Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist—Synthesis, Characterization, and In Vivo Activity.

Authors: Fuerst, Thomas R.^1,2, tfuerst@umd.edu, Marin, Alexander¹, Jeong, Sarah¹, Kulakova, Liudmila¹, Hlushko, Raman¹, Gorga, Katrina³, Toth, Eric A.¹, Singh, Nevil J.³, Andrianov, Alexander K.¹, tfuerst@umd.edu

Source: Journal of Functional Biomaterials; Jan2025, Vol. 16 Issue 1, p34, 20p

Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs.

Authors: Xiang, Yujiao¹ (AUTHOR), Liu, Jielu¹ (AUTHOR), Nie, Mu¹ (AUTHOR), Nilsson, Gunnar^2,3 (AUTHOR), Säfholm, Jesper^4,5 (AUTHOR), Adner, Mikael^1,6 (AUTHOR) mikael.adner@ki.se

Source: Respiratory Research. 11/29/2024, Vol. 25 Issue 1, p1-11. 11p.

Subject Terms: *TOLL-like receptor agonists, *INFLAMMATORY mediators, *RESPIRATORY organs, *RESPIRATORY syncytial virus, *MAST cells

Generating bat primary and immortalised cell-lines from wing biopsies.

Authors: Alcock, Dominic¹ (AUTHOR), Power, Sarahjane¹ (AUTHOR), Hogg, Bridget² (AUTHOR), Sacchi, Carlotta¹ (AUTHOR), Kacprzyk, Joanna¹ (AUTHOR), McLoughlin, Sarah¹ (AUTHOR), Bertelsen, Mads Frost³ (AUTHOR), Fletcher, Nicola F.⁴ (AUTHOR), O'Riain, Aidan⁴ (AUTHOR), Teeling, Emma C.¹ (AUTHOR) emma.teeling@ucd.ie

Source: Scientific Reports. 11/12/2024, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *TOLL-like receptor agonists, *CELL culture, *CELL lines, *OXIDATIVE stress, *CELLULAR aging

Cosmetically Applicable Soluble Agonists for Toll-like Receptor 2 Produced by Fermentation of Asparagus Extract Supplemented with Skimmed Milk Using Lactobacillus delbrueckii subsp. lactis TL24 Consist of Molecules Larger than 100 kDa and Can Be Stabilized by Lyophilization with Dextrin

Authors: Komatsu, Yasuhiko¹ (AUTHOR) k_matsunaga@snowden.co.jp, Matsunaga, Kanako¹ (AUTHOR)

Source: Molecules. Oct2024, Vol. 29 Issue 19, p4557. 15p.

Subject Terms: *TOLL-like receptor agonists, *LACTOBACILLUS delbrueckii, *LACTIC acid bacteria, *MOLECULAR size, *TIGHT junctions

Impact of Mygalin on Inflammatory Response Induced by Toll-like Receptor 2 Agonists and IFN-γ Activation.

Authors: Del Santos, Nayara¹ (AUTHOR) delsantosnayara@gmail.com, Vázquez-Ramírez, Ricardo² (AUTHOR) ricardo1v@yahoo.com, Mendes, Elizabeth¹ (AUTHOR), Silva Júnior, Pedro Ismael³ (AUTHOR) pisjr@butantna.gov.br, Borges, Monamaris Marques¹ (AUTHOR) delsantosnayara@gmail.com

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10555. 20p.

Subject Terms: *TOLL-like receptor agonists, *MOLECULAR structure, *IMMUNOREGULATION, *MOLECULAR docking, *TRANSCRIPTION factors

GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor.

Authors: Huang, Chenlu^1,2 (AUTHOR), Yang, Xinyu^1,2 (AUTHOR), Li, Huidong² (AUTHOR), Zhang, Li^1,2 (AUTHOR), Guo, Qing^1,2 (AUTHOR), Yu, Qingyu^1,2 (AUTHOR), Wang, Hai^1,2 (AUTHOR), Zhang, Linhua^1,2 (AUTHOR) zhanglinhua@bme.pumc.edu.cn, Zhu, Dunwan^1,2 (AUTHOR) zhudunwan@bme.pumc.edu.cn

Source: Journal of Nanobiotechnology. 9/5/2024, Vol. 22 Issue 1, p1-14. 14p.

Subject Terms: *TOLL-like receptor agonists, *APOPTOSIS, *INDOLEAMINE 2,3-dioxygenase, *IMMUNE checkpoint inhibitors, *PHOTODYNAMIC therapy

The Expression of Toll-like Receptors in Cartilage Endplate Cells: A Role of Toll-like Receptor 2 in Pro-Inflammatory and Pro-Catabolic Gene Expression.

