Nivolumab with or without ipilimumab in patients with recurrent or metastatic cervical cancer (CheckMate 358): a phase 1–2, open-label, multicohort trial

Authors: Oaknin, Ana ^*, Moore, Kathleen, Meyer, Tim, López-Picazo González, José, Devriese, Lot A, Amin, Asim, Lao, Christopher D, Boni, Valentina, Sharfman, William H, Park, Jong Chul, Tahara, Makoto, Topalian, Suzanne L, Magallanes, Manuel, Molina Alavez, Alejandro, Khan, Tariq Aziz, Copigneaux, Catherine, Lee, Michelle, Garnett-Benson, Charlie, Wang, Xuya, Naumann, R Wendel

Source: In The Lancet Oncology May 2024 25(5):588-602

Circulating cancer-specific CD8 T cell frequency is associated with response to PD-1 blockade in Merkel cell carcinoma

Authors: Pulliam, Thomas, Jani, Saumya, Jing, Lichen, Ryu, Heeju, Jojic, Ana, Shasha, Carolyn, Zhang, Jiajia, Kulikauskas, Rima, Church, Candice, Garnett-Benson, Charlie, Gooley, Ted, Chapuis, Aude, Paulson, Kelly, Smith, Kellie N., Pardoll, Drew M., Newell, Evan W., Koelle, David M., Topalian, Suzanne L., Nghiem, Paul

Source: In Cell Reports Medicine 20 February 2024 5(2)

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

Authors: Topalian, Suzanne L., Sznol, Mario, McDermott, David F., Kluger, Harriet M., Carvajal, Richard D., Sharfman, William H., Brahmer, Julie R., Lawrence, Donald P., Atkins, Michael B., Powderly, John D., Leming, Philip D., Lipson, Evan J., Puzanov, Igor, Smith, David C., Taube, Janis M., Wigginton, Jon M., Kollia, Georgia D., Gupta, Ashok, Pardoll, Drew M., Sosman, Jeffrey A., Hodi, F. Stephen

Source: Journal of clinical oncology. 41(5):943-954

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181430373.0x000001&indx=1&recIds=ETOCvdc_100181430373.0x000001

Neoadjuvant immune checkpoint blockade: A window of opportunity to advance cancer immunotherapy

Authors: Topalian, Suzanne L., Forde, Patrick M., Emens, Leisha A., Yarchoan, Mark, Smith, Kellie N., Pardoll, Drew M.

Source: In Cancer Cell 11 September 2023 41(9):1551-1566

Nivolumab With or Without Ipilimumab in Patients With Recurrent or Metastatic Merkel Cell Carcinoma: A Nonrandomized, Open-Label, International, Multicenter Phase I/II Study.

Authors: Bhatia, Shailender, Topalian, Suzanne L., Sharfman, William, Meyer, Tim, Steven, Neil, Lao, Christopher D., Fariñas-Madrid, Lorena, Devriese, Lot A., Moore, Kathleen, Ferris, Robert L., Honma, Yoshitaka, Elias, Ileana, Srirangam, Anjaiah, Garnett-Benson, Charlie, Lee, Michelle, Nghiem, Paul

Source: Journal of Clinical Oncology; 3/20/2025, Vol. 43 Issue 9, p1137-1147, 13p

A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types.

Authors: Zeng, Zhen, Zhang, Tianbei, Zhang, Jiajia, Li, Shuai, Connor, Sydney, Zhang, Boyang, Zhao, Yimin, Wilson, Jordan, Singh, Dipika, Kulikauskas, Rima, Church, Candice D., Pulliam, Thomas H., Jani, Saumya, Nghiem, Paul, Topalian, Suzanne L., Forde, Patrick M., Pardoll, Drew M., Ji, Hongkai, Smith, Kellie N.

