A broad analysis of resistance development in the malaria parasite

Authors: Victoria C. Corey, Amanda K. Lukens, Eva S. Istvan, Marcus C. S. Lee, Virginia Franco, Pamela Magistrado, Olivia Coburn-Flynn, Tomoyo Sakata-Kato, Olivia Fuchs, Nina F. Gnädig, Greg Goldgof, Maria Linares, Maria G. Gomez-Lorenzo, Cristina De Cózar, Maria Jose Lafuente-Monasterio, Sara Prats, Stephan Meister, Olga Tanaseichuk, Melanie Wree, Yingyao Zhou, Paul A. Willis, Francisco-Javier Gamo, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler

Source: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ce1be14e28304ebdb5d80a44a4d4e3b4

Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents.

Authors: Jian Huang, Yafei Yuan, Na Zhao, Debing Pu, Qingxuan Tang, Shuo Zhang, Shuchen Luo, Xikang Yang, Nan Wang, Yu Xiao, Tuan Zhang, Zhuoyi Liu, Tomoyo Sakata-Kato, Xin Jiang, Nobutaka Kato, Nieng Yan, Hang Yin

Source: Proceedings of the National Academy of Sciences of the United States of America; 1/19/2021, Vol. 118 Issue 3, p1-10, 10p

Subject Terms: ANTIMALARIALS, PLASMODIUM, GLUCOSE transporters, PLASMODIUM falciparum, SMALL molecules

Control of inflammation by stromal Hedgehog pathway activation restrains colitis.

Authors: Diehn, Maximilian, Zimdahl, Bryan, Kawano, Sally, Wan-Jin Lu, Beachy, Philip A., Lee, John J., Kunyoo Shin, Clarke, Michael F., Rothenberg, Michael E., Seeley, E. Scott, Chen, James K., Tomoyo Sakata-Kato

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/22/2016, Vol. 113 Issue 47, pE7545-E7553, 9p

Subject Terms: HEDGEHOG signaling proteins, INFLAMMATORY bowel diseases, COLITIS, INTERLEUKIN-10, COLON cancer

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Authors: Nobutaka Kato, Comer, Eamon, Tomoyo Sakata-Kato, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M., Bittker, Joshua A., Corey, Victoria, Clarke, David, Derbyshire, Emily R., Dornan, Gillian L., Duffy, Sandra, Eckley, Sean, Itoe, Maurice A., Koolen, Karin M. J., Lewis, Timothy A., Lui, Ping S., Lukens, Amanda K.

Source: Nature; 10/20/2016, Vol. 538 Issue 7625, p344-349, 22p, 3 Diagrams, 3 Charts, 8 Graphs

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

Authors: Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Luth, Madeline R., Ottilie, Sabine, Lukens, Amanda K., Sakata-Kato, Tomoyo Sakata-Kato, Vanaerschot, Manu, Owen, Edward, Rodriguez, Juan Carlos Jado, Maher, Steven P., Calla, Jaeson, Plouffe, David, Zhong, Yang, Chen, Kaisheng, Chaumeau, Victor, Conway, Amy J., McNamara, Case W., Ibanez, Maureen, Gagaring, Kerstin

Source: Science; 12/7/2018, Vol. 362 Issue 6419, p1129-1129, 1p, 1 Diagram