Management of cytomegalovirus in adult solid organ transplant patients: GESITRA-IC-SEIMC, CIBERINFEC, and SET recommendations update

Authors: Ruiz-Arabi, Elisa ^a, Torre-Cisneros, Julian ^{b, c, ⁎}, Aguilera, Victoria ^d, Alonso, Rodrigo ^e, Berenguer, Marina ^d, Bestard, Oriol ^f, Bodro, Marta ^{g, c}, Cantisán, Sara ^{b, c}, Carratalà, Jordi ^{h, c}, Castón, Juan José ^{b, c}, Cordero, Elisa ^{i, j, c}, Facundo, Carme ^k, Fariñas, María Carmen ^{l, c}, Fernández-Alonso, Mirian ^m, Fernández-Ruiz, Mario ^{n, c}, Fortún, Jesús ^{o, c}, García-Cosío, Maria Dolores ^p, Herrera, Sabina ^g, Iturbe-Fernández, David ^q, Len, Oscar ^{r, c}, López-Medrano, Francisco ^{n, c}, López-Oliva, María Ovidia ^s, Los-Arcos, Ibai ^r, Marcos, María Ángeles ^{t, c}, Martín-Dávila, Pilar ^{o, c}, Monforte, Víctor ^{u, v}, Muñoz, Patricia ^{w, v}, Navarro, David ^{x, c}, Páez-Vega, Aurora ^y, Pérez, Ana Belén ^{z, c}, Redondo, Natalia ^{n, c}, Álvarez R., Rodríguez ^aa, Rodríguez-Benot, Alberto ^ab, Rodríguez-Goncer, Isabel ^{n, c}, San-Juan, Rafael ^{n, c}, Sánchez-Céspedes, Javier ^{i, c}, Valerio, Maricela ^{w, v}, Vaquero, José Manuel ^ac, Viasus, Diego ^ad, Vidal, Elisa ^{b, c}, Aguado, José María ^{c, n, ⁎⁎}

Source: In Transplantation Reviews December 2024 38(4)

Invasive aspergillosis in liver transplant recipients in the current era

Authors: Kimura, Muneyoshi, Rinaldi, Matteo, Kothari, Sagar, Giannella, Maddalena, Anjan, Shweta, Natori, Yoichiro, Phoompoung, Pakpoom, Gault, Emily, Hand, Jonathan, D’Asaro, Matilde, Neofytos, Dionysios, Mueller, Nicolas J., Kremer, Andreas E., Rojko, Tereza, Ribnikar, Marija, Silveira, Fernanda P., Kohl, Joshua, Cano, Angela, Torre-Cisneros, Julian, San-Juan, Rafael, Aguado, Jose Maria, Mansoor, Armaghan-e-Rehman, George, Ige Abraham, Mularoni, Alessandra, Russelli, Giovanna, Luong, Me-Linh, AlJishi, Yamama A., AlJishi, Maram N., Hamandi, Bassem, Selzner, Nazia, Husain, Shahid

Source: In American Journal of Transplantation November 2024 24(11):2092-2107

How can we optimize the diagnostic and therapeutic approach to pneumonia? Expert opinion-based recommendations

Alternate Title: ¿Cómo podemos optimizar el abordaje diagnóstico y terapéutico de la neumonía? Recomendaciones basadas en una opinión de expertos (Spanish; Castilian)

Authors: Fernández-Ruiz, Mario, Castón, Juan José, del Pozo, José Luis, Carratalà, Jordi, Fortún, Jesús, Salavert, Miguel, Torre-Cisneros, Julián, Aguado, José María, Fernández Cruz, Ana, Ventura, Ana, Loeches, Belén, Dueñas, Carlos, Tomás, Cristina, Navarro, David, Oltra, Rosa, Resino-Foz, Elena, García Vázquez, Elisa, Míguez, Enrique, Merino, Esperanza, Braojos, Francisco, Martínez, Francisco Javier, López-Medrano Pérez, Francisco, Machuca, Isabel, Cobo, Javier, López Contreras, Joaquín, Reguera, José María, Ruiz Mesa, Juan Diego, Tiraboschi, Juan, Abella, Lucy, Masiá, Mar, del Toro López, María Dolores, Díaz López, María Dolores, Carrasco-Antón, Nerea, Merchante, Nicolás, Muñoz, Patricia, Torres, Rafael, Rodríguez, Regino, Mata-Forte, Tatiana, Abril, Vicente

