Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface

Authors: Shigdel, Uddhav K., Lee, Seung-Joo, Sowa, Mathew E., Bowman, Brian R., Robison, Keith, Zhou, Minyun, Pua, Khian Hong, Stiles, Dylan T., Blodgett, Joshua A. V., Udwary, Daniel W., Rajczewski, Andrew T., Mann, Alan S., Mostafavi, Siavash, Hardy, Tara, Arya, Sukrat, Weng, Zhigang, Stewart, Michelle, Kenyon, Kyle, Morgenstern, Jay P., Pan, Ende, Gray, Daniel C., Pollock, Roy M., Fry, Andrew M., Klausner, Richard D., Townson, Sharon A., Verdine, Gregory L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jul . 117(29), 17195-17203.

Access URL: https://www.jstor.org/stable/26935426

NMR 1H, 13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP

Authors: Sharma, Alok K., Lee, Seung-Joo, Rigby, Alan C., Townson, Sharon A.

Source: Biomolecular NMR assignments. 12(2):269-272

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128746400.0x000001&indx=1&recIds=ETOCvdc_100128746400.0x000001

Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface

Authors: Schmidt, Michael M., Townson, Sharon A., Andreucci, Amy J., King, Bracken M., Schirmer, Emily B., Murillo, Alec J., Dombrowski, Christian, Tisdale, Alison W., Lowden, Patricia A., Masci, Allyson L., Kovalchin, Joseph T., Erbe, David V., Wittrup, K. Dane, Furfine, Eric S., Barnes, Thomas M.

Source: In Structure 5 November 2013 21(11):1966-1978

Design of a superior cytokine antagonist for topical ophthalmic use

Authors: Hou, Jinzhao, Townson, Sharon A., Kovalchin, Joseph T., Masci, Allyson, Kiner, Olga, Shu, Yanqun, King, Bracken M., Schirmer, Emily, Golden, Kathryn, Thomas, Christoph, Garcia, K. Christopher, Zarbis-Papastoitsis, Gregory, Furfine, Eric S., Barnes, Thomas M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Mar 01. 110(10), 3913-3918.

Access URL: https://www.jstor.org/stable/41992296

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

Authors: Townson, Sharon A., Martinez-Hackert, Erik, Greppi, Chloe, Lowden, Patricia, Sako, Dianne, Liu, June, Ucran, Jeffrey A., Liharska, Katia, Underwood, Kathryn W., Seehra, Jasbir, Kumar, Ravindra, Grinberg, Asya V.

Source: In Journal of Biological Chemistry 10 August 2012 287(33):27313-27325

Tu1727 MRT-6160, A VAV1-DIRECTED MOLECULAR GLUE DEGRADER, INHIBITS DISEASE PROGRESSION IN A T-CELL TRANSFER MEDIATED MURINE COLITIS MODEL CONCOMITANT WITH REDUCED CALPROTECTIN EXPRESSION

Authors: Cartwright, Adam N., Desai, Foram, Roditi, Laura, Vora, Shailee, Gyger, Lucas, Nguyen, Sophia, Trouilloud, Alexandra, Lam, Daniel, Trenh, Peter, Lucas, Xavi, Zlotosch, Mary, Liardo, Elisa, Wible, Daric, Oleinikovas, Vladas, Lamberto, Ilaria, Demarco, Bradley, King, Chris, Bonenfant, Debora, Krishnan, Eswar, De Beukelaer, Steven, Townson, Sharon, Wallace, Owen B., Janku, Filip, McAllister, Laura, Paterson, Alison, Peluso, Marisa

Source: In Gastroenterology 18-21 May 2024 166(5) Supplement:S

High-Throughput, Cell-Free, Liposome-Based Approach for Assessing In Vitro Activity of Lipid Kinases

Authors: Demian, Douglas J., Clugston, Susan L., Foster, Meta M., Rameh, Lucia, Sarkes, Deborah, Townson, Sharon A., Yang, Lily, Zhang, Melvin, Charlton, Maura E. ^*

Source: In SLAS Discovery August 2009 14(7):838-844

BstYI Bound to Noncognate DNA Reveals a “Hemispecific” Complex: Implications for DNA Scanning

Authors: Townson, Sharon A., Samuelson, James C., Bao, Yongming, Xu, Shuang-yong, Aggarwal, Aneel K.

Source: In Structure April 2007 15(4):449-459

Implications for Switching Restriction Enzyme Specificities from the Structure of BstYI Bound to a BglII DNA Sequence

Authors: Townson, Sharon A., Samuelson, James C., Xu, Shuang-yong, Aggarwal, Aneel K. ^*

Source: In Structure 2005 13(5):791-801

The Structure and Dynamics of Tandem WW Domains in a Negative Regulator of Notch Signaling, Suppressor of Deltex

Authors: Fedoroff, Oleg Y. ^‡, Townson, Sharon A. ^{‡, §}, Golovanov, Alexander P. ^‡, Baron, Martin ^¶, Avis, Johanna M. ^{‡, ∥}

Source: In Journal of Biological Chemistry 13 August 2004 279(33):34991-35000

Crystal Structure of BstYI at 1.85 Å Resolution: A Thermophilic Restriction Endonuclease with Overlapping Specificities to BamHI and BglII

Authors: Townson, Sharon A., Samuelson, James C., Vanamee, Éva Scheuring, Edwards, Thomas A., Escalante, Carlos R., Xu, Shuang-yong, Aggarwal, Aneel K. ^∗

Source: In Journal of Molecular Biology 2004 338(4):725-733

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NMR ¹H,¹³C, ¹⁵N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp.

Authors: Sharma, Alok K., Lee, Seung-Joo, Zhou, Minyun, Rigby, Alan C., Townson, Sharon A.

Source: Biomolecular NMR Assignments; Apr2019, Vol. 13 Issue 1, p227-231, 5p

Small Molecule-Induced, Selective STAT3 Degradation Leads to Anti-Tumor Activity in STAT3-Dependent Heme Malignancies

Authors: Csibi, Fred ^*, Ji, Nan ^*, Yang, Bin ^*, Yuan, Karen ^*, Mayo, Michele ^*, Rong, Haojing ^*, Rusin, Scott ^*, Sharma, Kirti ^*, Loh, Christine ^*, Li, Henry ^*, Townson, Sharon ^*, Chen, Jesse ^*, Kamadurai, Hari ^*, Walker, Duncan, Gollob, Jared ^*, Mainolfi, Nello ^*

Source: In Blood 13 November 2019 134 Supplement 1:3803-3803

NMR ¹H,¹³C, ¹⁵N backbone and ¹³C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.

Authors: Sharma, Alok K., Lee, Seung-Joo, Rigby, Alan C., Townson, Sharon A.

Source: Biomolecular NMR Assignments; Oct2018, Vol. 12 Issue 2, p269-272, 4p

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Design of a superior cytokine antagonist for topical ophthalmic use.

Authors: Jinzhao Hou, Townson, Sharon A., Kovaichin, Joseph T., Masci, Allyson, Kiner, Olga, Yanqun Shu, King, Bracken M., Schirmer, Emily, Golden, Kathryn, Thomas, Christoph, Garcia, K. Christopher, Zarbis-Papastoitsis, Gregory, Furfine, Eric S., Barnes, Thomas M.

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/5/2013, Vol. 110 Issue 10, p3913-3918, 6p

Subject Terms: RHEUMATOID arthritis, NLRP3 protein, BIOTHERAPY, DRY eye syndromes, CHIMERISM