Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank

Authors: Beynon, Rhona A., Saunders, Fiona R., Ebsim, Raja, Frysz, Monika, Faber, Benjamin G., Gregory, Jennifer S., Lindner, Claudia, Sarmanova, Aliya, Aspden, Richard M., Harvey, Nicholas C., Cootes, Timothy, Tobias, Jonathan H.

Source: In Osteoarthritis and Cartilage Open June 2024 6(2)

Automatic Segmentation of Hip Osteophytes in DXA Scans Using U-Nets
25th Medical image computing and computer-assisted intervention International conference, MICCAI

Authors: Ebsim, Raja, Faber, Benjamin G., Saunders, Fiona, Frysz, Monika, Gregory, Jenny, Harvey, Nicholas C., Tobias, Jonathan H., Lindner, Claudia, Cootes, Timothy F.

Source: Lecture notes in computer science. 13435:3-12

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Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization

Authors: Zheng, Jie, Wheeler, Eleanor, Pietzner, Maik, Andlauer, Till F. M., Yau, Michelle S., Hartley, April E., Brumpton, Ben Michael, Rasheed, Humaira, Kemp, John P., Frysz, Monika, Robinson, Jamie, Reppe, Sjur, Prijatelj, Vid, Gautvik, Kaare M., Falk, Louise, Maerz, Winfried, Gergei, Ingrid, Peyser, Patricia A., Kavousi, Maryam, Vries, Paul S., Miller, Clint L., Bos, Maxime, Laan, Sander W., Malhotra, Rajeev, Herrmann, Markus, Scharnagl, Hubert, Kleber, Marcus, Dedoussis, George, Zeggini, Eleftheria, Nethander, Maria, Ohlsson, Claes, Lorentzon, Mattias, Wareham, Nick, Langenberg, Claudia, Holmes, Michael V., Davey Smith, George, Tobias, Jonathan H.

Source: Arthritis & rheumatology. 75(10):1781-1792

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Rare and Common Variants in GALNT3 May Affect Bone Mass Independently of Phosphate Metabolism

Authors: Hassan, Neelam, Gregson, Celia L., Tang, Haotian, Kamp, Marc, Leo, Paul, McInerney‐Leo, Aideen M., Zheng, Jie, Brandi, Maria Luisa, Tang, Jonathan C. Y., Fraser, William, Stone, Michael D., Grundberg, Elin, Brown, Matthew A., Duncan, Emma L., Tobias, Jonathan H.

Source: Journal of bone and mineral research. 38(5):678-691

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186842999.0x000001&indx=1&recIds=ETOCvdc_100186842999.0x000001

A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults

Authors: Faber, Benjamin G., Frysz, Monika, Hartley, April E., Ebsim, Raja, Boer, Cindy G., Saunders, Fiona R., Gregory, Jennifer S., Aspden, Richard M., Harvey, Nicholas C., Southam, Lorraine, Giles, William, Le Maitre, Christine L., Wilkinson, J. Mark, Meurs, Joyce B. J., Zeggini, Eleftheria, Cootes, Timothy, Lindner, Claudia, Kemp, John P., Davey Smith, George, Tobias, Jonathan H.

Source: Arthritis & rheumatology. 75(6):900-909

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The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses

Authors: Faber, Benjamin G., Frysz, Monika, Boer, Cindy G., Evans, Daniel S., Ebsim, Raja, Flynn, Kaitlyn A., Lundberg, Mischa, Southam, Lorraine, Hartley, April, Saunders, Fiona R., Lindner, Claudia, Gregory, Jennifer S., Aspden, Richard M., Lane, Nancy E., Harvey, Nicholas C., Evans, David M., Zeggini, Eleftheria, Davey Smith, George, Cootes, Timothy, Van Meurs, Joyce, Kemp, John P., Tobias, Jonathan H.

Source: In eBioMedicine September 2023 95

Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis

Authors: Zheng, Jiayi ^#, Frysz, Monika ^{†, ‡}, Faber, Benjamin G. ^{†, ‡}, Lin, Huandong ^{§, ¶}, Ebsim, Raja ^∥, Ge, Jieyu ^#, Yong, Yanling ^##, Saunders, Fiona R. ^††, Gregory, Jennifer S. ^††, Aspden, Richard M. ^††, Harvey, Nicholas C. ^{‡‡, §§}, Jiang, Bing-Hua ^##, Cootes, Timothy ^∥, Lindner, Claudia ^∥, Gao, Xin ^{§, ¶, *}, Wang, Sijia ^{#, **}, Tobias, Jonathan H. ^{†, ‡, ***}

Source: In Osteoarthritis and Cartilage October 2023

Telomere Length and Risk of Incident Fracture and Arthroplasty: Findings From UK Biobank

Authors: Curtis, Elizabeth M., Codd, Veryan, Nelson, Christopher, D'Angelo, Stefania, Wang, Qingning, Allara, Elias, Kaptoge, Stephen, Matthews, Paul M., Tobias, Jonathan H., Danesh, John, Cooper, Cyrus, Samani, Nilesh J., Harvey, Nicholas C.