Source: In Enfermedades infecciosas y microbiologia clinica (English ed.) October 2024 42(8):442-452

¿Cómo podemos optimizar el abordaje diagnóstico y terapéutico de la neumonía? Recomendaciones basadas en una opinión de expertos

Alternate Title: How can we optimize the diagnostic and therapeutic approach of pneumonia? Expert opinion-based recommendations (English)

Authors: Fernández-Ruiz, Mario, Castón, Juan José, del Pozo, José Luis, Carratalà, Jordi, Fortún, Jesús, Salavert, Miguel, Torre-Cisneros, Julián, Aguado, José María

Source: In Enfermedades Infecciosas y Microbiologia Clinica October 2024 42(8):442-452

QuantiFERON–CMV assay by chemiluminescence immunoassay: Is it more suitable for real-live monitoring of transplant patients?

Authors: Fernández-Moreno, Raquel, Páez-Vega, Aurora, Rodríguez-Cano, Diego, Salinas, Ana, Rodríguez-Cantalejo, Fernando, Jurado, Aurora, Torre-Cisneros, Julián, Cantisán, Sara

Source: In Journal of Clinical Virology April 2024 171

Efficacy of ceftazidime-avibactam in solid organ transplant recipients with bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae

Authors: Paul, Mical, Carratala, Jordi, Oriol, Isabel, Rodríguez-Álvarez, Regino José, Cordero, Elisa, Lepe, José Antonio, de Lucas, Esperanza Merino, Muñoz, Patricia, Fortún, Jesús, Coussement, Julien, Dewispelaere, Laurent, Eriksson, Britt Marie, van Delden, Christian, Manuel, Oriol, Clemente, Wanessa T., Strabelli, Tania Mara Varejão, Pilmis, Benoit, Roilides, Emmanuel, Ranganathan N, Iyer, Grossi, Paolo A., Soldani, Fabio, Rizzi, Marco, Tan, Ban Hock, Lowman, Warren, Gunseren, Filiz, Arslan, Hande, Tufan, Zeliha Koçak, Kazak, Esra, David, Miruna D., Steinke, Seema Mehta, Ostrander, Darin, Avery, Robin, Lease, Erika D., Pérez-Nadales, Elena, Fernández-Ruiz, Mario, Natera, Alejandra M., Gutiérrez-Gutiérrez, Belén, Mularoni, Alessandra, Russelli, Giovanna, Pierrotti, Ligia Camera, Pinheiro Freire, Maristela, Falcone, Marco, Tiseo, Giusy, Tumbarello, Mario, Raffaelli, Francesca, Abdala, Edson, Bodro, Marta, Gervasi, Elena, Fariñas, María Carmen, Seminari, Elena M., Castón, Juan José, Marín-Sanz, Juan Antonio, Gálvez-Soto, Víctor, Rana, Meenakshi M., Loeches, Belén, Martín-Dávila, Pilar, Pascual, Álvaro, Rodríguez-Baño, Jesús, Aguado, José María, Martínez-Martínez, Luis, Torre-Cisneros, Julián

