Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John’s wort

Authors: Chauveau, Antoine, Treyer, Andrea, Geirnaert, Annelies, Bircher, Lea, Babst, Angela, Abegg, Vanessa Fabienne, Simões-Wüst, Ana Paula, Lacroix, Christophe, Potterat, Olivier, Hamburger, Matthias

Source: In Biomedicine & Pharmacotherapy June 2023 162

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Authors: Hellinen, Laura, Koskela, Ali, Vattulainen, Elina, Liukkonen, Mikko, Wegler, Christine, Treyer, Andrea, Handin, Niklas, Svensson, Richard, Myöhänen, Timo, Poso, Antti, Kaarniranta, Kai, Artursson, Per, Urtti, Arto

Source: In Biomedicine & Pharmacotherapy February 2022 146

Hepatocyte size fractionation allows dissection of human liver zonation

Authors: Ölander, Magnus, Wegler, Christine, Flörkemeier, Inken, Treyer, Andrea, Handin, Niklas, Pedersen, Jenny M., Vildhede, Anna, Mateus, André, LeCluyse, Edward L., Urdzik, Jozef, Artursson, Per

Source: Journal of cellular physiology. 236(8):5885-5894

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130981221.0x000001&indx=1&recIds=ETOCvdc_100130981221.0x000001

Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeabilityElectronic supplementary information (ESI) available: Experimental procedures and characterisation for all new compounds. Experimental details and raw data for biological assays, 1H, 13C NMR, HRMS spectra and HPLC chromatograms for all novel compounds. See DOI: 10.1039/d0md00408a

Authors: Borsari, Chiara, Keles, Erhan, Treyer, Andrea, De Pascale, Martina, Hebeisen, Paul, Hamburger, Matthias, Wymann, Matthias P.

Source: RSC medicinal chemistry. 12(4):579-583

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120016664.0x000001&indx=1&recIds=ETOCvdc_100120016664.0x000001

Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System

Authors: Spiess, Deborah, Abegg, Vanessa, Chauveau, Antoine, Treyer, Andrea, Reinehr, Michael, Oufir, Mouhssin, Duong, Elisa, Potterat, Olivier, Hamburger, Matthias, Simões-Wüst, Ana

Source: Planta medica. 87(14):1192-1205

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191636118.0x000001&indx=1&recIds=ETOCvdc_100191636118.0x000001

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Authors: Mateus, André, Gordon, Laurie J., Wayne, Gareth J., Almqvist, Helena, Axelsson, Hanna, Seashore-Ludlow, Brinton, Treyer, Andrea, Matsson, Pär, Lundbäck, Thomas, West, Andy, Hann, Michael M., Artursson, Per

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jul . 114(30), E6231-E6239.

Access URL: https://www.jstor.org/stable/26486190

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

Authors: Treyer, Andrea, Mateus, André, Wiśniewski, Jacek R., Boriss, Hinnerk, Matsson, Pär, Artursson, Per

Source: Molecular pharmaceutics. 15(6):2224-2233

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN616278883&indx=1&recIds=ETOCRN616278883

Influence of Slco2b1‐knockout and SLCO2B1‐humanization on coproporphyrin I and III levels in rats.

Authors: Kinzi, Jonny, Hussner, Janine, Schäfer, Anima M., Treyer, Andrea, Seibert, Isabell, Tillmann, Annika, Mueller, Vanessa, Gherardi, Clarisse, Vonwyl, Celina, Hamburger, Matthias, Meyer zu Schwabedissen, Henriette E.

Source: British Journal of Pharmacology; Jan2024, Vol. 181 Issue 1, p36-53, 18p

Subject Terms: LABORATORY rats, MULTIDRUG resistance-associated proteins, WESTERN immunoblotting, RATS, DRUG interactions, FEMALES

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Authors: Treyer, Andrea, Ullah, Mohammed, Parrott, Neil, Molitor, Birgit, Fowler, Stephen, Artursson, Per

Source: AAPS journal. 21(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128521114.0x000001&indx=1&recIds=ETOCvdc_100128521114.0x000001

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu, cell)

Authors: Treyer, Andrea, Walday, Sandra, Boriss, Hinnerk, Matsson, Pär, Artursson, Per

Source: PHARMACEUTICAL RESEARCH. 36(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129428157.0x000001&indx=1&recIds=ETOCvdc_100129428157.0x000001

Transplacental passage of hyperforin, hypericin, and valerenic acid.

Authors: Spiess, Deborah, Abegg, Vanessa Fabienne, Chauveau, Antoine, Rath, Joshua, Treyer, Andrea, Reinehr, Michael, Kuoni, Sabrina, Oufir, Mouhssin, Potterat, Olivier, Hamburger, Matthias, Simões-Wüst, Ana Paula

Source: Frontiers in Pharmacology; 3/31/2023, Vol. 14, p1-15, 15p

Subject Terms: HYPERICIN, COTYLEDONS, MENTAL illness, ACIDS, PERFUSION, HYPERICUM perforatum

Geographic Terms: ST. John's (N.L.)