Source: Journal of bone and mineral research. 37(10):1997-2004

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The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.

Authors: Faber, Benjamin G, Frysz, Monika, Zheng, Jaiyi, Lin, Huandong, Flynn, Kaitlyn A, Ebsim, Raja, Saunders, Fiona R, Beynon, Rhona, Gregory, Jennifer S, Aspden, Richard M, Harvey, Nicholas C, Lindner, Claudia, Cootes, Timothy, Evans, David M, Smith, George Davey, Gao, Xin, Wang, Sijia, Kemp, John P, Tobias, Jonathan H

Source: Human Molecular Genetics; Feb2025, Vol. 34 Issue 3, p207-217, 11p

Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank

Authors: Faber, Benjamin G., Ebsim, Raja, Saunders, Fiona R., Frysz, Monika, Lindner, Claudia, Gregory, Jennifer S., Aspden, Richard M., Harvey, Nicholas C., Smith, George Davey, Cootes, Timothy, Tobias, Jonathan H.

Source: In Bone December 2021 153

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Authors: Loughlin, John, Arden, Nigel, Birrell, Fraser, Carr, Andrew, Deloukas, Panos, Doherty, Michael, McCaskie, Andrew W., Ollier, William E.R., Rai, Ashok, Ralston, Stuart H., Spector, Tim D., Wallis, Gillian A., Martinsen, Amy E., Willer, Cristen, Fors, Egil Andreas, Mundal, Ingunn, Hagen, Knut, Nilsen, Kristian Bernhard, Lie, Marie Udnesseter, Børte, Sigrid, Brumpton, Ben, Nielsen, Jonas Bille, Fritsche, Lars G., Zhou, Wei, Heuch, Ingrid, Storheim, Kjersti, Tyrpenou, Evangelos, Koukakis, Athanasios, Chytas, Dimitrios, Evangelopoulos, Dimitrios Stergios, Efstathios, Chronopoulos, Pneumaticos, Spiros, Nikolaou, Vasileios S., Malizos, Konstantinos, Anastasopoulou, Lydia, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Deubler, Andrew, Economides, Aris, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Karalis, Katia, Siminovitch, Katherine, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Bai, Xiaodong, Balasubramanian, Suganthi, Boutkov, Boris, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Krasheninina, Olga, Lanche, Rouel, Mansfield, Adam J., Maxwell, Evan K., Nafde, Mona, O’Keeffe, Sean, Orelus, Max, Panea, Razvan, Polanco, Tommy, Rasool, Ayesha, Salerno, William, Staples, Jeffrey C., Li, Dadong, Sharma, Deepika, Banerjee, Ilanjana, Bovijn, Jonas, Locke, Adam, Verweij, Niek, Haas, Mary, Hindy, George, De, Tanima, Akbari, Parsa, Sosina, Olukayode, Ferreira, Manuel A.R., Jones, Marcus B., Mighty, Jason, LeBlanc, Michelle G., Mitnaul, Lyndon J., Boer, Cindy G., Hatzikotoulas, Konstantinos, Southam, Lorraine, Stefánsdóttir, Lilja, Zhang, Yanfei, Coutinho de Almeida, Rodrigo, Wu, Tian T., Zheng, Jie, Hartley, April, Teder-Laving, Maris, Skogholt, Anne Heidi, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Barysenka, Andrei, Bjornsdottir, Gyda, Gabrielsen, Maiken E., Gilly, Arthur, Ingvarsson, Thorvaldur, Johnsen, Marianne B., Jonsson, Helgi, Kloppenburg, Margreet, Luetge, Almut, Lund, Sigrun H., Mägi, Reedik, Mangino, Massimo, Nelissen, Rob R.G.H.H., Shivakumar, Manu, Steinberg, Julia, Takuwa, Hiroshi, Thomas, Laurent F., Tuerlings, Margo, Babis, George C., Cheung, Jason Pui Yin, Kang, Jae Hee, Kraft, Peter, Lietman, Steven A., Samartzis, Dino, Slagboom, P. Eline, Stefansson, Kari, Thorsteinsdottir, Unnur, Tobias, Jonathan H., Uitterlinden, André G., Winsvold, Bendik, Zwart, John-Anker, Davey Smith, George, Sham, Pak Chung, Thorleifsson, Gudmar, Gaunt, Tom R., Morris, Andrew P., Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Ikegawa, Shiro, Hveem, Kristian, Esko, Tõnu, Wilkinson, J. Mark, Meulenbelt, Ingrid, Lee, Ming Ta Michael, van Meurs, Joyce B.J., Styrkársdóttir, Unnur, Zeggini, Eleftheria