Source: In American Journal of Transplantation July 2023 23(7):1022-1034

Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Authors: de la Serna, Almudena, Monteau, Sophie, Palomo, Virginia, Soriano, Elena, Gutierrez, David, Moreno, Elisa, Palacios, Zaira, Morales, Isabel, Maldonado, Natalia, Ciezar, Antonio Plata, Ruiz Mesa, Juan Diego, Diaz, Beatriz Sobrino, Gomez, Ignacio Marquez, Camacho, Ines Perez, Frutos-Adame, Azahara, Guzman-Puche, Julia, Gracia-Ahufinger, Irene, Perez-Nadales, Elena, Torre-Gimenez, Julian, Pyrpasopoulou, Athina, Iosifidis, Elias, Chorafa, Elsa, Radovanovic, Ivana, Petrovic, Sladjana, Cvetkovi, Slavica, Melentijevic, Srdjan-Sanja, Bicmen, Can, Senol, Gunes, Tubau, Fe, Camara, Jordi, Gumucio, Victor Daniel, Bassoulis, Dimitris, Deliolanis, John, Pitiriga, Vassiliki Ch., Triarides, Nikolaos, Argiti, Efstathia, Legakis, Nikolaos J., Margarita, Kyriakidou, Gijón-Cordero, Desirée, Ruiz-Garbajosa, Patricia, Bartoloni, Alessandro, Rossolini, Gian Maria, Florescu, Simin-Aysel, Nica, Maria, Benea, Serban, Talapan, Daniela, Medić, Deana, Prijić, Sanja Maričić, Caballero, Mireia Cantero, Parra Ramírez, Lina M., Korten, Volkan, Bilgin, Hüseyin, Dalekos, George N., Stefos, Aggelos, Spyridis, Nikolaos, Michos, Athanasios, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Petrosillo, Nicola, Dicaro, Antonio, Landini, Maria Paola, Ciofi degli Atti, Marta Luisa, Masanovic, Mileva, Matkovic, Dusan, Tsiodras, Sotirios, Blasi, Francesco, Di pasquale, Marta, Viscoli, Claudio, Vata, Andrei, Dorneanu, Olivia, Kapisyzi, Perlat, Vince, Adriana, Tsigou, Evdoxia, Maltezos, Efstratios, Komnos, Apostolos, Gogos, Charalampos, Franzetti, Fabio, Antonelli, Massimo, Lupse, Mihaela, Corneci, Dan, Tomescu, Dana, Georgescu, Anca, Bukarica, Ljiljana, Mitrović, Goran, Krstić, Nataša Lukić, Kurti, Arsim, Díaz-Pollán, Beatriz, Sabater, Julia Origüen, Muñoz, Patricia, Azap, Alpay, Sancak, Banu, Sahin, Arife, Akalin, Halis, Pérez-Galera, Salvador, Bravo-Ferrer, Jose M., Paniagua, María, Kostyanev, Tomislav, de Kraker, Marlieke E.A., Feifel, Jan, Sojo-Dorado, Jesús, Schotsman, Joost, Cantón, Rafael, Daikos, George L., Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K., Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Reguera, Jose María, Valiente de Santis, Lucía, Torre-Cisneros, Julián, Cano, Ángela, Roilides, Emmanuel, Radulovic, Lili, Kirakli, Cenk, Shaw, Evelyn, Falagas, Matthew E., Pintado, Vicente, Goossens, Herman, Bonten, Marc J., Gutiérrez-Gutiérrez, Belén, Rodriguez-Baño, Jesús

Source: In eClinicalMedicine March 2023 57

Slaying the "Troll of Transplantation"—new frontiers in cytomegalovirus management: A report from the CMV International Symposium 2023.

Authors: Kotton, Camille N.¹ (AUTHOR) ckotton@mgh.harvard.edu, Torre‐Cisneros, Julian^2,3 (AUTHOR), Yakoub‐Agha, Ibrahim⁴ (AUTHOR), Alain, Sophie⁵ (AUTHOR), Al‐Maghrabi, Reem⁶ (AUTHOR), Beauvais, David⁷ (AUTHOR), Bestard, Oriol⁸ (AUTHOR), Boeken, Udo⁹ (AUTHOR), Blumberg, Emily¹⁰ (AUTHOR), Chemaly, Roy¹¹ (AUTHOR), Desnica, Lana¹² (AUTHOR), Fernández‐Ruiz, Mario¹³ (AUTHOR), Greco, Raffaella¹⁴ (AUTHOR), Grossi, Paolo¹⁵ (AUTHOR), Kamar, Nassim¹⁶ (AUTHOR), Kaminski, Hannah¹⁷ (AUTHOR), Kneidinger, Nikolaus¹⁸ (AUTHOR), Kobbe, Guido¹⁹ (AUTHOR), Malagola, Michele²⁰ (AUTHOR), Martínez‐Muñoz, María E.²¹ (AUTHOR)

Source: Transplant Infectious Disease. Feb2024, Vol. 26 Issue 1, p1-14. 14p.

