First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer.

Authors: Shapiro, Roman M., Sheffer, Michal, Booker, Matthew A., Tolstorukov, Michael Y., Birch, Grace C., Sade-Feldman, Moshe, Fang, Jacy, Li, Shuqiang, Lu, Wesley, Ansuinelli, Michela, Dulery, Remy, Tarannum, Mubin, Baginska, Joanna, Dwivedi, Nishant, Kothari, Ashish, Penter, Livius, Abdulhamid, Yasmin Z., Kaplan, Isabel E., Khanhlinh, Dinh, Uppaluri, Ravindra

Source: Journal of Hematology & Oncology; 2/14/2025, Vol. 18 Issue 1, p1-16, 16p

Subject Terms: KILLER cells, HEAD & neck cancer, MEDICAL sciences, T cells, INTERLEUKIN-15

Standards for the classification of pathogenicity of somatic variants in cancer (oncogenicity): Joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC)

Authors: Horak, Peter, Griffith, Malachi, Danos, Arpad M., Pitel, Beth A., Madhavan, Subha, Liu, Xuelu, Chow, Cynthia, Williams, Heather, Carmody, Leigh, Barrow-Laing, Lisa, Rieke, Damian, Kreutzfeldt, Simon, Stenzinger, Albrecht, Tamborero, David, Benary, Manuela, Rajagopal, Padma Sheila, Ida, Cristiane M., Lesmana, Harry, Satgunaseelan, Laveniya, Merker, Jason D., Tolstorukov, Michael Y., Campregher, Paulo Vidal, Warner, Jeremy L., Rao, Shruti, Natesan, Maya, Shen, Haolin, Venstrom, Jeffrey, Roy, Somak, Tao, Kayoko, Kanagal-Shamanna, Rashmi, Xu, Xinjie, Ritter, Deborah I., Pagel, Kym, Krysiak, Kilannin, Dubuc, Adrian, Akkari, Yassmine M., Li, Xuan Shirley, Lee, Jennifer, King, Ian, Raca, Gordana, Wagner, Alex H., Li, Marylin M., Plon, Sharon E., Kulkarni, Shashikant, Griffith, Obi L., Chakravarty, Debyani, Sonkin, Dmitriy

Source: In Genetics in Medicine May 2022 24(5):986-998

Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status

Authors: Ricciuti, Biagio, Arbour, Kathryn C., Lin, Jessica J., Vajdi, Amir, Vokes, Natalie, Hong, Lingzhi, Zhang, Jianjun, Tolstorukov, Michael Y., Li, Yvonne Y., Spurr, Liam F., Cherniack, Andrew D., Recondo, Gonzalo, Lamberti, Giuseppe, Wang, Xinan, Venkatraman, Deepti, Alessi, Joao V., Vaz, Victor R., Rizvi, Hira, Egger, Jacklynn, Plodkowski, Andrew J., Khosrowjerdi, Sara, Digumarthy, Subba, Park, Hyesun, Vaz, Nuno, Nishino, Mizuki, Sholl, Lynette M., Barbie, David, Altan, Mehmet, Heymach, John V., Skoulidis, Ferdinandos, Gainor, Justin F., Hellmann, Matthew D., Awad, Mark M.

Source: In Journal of Thoracic Oncology March 2022 17(3):399-410

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development

Authors: Xie, Yajun, Kuan, Aaron T., Wang, Wengang, Herbert, Zachary T., Mosto, Olivia, Olukoya, Olubusola, Adam, Manal, Vu, Steve, Kim, Minsu, Tran, Diana, Gómez, Nicolás, Charpentier, Claire, Sorour, Ingie, Lacey, Tiara E., Tolstorukov, Michael Y., Sabatini, Bernardo L., Lee, Wei-Chung Allen, Harwell, Corey C.

Source: In Cell Reports 22 February 2022 38(8)

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Authors: Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

Source: In Cell 9 December 2021 184(25):6119-6137

Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis

Authors: Lion, Mattia, Muhire, Brejnev, Namiki, Yuka, Tolstorukov, Michael Y., Oettinger, Marjorie A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Mar 01. 117(10), 5453-5462.

