Implementation of new Westgard rules suggested by the Westgard Advisor software for five immunological parameters.

Authors: Cristelli, Lisa¹, Occhipinti, Francesca², Tumiatti, Daniel², Antonia, De Luisi², Jani, Erika², Daves, Massimo² massimo.daves@sabes.it

Source: Biochemia Medica. 2025, Vol. 35 Issue 1, p1-6. 6p.

Subject Terms: *LABORATORY management, *TRANSTHYRETIN, *CERULOPLASMIN, *QUALITY control, *IMMUNOGLOBULIN A

A Snapshot of the Most Recent Transthyretin Stabilizers.

Authors: Marotta, Carlo¹ (AUTHOR) carlo.marotta@phd.unipi.it, Ciccone, Lidia¹ (AUTHOR) armando.rossello@unipi.it, Orlandini, Elisabetta² (AUTHOR) elisabetta.orlandini@unipi.it, Rossello, Armando¹ (AUTHOR) susanna.nencetti@unipi.it, Nencetti, Susanna¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9969. 22p.

Subject Terms: *TRANSTHYRETIN, *SYMPTOMS, *RESEARCH personnel, *CLINICAL trials, *AMYLOIDOSIS

Assessment of transthyretin instability in patients with wild-type transthyretin amyloid cardiomyopathy.

Authors: Iino, Takuya^1,2, Nagao, Manabu³ mnagao@med.kobe-u.ac.jp, Tanaka, Hidekazu¹, Yoshikawa, Sachiko¹, Asakura, Junko¹, Nishimori, Makoto⁴, Shinohara, Masakazu^4,5, Harada, Amane², Watanabe, Shunsuke⁶, Ishida, Tatsuro^1,7, Hirata, Ken-ichi^1,3, Toh, Ryuji³

Source: Scientific Reports. 9/3/2024, Vol. 14 Issue 1, p1-9. 9p.

Subject Terms: *TRANSTHYRETIN, *AMYLOID, *CARDIOMYOPATHIES, *DENATURATION of proteins, *AMYLOIDOSIS

Structural Basis for Monoclonal Antibody Therapy for Transthyretin Amyloidosis.

Authors: Chakrabartty, Avi^1,2 (AUTHOR) avijit.chakrabartty@utoronto.ca

Source: Pharmaceuticals (14248247). Sep2024, Vol. 17 Issue 9, p1225. 13p.

Subject Terms: *PROTEIN structure, *TRANSTHYRETIN, *AMYLOID, *AMYLOIDOSIS, *CLINICAL trials, *MONOCLONAL antibodies

Probing the role of V30M mutation in human transthyretin aggregation using molecular simulations.

Authors: Vishwakarma, Kamini¹, Mittal, Sumit¹ sumit.mittal@vitbhopal.ac.in

Source: Current Science (00113891). 6/10/2024, Vol. 126 Issue 11, p1343-1348. 6p.

Subject Terms: *TRANSTHYRETIN, *STRUCTURAL dynamics, *HYDROGEN bonding, *MOLECULAR dynamics, *MONOMERS, *AMYLOID beta-protein

Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I TTR carriers in the general population.

Authors: Hendren, Nicholas S.^1,2 (AUTHOR), De Lemos, James A.^1,2 (AUTHOR), Berry, Jarett D.³ (AUTHOR), Kozlitina, Julia⁴ (AUTHOR), Saelices, Lorena⁵ (AUTHOR), Ji, Alan X.⁶ (AUTHOR), Shao, Zhili⁷ (AUTHOR), Liu, Chia-Feng⁷ (AUTHOR), Garg, Sonia^1,2 (AUTHOR), Farr, Maryjane A.^1,2 (AUTHOR), Drazner, Mark H.^1,2 (AUTHOR), Tang, W. H. Wilson^7,8 (AUTHOR), Grodin, Justin L.^1,2 (AUTHOR) Justin.Grodin@utsouthwestern.edu

Source: Amyloid. Jun2024, Vol. 31 Issue 2, p124-131. 8p.

Subject Terms: *CARRIER proteins, *TRANSTHYRETIN, *VITAMIN A, *CARDIAC amyloidosis, *KIDNEY physiology, *BLOOD sampling

Treatment characteristics of patients with hereditary transthyretin amyloidosis: a cohort study.

Authors: Qarni, Taha N.¹ (AUTHOR) taha.qarni@pennmedicine.upenn.edu, Jones, Felipe J. S.¹ (AUTHOR), Drachman, Brian^2,3 (AUTHOR), Khella, Sami^1,2 (AUTHOR), Pieretti, Janice^2,3 (AUTHOR), Bustamante, Nicolas Sarmiento¹ (AUTHOR), Karam, Chafic^1,3 (AUTHOR)

Source: Orphanet Journal of Rare Diseases. 5/8/2024, Vol. 19 Issue 1, p1-9. 9p.