Subject Terms: *HEMATOPOIETIC stem cell transplantation, *CELLULAR immunity, *CYTOMEGALOVIRUS diseases, *CYTOMEGALOVIRUSES, *CONFERENCES & conventions

Geographic Terms: BARCELONA (Spain)

Impact of ceftazidime/avibactam versus best available therapy on mortality from infections caused by carbapenemase-producing Enterobacterales (CAVICOR study)

Authors: Castón, Juan José, Cano, Angela, Pérez-Camacho, Inés, Aguado, Jose M, Carratalá, Jordi, Ramasco, Fernando, Soriano, Alex, Pintado, Vicente, Castelo-Corral, Laura, Sousa, Adrian, Fariñas, María Carmen, Muñoz, Patricia, Abril López De Medrano, Vicente, Sanz-Peláez, Óscar, Los-Arcos, Ibai, Gracia-Ahufinger, Irene, Pérez-Nadales, Elena, Vidal, Elisa, Doblas, Antonio, Natera, Clara, Martínez-Martínez, Luis, Torre-Cisneros, Julian

Source: Journal of antimicrobial chemotherapy. 77(5):1452-1460

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164171947.0x000001&indx=1&recIds=ETOCvdc_100164171947.0x000001

Proof‑of‑concept study to quantify changes in intestinal loads of KPC-producing Klebsiella pneumoniae in colonised patients following selective digestive decontamination with oral gentamicin

Authors: Pérez-Nadales, Elena, Natera, Alejandra M., Recio-Rufíán, Manuel, Guzmán-Puche, Julia, Cano, Ángela, Frutos-Adame, Azahara, Castón, Juan José, Elías-López, Cristina, Romero-Saldaña, Manuel, López-Cerero, Lorena, Martínez-Martínez, Luis, Torre-Cisneros, Julián

Source: In Journal of Global Antimicrobial Resistance September 2022 30:16-22

Real-World Experience of Imipenem–Relebactam Treatment as Salvage Therapy in Difficult-to-Treat Pseudomonas aeruginosa Infections (IMRECOR Study).

Authors: Machuca, Isabel, Dominguez, Arantxa, Amaya, Rosario, Arjona, Cristina, Gracia-Ahufinger, Irene, Carralon, Maravillas, Giron, Rosa, Gea, Isabel, De Benito, Natividad, Martin, Andres, Galan, Fatima, Martinez, Jose Antonio, Iglesias, Rayden, Revuelto, Jaume, Caston, Juan Jose, Cano, Angela, Ruiz-Arabi, Elisa, Martínez-Martínez, Luis, Torre-Cisneros, Julian

Source: Infectious Diseases & Therapy; Jan2025, Vol. 14 Issue 1, p283-292, 10p

Subject Terms: PSEUDOMONAS aeruginosa infections, MEDICAL sciences, SOFT tissue infections, MEDICAL microbiology, INTENSIVE care patients

Association between rectal colonisation by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae and mortality: a prospective, observational study

Authors: Cano, Ángela, Gutiérrez-Gutiérrez, Belén, Machuca, Isabel, Torre-Giménez, Julián, Frutos-Adame, Azahara, García-Gutiérrez, Manuel, Gallo-Marín, Marina, Gracia-Ahufinger, Irene, Artacho, María J., Natera, Alejandra M., Pérez-Nadales, Elena, Castón, Juan José, Mameli, Sabrina, Gómez-Delgado, Francisco, de la Fuente, Carmen, Salcedo, Inmaculada, Rodríguez-Baño, Jesús, Martínez-Martínez, Luis, Torre-Cisneros, Julián

Source: In Journal of Global Antimicrobial Resistance June 2022 29:476-482

Recommendations for prevention of infection in systemic autoimmune rheumatic diseases

Alternate Title: Recomendaciones SER sobre prevención de infección en enfermedades reumáticas autoinmunes sistémicas (Spanish; Castilian)

