A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research

Authors: Simuni, Tanya ^{*, *}, Chahine, Lana M ^*, Poston, Kathleen, Brumm, Michael, Buracchio, Teresa, Campbell, Michelle, Chowdhury, Sohini, Coffey, Christopher, Concha-Marambio, Luis, Dam, Tien, DiBiaso, Peter, Foroud, Tatiana, Frasier, Mark, Gochanour, Caroline, Jennings, Danna, Kieburtz, Karl, Kopil, Catherine M, Merchant, Kalpana, Mollenhauer, Brit, Montine, Thomas, Nudelman, Kelly, Pagano, Gennaro, Seibyl, John, Sherer, Todd, Singleton, Andrew, Stephenson, Diane, Stern, Matthew, Soto, Claudio, Tanner, Caroline M, Tolosa, Eduardo, Weintraub, Daniel, Xiao, Yuge, Siderowf, Andrew, Dunn, Billy, Marek, Kenneth

Source: In The Lancet Neurology February 2024 23(2):178-190

Cell-free mitochondrial DNA deletions in idiopathic, but not LRRK2, Parkinson's disease

Authors: Puigròs, Margalida, Calderon, Anna, Pérez-Soriano, Alexandra, de Dios, Cristina, Fernández, Manel, Colell, Anna, Martí, Maria-José, Tolosa, Eduardo, Trullas, Ramon

Source: In Neurobiology of Disease November 2022 174

α‐Synuclein Gene Hypomethylation in LRRK2 Parkinson's Disease Patients.

Authors: de Mena, Lorena, Parés, Guillem, Garrido, Alicia, Pilco‐Janeta, Daniel F., Fernández, Manel, Pérez, Jesica, Tolosa, Eduardo, Cámara, Ana, Valldeoriola, Francesc, Ezquerra, Mario, Martí, María‐José, Fernández‐Santiago, Rubén

Source: Movement Disorders; Mar2025, Vol. 40 Issue 3, p550-555, 6p

Salivary ATP13A2 is a potential marker of therapy-induced motor complications and is expressed by inclusions in submandibulary glands in Parkinson ́s disease

Authors: Fernández-Espejo, Emilio, Gavito, Ana L., Suárez, Juan, Tolosa, Eduardo, Vilas, Dolores, Aldecoa, Iban, Berenguer, Joan, Córdoba-Fernández, Antonio, Damas-Hermoso, Fátima, Rodríguez de Fonseca, Fernando

Source: In Clinical Parkinsonism & Related Disorders 2022 7

Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder

Authors: Farmen, Kristine, Nissen, Sara K., Stokholm, Morten G., Iranzo, Alex, Østergaard, Karen, Serradell, Mónica, Otto, Marit, Svendsen, Kristina B., Garrido, Alicia, Vilas, Dolores, Borghammer, Per, Santamaria, Joan, Møller, Arne, Gaig, Carles, Brooks, David J., Tolosa, Eduardo, Pavese, Nicola, Romero-Ramos, Marina

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Mar 01. 118(10), 1-7.

Access URL: https://www.jstor.org/stable/27027544

Consensus on the treatment of dysphagia in Parkinson's disease

Authors: Schindler, Antonio, Pizzorni, Nicole, Cereda, Emanuele, Cosentino, Giuseppe, Avenali, Micol, Montomoli, Cristina, Abbruzzese, Giovanni, Antonini, Angelo, Barbiera, Filippo, Benazzo, Marco, Benarroch, Eduardo, Bertino, Giulia, Clavè, Pere, Cortelli, Pietro, Eleopra, Roberto, Ferrari, Chiara, Hamdy, Shaheen, Huckabee, Maggie-Lee, Lopiano, Leonardo, Marchese-Ragona, Rosario, Masiero, Stefano, Michou, Emilia, Occhini, Antonio, Pacchetti, Claudio, Pfeiffer, Ronald F., Restivo, Domenico A., Rondanelli, Mariangela, Ruoppolo, Giovanni, Sandrini, Giorgio, Schapira, Anthony, Stocchi, Fabrizio, Tolosa, Eduardo, Valentino, Francesca, Zamboni, Mauro, Zangaglia, Roberta, Zappia, Mario, Tassorelli, Cristina, Alfonsi, Enrico

