ^h, Bojarski, Christian ^k, Britzen-Laurent, Nathalie ^l, Bosch-Voskens, Caroline ^m, Chang, Hyun-Dong ⁿ, Diefenbach, Andreas ^o, Günther, Claudia ^h, Hegazy, Ahmed N. ^k, Hildner, Kai ^h, Klose, Christoph S.N. ^o, Koop, Kristina ^h, Krug, Susanne ^k, Kühl, Anja A. ^k, Leppkes, Moritz ^h, López-Posadas, Rocío ^h, Ludwig, Leif S.-H. ^{p, q}, Neufert, Clemens ^h, Neurath, Markus ^h, Patankar, Jay V. ^h, Plattner, Christina ^r, Prüß, Magdalena ^h, Radbruch, Andreas ⁿ, Romagnani, Chiara ^s, Ronchi, Francesca ^o, Sanders, Ashley ^{k, q}, Scheffold, Alexander ⁱ, Schulzke, Jörg-Dieter ^k, Schumann, Michael ^k, Schürmann, Sebastian ^t, Siegmund, Britta ^k, Stürzl, Michael ^l, Trajanoski, Zlatko ^r, Triantafyllopoulou, Antigoni ⁿ, Waldner, Maximilian ^h, Weidinger, Carl ^k, Wirtz, Stefan ^h, Zundler, Sebastian ^h, Erkert, Lena ^a, Ruder, Barbara ^{a, 1}, Kabisch, Melanie ^a, Gamez Belmonte, Reyes ^a, Gonzalez Acera, Miguel ^a, Schödel, Lena ^a, Chiriac, Mircea T. ^a, Cineus, Roodline ^c, Gnafakis, Stylianos ^d, Leupold, Tamara ^a, Thoma, Oana-Maria ^{a, b}, Stolzer, Iris ^a, Taut, Astrid ^a, Thonn, Veronika ^a, Basic, Marijana ^g, Bleich, André ^g, Neurath, Markus F. ^{a, b}

Source: In Mucosal Immunology January 2025

Amplification of autoimmune organ damage by NKp46-activated ILC1s

Authors: Biniaris-Georgallis, Stylianos-Iason, Aschman, Tom, Stergioula, Katerina, Schreiber, Frauke, Jafari, Vajiheh, Taranko, Anna, Karmalkar, Tejal, Kasapi, Ana, Lenac Rovis, Tihana, Jelencic, Vedrana, Bejarano, David A., Fabry, Lea, Papacharalampous, Michail, Mattiola, Irene, Molgora, Martina, Hou, Jinchao, Hublitz, Karolin W., Heinrich, Frederik, Guerra, Gabriela Maria, Durek, Pawel, Patone, Giannino, Lindberg, Eric L., Maatz, Henrike, Hölsken, Oliver, Krönke, Gerhard, Mortha, Arthur, Voll, Reinhard E., Clarke, Alexander J., Hauser, Anja E., Colonna, Marco, Thurley, Kevin, Schlitzer, Andreas, Schneider, Christoph, Stamatiades, Efstathios G., Mashreghi, Mir-Farzin, Jonjic, Stipan, Hübner, Norbert, Diefenbach, Andreas, Kanda, Masatoshi, Triantafyllopoulou, Antigoni

Source: Nature; October 2024, Vol. 634 Issue: 8035 p952-960, 9p

DNA damage signaling and polyploid macrophages in chronic inflammation

Authors: Horn, Veronika, Triantafyllopoulou, Antigoni

Source: In Current Opinion in Immunology February 2018 50:55-63

Interleukin-22 protects intestinal stem cells against genotoxic stress

Authors: Gronke, Konrad, Hernández, Pedro, Zimmermann, Jakob, Klose, Christoph, Kofoed-Branzk, Michael, Guendel, Fabian, Witkowski, Mario, Tizian, Caroline, Amann, Lukas, Schumacher, Fabian, Glatt, Hansruedi, Triantafyllopoulou, Antigoni, Diefenbach, Andreas

Source: Nature. 566(7743):249-253

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112268381.0x000001&indx=1&recIds=ETOCvdc_100112268381.0x000001

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

Authors: Herrtwich, Laura, Nanda, Indrajit, Evangelou, Konstantinos, Nikolova, Teodora, Horn, Veronika, Sagar, Erny, Daniel, Stefanowski, Jonathan, Rogell, Leif, Klein, Claudius, Gharun, Kourosh, Follo, Marie, Seidl, Maximilian, Kremer, Bernhard, Münke, Nikolas, Senges, Julia, Fliegauf, Manfred, Aschman, Tom, Pfeifer, Dietmar, Sarrazin, Sandrine, Sieweke, Michael H., Wagner, Dirk, Dierks, Christine, Haaf, Thomas, Ness, Thomas, Zaiss, Mario M., Voll, Reinhard E., Deshmukh, Sachin D., Prinz, Marco, Goldmann, Torsten, Hölscher, Christoph, Hauser, Anja E., Lopez-Contreras, Andres J., Grün, Dominic, Gorgoulis, Vassilis, Diefenbach, Andreas, Henneke, Philipp, Triantafyllopoulou, Antigoni

Source: In Cell 17 November 2016 167(5):1264-1280

MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution.

