Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I

Authors: Duarte, Margarida, Ferreira, Cleide, Khandpur, Gurleen Kaur, Flohr, Tamara, Zimmermann, Jannik, Castro, Helena, Herrmann, Johannes M., Morgan, Bruce, Tomás, Ana M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Oct . 118(42), 1-11.

Access URL: https://www.jstor.org/stable/27093483

Covalent Conjugation of Amphotericin B to Hyaluronic Acid: An Injectable Water-Soluble Conjugate with Reduced Toxicity and Anti-Leishmanial Potential

Authors: Silva-Carvalho, Ricardo, Leão, Teresa, Gama, Francisco M., Tomás, Ana M.

Source: Biomacromolecules. 23(3):1169-1182

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632323312&indx=1&recIds=ETOCRN632323312

Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents

Authors: Castro, Helena ^{a, b}, Cruz, Tânia ^{a, b}, de Aguiar Amaral, Patrícia ^c, da Silva Cardoso, Paula ^{c, d}, Alsaffar, Ahmed ^d, Farrell, Patrick ^d, Tomás, Ana M. ^{a, b, e}, Barlow, James W. ^{d, ∗}

Source: In Heliyon March 2020 6(3)

Calcium and magnesium ions modulate the oligomeric state and function of mitochondrial 2-Cys peroxiredoxins in Leishmania parasites

Authors: Morais, Mariana A.B., Giuseppe, Priscila O., Souza, Tatiana A. C.B., Castro, Helena, Honorato, Rodrigo V., Oliveira, Paulo S.L., Netto, Luis E.S. ^**, Tomas, Ana M., Murakami, Mario T.

Source: In Journal of Biological Chemistry 28 April 2017 292(17):7023-7039

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum

Authors: Gómez Pérez, Verónica, García-Hernandez, Raquel, Corpas-López, Victoriano, Tomás, Ana M., Martín-Sanchez, Joaquina, Castanys, Santiago, Gamarro, Francisco

Source: In International Journal for Parasitology: Drugs and Drug Resistance August 2016 6(2):133-139

Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems

Authors: Gaspar, Maria Manuela, Calado, Susana, Pereira, Joana, Ferronha, Helena, Correia, Ivone, Castro, Helena, Tomás, Ana M., Cruz, Maria Eugénia Meirinhos

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine October 2015 11(7):1851-1860

New insights into neutrophil and Leishmania infantum in vitro immune interactions

Authors: Marques, Cláudia S., Passero, Luiz Felipe D., Vale-Gato, Inês, Rodrigues, Armanda, Rodrigues, Olivia Roos, Martins, Catarina, Correia, Ivone, Tomás, Ana M., Alexandre-Pires, Graça, Ferronha, M. Helena, Santos-Gomes, Gabriela M.

Source: In Comparative Immunology, Microbiology and Infectious Diseases June 2015 40:19-29

Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli

Authors: Marani, Mariela M., Perez, Luis O., de Araujo, Alyne Rodrigues, Plácido, Alexandra, Sousa, Carla F., Quelemes, Patrick Veras, Oliveira, Mayara, Gomes-Alves, Ana G., Pueta, Mariana, Gameiro, Paula, Tomás, Ana M., Delerue-Matos, Cristina, Eaton, Peter, Camperi, Silvia A., Basso, Néstor G., de Souza de Almeida Leite, Jose Roberto

Source: Gene. 605:70-80

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100047524128.0x000001&indx=1&recIds=ETOCvdc_100047524128.0x000001

Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum

Authors: Sousa, André F., Gomes-Alves, Ana G., Benítez, Diego, Comini, Marcelo A., Flohé, Leopold, Jaeger, Timo, Passos, Joana, Stuhlmann, Friedrich, Tomás, Ana M., Castro, Helena

Source: In Free Radical Biology and Medicine August 2014 73:229-238

Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum

Authors: Teixeira, Filipa, Castro, Helena, Cruz, Tânia, Tse, Eric, Koldewey, Philipp, Southworth, Daniel R., Tomás, Ana M., Jakob, Ursula

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Feb . 112(7), E616-E624.