Authors: Mengis, Tamara^1,2 (AUTHOR) florian.brunner@balgrist.ch, Bernhard, Laura^1,2 (AUTHOR) jan.devan@usz.ch, Nüesch, Andrea³ (AUTHOR) a.nuesch@sheffield.ac.uk, Heggli, Irina^1,2,4 (AUTHOR) oliver.distler@usz.ch, Herger, Nick^1,2 (AUTHOR) stefan.dudli@usz.ch, Devan, Jan^1,2 (AUTHOR), Marcus, Roy⁵ (AUTHOR), Laux, Christoph J.⁶ (AUTHOR) christoph.laux@balgrist.ch, Brunner, Florian² (AUTHOR), Farshad, Mazda⁶ (AUTHOR) mazda.farshad@balgrist.ch, Distler, Oliver^1,2 (AUTHOR), Le Maitre, Christine L.³ (AUTHOR) c.lemaitre@sheffield.ac.uk, Dudli, Stefan^1,2 (AUTHOR)

Source: Cells (2073-4409). Sep2024, Vol. 13 Issue 17, p1402. 20p.

Subject Terms: *TOLL-like receptor agonists, *CHRONIC pain, *GENE expression, *LIGANDS (Biochemistry), *TUMOR necrosis factors

An adjuvant formulation containing Toll-like Receptor 7 agonist stimulates protection against morbidity and mortality due to Anaplasma marginale in a highly endemic region of west Africa.

Authors: Futse, James E.¹ (AUTHOR) jefutse@ug.edu.gh, Zumor-Baligi, Songliedong¹ (AUTHOR), Ashiagbor, Charles N. K.¹ (AUTHOR), Noh, Susan M.^2,3,4 (AUTHOR), Fox, Christopher B.^5,6 (AUTHOR), Palmer, Guy H.^4,7 (AUTHOR)

Source: PLoS ONE. 8/29/2024, Vol. 19 Issue 8, p1-12. 12p.

Subject Terms: *TOLL-like receptor agonists, *ANAPLASMA marginale, *PROTOZOAN diseases, *VACCINE effectiveness, *BACTERIAL diseases

Comparative network-based analysis of toll-like receptor agonist, L-pampo signaling pathways in immune and cancer cells.

Authors: Park, Sera¹ (AUTHOR), Kim, Geuntae² (AUTHOR), Choi, Ahyoung¹ (AUTHOR), Kim, Sun^1,3,4 (AUTHOR), Yum, Jung Sun² (AUTHOR), Chun, Eunyoung² (AUTHOR) echun@chamc.co.kr, Shin, Hyunjin¹ (AUTHOR) hyunjin.shin@mogam.re.kr

Source: Scientific Reports. 7/26/2024, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *TOLL-like receptor agonists, *TOLL-like receptors, *CANCER cells, *CELLULAR signal transduction, *GENE expression, *GENE regulatory networks

Vaccine adjuvants for infectious disease in the clinic.

Authors: Goetz, Morgan^1,2 (AUTHOR), Thotathil, Naaz³ (AUTHOR), Zhao, Zongmin⁴ (AUTHOR) zhaozm@uic.edu, Mitragotri, Samir^1,2 (AUTHOR) mitragotri@seas.harvard.edu

Source: Bioengineering & Translational Medicine. Jul2024, Vol. 9 Issue 4, p1-26. 26p.

Subject Terms: *TOLL-like receptor agonists, *VACCINE effectiveness, *GENETIC vectors, *COMMUNICABLE diseases, *IMMUNE response

Company/Entity: UNITED States. Food & Drug Administration

TLR Agonists Modify NK Cell Activation and Increase Its Cytotoxicity in Acute Lymphoblastic Leukemia.

Authors: Gallardo-Zapata, Janet^1,2 (AUTHOR), Pérez-Figueroa, Erandi¹ (AUTHOR), Olivar-López, Víctor³ (AUTHOR), Medina-Sansón, Aurora⁴ (AUTHOR) auroramedina@aol.com.mx, Jiménez-Hernández, Elva⁵ (AUTHOR), Ortega, Enrique⁶ (AUTHOR), Maldonado-Bernal, Carmen¹ (AUTHOR) cmaldobe@yahoo.com

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 13, p7500. 20p.