Phytochemical Comparison of Medicinal Cannabis Extracts and Study of Their CYP-Mediated Interactions with Coumarinic Oral Anticoagulants.

Authors: Treyer, Andrea¹, Reinhardt, Jakob K.¹, Eigenmann, Daniela Elisabeth², Oufir, Mouhssin^1,3, Hamburger, Matthias¹

Source: Medical Cannabis & Cannabinoids. 2023, Vol. 6 Issue 1, p21-31. 11p.

Subject Terms: *PHYTOCHEMICALS, *ANTICOAGULANTS, *MICROSOMES, *DECARBOXYLATION

Placental Passage of Protopine in an Ex Vivo Human Perfusion System.

Authors: Spiess, Deborah, Abegg, Vanessa Fabienne, Chauveau, Antoine, Treyer, Andrea, Reinehr, Michael, Oufir, Mouhssin, Duong, Elisa, Potterat, Olivier, Hamburger, Matthias, Simões-Wüst, Ana Paula

Source: Planta Medica; Feb2023, Vol. 89 Issue 2, p194-207, 14p

Subject Terms: MATERNAL-fetal exchange, ALKALOIDS, PLACENTA, PLANT extracts, MOLECULAR structure, PERFUSION

Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System^#.

Authors: Spiess, Deborah, Abegg, Vanessa Fabienne, Chauveau, Antoine, Treyer, Andrea, Reinehr, Michael, Oufir, Mouhssin, Duong, Elisa, Potterat, Olivier, Hamburger, Matthias, Simões-Wüst, Ana Paula

Source: Planta Medica; 2021, Vol. 87 Issue 14, p1192-1205, 14p

Subject Terms: BIOLOGICAL models, CITALOPRAM, MATERNAL-fetal exchange, ALKALOIDS, CELL survival, GONADOTROPIN, PLACENTA, MASS spectrometry, DESCRIPTIVE statistics, PLANT extracts, MOLECULAR structure, PERFUSION, DIAZEPAM

4‑(Difluoromethyl)-5-(4-((3R,5S)‑3,5-dimethylmorpholino)-6-((R)‑3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders.

Authors: Borsari, Chiara, Keles, Erhan, Rageot, Denise, Treyer, Andrea, Bohnacker, Thomas, Bissegger, Lukas, De Pascale, Martina, Melone, Anna, Sriramaratnam, Rohitha, Beaufils, Florent, Hamburger, Matthias, Hebeisen, Paul, Löscher, Wolfgang, Fabbro, Doriano, Hillmann, Petra, Wymann, Matthias P.

Source: Journal of Medicinal Chemistry; 11/25/2020, Vol. 63 Issue 22, p13595-13617, 23p

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Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase‐CYP substrates.

Authors: Izat, Nihan¹ (AUTHOR), Bolleddula, Jayaprakasam² (AUTHOR), Carione, Pasquale³ (AUTHOR), Huertas Valentin, Leticia⁴ (AUTHOR), Jones, Robert S.³ (AUTHOR), Kulkarni, Priyanka⁵ (AUTHOR), Moss, Darren⁶ (AUTHOR), Peterkin, Vincent C.⁷ (AUTHOR), Tian, Dan‐Dan⁸ (AUTHOR), Treyer, Andrea⁶ (AUTHOR), Venkatakrishnan, Karthik² (AUTHOR), Zientek, Michael A.⁵ (AUTHOR), Barber, Jill¹ (AUTHOR), Houston, J. Brian¹ (AUTHOR), Galetin, Aleksandra¹ (AUTHOR), Scotcher, Daniel¹ (AUTHOR) daniel.scotcher@manchester.ac.uk

Source: CPT: Pharmacometrics & Systems Pharmacology. Oct2024, p1. 15p. 6 Illustrations.

Subject Terms: *BIOCHEMICAL substrates, *SMALL molecules, *KETOCONAZOLE, *ZIPRASIDONE, *CYTOCHROME P-450 CYP3A

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell).

Authors: Treyer, Andrea¹ (AUTHOR), Walday, Sandra¹ (AUTHOR), Boriss, Hinnerk² (AUTHOR), Matsson, Pär¹ (AUTHOR), Artursson, Per^1,3,4 (AUTHOR) per.artursson@farmaci.uu.se

Source: Pharmaceutical Research. Dec2019, Vol. 36 Issue 12, pN.PAG-N.PAG. 1p. 5 Graphs.

Subject Terms: *CELL determination, *CELL compartmentation, *PHOSPHOLIPIDS, *CELL anatomy, *CELL membranes, *SUBSPECIES, *BILAYER lipid membranes

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell).

Authors: Treyer, Andrea, Walday, Sandra, Boriss, Hinnerk, Matsson, Pär, Artursson, Per

Source: Pharmaceutical Research; Dec2019, Vol. 36 Issue 12, pN.PAG-N.PAG, 1p, 5 Graphs

Subject Terms: CELL determination, CELL compartmentation, PHOSPHOLIPIDS, CELL anatomy, CELL membranes, SUBSPECIES, BILAYER lipid membranes