Authors: Rúa-Figueroa Fernández de Larrinoa, Íñigo, Carreira, Patricia E., Brito García, Noé, Díaz del Campo Fontecha, Petra, Pego Reigosa, José María, Gómez Puerta, José A., Ortega-Castro, Rafaela, Tejera Segura, Beatriz, Aguado García, José María, Torre-Cisneros, Julián, Valencia-Martín, José L., Pereda, Claudia Alejandra, Nishishinya-Aquino, María Betina, Otón Sánchez, María Teresa, Silva Fernández, Lucía, Maese Manzano, Jesús, Chamizo Carmona, Eugenio, Correyero Plaza, María

Source: In Reumatología clínica (English Edition) June-July 2022 18(6):317-330

Recomendaciones SER sobre prevención de infección en enfermedades reumáticas autoinmunes sistémicas

Alternate Title: Recommendations for prevention of infection in systemic autoimmune rheumatic diseases (English)

Authors: Rúa-Figueroa Fernández de Larrinoa, Íñigo, Carreira, Patricia E., Brito García, Noé, Díaz del Campo Fontecha, Petra, Pego Reigosa, José María, Gómez Puerta, José A., Ortega-Castro, Rafaela, Tejera Segura, Beatriz, Aguado García, José María, Torre-Cisneros, Julián, Valencia-Martín, José L., Pereda, Claudia Alejandra, Nishishinya-Aquino, María Betina, Otón Sánchez, María Teresa, Silva Fernández, Lucía, Maese Manzano, Jesús, Chamizo Carmona, Eugenio, Correyero Plaza, María

Source: In Reumatologia Clinica June-July 2022 18(6):317-330

Seven-versus 14-day course of antibiotics for the treatment of bloodstream infections by Enterobacterales: a randomized, controlled trial

Authors: Solano, Blanca, González-Galán, Verónica, Hinojosa, Esteban, López-Bernal, Francisco, Suñer, Marta, Noval, José Ángel, Giráldez, Álvaro, Navarro, Antonio, Rodríguez-Hernández, María Jesús, Borrego, Yolanda, Gil, Paloma, Lepe, José Antonio, Morales, Isabel, Retamar, Pilar, de Cueto, Marina, Castón, Juan José, Vidal, Elisa, Molina, José, Montero-Mateos, Enrique, Praena-Segovia, Julia, León-Jiménez, Eva, Natera, Clara, López-Cortés, Luis E., Valiente, Lucía, Rosso-Fernández, Clara M., Herrero, Marta, Aller-García, Ana I., Cano, Ángela, Gutiérrez-Gutiérrez, Belén, Márquez-Gómez, Ignacio, Álvarez-Marín, Rocío, Infante, Carmen, Roca, Cristina, Valiente-Méndez, Adoración, Pachón, Jerónimo, Reguera, José María, Corzo-Delgado, Juan Enrique, Torre-Cisneros, Julián, Rodríguez-Baño, Jesús, Cisneros, José Miguel

Source: In Clinical Microbiology and Infection April 2022 28(4):550-557

Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences

Authors: Álvarez-Marín, Rocío, Lepe, José Antonio, Gasch-Blasi, Oriol, Rodríguez-Martínez, José Manuel, Calvo-Montes, Jorge, Lara-Contreras, Rosario, Martín-Gandul, Cecilia, Tubau-Quintano, Fe, Cano-García, María Eliecer, Rodríguez-López, Fernando, Rodríguez-Baño, Jesús, Pujol-Rojo, Miquel, Torre-Cisneros, Julián, Martínez-Martínez, Luis, Pascual-Hernández, Álvaro, Jiménez-Mejías, Manuel E.