Subject Terms: *TOLL-like receptor agonists, *MONONUCLEAR leukocytes, *LYMPHOBLASTIC leukemia, *CYTOTOXINS, *ACUTE leukemia, *CHEMOKINE receptors

Trypanocidal and Anti-Inflammatory Effects of Three ent -Kaurane Diterpenoids from Gymnocoronis spilanthoides var. subcordata (Asteraceae).

Authors: Selener, Mariana G.^1,2 (AUTHOR) m.selener@docente.ffyb.uba.ar, Borgo, Jimena^1,2 (AUTHOR) jborgo@docente.ffyb.uba.ar, Sarratea, Maria Belen³ (AUTHOR) mbsarratea@ffyb.uba.ar, Delfino, Maria Alicia⁴ (AUTHOR) madelfino@docente.ffyb.uba.ar, Laurella, Laura C.^1,2 (AUTHOR) c.laurella@docente.ffyb.uba.ar, Cerny, Natacha⁵ (AUTHOR) ncerny@docente.ffyb.uba.ar, Gomez, Jessica⁶ (AUTHOR) jgomez@mendoza-conicet.gob.ar, Coll, Mauro⁶ (AUTHOR) mauro.coll16@gmail.com, Malchiodi, Emilio L.^3,4 (AUTHOR) emalchio@ffyb.uba.ar, Bivona, Augusto E.^3,4 (AUTHOR) aebivona@ffyb.uba.ar, Barrera, Patricia⁶ (AUTHOR) pbarrera@mendoza-conicet.gob.ar, Redko, Flavia C.^1,2 (AUTHOR) fredko@ffyb.uba.ar, Catalán, César A. N.⁷ (AUTHOR) cancatalan@gmail.com, Alberti, Andrés Sánchez^3,5 (AUTHOR) aalberti@ffyb.uba.ar, Sülsen, Valeria P.^1,2 (AUTHOR) aalberti@ffyb.uba.ar

Source: Pharmaceutics. Mar2024, Vol. 16 Issue 3, p415. 20p.

Subject Terms: *DITERPENES, *TOLL-like receptor agonists, *CHAGAS' disease, *ASTERACEAE, *COLUMN chromatography, *DICHLOROMETHANE

Pentraxin-3 is a novel marker for the diagnosis of endometriosis.

Authors: Gercik Arzik, Ilayda¹ (AUTHOR), Saglam, Ceren² (AUTHOR), Giray, Burak³ (AUTHOR) burakgiray@gmail.com, Arzik, Ali Onur¹ (AUTHOR), Purut, Yunus Emre⁴ (AUTHOR), Kahyaoglu, Serkan¹ (AUTHOR)

Source: Journal of Endometriosis & Pelvic Pain Disorders. Mar2025, Vol. 17 Issue 1, p28-32. 5p.

Subject Terms: *TOLL-like receptor agonists, *TUBAL sterilization, *MYELOID cells, *DENDRITIC cells, *ENDOMETRIOSIS

G-protein–coupled estrogen receptor 30 regulation of signaling downstream of protein kinase Cε mediates sex dimorphism in hyaluronan-induced antihyperalgesia.

Authors: Bonet, Ivan J.M.¹ (AUTHOR) ivan.bonet@ucsf.edu, Araldi, Dionéia¹ (AUTHOR) Dioneia.Araldi@ucsf.edu, Khomula, Eugen V.¹ (AUTHOR) Ievgen.Khomula@ucsf.edu, Bogen, Oliver¹ (AUTHOR) oliver.bogen@ucsf.edu, Green, Paul G.^1,2 (AUTHOR) paul.green@ucsf.edu, Levine, Jon D.^1,3 (AUTHOR) Jon.Levine@ucsf.edu

Source: PAIN. Mar2025, Vol. 166 Issue 3, p539-556. 18p.

Subject Terms: *PATTERN perception receptors, *TOLL-like receptor agonists, *SECOND messengers (Biochemistry), *SEXUAL dimorphism, *INFLAMMATORY mediators

Development and Characterization of Biocompatible Cellulose Acetate Substrate for Flexible Electrochemical Biosensors

Authors: Rao, K.T., Gangwar, R., Bhagavathi, K.A., Khatun, S., Sahu, P.K., Rengan, A.K., Subrahmanyam, C., Garlapati, S.K., Vanjari, S.R.K.

Source: IEEE Journal on Flexible Electronics IEEE Flex. Electron. Flexible Electronics, IEEE Journal on. 3(7):312-319 Jul, 2024

Regional immune mechanisms enhance efficacy of an autologous cellular cancer vaccine with intraperitoneal administration.