Source: In Cell 2 September 2021 184(18):4784-4818

The influence of adult hip shape genetic variants on adolescent hip shape: Findings from a population-based DXA study

Authors: Frysz, Monika, Baird, Denis, Gregory, Jenny S., Aspden, Richard M., Lane, Nancy E., Ohlsson, Claes, Pettersson-Kymmer, Ulrika, Karasik, David, Tobias, Jonathan H., Paternoster, Lavinia

Source: In Bone February 2021 143

GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels

Authors: Gergei, Ingrid, Zheng, Jie, Andlauer, Till F M, Brandenburg, Vincent, Mirza-Schreiber, Nazanin, Müller-Myhsok, Bertram, Krämer, Bernhard K, Richard, Daniel, Falk, Louise, Movérare-Skrtic, Sofia, Ohlsson, Claes, Davey Smith, George, März, Winfried, Voelkl, Jakob, Tobias, Jonathan H

Source: Human molecular genetics. 31(5):792-802

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Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis.

Authors: Faber, Benjamin G., Macrae, Fiona, Mijin Jung, Zucker, Benjamin E., Beynon, Rhona A., Tobias, Jonathan H.

Source: Frontiers in Endocrinology; 2024, p1-11, 11p

Subject Terms: SEX factors in disease, HIP osteoarthritis, BODY composition, DISEASE prevalence, ARTHRITIS

The effect of pubertal timing, as reflected by height tempo, on proximal femur shape: Findings from a population-based study in adolescents

Authors: Frysz, Monika, Gregory, Jennifer S., Aspden, Richard M., Paternoster, Lavinia, Tobias, Jonathan H.

Source: In Bone February 2020 131

Deciphering osteoarthritis genetics across 826, 690 individuals from 9 populations

Authors: Boer, Cindy G., Hatzikotoulas, Konstantinos, Southam, Lorraine, Stefánsdóttir, Lilja, Zhang, Yanfei, Coutinho de Almeida, Rodrigo, Wu, Tian T., Zheng, Jie, Hartley, April, Teder-Laving, Maris, Skogholt, Anne Heidi, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Barysenka, Andrei, Bjornsdottir, Gyda, Gabrielsen, Maiken E., Gilly, Arthur, Ingvarsson, Thorvaldur, Johnsen, Marianne B., Jonsson, Helgi, Kloppenburg, Margreet, Luetge, Almut, Lund, Sigrun H., Mägi, Reedik, Mangino, Massimo, Nelissen, Rob R.G.H.H., Shivakumar, Manu, Steinberg, Julia, Takuwa, Hiroshi, Thomas, Laurent F., Tuerlings, Margo, Babis, George C., Yin Cheung, Jason Pui, Kang, Jae Hee, Kraft, Peter, Lietman, Steven A., Samartzis, Dino, Slagboom, P. Eline, Stefansson, Kari, Thorsteinsdottir, Unnur, Tobias, Jonathan H., Uitterlinden, André G., Winsvold, Bendik, Zwart, John-Anker, Smith, George Davey, Sham, Pak Chung, Thorleifsson, Gudmar, Gaunt, Tom R., Morris, Andrew P., Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Ikegawa, Shiro, Hveem, Kristian, Esko, Tõnu, Wilkinson, J. Mark, Meulenbelt, Ingrid, Michael Lee, Ming Ta, van Meurs, Joyce B.J., Styrkársdóttir, Unnur, Zeggini, Eleftheria

Source: Cell. 184(24):6003-6005

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151157067.0x000001&indx=1&recIds=ETOCvdc_100151157067.0x000001

