Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)

Authors: Tomaselli, Daniela, Mautone, Nicola, Mai, Antonello, Rotili, Dante

Source: In European Journal of Medicinal Chemistry 1 December 2020 207

Epigenetic polypharmacology: A new frontier for epi‐drug discovery

Authors: Tomaselli, Daniela, Lucidi, Alessia, Rotili, Dante, Mai, Antonello

Source: Medicinal research reviews. 40(1):190-244

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096273593.0x000001&indx=1&recIds=ETOCvdc_100096273593.0x000001

Epigenetic Metalloenzymes

Authors: Blanquart, Christophe, Linot, Camille, Cartron, Pierre-Francois, Tomaselli, Daniela, Mai, Antonello, Bertrand, Philippe

Source: Current medicinal chemistry. 26(15):2748-2785

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100086247374.0x000001&indx=1&recIds=ETOCvdc_100086247374.0x000001

Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches

Authors: Sabatino, Manuela, Rotili, Dante, Patsilinakos, Alexandros, Forgione, Mariantonietta, Tomaselli, Daniela, Alby, Fréderic, Arimondo, Paola B., Mai, Antonello, Ragno, Rino

Source: Journal of computer-aided molecular design. 32(3):435-458

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104193742.0x000001&indx=1&recIds=ETOCvdc_100104193742.0x000001

Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.

Authors: Pannek, Martin, Alhalabi, Zayan, Tomaselli, Daniela, Menna, Martina, Fiorentino, Francesco, Robaa, Dina, Weyand, Michael, Puhlmann, Maximilian, Tomassi, Stefano, Barreca, Federica, Tafani, Marco, Zaganjor, Elma, Haigis, Marcia C., Sippl, Wolfgang, Rotili, Dante, Mai, Antonello, Steegborn, Clemens

Source: Journal of Medicinal Chemistry; 2/8/2027, Vol. 67 Issue 3, p1843-1860, 18p

Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors

Authors: Milelli, Andrea, Marchetti, Chiara, Turrini, Eleonora, Catanzaro, Elena, Mazzone, Roberta, Tomaselli, Daniela, Fimognari, Carmela, Tumiatti, Vincenzo, Minarini, Anna

Source: In Bioorganic & Medicinal Chemistry Letters 1 April 2018 28(6):1001-1004

Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer.

Authors: Tomaselli, Daniela, Steegborn, Clemens, Mai, Antonello, Rotili, Dante

Source: Frontiers in Oncology; 4/15/2020, p1-7, 7p

Subject Terms: NAD (Coenzyme), TUMOR suppressor proteins, FATTY liver, METABOLIC regulation, METABOLISM, ENZYMES

α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.

Authors: Nocentini, Alessio, Lucidi, Alessia, Perut, Francesca, Massa, Annamaria, Tomaselli, Daniela, Gratteri, Paola, Baldini, Nicola, Rotili, Dante, Mai, Antonello, Supuran, Claudiu T.

Source: ACS Medicinal Chemistry Letters; 2019, Vol. 10 Issue 4, p661-665, 5p

Effect of α‑Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3H)‑ones.

Authors: Nawrozkij, Maxim B., Forgione, Mariantonietta, Yablokov, Alexandre S., Lucidi, Alessia, Tomaselli, Daniela, Patsilinakos, Alexandros, Panella, Cristina, Hailu, Gebremedhin S., Kirillov, Ivan A., Badia, Roger, Riveira-Muñoz, Eva, Crespan, Emmanuele, Armijos Rivera, Jorge I., Cirilli, Roberto, Ragno, Rino, Esté, José A., Maga, Giovanni, Mai, Antonello, Rotili, Dante

Source: Journal of Medicinal Chemistry; 2/24/2019, Vol. 62 Issue 3, p604-621, 18p

Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni(SmSirt2)

Authors: Monaldi, Daria, Rotili, Dante, Lancelot, Julien, Marek, Martin, Wössner, Nathalie, Lucidi, Alessia, Tomaselli, Daniela, Ramos-Morales, Elizabeth, Romier, Christophe, Pierce, Raymond J., Mai, Antonello, Jung, Manfred

Source: Journal of Medicinal Chemistry; October 2019, Vol. 62 Issue: 19 p8733-8759, 27p

Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3H)-ones

Authors: Nawrozkij, Maxim B., Forgione, Mariantonietta, Yablokov, Alexandre S., Lucidi, Alessia, Tomaselli, Daniela, Patsilinakos, Alexandros, Panella, Cristina, Hailu, Gebremedhin S., Kirillov, Ivan A., Badia, Roger, Riveira-Muñoz, Eva, Crespan, Emmanuele, Armijos Rivera, Jorge I., Cirilli, Roberto, Ragno, Rino, Esté, José A., Maga, Giovanni, Mai, Antonello, Rotili, Dante

Source: Journal of Medicinal Chemistry; December 2018, Vol. 62 Issue: 2 p604-621, 18p

Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer.

Authors: Carafa, Vincenzo, Poziello, Angelita, Della Torre, Laura, Giovannelli, Pia, Di Donato, Marzia, Safadeh, Elham, Yu, Zhijun, Baldi, Alfonso, Castoria, Gabriella, Tomaselli, Daniela, Mai, Antonello, Rotili, Dante, Nebbioso, Angela, Altucci, Lucia

Source: International Journal of Molecular Sciences; Nov2019, Vol. 20 Issue 22, p5654-5654, 1p

Subject Terms: CELL cycle regulation, CELL migration inhibition, CELLULAR control mechanisms, SIRTUINS, CELL death, STRUCTURE-activity relationships

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