TTN:c.12478del in proximal I-band of titin represents a common molecular cause of dilated cardiomyopathy in Slovenian patients

Authors: Nina Vodnjov, Andraž Cerar, Aleš Maver, Borut Peterlin, Karin Writzl

Source: Orphanet Journal of Rare Diseases, Vol 20, Iss 1, Pp 1-9 (2025)

Subject Terms: Titin, TTNtv, I-band, TTN:c.12478del, Dilated cardiomyopathy, DCM, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/12ad3d5bb09541daa65205fccb4869a6

Titin fragment is a sensitive biomarker in Duchenne muscular dystrophy model mice carrying full-length human dystrophin gene on human artificial chromosome

Authors: Yosuke Hiramuki, Miwa Hosokawa, Kayo Osawa, Taku Shirakawa, Yasuhiro Watanabe, Ritsuko Hanajima, Hiroyuki Kugoh, Hiroyuki Awano, Masafumi Matsuo, Yasuhiro Kazuki

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)

Subject Terms: Duchenne muscular dystrophy, Dystrophin, Creatine kinase, Titin, Human artificial chromosome, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a18ced02baad4a71abbf24d977c4861f

Attenuated titin protein expression is associated with advanced stages of ovarian cancer

Authors: Harvey Sharma, Jaskaran Aujla, Asad Nawaz, Thabet Khasawneh, Ayesha Alvero, Robert T. Morris, Asma Basha, Laila Tutunji, Toshima Z. Parris, Khalil Helou, Ghassan M. Saed

Source: Molecular Therapy: Oncology, Vol 33, Iss 1, Pp 200932- (2025)

Subject Terms: MT: Regular Issue, attenuated titin expression, chemoresistance, ovarian cancer, therapeutic marker, titin mutations, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329925000013; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/4e8a6e6eb7294730a034e2eec3dacbfa

Fatiguing exercise reduces cellular passive Young's modulus in human vastus lateralis muscle

Authors: Grace E. Privett, Austin W. Ricci, Larry L. David, Karen Wiedenfeld Needham, Yong How Tan, Karina H. Nakayama, Damien M. Callahan

Source: Experimental Physiology, Vol 109, Iss 11, Pp 1922-1937 (2024)

Subject Terms: cellular stiffness, fatigue, passive mechanics, skeletal muscle, titin, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/0958-0670; https://doaj.org/toc/1469-445X

Access URL: https://doaj.org/article/724d0351a9604e5b9d8e62fb96598d03

Sacubitril/valsartan improves diastolic left ventricular stiffness with increased titin phosphorylation via cGMP-PKG activation in diabetic mice

Authors: Nozomi Furukawa, Hiroki Matsui, Hiroaki Sunaga, Kohzo Nagata, Masaaki Hirayama, Hideru Obinata, Tomoyuki Yokoyama, Kinji Ohno, Masahiko Kurabayashi, Norimichi Koitabashi

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Titin, HFpEF, Cardiomyopathy, Diabetes, Diastolic dysfunction, Myocardial stiffness, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f568275c3d9b49dea4d6549c5c5d86e5

A clinical case of reverse left ventricular remodeling in patient with pathogenic TTN mutation. Case report

Authors: Svetlana N. Nasonova, Aleksei N. Meshkov, Igor V. Zhirov, Yulia F. Osmolovskaya, Anastasiia A. Shoshina, Alan V. Gagloev, Irina H. Dzhumaniiazova, Elena A. Zelenova, Veronika V. Erema, Mariia S. Gusakova, Mikhail V. Ivanov, Mikhail V. Terekhov, Daria A. Kashtanova, Alexsandra I. Nekrasova, Sergey I. Mitrofanov, Andrey S. Shingaliev, Vladimir S. Yudin, Anton A. Keskinov, Nataliya V. Gomyranova, Uliana V. Chubykina, Marat V. Ezhov, Sergey N. Tereshchenko, Sergey M. Yudin, Sergey A. Boytsov

Source: Терапевтический архив, Vol 96, Iss 09, Pp 901-908 (2024)

Subject Terms: dilated cardiomyopathy, titin, sequencing, chronic heart failure, reverse remodeling, Medicine

File Description: electronic resource

Relation: https://ter-arkhiv.ru/0040-3660/article/viewFile/634502/pdf; https://doaj.org/toc/0040-3660; https://doaj.org/toc/2309-5342