Subject Terms: *TRANSTHYRETIN, *ELECTRONIC health records, *AMYLOIDOSIS, *COHORT analysis, *GENE therapy

Trypsin‐induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis.

Authors: Mizuguchi, Mineyuki¹ (AUTHOR) mineyuki@pha.u-toyama.ac.jp, Obita, Takayuki¹ (AUTHOR), Yamada, Seiya¹ (AUTHOR), Nabeshima, Yuko¹ (AUTHOR)

Source: FEBS Journal. Apr2024, Vol. 291 Issue 8, p1732-1743. 12p.

Subject Terms: *TRANSTHYRETIN, *AMYLOIDOSIS, *VALINE, *TRYPSIN, *AMINO acids, *MONOMERS

Effect of long‐term tafamidis treatment on health‐related quality of life in patients with transthyretin amyloid cardiomyopathy.

Authors: Grogan, Martha¹ (AUTHOR) grogan.martha@mayo.edu, Davis, Margot K.² (AUTHOR), Crespo‐Leiro, Maria G.³ (AUTHOR), Sultan, Marla B.⁴ (AUTHOR), Gundapaneni, Balarama⁵ (AUTHOR), Stedile Angeli, Franca⁶ (AUTHOR), Hanna, Mazen⁷ (AUTHOR)

Source: European Journal of Heart Failure. Mar2024, Vol. 26 Issue 3, p612-615. 4p.

Subject Terms: *QUALITY of life, *TRANSTHYRETIN, *AMYLOID, *CARDIOMYOPATHIES

Geographic Terms: KANSAS City (Kan.)

Patient-reported outcome measures for transthyretin cardiac amyloidosis: the ITALY study.

Authors: Aimo, Alberto^1,2 (AUTHOR) a.aimo@santannapisa.it, Teresi, Lucio^1,3 (AUTHOR), Castiglione, Vincenzo^1,2 (AUTHOR), Picerni, Anna Lisa² (AUTHOR), Niccolai, Martina² (AUTHOR), Severino, Silvia² (AUTHOR), Agazio, Assunta² (AUTHOR), Carnevale Baraglia, Anna⁴ (AUTHOR), Obici, Laura⁴ (AUTHOR), Palladini, Giovanni⁴ (AUTHOR), Ponti, Lucia^5,6 (AUTHOR), Argirò, Alessia^5,6 (AUTHOR), Cappelli, Francesco^5,6 (AUTHOR), Perfetto, Federico^5,6 (AUTHOR), Serenelli, Matteo⁷ (AUTHOR), Trimarchi, Giancarlo³ (AUTHOR), Licordari, Roberto³ (AUTHOR), Di Bella, Gianluca³ (AUTHOR), Chubuchna, Olena¹ (AUTHOR), Quattrone, Filippo¹ (AUTHOR)

Source: Amyloid. Mar2024, Vol. 31 Issue 1, p52-61. 10p.

Subject Terms: *CARDIAC amyloidosis, *TRANSTHYRETIN, *BETA (Finance)

Geographic Terms: ITALY

Inhibitors of Transthyretin Amyloidosis: How to Rank Drug Candidates Using X-ray Crystallography Data.

Authors: Leite, José P.¹ (AUTHOR), Costa-Rodrigues, Diogo^1,2,3 (AUTHOR), Gales, Luís^1,2,3 (AUTHOR) lgales@ibmc.up.pt

Source: Molecules. Feb2024, Vol. 29 Issue 4, p895. 12p.

Subject Terms: *X-ray crystallography, *TRANSTHYRETIN, *AMYLOIDOSIS, *QUATERNARY structure, *ALZHEIMER'S disease

Assessment of potential transthyretin amyloid cardiomyopathy cases in the Brazilian public health system using a machine learning model.

Authors: Zuppo Laper, Isabella¹ (AUTHOR), Camacho-Hubner, Cecilia² (AUTHOR), Vansan Ferreira, Rafaela¹ (AUTHOR), Leite Bertoli de Souza, Claudenice³ (AUTHOR), Simões, Marcus Vinicius⁴ (AUTHOR), Fernandes, Fabio⁵ (AUTHOR), de Barros Correia, Edileide⁶ (AUTHOR), de Jesus Lopes de Abreu, Ariane¹ (AUTHOR), Silva Julian, Guilherme³ (AUTHOR) guilherme.julian@pfizer.com

Source: PLoS ONE. 2/15/2024, Vol. 19 Issue 2, p1-23. 23p.

Subject Terms: *MACHINE learning, *TRANSTHYRETIN, *CARDIOMYOPATHIES, *PUBLIC health

Geographic Terms: BRAZIL

Cardiac [^99mTc]Tc-hydroxydiphosphonate uptake on bone scintigraphy in patients with hereditary transthyretin amyloidosis: an early follow-up marker?