Access URL: https://www.jstor.org/stable/26461630

The glyoxalase pathway in protozoan parasites

Authors: Sousa Silva, Marta, Ferreira, António E.N., Gomes, Ricardo, Tomás, Ana M., Ponces Freire, Ana, Cordeiro, Carlos

Source: In International Journal of Medical Microbiology October 2012 302(4-5):225-229

Enlightening the molecular basis of trypanothione specificity in trypanosomatids: Mutagenesis of Leishmania infantum glyoxalase II

Authors: Barata, Lídia, Sousa Silva, Marta, Schuldt, Linda, Ferreira, António E.N., Gomes, Ricardo A., Tomás, Ana M., Weiss, Manfred S., Ponces Freire, Ana, Cordeiro, Carlos

Source: In Experimental Parasitology December 2011 129(4):402-408

Chaperone activation and client binding of a 2-cysteine peroxiredoxin

Authors: Teixeira, Filipa, Tse, Eric, Castro, Helena, Makepeace, Karl A. T., Meinen, Ben A., Borchers, Christoph H., Poole, Leslie B., Bardwell, James C., Tomás, Ana M., Southworth, Daniel R., Jakob, Ursula

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131084266.0x000001&indx=1&recIds=ETOCvdc_100131084266.0x000001

The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival

Authors: Romao, Susana, Castro, Helena, Sousa, Carla, Carvalho, Sandra, Tomás, Ana M.

Source: In International Journal for Parasitology 2009 39(6):703-711

Heme as a source of iron to Leishmania infantum amastigotes

Authors: Carvalho, Sandra, Cruz, Tânia, Santarém, Nuno, Castro, Helena, Costa, Vítor, Tomás, Ana M.

Source: In Acta Tropica 2009 109(2):131-135

Structure–Activity Relationship Studies of 9-Alkylamino-1,2,3,4-tetrahydroacridines against Leishmania (Leishmania) infantum Promastigotes.

Authors: Silva, Carlos F. M., Leão, Teresa, Dias, Filipa, Tomás, Ana M., Pinto, Diana C. G. A., Oliveira, Eduardo F. T., Oliveira, Ana, Fernandes, Pedro A., Silva, Artur M. S.

Source: Pharmaceutics; Feb2023, Vol. 15 Issue 2, p669, 15p

Subject Terms: STRUCTURE-activity relationships, LEISHMANIA, HETEROCYCLIC compounds, NEGLECTED diseases, LEISHMANIASIS, ACRIDINE derivatives, DIAMINES

Cloning, promoter analysis and expression in response to bacterial exposure of sea bass ( Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits

Authors: Nascimento, Diana S., Vale, Ana do, Tomás, Ana M., Zou, Jun, Secombes, Christopher J., dos Santos, Nuno M.S.

Source: In Molecular Immunology 2007 44(9):2277-2291

Two linked genes of Leishmania infantum encode tryparedoxins localised to cytosol and mitochondrion

Authors: Castro, Helena, Sousa, Carla, Novais, Marta, Santos, Marta, Budde, Heike, Cordeiro-da-Silva, Anabela, Flohé, Leopold, Tomás, Ana M.

Source: In Molecular & Biochemical Parasitology 2004 136(2):137-147

Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

Authors: Alves Ana C, Lopes Dinora, Castro Helena, Neto Zoraima, Afonso Ana, Tomás Ana M, Rosário Virgílio D

Source: Malaria Journal, Vol 9, Iss 1, p 135 (2010)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.malariajournal.com/content/9/1/135; https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/1dd107bedb21431991903e8735fa14ba

Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum

Authors: Castro, Helena, Sousa, Carla, Santos, Marta, Cordeiro-da-Silva, Anabela ^*, Flohé, Leopold, Tomás, Ana M ^*

Source: In Free Radical Biology and Medicine 2002 33(11):1552-1562