Access URL: https://doaj.org/article/a8708c4436734c58bb4e28c604e1b7c4

Cardiac titin isoforms: Practice in interpreting results of electrophoretic analysis

Authors: Yakupova, Elmira I. ^{a, ⁎}, Abramicheva, Polina A. ^a, Rogachevsky, Vadim V. ^b, Shishkova, Elena A. ^b, Bocharnikov, Alexey D. ^a, Plotnikov, Egor Y. ^a, Vikhlyantsev, Ivan M. ^{c, d, ⁎}

Source: In Methods April 2025 236:17-25

Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin

Authors: Ye, Qilu ¹, Henrickson, Amy ², Demeler, Borries ², Balasco Serrão, Vitor Hugo ^{3, 4}, Davies, Peter L. ^{1, ∗}

Source: In Journal of Biological Chemistry February 2025 301(2)

Genetic Landscape of Patients With Dilated Cardiomyopathy and a Systemic Immune-Mediated Disease

Authors: Stroeks, Sophie L.V.M. ^{a, b, c, g}, Henkens, Michiel T.H.M. ^{a, d, e}, Dominguez, Fernando ^{c, j, k}, Merlo, Marco ^{c, f}, Hellebrekers, Debby M.E.I. ^{c, g}, Gonzalez-Lopez, Esther ^{c, j, k}, dal Ferro, Matteo ^{c, f}, Ochoa, Juan Pablo ^{c, j, k}, Venturelli, Francesco ^{c, f}, Claes, Godelieve R.F. ^{c, g}, Venner, Max F.G.H.M. ^a, Krapels, Ingrid P.C. ^{c, g}, Vanhoutte, Els K. ^{c, g}, van Paassen, Pieter ^h, van den Wijngaard, Arthur ^{c, e}, Sikking, Maurits A. ^a, van Leeuwen, Rick ^a, Abdul Hamid, Myrurgia ^d, Li, Xiaofei ^d, Brunner, Han G. ^{g, i}, Sinagra, Gianfranco ^{c, f}, Garcia-Pavia, Pablo ^{c, j, k}, Heymans, Stephane R.B. ^{a, b}, Verdonschot, Job A.J. ^{a, c, g, ∗}

Source: In JACC: Heart Failure January 2025 13(1):133-145

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

Authors: Judith Hüttemeister, Franziska Rudolph, Michael H Radke, Claudia Fink, Dhana Friedrich, Stephan Preibisch, Martin Falcke, Eva Wagner, Stephan E Lehnart, Michael Gotthardt

Source: eLife, Vol 13 (2024)

Subject Terms: muscle, sarcomere, titin, regeneration, live imaging, proteostasis, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/95597; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/ae88f7936ce54f1398b374a04ef05988

Mechanism-based myofilament manipulation to treat diastolic dysfunction in HFpEF

Authors: Katherine L. Dominic, Alexandra V. Schmidt, Henk Granzier, Kenneth S. Campbell, Julian E. Stelzer

Source: Frontiers in Physiology, Vol 15 (2024)

Subject Terms: HFpEF, heart failure with preserved ejection fraction, cMyBP-C, cTnI, cardiac troponin I, titin, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2024.1512550/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/bc48eeacf92a488ba39f62c1b920bc0f

Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells

Authors: Xu Zhou, Xiaohan Kong, Jun Lu, Heng Wang, Meng Liu, Shuchao Zhao, Zhaozhi Xia, Qinggong Liu, Hongrui Sun, Xin Gao, Chaoqun Ma, Zheyu Niu, Faji Yang, Xie Song, Hengjun Gao, Shizhe Zhang, Huaqiang Zhu

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)

Subject Terms: Cholangiocarcinoma, Circulating tumor cells, Exosome, Titin-antisense RNA1, Metastasis, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/3d437992ab7f41b4b1624bfc21aa5eca

A three filament mechanistic model of musculotendon force and impedance

Authors: Matthew Millard, David W Franklin, Walter Herzog

Source: eLife, Vol 12 (2024)

Subject Terms: muscle model, crossbridge model, titin model, simulation, eccentric, impedance, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/88344; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/142c14f651124b53bb5f5be0df346881

Alterations in cardiac contractile and regulatory proteins contribute to age‐related cardiac dysfunction in male rats

Authors: Young Soo Han, Madona Pakkam, Matthew J. Fogarty, Gary C. Sieck, Frank V. Brozovich

Source: Physiological Reports, Vol 12, Iss 16, Pp n/a-n/a (2024)