Access URL: https://www.jstor.org/stable/26929258

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Authors: Chakraborty, Abhishek A., Laukka, Tuomas, Myllykoski, Matti, Ringel, Alison E., Booker, Matthew A., Tolstorukov, Michael Y., Meng, Yuzhong Jeff, Meier, Samuel R., Jennings, Rebecca B., Creech, Amanda L., Herbert, Zachary T., McBrayer, Samuel K., Olenchock, Benjamin A., Jaffe, Jacob D., Haigis, Marcia C., Beroukhim, Rameen, Signoretti, Sabina, Koivunen, Peppi, Kaelin, William G.

Source: Science, 2019 Mar . 363(6432), 1217-1222.

Access URL: https://www.jstor.org/stable/26630549

Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes.

Authors: Venkadakrishnan, Varadha Balaji, Presser, Adam G., Singh, Richa, Booker, Matthew A., Traphagen, Nicole A., Weng, Kenny, Voss, Nathaniel C. E., Mahadevan, Navin R., Mizuno, Kei, Puca, Loredana, Idahor, Osasenaga, Ku, Sheng-Yu, Bakht, Martin K., Borah, Ashir A., Herbert, Zachary T., Tolstorukov, Michael Y., Barbie, David A., Rickman, David S., Brown, Myles, Beltran, Himisha

Source: Nature Communications; 8/8/2024, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: CASTRATION-resistant prostate cancer, PROSTATE cancer, NATURAL immunity, HORMONE therapy, DISEASE progression

Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome

Authors: Kaye, Emily G., Booker, Matthew, Kurland, Jesse V., Conicella, Alexander E., Fawzi, Nicolas L., Bulyk, Martha L., Tolstorukov, Michael Y., Larschan, Erica

Source: In Cell Reports 20 March 2018 22(12):3227-3239

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation

Authors: Yoshida, Toshimi, Hu, Yeguang, Zhang, Zhihong, Emmanuel, Akinola O., Galani, Kiriaki, Muhire, Brejnev, Snippert, Hugo J., Williams, Christine J., Tolstorukov, Michael Y., Gounari, Fotini

Source: Genes & development. 33(13/14):763-781

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620772183&indx=1&recIds=ETOCRN620772183

Resolving Heart Regeneration by Replacement Histone Profiling

Authors: Goldman, Joseph Aaron, Kuzu, Guray, Lee, Nutishia, Karasik, Jaclyn, Gemberling, Matthew, Foglia, Matthew J., Karra, Ravi, Dickson, Amy L., Sun, Fei, Tolstorukov, Michael Y., Poss, Kenneth D.

Source: In Developmental Cell 27 February 2017 40(4):392-404

Bioinformatic Analysis of Nucleosome and Histone Variant Positioning

Authors: Mieczkowski, Jakub, Tolstorukov, Michael Y.

Source: Methods in molecular biology. 1832:185-206

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617038297&indx=1&recIds=ETOCRN617038297

Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination

Authors: Pulivarthy, Sandhya R., Lion, Mattia, Kuzu, Guray, Matthews, Adam G. W., Borowsky, Mark L., Morris, John, Kingston, Robert E., Dennis, Jonathan H., Tolstorukov, Michael Y., Oettinger, Marjorie A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Oct . 113(42), E6427-E6436.

Access URL: https://www.jstor.org/stable/26472146

Single‐Assay Profiling of Nucleosome Occupancy and Chromatin Accessibility

Authors: Cook, April, Mieczkowski, Jakub, Tolstorukov, Michael Y.

Source: Current protocols in molecular biology. 120(1):21.34.1-21.34.18

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111785829.0x000001&indx=1&recIds=ETOCvdc_100111785829.0x000001

Widespread changes in nucleosome accessibility without changes in nucleosome occupancy during a rapid transcriptional induction

Authors: Mueller, Britta, Mieczkowski, Jakub, Kundu, Sharmistha, Wang, Peggy, Sadreyev, Ruslan, Tolstorukov, Michael Y., Kingston, Robert E.

