Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer

Authors: Luís Nunes, Jakob Mørkved Stenersen, Kushtrim Kryeziu, Tobias Sjöblom, Bengt Glimelius, Ragnhild A. Lothe, Anita Sveen

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)

Subject Terms: CRC, Locoregional, Metastatic, MSS, Survival, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context

Authors: Xiaonan Zhang, Natallia Rameika, Lei Zhong, Verónica Rendo, Margus Veanes, Snehangshu Kundu, Sandro Nuciforo, Jordan Dupuis, Muhammad Al Azhar, Ioanna Tsiara, Pauline Seeburger, Shahed Al Nassralla, Viktor Ljungström, Richard Svensson, Ivaylo Stoimenov, Per Artursson, Markus H. Heim, Daniel Globisch, Tobias Sjöblom

Source: EBioMedicine, Vol 109, Iss , Pp 105368- (2024)

Subject Terms: Loss of heterozygosity, Loss of function, Hepatocellular carcinomas, CYP2D6 and talazoparib, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004043; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/c93831231c574e67b595b2f52334f442

Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography

Authors: Ali Teymur Kahraman, Tomas Fröding, Dimitris Toumpanakis, Christian Jamtheim Gustafsson, Tobias Sjöblom

Source: Heliyon, Vol 10, Iss 19, Pp e38118- (2024)

Subject Terms: Computed tomography pulmonary angiography, Pulmonary embolism, nnU-net, Deep learning, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024141497; https://doaj.org/toc/2405-8440

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Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

Authors: Snehangshu Kundu, Luís Nunes, Jeremy Adler, Lucy Mathot, Ivaylo Stoimenov, Tobias Sjöblom

Source: Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)

Subject Terms: Ephrin signalling, Metastasis, Colorectal cancer, Compartmentalisation assay, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/b87e40cc59cf4203a1ef3a43dd978c0d

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Authors: Xi Lu, Lei Zhong, Emma Lindell, Margus Veanes, Jing Guo, Miao Zhao, Maede Salehi, Fredrik J. Swartling, Xingqi Chen, Tobias Sjöblom, Xiaonan Zhang

Source: Cell Death and Disease, Vol 14, Iss 10, Pp 1-13 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/bfee95fe23424e87b63444b9fffa0168

Automated detection, segmentation and measurement of major vessels and the trachea in CT pulmonary angiography

Authors: Ali T. Kahraman, Tomas Fröding, Dimitrios Toumpanakis, Nataša Sladoje, Tobias Sjöblom

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ee70ec89a31740dc8048c7bbbd6d34b3

Next generation pan-cancer blood proteome profiling using proximity extension assay

Authors: María Bueno Álvez, Fredrik Edfors, Kalle von Feilitzen, Martin Zwahlen, Adil Mardinoglu, Per-Henrik Edqvist, Tobias Sjöblom, Emma Lundin, Natallia Rameika, Gunilla Enblad, Henrik Lindman, Martin Höglund, Göran Hesselager, Karin Stålberg, Malin Enblad, Oscar E. Simonson, Michael Häggman, Tomas Axelsson, Mikael Åberg, Jessica Nordlund, Wen Zhong, Max Karlsson, Ulf Gyllensten, Fredrik Ponten, Linn Fagerberg, Mathias Uhlén

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/79c8c836701a4495bc528c7ba433a269

An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancersResearch in context

Authors: Artur Mezheyeuski, Max Backman, Johanna Mattsson, Alfonso Martín-Bernabé, Chatarina Larsson, Ina Hrynchyk, Klara Hammarström, Simon Ström, Joakim Ekström, Siarhei Mauchanski, Salome Khelashvili, Amanda Lindberg, Margrét Agnarsdóttir, Per-Henrik Edqvist, Jutta Huvila, Ulrika Segersten, Per-Uno Malmström, Johan Botling, Björn Nodin, Charlotta Hedner, David Borg, Jenny Brändstedt, Hanna Sartor, Karin Leandersson, Bengt Glimelius, Anna Portyanko, Fredrik Ponten, Karin Jirström, Patrick Micke, Tobias Sjöblom

Source: EBioMedicine, Vol 88, Iss , Pp 104452- (2023)

Subject Terms: Tumour immunology, Macrophages, Immunoscore, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423000178; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/21d6bb4dde9a4bcc8ada77b8353d03fb