Subject Terms: Ca2+ sensitivity, Ca2+ transient, cross‐bridge cycling, myosin binding protein C, myosin heavy chain, titin, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/f577a9b7cdf84a6c8ed5051c85411fc2

Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies

Authors: Amir Ghaffari Jolfayi, Erfan Kohansal, Serwa Ghasemi, Niloofar Naderi, Mahshid Hesami, MohammadHossein MozafaryBazargany, Maryam Hosseini Moghadam, Amir Farjam Fazelifar, Majid Maleki, Samira Kalayinia

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-37 (2024)

Subject Terms: TTN, Titin, Cardiomyopathy, Variant, Genetic, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/46596c2876cf453eb68b68e370b610e2

Cocaine, amphetamine, or titin: Unraveling the genetic underpinnings of dilated cardiomyopathy

Authors: Binay Kumar Panjiyar, Nikita Changlani, Clarisa Medina, Lisa R. Trevino

Source: Clinical Case Reports, Vol 12, Iss 6, Pp n/a-n/a (2024)

Subject Terms: cardiology, dilated cardiomyopathy, heart failure, ischemic cardiomyopathy, titin mutation, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0904

Access URL: https://doaj.org/article/a1d1a9d7cf724cde8771919ebcc8717a

Titin: roles in cardiac function and diseases

Authors: Dawson Stroik, Zachery R. Gregorich, Farhan Raza, Ying Ge, Wei Guo

Source: Frontiers in Physiology, Vol 15 (2024)

Subject Terms: titin, passive stiffness, dilated cardiomyopathy (DCM), heart failure with preserved ejection fraction (HFpEF), diabetic cardiomyopathy (DbCM), Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2024.1385821/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/466e9e387fa344bab7c6ed4af6bf26b9

Comparative analysis of ventricular stiffness across species

Authors: Yuu Usui, Akira Hanashima, Ken Hashimoto, Misaki Kimoto, Momoko Ohira, Satoshi Mohri

Source: Physiological Reports, Vol 12, Iss 8, Pp n/a-n/a (2024)

Subject Terms: collagen, end‐diastolic pressure‐volume relationship, Titin (Connectin), ventricular stiffness, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/713f85017153452d816fb63131313657

Molecular World Today and Tomorrow: Recent Trends in Biological Sciences

Contributors: Zaman, Wajid

Subject Terms: autophagy-related protein, degradation, ubiquitin, proteasome, autophagy, Bacillus thuringiensis, Cry toxin, nematicidal activity, pore-formation, diabetes, vaccines, clinical trials, insulin, GLP, nitric oxide, antioxidants, metal-stress related transcripts, rice, Pb-stress, Aurisin A, beta-cyclodextrins, inclusion complex, lung cancer, ruxolitinib, JAK inhibitor, rheumatoid arthritis, molecular modeling, TOR, photosynthesis, cell growth, AZD8055, Auxenochlorella pyrenoidosa, ovarian cancer, somatic BRCA mutational status, digital pathology, machine learning, artificial intelligence, super-secondary structure, 3β-corner, folding nuclei, structure stability, H Ferritin subunit, PRDX6, protein-protein interaction, seed-specific transcription factors, signaling pathways, seed size, seed development, juvenile idiopathic arthritis, transcriptome-wide association study, gene-based association analysis, enrichment analysis, gene regulatory network, computational cancer biology, precision medicine, oxaliplatin and capecitabine (XELOX), data bank, AlphaFold 2.0, graph neural network, protein features, nasopharyngeal carcinoma, bioinformatics, genes, melon, CmSUN, IQ67 domain, expression analysis, overexpression phenotype, fruit shape regulation, protein interaction, smooth muscle titin, protein aggregates, amyloid aggregation, amyloids, cross-β, Research and information: general, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/98917
https://mdpi.com/books/pdfview/book/6970

Altered serum levels of cytokines in patients with myasthenia gravis

Authors: Wei, Shu-Li ^a, Yang, Chun-Lin ^{b, c, d}, Si, Wei-Yue ^a, Dong, Jing ^b, Zhao, Xue-Lu ^b, Zhang, Peng ^{b, c, d}, Li, Heng ^{b, c, d}, Wang, Cong-Cong ^{b, c, d}, Zhang, Min ^{b, c, d}, Li, Xiao-Li ^{b, c, d, ∗}, Duan, Rui-Sheng ^{a, b, c, d, ∗∗}

Source: In Heliyon 15 January 2024 10(1)