ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile.

Authors: Steven E Kauder, Tracy C Kuo, Ons Harrabi, Amy Chen, Emma Sangalang, Laura Doyle, Sony S Rocha, Sangeetha Bollini, Bora Han, Janet Sim, Jaume Pons, Hong I Wan

Source: PLoS ONE, Vol 13, Iss 8, p e0201832 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6104973?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3ebc34039c37468dbf22b9ca99bbcb93

Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

Authors: Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons, Hong I. Wan

Source: Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2020)

Subject Terms: SIRPα, CD47, Macrophage, Phagocytosis, Immunotherapy, Innate immune checkpoint, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/aafee68f22694b6fb3c27f80eac48cb0