Source: Nature Communications; 2/3/2025, Vol. 16 Issue 1, p1-17, 17p

Subject Terms: TUMOR antigens, MEDICAL sciences, GENE expression, T cells, FUNCTIONAL programming (Computer science), LUNGS

Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma

Authors: Anagnostou, Valsamo, Bruhm, Daniel C., Niknafs, Noushin, White, James R., Shao, Xiaoshan M., Sidhom, John William, Stein, Julie, Tsai, Hua-Ling, Wang, Hao, Belcaid, Zineb, Murray, Joseph, Balan, Archana, Ferreira, Leonardo, Ross-Macdonald, Petra, Wind-Rotolo, Megan, Baras, Alexander S., Taube, Janis, Karchin, Rachel, Scharpf, Robert B., Grasso, Catherine, Ribas, Antoni, Pardoll, Drew M., Topalian, Suzanne L., Velculescu, Victor E.

Source: In Cell Reports Medicine 17 November 2020 1(8)

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

Authors: Grasso, Catherine S., Tsoi, Jennifer, Onyshchenko, Mykola, Abril-Rodriguez, Gabriel, Ross-Macdonald, Petra, Wind-Rotolo, Megan, Champhekar, Ameya, Medina, Egmidio, Torrejon, Davis Y., Shin, Daniel Sanghoon, Tran, Phuong, Kim, Yeon Joo, Puig-Saus, Cristina, Campbell, Katie, Vega-Crespo, Agustin, Quist, Michael, Martignier, Christophe, Luke, Jason J., Wolchok, Jedd D., Johnson, Douglas B., Chmielowski, Bartosz, Hodi, F. Stephen, Bhatia, Shailender, Sharfman, William, Urba, Walter J., Slingluff, Craig L., Jr., Diab, Adi, Haanen, John B.A.G., Algarra, Salvador Martin, Pardoll, Drew M., Anagnostou, Valsamo, Topalian, Suzanne L., Velculescu, Victor E., Speiser, Daniel E., Kalbasi, Anusha, Ribas, Antoni

Source: In Cancer Cell 12 October 2020 38(4):500-515

Cancer Regression and Autoimmunity Induced by Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade in Patients with Metastatic Melanoma

Authors: Phan, Giao Q., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., Restifo, Nicholas P., Haworth, Leah R., Seipp, Claudia A., Freezer, Linda J., Morton, Kathleen E., Mavroukakis, Sharon A., Duray, Paul H., Steinberg, Seth M., Allison, James P., Davis, Thomas A., Rosenberg, Steven A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Jul 01. 100(14), 8372-8377.

Access URL: https://www.jstor.org/stable/3139934

Th17 immune microenvironment in Epstein-Barr virus–negative Hodgkin lymphoma: implications for immunotherapy

Authors: Duffield, Amy S. ^{1, 2, *}, Ascierto, Maria Libera ^{2, 3, *}, Anders, Robert A. ^{1, 2}, Taube, Janis M. ^{2, 4}, Meeker, Alan K. ^{1, 2}, Chen, Shuming ^{2, 5}, McMiller, Tracee L. ^{2, 5}, Phillips, Neil A. ^{2, 5}, Xu, Haiying ^{2, 4}, Ogurtsova, Aleksandra ^{2, 4}, Berger, Alan E. ^{2, 6}, Pardoll, Drew M. ^{2, 3}, Topalian, Suzanne L. ^{2, 5}, Ambinder, Richard F. ^{2, 3}

Source: In Blood Advances 25 July 2017 1(17):1324-1334

Cancer Regression and Autoimmunity in Patients after Clonal Repopulation with Antitumor Lymphocytes

Authors: Dudley, Mark E., Wunderlich, John R., Robbins, Paul F., Yang, James C., Hwu, Patrick, Schwartzentruber, Douglas J., Topalian, Suzanne L., Sherry, Richard, Restifo, Nicholas P., Hubicki, Amy M., Robinson, Michael R., Raffeld, Mark, Duray, Paul, Seipp, Claudia A., Rogers-Freezer, Linda, Morton, Kathleen E., Mavroukakis, Sharon A., White, Donald E., Rosenberg, Steven A.

Source: Science, 2002 Oct . 298(5594), 850-854.