Source: In Journal of the Neurological Sciences 15 November 2021 430

Challenges in the diagnosis of Parkinson's disease

Authors: Tolosa, Eduardo ^*, Garrido, Alicia, Scholz, Sonja W, Poewe, Werner

Source: In The Lancet Neurology May 2021 20(5):385-397

Dysphagia in multiple system atrophy consensus statement on diagnosis, prognosis and treatment

Authors: Calandra-Buonaura, Giovanna, Alfonsi, Enrico, Vignatelli, Luca, Benarroch, Eduardo E., Giannini, Giulia, Iranzo, Alex, Low, Phillip A., Martinelli, Paolo, Provini, Federica, Quinn, Niall, Tolosa, Eduardo, Wenning, Gregor K., Abbruzzese, Giovanni, Bower, Pamela, Antonini, Angelo, Bhatia, Kailash P., Bonavita, Jacopo, Pellecchia, Maria Teresa, Pizzorni, Nicole, Tison, François, Ghorayeb, Imad, Meissner, Wassilios G., Ozawa, Tetsutaro, Pacchetti, Claudio, Pozzi, Nicolò Gabriele, Vicini, Claudio, Schindler, Antonio, Cortelli, Pietro, Kaufmann, Horacio

Source: In Parkinsonism and Related Disorders May 2021 86:124-132

Cuneus atrophy and Parkinsonian phenoconversion in cognitively unimpaired patients with isolated REM sleep behavior disorder.

Authors: Baun, Andreas Myhre, Iranzo, Alex, Terkelsen, Miriam Højholt, Stokholm, Morten Gersel, Stær, Kristian, Serradell, Mónica, Otto, Marit, Svendsen, Kristina Bacher, Garrido, Alicia, Vilas, Dolores, Santamaria, Joan, Møller, Arne, Gaig, Carles, Brooks, David J., Borghammer, Per, Tolosa, Eduardo, Eskildsen, Simon Fristed, Pavese, Nicola

Source: Journal of Neurology; Jan2025, Vol. 272 Issue 1, p1-14, 14p

Cholinergic dysfunction in isolated rapid eye movement sleep behaviour disorder links to impending phenoconversion.

Authors: Terkelsen, Miriam H., Iranzo, Alex, Serradell, Mónica, Baun, Andreas M., Stokholm, Morten G., Danielsen, Erik Hvid, Østergaard, Karen, Otto, Marit, Svendsen, Kristina B., Møller, Mette, Johnsen, Erik L., Garrido, Alicia, Vilas, Dolores, Santamaria, Joan, Møller, Arne, Gaig, Carles, Brooks, David J., Borghammer, Per, Tolosa, Eduardo, Pavese, Nicola

Source: European Journal of Neurology; Dec2024, Vol. 31 Issue 12, p1-10, 10p

Subject Terms: DOPAMINERGIC imaging, RAPID eye movement sleep, LEWY body dementia, SLEEP, POSITRON emission tomography

Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder

Authors: Stær, Kristian, Iranzo, Alex, Stokholm, Morten G., Østergaard, Karen, Serradell, Mónica, Otto, Marit, Svendsen, Kristina B., Garrido, Alicia, Vilas, Dolores, Santamaria, Joan, Møller, Arne, Gaig, Carles, Brooks, David J., Borghammer, Per, Tolosa, Eduardo, Pavese, Nicola

