Investigation of the inhibitory properties of azo-dyes on chorismate synthase from Paracoccidioides brasiliensis.

Authors: Fuchs, Katharina¹ (AUTHOR), Totaro, Massimo G.¹ (AUTHOR), Toplak, Marina¹ (AUTHOR), Bijelic, Aleksandar¹ (AUTHOR), Macheroux, Peter¹ (AUTHOR) peter.macheroux@tugraz.at

Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-14. 14p.

Subject Terms: *PARACOCCIDIOIDES brasiliensis, *COMPUTATIONAL chemistry, *BINDING sites, *PHARMACEUTICAL chemistry, *MOLECULAR docking

Loop 6 and the β‐hairpin flap are structural hotspots that determine cofactor specificity in the FMN‐dependent family of ene‐reductases.

Authors: Kerschbaumer, Bianca¹ (AUTHOR), Totaro, Massimo G.¹ (AUTHOR), Friess, Michael² (AUTHOR), Breinbauer, Rolf² (AUTHOR), Bijelic, Aleksandar¹ (AUTHOR) aleksandar.bijelic@tugraz.at, Macheroux, Peter¹ (AUTHOR) peter.macheroux@tugraz.at

Source: FEBS Journal. Apr2024, Vol. 291 Issue 7, p1560-1574. 15p.

Subject Terms: *COFACTORS (Biochemistry), *FLAVIN mononucleotide, *MOLECULAR dynamics, *CARBON-carbon bonds, *TOMATOES, *COENZYMES, *OXIDOREDUCTASES, *NICOTINAMIDE

ESM‐scan—A tool to guide amino acid substitutions.

Authors: Totaro, Massimo G., Vide, Uršula, Zausinger, Regina, Winkler, Andreas, Oberdorfer, Gustav

Source: Protein Science: A Publication of the Protein Society; Dec2024, Vol. 33 Issue 12, p1-12, 12p

A Novel High-Throughput Nanopore-Sequencing-Based Strategy for Rapid and Automated S-Protein Typing of SARS-CoV-2 Variants.

Authors: Wagner, Gabriel E.¹ (AUTHOR) gabriel.wagner-lichtenegger@medunigraz.at, Totaro, Massimo G.² (AUTHOR) massimo.totaro@tugraz.at, Volland, André³ (AUTHOR) andre.volland@i-med.ac.at, Lipp, Michaela¹ (AUTHOR) sabine.saiger@medunigraz.at, Saiger, Sabine¹ (AUTHOR) sabine.lichtenegger@medunigraz.at, Lichtenegger, Sabine¹ (AUTHOR) patrick.forstner@medunigraz.at, Forstner, Patrick¹ (AUTHOR), von Laer, Dorothee³ (AUTHOR) dorothee.von-laer@i-med.ac.at, Oberdorfer, Gustav² (AUTHOR) gustav.oberdorfer@tugraz.at, Steinmetz, Ivo¹ (AUTHOR) gabriel.wagner-lichtenegger@medunigraz.at

Source: Viruses (1999-4915). Dec2021, Vol. 13 Issue 12, p2548-2548. 1p.

Subject Terms: *SARS-CoV-2, *VITRONECTIN, *NUCLEOTIDE sequencing, *DNA primers, *AMINO acids

Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases.

Authors: Vide, Uršula¹, Kasapović, Dženita¹, Fuchs, Maximilian¹, Heimböck, Martin P.¹, Totaro, Massimo G.¹, Zenzmaier, Elfriede¹, Winkler, Andreas^1,2 andreas.winkler@tugraz.at

Source: Science Advances. 8/4/2023, Vol. 9 Issue 31, p1-14. 14p.

Subject Terms: *CYCLASES, *COFACTORS (Biochemistry), *DNA adducts, *GTPASE-activating protein, *PROTEINS, *NUCLEAR membranes