Source: In Journal of Global Antimicrobial Resistance June 2021 25:351-358

Oral decontamination with colistin plus neomycin in solid organ transplant recipients colonized by multidrug-resistant Enterobacterales: a multicentre, randomized, controlled, open-label, parallel-group clinical trial

Authors: Armiñanzas, Carlos, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Cuadrado, Antonio, Flor, Virginia, Fábrega, Emilio, Gozalo, Mónica, Illaro, Aitziber, Rodrigo, Emilio, Fernández, Ana, Graus, Javier, Martin Dávil, Pilar, Martínez, Adolfo, Ruiz Garbajosa, Patricia, Sánchez-Díaz, Ana M., Linares, Laura, Cofan, Frederic, Marco, Francesc, Navasa, Miquel, Aranzamendi, Maitane, Blanco, María José, Agnelli Bento, Caroline, Machado, Marina, Olmedo, María, Rincón Sanz, Cristina, Rodríguez Ferrero, María Luisa, Sánchez Cámara, Luis Alberto, Vicente-Rangel, Teresa, Gracia-Ahufinger, Irene, Rodríguez, Fernando, Torre-Cisneros, Julián, Páez Vega, Aurora, Aguadov, José María, Chaves, Fernando, Resino, Elena, Fariñas, Maria Carmen, González-Rico, Claudia, Fernández-Martínez, Marta, Fortún, Jesús, Escudero-Sanchez, Rosa, Moreno, Asunción, Bodro, Marta, Muñoz, Patricia, Valerio, Maricela, Montejo, Miguel, Nieto, Javier, Ruiz-San Millan, Juan Carlos, Casafont-Morencos, Fernando, Martinez-Martínez, Luis, Fariñas-Álvarez, Concepción

Source: In Clinical Microbiology and Infection June 2021 27(6):856-863

Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial

Authors: Bassetti, Matteo, Echols, Roger, Matsunaga, Yuko, Ariyasu, Mari, Doi, Yohei, Ferrer, Ricard, Lodise, Thomas P, Naas, Thierry, Niki, Yoshihito, Paterson, David L, Portsmouth, Simon, Torre-Cisneros, Julian, Toyoizumi, Kiichiro, Wunderink, Richard G, Nagata, Tsutae D ^*

Source: In The Lancet Infectious Diseases February 2021 21(2):226-240

Safety, immunogenicity, and efficacy of a Clostridioides difficile toxoid vaccine candidate: a phase 3 multicentre, observer-blind, randomised, controlled trial

Authors: de Bruyn, Guy ^*, Gordon, David L, Steiner, Theodore, Tambyah, Paul, Cosgrove, Catherine, Martens, Mark, Bassily, Ehab, Chan, Eng-Soon, Patel, Dhaval, Chen, Josh, Torre-Cisneros, Julian, Fernando De Magalhães Francesconi, Carlos, Gesser, Richard, Jeanfreau, Robert, Launay, Odile, Laot, Thelma, Morfin-Otero, Rayo, Oviedo-Orta, Ernesto, Park, Yoon Soo, Piazza, Franco M, Rehm, Christine, Rivas, Enrique, Self, Steve, Gurunathan, Sanjay

Source: In The Lancet Infectious Diseases February 2021 21(2):252-262

Invasive aspergillosis in solid organ transplantation: Diagnostic challenges and differences in outcome in a Spanish national cohort (Diaspersot study)

Authors: Gioia, Francesca, Filigheddu, Eta, Corbella, Laura, Fernández‐Ruiz, Mario, López‐Medrano, Francisco, Pérez‐Ayala, Ana, Aguado, Jose María, Fariñas, Maria Carmen, Arnaiz, Francisco, Calvo, Jorge, Cifrian, Jose Maria, Gonzalez‐Rico, Claudia, Vidal, Elisa, Torre‐Cisneros, Julian, Ras, Maria Mar, Pérez, Sandra, Sabe, Nuria, López‐Soria, Leyre Monica, Rodríguez‐Alvarez, Regino Jose, Montejo, José Miguel, Valerio, Maricela, Machado, Marina, Muñoz, Patricia, Linares, Laura, Bodro, Marta, Moreno, Asuncion, Fernández‐Cruz, Ana, Cantón, Rafael, Moreno, Santiago, Martin‐Davila, Pilar, Fortún, Jesús

Source: Mycoses. 64(11):1334-1345

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132344696.0x000001&indx=1&recIds=ETOCvdc_100132344696.0x000001