Access URL: https://www.jstor.org/stable/3832666

Cloning Genes Encoding MHC Class II-Restricted Antigens: Mutated CDC27 as a Tumor Antigen

Authors: Wang, Rong-Fu, Wang, Xiang, Atwood, Alicia C., Topalian, Suzanne L., Rosenberg, Steven A.

Source: Science, 1999 May . 284(5418), 1351-1354.

Access URL: https://www.jstor.org/stable/2899093

Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy

Authors: Miller, Natalie, Church, Candice, Fling, Steven, Kulikauskas, Rima, Ramchurren, Nirasha, Shinohara, Michi, Kluger, Harriet, Bhatia, Shailender, Lundgren, Lisa, Cheever, Martin, Topalian, Suzanne, Nghiem, Paul

Source: Journal for immunotherapy of cancer. 6(1):1-9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184626891.0x000001&indx=1&recIds=ETOCvdc_100184626891.0x000001

Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab

Authors: Giraldo, Nicolas, Nguyen, Peter, Engle, Elizabeth, Kaunitz, Genevieve, Cottrell, Tricia, Berry, Sneha, Green, Benjamin, Soni, Abha, Cuda, Jonathan, Stein, Julie, Sunshine, Joel, Succaria, Farah, Xu, Haiying, Ogurtsova, Aleksandra, Danilova, Ludmila, Church, Candice, Miller, Natalie, Fling, Steve, Lundgren, Lisa, Ramchurren, Nirasha, Yearley, Jennifer, Lipson, Evan, Cheever, Mac, Anders, Robert, Nghiem, Paul, Topalian, Suzanne, Taube, Janis

Source: Journal for immunotherapy of cancer. 6(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184070318.0x000001&indx=1&recIds=ETOCvdc_100184070318.0x000001

Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade.

Authors: Chen, Shuming, McMiller, Tracee L., Soni, Abha, Succaria, Farah, Sidhom, John-William, Cappelli, Laura C., Casciola-Rosen, Livia A., Morales, Isaac R., Sankaran, Preethi, Berger, Alan E., Deutsch, Julie Stein, Zhu, Qingfeng C., Anders, Robert A., Hooper, Jody E., Pardoll, Drew M., Lipson, Evan J., Taube, Janis M., Topalian, Suzanne L.

Source: Journal of Translational Medicine; 3/5/2024, Vol. 22 Issue 1, p1-12, 12p

Subject Terms: IMMUNE checkpoint proteins, DRUG side effects, IPILIMUMAB, IMMUNITY, T cell receptors, GENE expression profiling, BIOMARKERS

Antagonists of PD-1 and PD-L1 in Cancer Treatment

Authors: Lipson, Evan J., Forde, Patrick M., Hammers, Hans-Joerg, Emens, Leisha A., Taube, Janis M., Topalian, Suzanne L.

Source: In Seminars in Oncology August 2015 42(4):587-600

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

Authors: Topalian, Suzanne L., Drake, Charles G., Pardoll, Drew M.

Source: In Cancer Cell 13 April 2015 27(4):450-461

Prediction of Response to Immune Checkpoint Inhibitor Therapy Using Early-Time-Point ^1^8F-FDG PET/CT Imaging in Patients with Advanced Melanoma

Authors: Cho, Steve Y., Lipson, Evan J., Im, Hyung-Jun, Rowe, Steven P., Gonzalez, Esther Mena, Blackford, Amanda, Chirindel, Alin, Pardoll, Drew M., Topalian, Suzanne L., Wahl, Richard L.

Source: Journal of nuclear medicine. 58(9):1421-1428

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612790952&indx=1&recIds=ETOCRN612790952

Balance and Imbalance in the Immune System: Life on the Edge

Authors: Topalian, Suzanne L., Sharpe, Arlene H.

Source: In Immunity 20 November 2014 41(5):682-684

Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3

Authors: Deng, Lu, Langley, Ries J., Wang, Qian, Topalian, Suzanne L., Mariuzza, Roy A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Sep 01. 109(37), 14960-14965.

Access URL: https://www.jstor.org/stable/41706328