Source: In Parkinsonism and Related Disorders December 2020 81:89-93

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study

Authors: Arnedo, Vanessa, Clark, Adrienne, Fraiser, Mark, Kopil, Catherine, Chowdhury, Sohini, Sherer, Todd, Daegele, Nichole, Casaceli, Cynthia, Dorsey, Ray, Wilson, Renee, Mahes, Sugi, Salerno, Christina, Crawford, Karen, Casalin, Paola, Malferrari, Giulia, Weisz, Mali Gani, Orr-Urtreger, Avi, Montine, Thomas, Baglieri, Chris, Christini, Amanda, Russell, David, Dahodwala, Nabila, Giladi, Nir, Factor, Stewart, Hogarth, Penelope, Standaert, David, Hauser, Robert, Jankovic, Joseph, Saint-Hilaire, Marie, Richard, Irene, Shprecher, David, Fernandez, Hubert, Brockmann, Katrina, Rosenthal, Liana, Barone, Paolo, Espay, Alberto, Rowe, Dominic, Marder, Karen, Santiago, Anthony, Hu, Shu-Ching, Isaacson, Stuart, Corvol, Jean-Christophe, Ruiz Martinez, Javiar, Tolosa, Eduardo, Tai, Yen, Politis, Marios, Smejdir, Debra, Rees, Linda, Williams, Karen, Kausar, Farah, Richardson, Whitney, Willeke, Diana, Peacock, Shawnees, Sommerfeld, Barbara, Freed, Alison, Wakeman, Katrina, Blair, Courtney, Guthrie, Stephanie, Harrell, Leigh, Hunter, Christine, Thomas, Cathi-Ann, James, Raymond, Zimmerman, Grace, Brown, Victoria, Mule, Jennifer, Hilt, Ella, Ribb, Kori, Ainscough, Susan, Wethington, Misty, Ranola, Madelaine, Mejia Santana, Helen, Moreno, Juliana, Raymond, Deborah, Speketer, Krista, Carvajal, Lisbeth, Carvalo, Stephanie, Croitoru, Ioana, Garrido, Alicia, Payne, Laura Marie, Viswanth, Veena, Severt, Lawrence, Facheris, Maurizio, Soares, Holly, Mintun, Mark A., Cedarbaum, Jesse, Taylor, Peggy, Biglan, Kevin, Vandenbroucke, Emily, Haider Sheikh, Zulfiqar, Bingol, Baris, Fischer, Tanya, Sardi, Pablo, Forrat, Remi, Reith, Alastair, Egebjerg, Jan, Ahlberg Hillert, Gabrielle, Saba, Barbara, Min, Chris, Umek, Robert, Mather, Joe, De Santi, Susan, Post, Anke, Boess, Frank, Taylor, Kirsten, Grachev, Igor, Avbersek, Andreja, Muglia, Pierandrea, Merchant, Kaplana, Tauscher, Johannes, Simuni, Tanya ^*, Uribe, Liz, Cho, Hyunkeun Ryan, Caspell-Garcia, Chelsea, Coffey, Christopher S, Siderowf, Andrew, Trojanowski, John Q, Shaw, Leslie M, Seibyl, John, Singleton, Andrew, Toga, Arthur W, Galasko, Doug, Foroud, Tatiana, Tosun, Duygu, Poston, Kathleen, Weintraub, Daniel, Mollenhauer, Brit, Tanner, Caroline M, Kieburtz, Karl, Chahine, Lana M, Reimer, Alyssa, Hutten, Samantha J, Bressman, Susan, Marek, Kenneth

Source: In The Lancet Neurology January 2020 19(1):71-80

Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease

Authors: Podlesniy, Petar, Puigròs, Margalida, Serra, Núria, Fernández-Santiago, Rubén, Ezquerra, Mario, Tolosa, Eduardo, Trullas, Ramon

Source: In EBioMedicine October 2019 48:554-567

Progression of two Progressive Supranuclear Palsy phenotypes with comparable initial disability

Authors: Shoeibi, Ali, Litvan, Irene, Tolosa, Eduardo, Ser, Teodoro del, Lee, Euyhyun

