Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

Authors: Yumi Tamura, Shun Ohki, Haruna Nagai, Rin Yoshizato, Shizuki Nishi, Yuqi Jin, Yasuo Kitajima, Yun Guo, Tatsuo Ichinohe, Satoshi Okada, Yohei Kawano, Tomoharu Yasuda

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: tumor immunity, CD4+ cytotoxic T cells, leukemia, lymphoma, EB virus, B7-H3, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560383/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a3b30b1ce0b54c78b3547de8a2ab2521

Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten

Authors: Rin Yoshizato, Mariko Miura, Kiyomi Shitaoka, Yuri Matsuoka, Akifumi Higashiura, Akima Yamamoto, Yun Guo, Hitoshi Azuma, Yohei Kawano, Shouichi Ohga, Tomoharu Yasuda

Source: Heliyon, Vol 10, Iss 23, Pp e40837- (2024)

Subject Terms: Monoclonal antibody, Memory B cells, B cell receptor, Single cell, Affinity maturation, IgM, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024168685; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/d9668eb981594ab18c46ba8ed36326df

Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury

Authors: Yun Guo, Shun Ohki, Yohei Kawano, Weng Sheng Kong, Yoshinori Ohno, Hiroaki Honda, Masamoto Kanno, Tomoharu Yasuda

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: iNKT, Eed, H3K27me3, PRC2, liver injury, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1467774/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0d1ac6422def4d47bed843239498ae74

Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants

Authors: Kiyomi Shitaoka, Akifumi Higashiura, Yohei Kawano, Akima Yamamoto, Yoko Mizoguchi, Takao Hashiguchi, Norihisa Nishimichi, Shiyu Huang, Ayano Ito, Shun Ohki, Miyuki Kanda, Tomohiro Taniguchi, Rin Yoshizato, Hitoshi Azuma, Yasuo Kitajima, Yasuyuki Yokosaki, Satoshi Okada, Takemasa Sakaguchi, Tomoharu Yasuda

Source: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/96f2a92e9f1b48ba9b2c8c1e2c571259

Potential role of inducible GPR3 expression under stimulated T cell conditions

Authors: Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 307-314 (2022)

Subject Terms: GPR3, T cell, NR4A2, cAMP, Gαs protein, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861322000056; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/404c9a5e05b5429a86af4e272363a08c

A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse

Authors: Yuma Sugiyama, Tanenobu Harada, Yuka Kamei, Tomoharu Yasuda, Tomoji Mashimo, Akihiko Nishikimi, Mitsuo Maruyama

Source: Experimental Gerontology, Vol 174, Iss , Pp 112130- (2023)

Subject Terms: Aging, p16, Immunotoxin, Immunosenescence, naïve T, SA-T, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0531556523000517; https://doaj.org/toc/1873-6815

Access URL: https://doaj.org/article/17a093493d1b4f5ba33f2b79ac5669ca

Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis

Authors: Shintaro Mise, Akinobu Matsumoto, Keisuke Shimada, Toshiaki Hosaka, Masatomo Takahashi, Kazuya Ichihara, Hideyuki Shimizu, Chisa Shiraishi, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Toru Ide, Yoshihiro Izumi, Takeshi Bamba, Tomomi Kimura-Someya, Mikako Shirouzu, Haruhiko Miyata, Masahito Ikawa, Keiichi I. Nakayama

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3779cfb8e45643108b988769fd650048

Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells

Authors: Tomoharu Yasuda, Yuichi Saito, Chisato Ono, Kazuhiko Kawata, Akemi Baba, Yoshihiro Baba

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c9d7f962546b4556b38d6cddb656c148

A ubiquitin-like protein encoded by the 'noncoding' RNA TINCR promotes keratinocyte proliferation and wound healing

Authors: Akihiro Nita, Akinobu Matsumoto, Ronghao Tang, Chisa Shiraishi, Kazuya Ichihara, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Gaku Tsuji, Masutaka Furue, Bumpei Katayama, Toshiyuki Ozawa, Teruasa Murata, Teruki Dainichi, Kenji Kabashima, Atsushi Hatano, Masaki Matsumoto, Keiichi I. Nakayama

Source: PLoS Genetics, Vol 17, Iss 8 (2021)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341662/?tool=EBI; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/f46a5fce71d54ba5940fbc4265bdbeca

Pathologically Relevant Mouse Models for Epstein–Barr Virus–Associated B Cell Lymphoma

Authors: Shiyu Huang, Tomoharu Yasuda

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: Epstein-Barr virus, B cell lymphoma, immune surveillance, mouse model, lymphoproliferative disease, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.639844/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c197bae4d7864ebfb6317f548b6a9649

Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration

Authors: Yasuo Kitajima, Ryoka Tsukahara, Shohei Nakamoto, Tomoharu Yasuda

Source: Cells, Vol 11, Iss 11, p 1754 (2022)

Subject Terms: muscle regeneration, lymphocytes, myogenic cells, Percoll, CD45 beads, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/11/1754; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/22e3e18c6742405691b1d0d037f47b1b

Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

Authors: Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito, Sho Yamasaki

Source: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f1cf2521c0344d9887bd758bdb76df35

Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis

Authors: Koshi Imami, Tomoharu Yasuda

Source: Bio-Protocol, Vol 9, Iss 8 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://bio-protocol.org/en/bpdetail?id=3215&type=0; https://doaj.org/toc/2331-8325

Access URL: https://doaj.org/article/de3bd2a023034937a3c679f8f358b305

Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.

Authors: Sommermann, Thomas¹ Thomas.Sommermann@mdc-berlin.de, Tomoharu Yasuda¹, Ronen, Jonathan², Wirtz, Tristan¹, Weber, Timm¹, Sack, Ulrike¹, Caeser, Rebecca³, Jingwei Zhang¹, Xun Li¹, Van Trung Chu¹, Jauch, Anna⁴, Unger, Kristian^5,6, Hodson, Daniel J.³, Akalin, Altuna², Rajewsky, Klaus¹ klaus.rajewsky@mdc-berlin.de

Source: Proceedings of the National Academy of Sciences of the United States of America. 6/23/2020, Vol. 117 Issue 25, p1-12. 12p.

Subject Terms: *B cells, *B cell differentiation, *EPSTEIN-Barr virus, *PLASMA cells, *CELL transformation

Mouse model for acute Epstein--Barr virus infection.

Authors: Wirtz, Tristan, Weber, Timm, Sommermann, Thomas, Rajewsky, Klaus, Tomoharu Yasuda, Kracker, Sven

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/29/2016, Vol. 113 Issue 48, p13821-13826, 6p

Subject Terms: EPSTEIN-Barr virus diseases, CELL proliferation, B cells, T cell receptors, LYMPHOPROLIFERATIVE disorders, IMMUNITY

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.

Authors: Derudder, Emmanuel, Herzog, Sebastian, Labi, Verena, Tomoharu Yasuda, Köchert, Karl, Janz, Martin, Villunger, Andreas, Schmidt-Supprian, Marc, Rajewsky, Klaus

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/3/2016, Vol. 113 Issue 18, p5065-5070, 6p

Subject Terms: B cells, NF-kappa B, CELL differentiation, KINASES, TRANSCRIPTION factors

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation.

Authors: Hisaaki Shinohara¹, Behar, Marcelo^2,3, Kentaro Inoue¹, Michio Hiroshima^4,5, Tomoharu Yasuda^6,7, Takeshi Nagashima^1,8, Shuhei Kimura⁹, Hideki Sanjo^6,10, Shiori Maeda⁶, Noriko Yumoto¹, Sewon Ki¹, Shizuo Akira¹¹, Yasushi Sako⁵, Hoffmann, Alexander^2,3, ahoffmann@ucla.edu, Tomohiro Kurosaki^6,12, kurosaki@rcai.riken.jp, Mariko Okada-Hatakeyama¹, marikoh@rcai.riken.jp

Source: Science; 5/16/2014, Vol. 344 Issue 6185, p760-764, 5p

Studying Epstein-Barr Virus Pathologies and Immune Surveillance by Reconstructing EBV Infection in Mice.

Authors: TOMOHARU YASUDA¹ tomoharu.yasuda@mdc-berlin.de, WIRTZ, TRISTAN¹, BAOCHUN ZHANG², WUNDERLICH, THOMAS³, SCHMIDT-SUPPRIAN, MARC⁴, SOMMERMANN, THOMAS^1,3, RAJEWSKY, KLAUS¹ klaus.rajewsky@mdc-berlin.de

Source: Cold Spring Harbor Symposia on Quantitative Biology. 2013, Vol. 78, p259-263. 5p.

Subject Terms: *IMMUNE response, *LABORATORY mice, *B cells, *GENE expression

Dok-1 and Dok-2 are negative regulators of T cell receptor signaling.

Authors: Tomoharu Yasuda¹, Kenji Bundo¹, Ayako Hino², Kazuho Honda³, Akane Inoue¹, Masaki Shirakata¹, Mitsujiro Osawa⁴, Toshiki Tamura⁵, Hideo Nariuchi⁶, Hideaki Oda⁷, Tadashi Yamamoto⁸, Yuji Yamanashi¹

Source: International Immunology. Apr2007, Vol. 19 Issue 4, p487-495. 9p.

Subject Terms: *T cells, *MICE, *THYMUS, *AMINO acids