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Authors: Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Louis P. Conway, Veronica Rendo, Per Artursson, Liqun He, Daniel Globisch, Tobias Sjöblom

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)

Subject Terms: Ras pathway, KRAS, BRAF, Colorectal cancer, Isogenic cell models, Integrative -omics analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/c6b41f70605140fe8ae77d5c5efb4251

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Authors: Veronica Rendo, Snehangshu Kundu, Natallia Rameika, Viktor Ljungström, Richard Svensson, Kimmo Palin, Lauri Aaltonen, Ivaylo Stoimenov, Tobias Sjöblom

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0075eeada5c6431e9aaae378bc12e7b8

KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer

Authors: Emerik Osterlund, Ari Ristimäki, Soili Kytölä, Teijo Kuopio, Eetu Heervä, Timo Muhonen, Päivi Halonen, Raija Kallio, Leena-Maija Soveri, Jari Sundström, Mauri Keinänen, Annika Ålgars, Raija Ristamäki, Halfdan Sorbye, Per Pfeiffer, Luís Nunes, Tapio Salminen, Annamarja Lamminmäki, Markus J. Mäkinen, Tobias Sjöblom, Helena Isoniemi, Bengt Glimelius, Pia Osterlund

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: colorectal cancer, metastatic, KRAS mutation, KRAS-G12C mutation, population-based, real-world, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.826073/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/decb120b6a4a470ea68f4e7d8f7c7d6d

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Authors: Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom

Source: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f0524ece03f240dd980cb46a0462a392

Targeting tumor vulnerabilities associated with loss of heterozygosity

Authors: Veronica Rendo, Ivaylo Stoimenov, Tobias Sjöblom

Source: Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)

Subject Terms: loh, nat2, colorectal cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2372-3556

Access URL: https://doaj.org/article/f26f6a1f8d8642699b7d0821aa9737a7

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Authors: Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Narendra Padhan, Jimmy Larsson, Maria Karoutsou, Kenneth Ban, Jacek R. Wiśniewski, Per Artursson, Liqun He, Mats Hellström, Tobias Sjöblom

Source: Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)

Subject Terms: Forward genetics, piggyBac transposon, Colorectal cancer, Ras pathway, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-017-0511-4; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/e59e8395c9b944bfa4183f634a16c9e7

Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition

Authors: Chatarina Larsson, Muhammad Akhtar Ali, Tatjana Pandzic, Anders M. Lindroth, Liqun He, Tobias Sjöblom

Source: BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)

Subject Terms: Cancer, DIP2C, Gene knockout, rAAV-mediated gene targeting, Tumour cell biology, DNA methylation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-017-3472-5; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/ddac88b976794771a048274bda4d2f3e

Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy

Authors: Malte Kühnemund, Qingshan Wei, Evangelia Darai, Yingjie Wang, Iván Hernández-Neuta, Zhao Yang, Derek Tseng, Annika Ahlford, Lucy Mathot, Tobias Sjöblom, Aydogan Ozcan, Mats Nilsson

Source: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/747627d1b30b4d9285a595720e9b3738

Author Correction: Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort

Authors: Argyri Mathioudaki, Viktor Ljungström, Malin Melin, Maja Louise Arendt, Jessika Nordin, Åsa Karlsson, Eva Murén, Pushpa Saksena, Jennifer R. S. Meadows, Voichita D. Marinescu, Tobias Sjöblom, Kerstin Lindblad-Toh

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/05a9286da6e546c984a1841ce12545d4

Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Authors: Xiaonan Zhang, Tobias Sjöblom

Source: Pharmaceuticals, Vol 14, Iss 1, p 57 (2021)

Subject Terms: loss of heterozygosity, cancer therapy, drug development and cancer evolution, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/1/57; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/5fc967f65f7f455c802a5e5b55af07aa

Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers.

Authors: Sara Kiflemariam, Sandra Andersson, Anna Asplund, Fredrik Pontén, Tobias Sjöblom

Source: PLoS ONE, Vol 7, Iss 3, p e32927 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3297615?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/88615485cd804e50b38d3c169bb1f8b2

Automated genotyping of biobank samples by multiplex amplification of insertion/deletion polymorphisms.

Authors: Lucy Mathot, Elin Falk-Sörqvist, Lotte Moens, Marie Allen, Tobias Sjöblom, Mats Nilsson

Source: PLoS ONE, Vol 7, Iss 12, p e52750 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3531329?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5d24bdfaa5924118bff84355a2d603f6