Authors: Marwedel, Ben¹ (AUTHOR), Medina, Lorél Y.¹ (AUTHOR), De May, Henning² (AUTHOR), Adogla, Joshua E.¹ (AUTHOR), Kennedy, Ellie¹ (AUTHOR), Flores, Erica¹ (AUTHOR), Lim, Eunju¹ (AUTHOR), Adams, Sarah² (AUTHOR), Bartee, Eric¹ (AUTHOR), Serda, Rita E.¹ (AUTHOR) rserda@salud.unm.edu

Source: OncoImmunology. 2024, Vol. 13 Issue 1, p1-15. 15p.

Subject Terms: *TOLL-like receptor agonists, *MYELOID cells, *IMMUNE checkpoint inhibitors, *VACCINE effectiveness, *GASTROINTESTINAL cancer, *DNA mismatch repair

Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade.

Authors: Rwandamuriye, Francois Xavier¹ (AUTHOR), Wang, Tao¹ (AUTHOR), Zhang, Hanfu² (AUTHOR), Elaskalani, Omar¹ (AUTHOR), Kuster, Jorren¹ (AUTHOR), Ye, Xueting¹ (AUTHOR), Vitali, Breana¹ (AUTHOR), Schreurs, Juliët¹ (AUTHOR), Orozco Morales, M. Lizeth¹ (AUTHOR), Norret, Marck² (AUTHOR), Evans, Cameron W.² (AUTHOR), Zemek, Rachael M.¹ (AUTHOR), Iyer, K. Swaminathan² (AUTHOR), Lesterhuis, W. Joost¹ (AUTHOR), Wylie, Ben¹ (AUTHOR) ben.wylie@telethonkids.org.au

Source: OncoImmunology. 2024, Vol. 13 Issue 1, p1-10. 10p.

Subject Terms: *TOLL-like receptor agonists, *IMMUNE checkpoint proteins, *IMMUNOMODULATORS, *TUMOR growth, *TOLL-like receptors

Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer.

Authors: Poinot, Hélène^1,2 (AUTHOR), Dupuychaffray, Eloïse^1,2 (AUTHOR), Arnoux, Grégoire³ (AUTHOR), Alvarez, Montserrat^1,2 (AUTHOR), Tachet, Jérémie^1,2 (AUTHOR), Ezzar, Ounss^1,2 (AUTHOR), Moore, Jonathan⁴ (AUTHOR), Bejuy, Olivia⁵ (AUTHOR), Olesti, Eulalia^1,2 (AUTHOR), Visconti, Gioele^1,2 (AUTHOR), González-Ruiz, Víctor^1,2 (AUTHOR), Rudaz, Serge^1,2 (AUTHOR), Tille, Jean-Christophe⁶ (AUTHOR), Voegel, Clarissa D.⁷ (AUTHOR), Nowak-Sliwinska, Patrycja^1,2,4 (AUTHOR), Bourquin, Carole^1,2,8 (AUTHOR) carole.bourquin@unige.ch, Pommier, Aurélien^1,2 (AUTHOR) p_aurelien15@hotmail.fr

Source: OncoImmunology. 2024, Vol. 13 Issue 1, p1-11. 11p.

Subject Terms: *TOLL-like receptor agonists, *MONONUCLEAR leukocytes, *TUMOR-infiltrating immune cells, *IMMUNE checkpoint inhibitors, *RENAL cell carcinoma

Toll-like receptor 2-mediated ERK activation significantly upregulates interleukin-6 expression in M2-polarized macrophages.

Authors: Jo, Wol Soon¹, Kim, Sung Dae², Jeong, Soo Kyung¹, Oh, Su Jung¹, Baik, Ji Sue¹, Seo, Ji An¹, Baek, Jeong-Hwa¹, Lee, Chang Geun¹, Kang, Young-Rok¹, Jeong, Min Ho³, mhjeong@dau.ac.kr, Park, Moon-Taek¹, mtpark@dirams.re.kr

Source: Turkish Journal of Biochemistry / Turk Biyokimya Dergisi; Dec2024, Vol. 49 Issue 6, p748-756, 9p

Targeting anticancer immunity in melanoma tumour microenvironment: unleashing the potential of adjuvants, drugs, and phytochemicals.

Authors: Wang, Jingping¹ (AUTHOR), Wang, Yaping² (AUTHOR) wyp30480963@163.com, Jiang, Xiaofang² (AUTHOR)

Source: Journal of Drug Targeting. Nov2024, Vol. 32 Issue 9, p1052-1072. 21p.

Subject Terms: *CYTOTOXIC T cells, *TOLL-like receptor agonists, *MYELOID cells, *CANCER cells, *TUMOR microenvironment