Source: In Parkinsonism and Related Disorders September 2019 66:87-93

Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study

Authors: Pagonabarraga, Javier, Valldeoriola, Francesc, Hernández-Vara, Jorge, Classen, Serge Jauma, Puente, Victor, Pont, Claustre, Caballol, Núria, Tolosa, Eduardo, Bayes, Angels, Campdelacreu, Jaume, de Fàbregues, Oriol, Ávila, Asunción, Calopa, Matilde, Gaig, Carles, Fabregat, Neus, Pastor, Pau, Aguilar, Miquel, Pujol, Montserrat, Sánchez, Almudena, Planellas, Lluís, Ezquerra, Mario, Fernández-Santiago, Rubén, Botta, Teresa, Tartaglia, Gian, Compta, Yaroslau, Dias, Sara P., Giraldo, Darly M., Pérez-Soriano, Alexandra, Muñoz, Esteban, Saura, Josep, Fernández, Manel, Bravo, Paloma, Cámara, Ana, Pulido-Salgado, Marta, Painous, Cèlia, Ríos, José, Martí, María José

Source: In Parkinsonism and Related Disorders August 2019 65:3-12

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

Authors: di Domenico, Angelique, Carola, Giulia, Calatayud, Carles, Pons-Espinal, Meritxell, Muñoz, Juan Pablo, Richaud-Patin, Yvonne, Fernandez-Carasa, Irene, Gut, Marta, Faella, Armida, Parameswaran, Janani, Soriano, Jordi, Ferrer, Isidro, Tolosa, Eduardo, Zorzano, Antonio, Cuervo, Ana Maria, Raya, Angel, Consiglio, Antonella

Source: In Stem Cell Reports 12 February 2019 12(2):213-229

Axial motor clues to identify atypical parkinsonism: A multicentre European cohort study

Authors: Østergaard, Karen, Stamelou, Maria, Tolosa, Eduardo, Kostic, Vladimir S., Cortelli, Pietro, Klockgether, Thomas, Dodel, Richard, Abele, Michael, Meissner, Wassilios, Reichmann, Heinz, Lynch, Tim, Slawek, Jaroslaw, Poewe, Werner, Wenning, Gregor K., Klaus Seppi, Mag, Krismer, Florian, Berg, Daniela, Ferreira, Joaquim, Houlden, Henry, Quinn, Niall P., Widner, Håkan, Gerhard, Alexander, Eggert, Karla Maria, Albanese, Alberto, Sorbo, Francesca del, Barone, Paolo, Pellecchia, Maria T., Bloem, Bas, Borm, Carlijn, Djaldetti, Ruth, Berardelli, Alfredo, Colosimo, Carlo, Berciano, Jose, Traykov, Latchezar, Giladi, Nir, Gurevich, Tanya, Rascol, Olivier, Galitzky, Monique, Gasser, Thomas, Borm, Carlijn D.J.M., Seppi, Klaus, Pellecchia, Maria Teresa, Johnsen, Erik L., Sambati, Luisa, Petrović, Igor, Kostić, Vladimir S., Brožová, Hana, Růžička, Evžen, Marti, Maria Jose, Canesi, Margherita, Post, Bart, Nonnekes, Jorik, Bloem, Bastiaan R.

Source: In Parkinsonism and Related Disorders November 2018 56:33-40

Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder

Authors: Stokholm, Morten Gersel, Iranzo, Alex, Østergaard, Karen, Serradell, Mónica, Otto, Marit, Bacher Svendsen, Kristina, Garrido, Alicia, Vilas, Dolores, Parbo, Peter, Borghammer, Per, Santamaria, Joan, Møller, Arne, Gaig, Carles, Brooks, David J., Tolosa, Eduardo, Pavese, Nicola

Source: In Neurobiology of Disease July 2018 115:9-16

Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder

Authors: Gámez-Valero, Ana, Iranzo, Alex, Serradell, Monica, Vilas, Dolores, Santamaria, Joan, Gaig, Carles, Álvarez, Ramiro, Ariza, Aurelio, Tolosa, Eduardo, Beyer, Katrin

Source: In Parkinsonism and Related Disorders May 2018 50:94-98

Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study

Authors: Stokholm, Morten Gersel, Iranzo, Alex, Østergaard, Karen, Serradell, Mónica, Otto, Marit, Svendsen, Kristina Bacher, Garrido, Alicia, Vilas, Dolores, Borghammer, Per, Santamaria, Joan, Møller, Arne, Gaig, Carles, Brooks, David J, Tolosa, Eduardo, Pavese, Nicola

Source: In The Lancet Neurology October 2017 16(10):789-796