Authors: Tingen, H. S. A.¹ (AUTHOR) h.s.a.tingen@umcg.nl, Tubben, A.² (AUTHOR), Bijzet, J.³ (AUTHOR), van den Berg, M. P.² (AUTHOR), van der Meer, P.² (AUTHOR), Houwerzijl, E. J.⁴ (AUTHOR), Muntinghe, F. L. H.⁴ (AUTHOR), van der Zwaag, P. A.⁵ (AUTHOR), Glaudemans, A. W. J. M.¹ (AUTHOR), Oerlemans, M. I. F. J.⁶ (AUTHOR), Knackstedt, C.⁷ (AUTHOR), Michels, M.⁸ (AUTHOR), Hirsch, A.⁹ (AUTHOR), Hazenberg, B. P. C.³ (AUTHOR), Slart, R. H. J. A.^1,10 (AUTHOR), Nienhuis, H. L. A.⁴ (AUTHOR)

Source: European Journal of Nuclear Medicine & Molecular Imaging. Feb2024, Vol. 51 Issue 3, p681-690. 10p.

Subject Terms: *RADIONUCLIDE imaging, *TRANSTHYRETIN, *AMYLOIDOSIS, *DISEASE progression, *TROPONIN

Deep phenotyping of p.(V142I)‐associated variant transthyretin amyloid cardiomyopathy: Distinct from wild‐type transthyretin amyloidosis?

Authors: Razvi, Yousuf¹ (AUTHOR), Ioannou, Adam¹ (AUTHOR), Patel, Rishi K.¹ (AUTHOR), Chacko, Liza¹ (AUTHOR), Karia, Nina² (AUTHOR), Riefolo, Mattia¹ (AUTHOR), Porcari, Aldostefano^1,3 (AUTHOR), Rauf, Muhammad Umaid¹ (AUTHOR), Starr, Neasa¹ (AUTHOR), Ganesananthan, Sashiananthan⁴ (AUTHOR), Blakeney, Iona¹ (AUTHOR), Kaza, Nandita⁴ (AUTHOR), Filisetti, Stefano¹ (AUTHOR), Bolhuis, Roos Eline¹ (AUTHOR), Rowczenio, Dorota¹ (AUTHOR), Gilbertson, Janet¹ (AUTHOR), Hutt, David¹ (AUTHOR), Mahmood, Shameem¹ (AUTHOR), Lachmann, Helen J.¹ (AUTHOR), Wechalekar, Ashutosh D.¹ (AUTHOR)

Source: European Journal of Heart Failure. Feb2024, Vol. 26 Issue 2, p383-393. 11p.

Subject Terms: *CARDIAC amyloidosis, *TRANSTHYRETIN, *CARDIAC magnetic resonance imaging, *AMYLOID, *RIGHT ventricular dysfunction, *CARDIOMYOPATHIES

Phenotypic characteristics of F64L, I68L, I107V, and S77Y ATTRv genotypes from the Transthyretin Amyloidosis Outcomes Survey (THAOS).

Authors: Gentile, Luca¹ (AUTHOR), Diemberger, Igor^2,3 (AUTHOR) igor.diemberger@unibo.it, Plante-Bordeneuve, Violaine⁴ (AUTHOR), Mazzeo, Anna¹ (AUTHOR), Dori, Amir⁵ (AUTHOR), Luigetti, Marco^6,7 (AUTHOR), Di Paolantonio, Andrea^7,8 (AUTHOR), Dispenzieri, Angela⁹ (AUTHOR), Grogan, Martha¹⁰ (AUTHOR), Waddington Cruz, Márcia¹¹ (AUTHOR), Adams, David¹² (AUTHOR), Inamo, Jocelyn¹³ (AUTHOR), Kristen, Arnt V.¹⁴ (AUTHOR), Lino Cirami, Calogero¹⁵ (AUTHOR), Chapman, Doug¹⁶ (AUTHOR), Gupta, Pritam¹⁶ (AUTHOR), Glass, Oliver¹⁶ (AUTHOR), Amass, Leslie¹⁶ (AUTHOR)

Source: PLoS ONE. 1/19/2024, Vol. 19 Issue 1, p1-14. 14p.

Subject Terms: *AMYLOIDOSIS, *TRANSTHYRETIN, *GENOTYPES, *PHENOTYPES, *DEMOGRAPHIC characteristics, *CUCUMBER mosaic virus

Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer's Disease.