Source: Genes & development. 31(5):451-462

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN610869577&indx=1&recIds=ETOCRN610869577

Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP

Authors: Rieder, Leila E., Koreski, Kaitlin P., Boltz, Kara A., Kuzu, Guray, Urban, Jennifer A., Bowman, Sarah K., Zeidman, Anna, Jordan, William T., Tolstorukov, Michael Y., Marzluff, William F.

Source: Genes & development. 31(14):1494-1508

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612858443&indx=1&recIds=ETOCRN612858443

The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

Authors: West, Jason A., Davis, Christopher P., Sunwoo, Hongjae, Simon, Matthew D., Sadreyev, Ruslan I., Wang, Peggy I., Tolstorukov, Michael Y., Kingston, Robert E.

Source: In Molecular Cell 4 September 2014 55(5):791-802

Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters

Authors: Tolstorukov, Michael Y., Sansam, Courtney G., Lu, Ping, Koellhoffer, Edward C., Helming, Katherine C., Alver, Burak H., Tillman, Erik J., Evans, Julia A., Wilson, Boris G., Park, Peter J., Roberts, Charles W. M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jun . 110(25), 10165-10170.

Access URL: https://www.jstor.org/stable/42706161

Histone Variant H2A.Bbd Is Associated with Active Transcription and mRNA Processing in Human Cells

Authors: Tolstorukov, Michael Y., Goldman, Joseph A., Gilbert, Cristele, Ogryzko, Vasily, Kingston, Robert E., Park, Peter J.

Source: In Molecular Cell 24 August 2012 47(4):596-607

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

Authors: The modeENCODE Consortium, Roy, Sushmita, Ernst, Jason, Kharchenko, Peter V., Kheradpour, Pouya, Negre, Nicolas, Eaton, Matthew L., Landolin, Jane M., Bristow, Christopher A., Ma, Lijia, Lin, Michael F., Washietl, Stefan, Arshinoff, Bradley I., Ay, Ferhat, Meyer, Patrick E., Robine, Nicolas, Washington, Nicole L., Di Stefano, Luisa, Berezikov, Eugene, Brown, Christopher D., Candeias, Rogerio, Carlson, Joseph W., Carr, Adrian, Jungreis, Irwin, Marbach, Daniel, Sealfon, Rachel, Tolstorukov, Michael Y., Will, Sebastian, Alekseyenko, Artyom A., Artieri, Carlo, Booth, Benjamin W., Brooks, Angela N., Dai, Qi, Davis, Carrie A., Duff, Michael O., Feng, Xin, Gorchakov, Andrey A., Gu, Tingting, Henikoff, Jorja G., Kapranov, Philipp, Li, Renhua, MacAlpine, Heather K., Malone, John, Minoda, Aki, Nordman, Jared, Okamura, Katsutomo, Perry, Marc, Powell, Sara K., Riddle, Nicole C., Sakai, Akiko, Samsonova, Anastasia, Sandler, Jeremy E., Schwartz, Yuri B., Sher, Noa, Spokony, Rebecca, Sturgill, David, van Baren, Marijke, Wan, Kenneth H., Yang, Li, Yu, Charles, Feingold, Elise, Good, Peter, Guyer, Mark, Lowdon, Rebecca, Ahmad, Kami, Andrews, Justen, Berger, Bonnie, Brenner, Steven E., Brent, Michael R., Cherbas, Lucy, Elgin, Sarah C. R., Gingeras, Thomas R., Grossman, Robert, Hoskins, Roger A., Kaufman, Thomas C., Kent, William, Kuroda, Mitzi I., Orr-Weaver, Terry, Perrimon, Norbert, Pirrotta, Vincenzo, Posakony, James W., Ren, Bing, Russell, Steven, Cherbas, Peter, Graveley, Brenton R., Lewis, Suzanna, Micklem, Gos, Oliver, Brian, Park, Peter J., Celniker, Susan E., Henikoff, Steven, Karpen, Gary H., Lai, Eric C., MacAlpine, David M., Stein, Lincoln D., White, Kevin P., Kellis, Manolis

Source: Science, 2010 Dec . 330(6012), 1787-1797.

Access URL: https://www.jstor.org/stable/40986582