Authors: Mertens, Till Fabian, Liebheit, Alina Tabea, Ehl, Johanna, Köhler, Ralf, Rakhymzhan, Asylkhan, Woehler, Andrew, Katthän, Lukas, Ebel, Gernot, Liublin, Wjatscheslaw, Kasapi, Ana, Triantafyllopoulou, Antigoni, Schulz, Tim Julius, Niesner, Raluca Aura, Hauser, Anja Erika

Source: Nature Communications; 2/27/2024, Vol. 15 Issue 1, p1-19, 19p

Subject Terms: BONE marrow cells, CELL analysis, CARDIOVASCULAR system, BONE marrow, MYELOID cells, MACHINE learning

Proliferative Lesions and Metalloproteinase Activity in Murine Lupus Nephritis Mediated by Type I Interferons and Macrophages

Authors: Triantafyllopoulou, Antigoni, Franzke, Claus-Werner, Seshan, Surya V., Perino, Giorgio, Kalliolias, George D., Ramanujam, Meera, van Rooijen, Nico, Davidson, Anne, Ivashkiv, Lionel B., Glimcher, Laurie H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Feb 01. 107(7), 3012-3017.

Access URL: https://www.jstor.org/stable/40536808

Der Rolle der DNA-Schadensantwort bei granulomatösen Erkrankungen. (German)

Alternate Title: The role of the response to DNA damage in granulomatous diseases. (English)

Authors: Fabry, Lea A. R., Triantafyllopoulou, Antigoni

Source: Zeitschrift für Rheumatologie; Dec2022, Vol. 81 Issue 10, p881-887, 7p

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

Authors: Herrtwich, Laura, Nanda, Indrajit, Evangelou, Konstantinos, Nikolova, Teodora, Horn, Veronika, Erny, Daniel, Stefanowski, Jonathan, Rogell, Leif, Klein, Claudius, Gharun, Kourosh, Follo, Marie, Seidl, Maximilian, Kremer, Bernhard, Münke, Nikolas, Senges, Julia, Fliegauf, Manfred, Aschman, Tom, Pfeifer, Dietmar, Sarrazin, Sandrine, Sieweke, Michael H., Wagner, Dirk, Dierks, Christine, Haaf, Thomas, Ness, Thomas, Zaiss, Mario M., Voll, Reinhard E., Deshmukh, Sachin D., Prinz, Marco, Goldmann, Torsten, Hölscher, Christoph, Hauser, Anja E., Lopez-Contreras, Andres J., Grün, Dominic, Gorgoulis, Vassilis, Diefenbach, Andreas, Henneke, Philipp, Triantafyllopoulou, Antigoni

Source: Cell. 174(5):1325-1326

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114115594.0x000001&indx=1&recIds=ETOCvdc_100114115594.0x000001

Monocyte progenitors give rise to multinucleated giant cells.

Authors: Lösslein, Anne Kathrin, Lohrmann, Florens, Scheuermann, Lisa, Gharun, Kourosh, Neuber, Jana, Kolter, Julia, Forde, Aaron James, Kleimeyer, Christian, Poh, Ying Yee, Mack, Matthias, Triantafyllopoulou, Antigoni, Dunlap, Micah D., Khader, Shabaana A., Seidl, Maximilian, Hölscher, Alexandra, Hölscher, Christoph, Guan, Xue Li, Dorhoi, Anca, Henneke, Philipp

Source: Nature Communications; 4/1/2021, Vol. 12 Issue 1, p1-22, 22p

Subject Terms: MULTINUCLEATED giant cells, MYCOBACTERIAL diseases, MONOCYTES, CELL transformation, CHOLESTEROL metabolism, CELL cycle, EOSINOPHILIC granuloma, DNA damage

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Autoimmunity and Coxsackievirus Infection in Primary Sjögren's Syndrome.

Authors: TRIANTAFYLLOPOULOU, ANTIGONI^1,2, MOUTSOPOULOS, HARALAMPOS M.¹

Source: Annals of the New York Academy of Sciences; 2005, Vol. 1050 Issue 1, p389-396, 8p