Authors: Joshi, Sameer M.^1,2 (AUTHOR) sameerjoshi94@gmail.com, Wilson, Thomas C.³ (AUTHOR) tcwilson1610@gmail.com, Li, Zibo^2,4 (AUTHOR), Preshlock, Sean³ (AUTHOR) veronique.gouverneur@chem.ox.ac.uk, Gómez-Vallejo, Vanessa¹ (AUTHOR) vgomez@cicbiomagune.es, Gouverneur, Véronique³ (AUTHOR), Llop, Jordi¹ (AUTHOR) jllop@cicbiomagune.es, Arsequell, Gemma⁵ (AUTHOR) jllop@cicbiomagune.es

Source: Molecules. Jan2024, Vol. 29 Issue 2, p488. 11p.

Subject Terms: *ALZHEIMER'S disease, *TRANSTHYRETIN, *DIAGNOSTIC imaging, *ORAL drug administration, *RADIOCHEMICAL purification, *URINE, *POSITRON emission tomography, *NEUROFIBRILLARY tangles

Best Practices in Nuclear Imaging for the Diagnosis of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in KSA: The Eagle Eyes of Local Experts.

Authors: Alqarni, Abdullah¹ (AUTHOR) aoalqarni@psmmc.med.sa, Aljizeeri, Ahmed^2,3,4 (AUTHOR) aljizeeri@yahoo.com, Bakhsh, Aquib Mohammadidrees⁵ (AUTHOR) bakhsh.a2@kamc.med.sa, El-Zeftawy, Hossam Ahmed Maher⁶ (AUTHOR) helzeftawy@kfshrc.edu.sa, Farghaly, Hussein R.¹ (AUTHOR) hfarghaly@psmmc.med.sa, Alqadhi, Mukhtar Ahmed M.⁷ (AUTHOR) maalqadhi@moh.gov.sa, Algarni, Mushref⁸ (AUTHOR) mushref@kfmmc.med.sa, Asiri, Zain Mohammed⁹ (AUTHOR) z.assiri@ksmc.med.sa, Osman, Ahmed¹⁰ (AUTHOR) ahmed.osman3@pfizer.com, Haddadin, Haya¹¹ (AUTHOR) haya.haddadin@pfizer.com, Alayary, Islam¹⁰ (AUTHOR), Al-Mallah, Mouaz H.¹² (AUTHOR) mal-mallah@houstonmethodist.org

Source: Diagnostics (2075-4418). Jan2024, Vol. 14 Issue 2, p212. 12p.

Subject Terms: *CARDIAC magnetic resonance imaging, *TRANSTHYRETIN, *CARDIAC amyloidosis, *MEDICAL personnel, *BEST practices, *CEREBRAL amyloid angiopathy, *DELAYED diagnosis

Geographic Terms: SAUDI Arabia

Can Outpatient Worsening Heart Failure Serve as an Endpoint in Clinical Trials of Transthyretin Amyloidosis?

Authors: Cheng, Richard K.¹ (AUTHOR), Leedy, Douglas¹ (AUTHOR), Ruberg, Frederick L.^1,2 (AUTHOR)

Source: Journal of the American College of Cardiology (JACC). Feb2025, Vol. 85 Issue 7, p762-765. 4p.

Subject Terms: *TRANSTHYRETIN, *HEART failure, *CLINICAL trials, *AMYLOIDOSIS

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy.

Authors: Fontana, M., marianna.fontana@nhs.net, Berk, J. L., Gillmore, J. D., Witteles, R. M., Grogan, M., Drachman, B., Damy, T., Garcia-Pavia, P., Taubel, J., Solomon, S. D., Sheikh, F. H., Tahara, N., Gonzalez-Costello, J., Tsujita, K., Morbach, C., Pozsonyi, Z., Petrie, M. C., Delgado, D., Van der Meer, P., Jabbour, A.

Source: New England Journal of Medicine; 1/2/2025, Vol. 392 Issue 1, p33-44, 12p

Interdisciplinary Multidimensional Assessment of Transthyretin Amyloidosis before and after Tafamidis.

Authors: Pennisi, Manuela¹ (AUTHOR) manuela.pennisi@unict.it, Lanza, Giuseppe^2,3 (AUTHOR) avitello@oasi.en.it, Vitello, Girolamo Aurelio³ (AUTHOR), Faro, Denise Cristiana² (AUTHOR) inemonte@unict.it, Fisicaro, Francesco¹ (AUTHOR) drfrancescofisicaro@gmail.com, Cappellani, Francesco⁴ (AUTHOR) francescocappellani@hotmail.com, Bella, Rita⁵ (AUTHOR) rbella@unict.it, Monte, Ines Paola² (AUTHOR)

Source: Life (2075-1729). Dec2023, Vol. 13 Issue 12, p2305. 9p.

Subject Terms: *TRANSTHYRETIN, *AMYLOIDOSIS, *NEUROLOGICAL disorders, *EARLY diagnosis, *PATHOLOGICAL physiology