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Authors: Medina-Gomez, Carolina, Kemp, John P., Trajanoska, Katerina, Luan, Jian’an, Chesi, Alessandra, Ahluwalia, Tarunveer S., Mook-Kanamori, Dennis O., Ham, Annelies, Hartwig, Fernando P., Evans, Daniel S., Joro, Raimo, Nedeljkovic, Ivana, Zheng, Hou-Feng, Zhu, Kun, Atalay, Mustafa, Liu, Ching-Ti, Nethander, Maria, Broer, Linda, Porleifsson, Gudmar, Mullin, Benjamin H., Handelman, Samuel K., Nalls, Mike A., Jessen, Leon E., Heppe, Denise H.M., Richards, J. Brent, Wang, Carol, Chawes, Bo, Schraut, Katharina E., Amin, Najaf, Wareham, Nick, Karasik, David, Van der Velde, Nathalie, Ikram, M. Arfan, Zemel, Babette S., Zhou, Yanhua, Carlsson, Christian J., Liu, Yongmei, McGuigan, Fiona E., Boer, Cindy G., Bønnelykke, Klaus, Ralston, Stuart H., Robbins, John A., Walsh, John P., Zillikens, M. Carola, Langenberg, Claudia, Li-Gao, Ruifang, Williams, Frances M.K., Harris, Tamara B., Akesson, Kristina, Jackson, Rebecca D., Sigurdsson, Gunnar, den Heijer, Martin, van der Eerden, Bram C.J., van de Peppel, Jeroen, Spector, Timothy D., Pennell, Craig, Horta, Bernardo L., Felix, Janine F., Zhao, Jing Hua, Wilson, Scott G., de Mutsert, Renée, Bisgaard, Hans, Styrkársdóttir, Unnur, Jaddoe, Vincent W., Orwoll, Eric, Lakka, Timo A., Scott, Robert, Grant, Struan F.A., Lorentzon, Mattias, van Duijn, Cornelia M., Wilson, James F., Stefansson, Kari, Psaty, Bruce M., Kiel, Douglas P., Ohlsson, Claes, Ntzani, Evangelia, van Wijnen, Andre J., Forgetta, Vincenzo, Ghanbari, Mohsen, Logan, John G., Williams, Graham R., Bassett, J.H. Duncan, Croucher, Peter I., Evangelou, Evangelos, Uitterlinden, Andre G., Ackert-Bicknell, Cheryl L., Tobias, Jonathan H., Evans, David M., Rivadeneira, Fernando

Source: In The American Journal of Human Genetics 4 January 2018 102(1):88-102

Identification of Novel Loci Associated With Hip Shape: A Meta‐Analysis of Genomewide Association Studies

Authors: Baird, Denis A, Evans, Daniel S, Kamanu, Frederick K, Gregory, Jennifer S, Saunders, Fiona R, Giuraniuc, Claudiu V, Barr, Rebecca J, Aspden, Richard M, Jenkins, Deborah, Kiel, Douglas P, Orwoll, Eric S, Cummings, Steven R, Lane, Nancy E, Mullin, Benjamin H, Williams, Frances MK, Richards, J Brent, Wilson, Scott G, Spector, Tim D, Faber, Benjamin G, Lawlor, Deborah A, Grundberg, Elin, Ohlsson, Claes, Pettersson‐Kymmer, Ulrika, Capellini, Terence D, Richard, Daniel, Beck, Thomas J, Evans, David M, Paternoster, Lavinia, Karasik, David, Tobias, Jonathan H

Source: Journal of bone and mineral research. 34(2):241-251

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128335296.0x000001&indx=1&recIds=ETOCvdc_100128335296.0x000001

Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo‐Controlled Trial

Authors: Duckworth, Andrew D, McQueen, Margaret M, Tuck, Christopher E, Tobias, Jonathan H, Wilkinson, Jeremy Mark, Biant, Leela C, Pulford, Elizabeth Claire, Aldridge, Stephen, Edwards, Claire, Roberts, Chris P, Ramachandran, Manoj, McAndrew, Andrew Richard, Cheng, Kenneth CK, Johnston, Phillip, Shah, Nasir H, Mathew, Philip, Harvie, John, Hanusch, Birgit C, Harkess, Ronnie, Rodriguez, Aryelly, Murray, Gordon D, Ralston, Stuart H

Source: Journal of bone and mineral research. 34(6):1025-1032

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095083639.0x000001&indx=1&recIds=ETOCvdc_100095083639.0x000001

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

Authors: Zheng, Jie, Maerz, Winfried, Gergei, Ingrid, Kleber, Marcus, Drechsler, Christiane, Wanner, Christoph, Brandenburg, Vincent, Reppe, Sjur, Gautvik, Kaare M, Medina‐Gomez, Carolina, Shevroja, Enisa, Gilly, Arthur, Park, Young‐Chan, Dedoussis, George, Zeggini, Eleftheria, Lorentzon, Mattias, Henning, Petra, Lerner, Ulf H, Nilsson, Karin H, Movérare‐Skrtic, Sofia, Baird, Denis, Elsworth, Benjamin, Falk, Louise, Groom, Alix, Capellini, Terence D, Grundberg, Elin, Nethander, Maria, Ohlsson, Claes, Davey Smith, George, Tobias, Jonathan H

Source: Journal of bone and mineral research. 34(10):1824-1836

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100092789707.0x000001&indx=1&recIds=ETOCvdc_100092789707.0x000001