Determination of the zebrafish embryo developmental toxicity assessment (ZEDTA) as an alternative non-mammalian approach for the safety assessment of agrochemicals

Authors: Ball, Jonathan S. ^{a, ⁎}, Tochwin, Anna ^a, Winter, Matthew J. ^a, Trznadel, Maciej ^a, Currie, Richard ^b, Wolton, Kathryn ^b, French, Julian M. ^b, Hetheridge, Malcolm J. ^a, Tyler, Charles R. ^a

Source: In Reproductive Toxicology March 2025 132

Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood

Authors: Choi, Min-Kyeung ^{1, ∗}, Cook, Alexander ², Mungikar, Kanak ², Eachus, Helen ^{1, 3}, Tochwin, Anna ¹, Linke, Matthias ², Gerber, Susanne ², Ryu, Soojin ^{1, 4, ∗∗}

Source: In iScience 19 July 2024 27(7)

Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms

Authors: Winter, Matthew J., Pinion, Joseph, Tochwin, Anna, Takesono, Aya, Ball, Jonathan S., Grabowski, Piotr, Metz, Jeremy, Trznadel, Maciej, Tse, Karen, Redfern, Will S., Hetheridge, Malcolm J., Goodfellow, Marc, Randall, Andrew D., Tyler, Charles R.

Source: British journal of pharmacology. 178(13):2671-2689

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127556821.0x000001&indx=1&recIds=ETOCvdc_100127556821.0x000001

Screening for drugs to reduce zebrafish aggression identifies caffeine and sildenafil

Authors: Gutiérrez, Héctor Carreño, Vacca, Irene, Schoenmacker, Gido, Cleal, Madeleine, Tochwin, Anna, O'Connor, Bethan, Young, Andrew M.J., Vasquez, Alejandro Arias, Winter, Matthew J., Parker, Matthew O., Norton, William H.J.

Source: In European Neuropsychopharmacology January 2020 30:17-29

Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish.

Authors: Eachus, Helen, Choi, Min-Kyeung, Tochwin, Anna, Kaspareit, Johanna, Ho, May, Ryu, Soojin

Source: Communications Biology; 4/5/2024, Vol. 7 Issue 1, p1-14, 14p

Subject Terms: DEVELOPMENTAL neurobiology, NEUROGENESIS, BRACHYDANIO, GLUCOCORTICOIDS, GENETIC transcription regulation, NEURAL development

Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation.

Authors: Tochwin, Anna¹ annatoffi.at@gmail.com, El-Betany, Alaa¹ alaaelbetany@gmail.com, Hongyun Tai¹ h.tai@bangor.ac.uk, Kai Yu Chan¹ chu037@bangor.ac.uk, Blackburn, Chester¹ chu230@bangor.ac.uk, Wenxin Wang² wenxin.wang@ucd.ie

Source: Polymers (20734360). Sep2017, Vol. 9 Issue 9, p443. 23p. 2 Color Photographs, 7 Diagrams, 2 Charts, 11 Graphs.

Subject Terms: *THERMORESPONSIVE polymers, *POLYMERIZATION, *POLYETHYLENE glycol, *DISULFIDES, *NUCLEAR magnetic resonance spectroscopy

A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation.

Authors: Winter, Matthew J., Ono, Yosuke, Ball, Jonathan S., Walentinsson, Anna, Michaelsson, Erik, Tochwin, Anna, Scholpp, Steffen, Tyler, Charles R., Rees, Steve, Hetheridge, Malcolm J, Bohlooly-Y, Mohammad

Source: Frontiers in Pharmacology; 4/25/2022, Vol. 13, p1-17, 17p

Subject Terms: BRACHYDANIO, CRISPRS, PHENOTYPES, GENOME editing, GENETIC variation, CARDIOVASCULAR system, ETIOLOGY of diseases, EXOMES

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Biodegradable and Biocompatible PDLLA-PEG1k-PDLLA Diacrylate Macromers: Synthesis, Characterisation and Preparation of Soluble Hyperbranched Polymers and Crosslinked Hydrogels.

Authors: Hughes, Alan, Hongyun Tai, Tochwin, Anna, Wenxin Wang

Source: Processes; 2017, Vol. 5 Issue 2, p18, 17p

Subject Terms: COPOLYMERS, ACRYLATES, HYDROGELS, COLLOIDAL gels, REGENERATIVE medicine

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