Combinatorial immunotherapy with anti-ROR1 CAR NK cells and an IL-21 secreting oncolytic virus against neuroblastoma

Authors: Yaya Chu, Meijuan Tian, Uksha Saini, Jessica Ayala-Cuesta, Kayleigh Klose, Alyssa S. Mendelowitz, Keira Foley, Mehmet F. Ozkaynak, Wen Luo, Timothy P. Cripe, Dean A. Lee, Kevin A. Cassady, Mitchell S. Cairo

Source: Molecular Therapy: Oncology, Vol 33, Iss 1, Pp 200927- (2025)

Subject Terms: neuroblastoma, chimeric antigen receptor, CAR, ROR1, natural killer cells, oncolytic herpes simplex virus, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924001693; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/890724d086f648c186b0f186148081c8

Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning 'Two Keys' simultaneously

Authors: Wen Luo, Hai Hoang, Katherine E. Miller, Hongwen Zhu, Serena Xu, Xiaokui Mo, Elizabeth A. R. Garfinkle, Heather Costello, Saranga Wijeratne, Wiebke Chemnitz, Ronan Gandhi, Yanling Liao, Janet Ayello, Aliza Gardenswartz, Jeremy M. Rosenblum, Kevin A. Cassady, Elaine R. Mardis, Dean A. Lee, Timothy P. Cripe, Mitchell S. Cairo

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)

Subject Terms: CD47 blockade, Chemotherapy, Macrophages, Ewing sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/ef612054309d4f2fb16fbb5249bba11b

Employing splice-switching oligonucleotides and AAVrh74.U7 snRNA to target insulin receptor splicing and cancer hallmarks in osteosarcoma

Authors: Safiya Khurshid, Akila S. Venkataramany, Matias Montes, John F. Kipp, Ryan D. Roberts, Nicolas Wein, Frank Rigo, Pin-Yi Wang, Timothy P. Cripe, Dawn S. Chandler

Source: Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200908- (2024)

Subject Terms: MT: Regular Issue, alternative splicing, insulin receptor, splice-switching oligonucleotides, U7 snRNA, osteosarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924001504; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/64d96cc962ff4b389d77c5c42a9d9331

Trabectedin promotes oncolytic virus antitumor efficacy, viral gene expression, and immune effector function in models of bone sarcoma

Authors: Emily M. Ringwalt, Mark A. Currier, Andrea M. Glaspell, Chun-Yu Chen, Matthew V. Cannon, Maren Cam, Amy C. Gross, Matthew Gust, Pin-Yi Wang, Louis Boon, Laura E. Biederman, Emily Schwarz, Prajwal Rajappa, Dean A. Lee, Elaine R. Mardis, William E. Carson, 3rd, Ryan D. Roberts, Timothy P. Cripe

Source: Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200886- (2024)

Subject Terms: osteosarcoma, Ewing sarcoma, cancer immunotherapy, trabectedin, viroimmunotherapy, synergy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924001280; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/9f97543ab8ef4ba1b69298b70f6f6188

Corrigendum: Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors

Authors: Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Timothy P. Cripe

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: malignant peripheral nerve sheath tumors, immunotherapy, tumor microenvironment, oncolytic virotherapy, macrophage targeting, trabectedin, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456897/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/aea62abb85594bdd81547a1e4aff9626

Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts

Authors: Yaya Chu, Gaurav Nayyar, Meijuan Tian, Dean A. Lee, Mehmet F. Ozkaynak, Jessica Ayala-Cuesta, Kayleigh Klose, Keira Foley, Alyssa S. Mendelowitz, Wen Luo, Yanling Liao, Janet Ayello, Gregory K. Behbehani, Stanley Riddell, Timothy P. Cripe, Mitchell S. Cairo

Source: Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200820- (2024)

Subject Terms: MT: Regular Issue, neuroblastoma, chimerical antigen receptor, ROR1, expanded natural killer cells, targeted immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924000626; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/2644140197174223981934890cc1a2e8

Enhanced IL-12 transgene expression improves oncolytic viroimmunotherapy

Authors: Yeaseul Kim, Uksha Saini, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Xiaokui Mo, Timothy P. Cripe, James Markert, Kevin A. Cassady, Ravi Dhital

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: IL-12, oncolytic herpes simplex virus (oHSV), malignant peripheral nerve sheath tumor (MPNST), CD4+ T cells, dendritic cells, Interferon-gamma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375413/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5f74ff6d85764633914ea8330bf8e162

Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors

Authors: Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Timothy P. Cripe

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: malignant peripheral nerve sheath tumors, immunotherapy, tumor microenvironment, oncolytic virotherapy, macrophage targeting, trabectedin, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1384623/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/30c6602860ac408d8659f1b13326bd9a

Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution

Authors: Jack Hedberg, Adam Studebaker, Luke Smith, Chun-Yu Chen, Jesse J. Westfall, Maren Cam, Amy Gross, Ilse Hernandez-Aguirre, Alexia Martin, Doyeon Kim, Ravi Dhital, Yeaseul Kim, Ryan D. Roberts, Timothy P. Cripe, Elaine R. Mardis, Kevin A. Cassady, Jeffrey Leonard, Katherine E. Miller

Source: Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 39-55 (2023)

Subject Terms: oncolytic virus, medulloblastoma, brain tumors, cancer immunotherapy, pediatric cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770523000505; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/4ec2f4c531974d0cbbb997bdf92d6293

The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope?

Authors: Siddhi N. Paudel, Brian Hutzen, Timothy P. Cripe

Source: Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 227-237 (2023)

Subject Terms: malignant peripheral nerve sheath tumors, immunotherapy, tumor microenvironment, immune checkpoint inhibitors, oncolytic virotherapy, soft tissue sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770523000530; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/949fc306ceb841be80f2c1ec4537c149

Reviving the lost art of meeting reports

Authors: Timothy P. Cripe

Source: Molecular Therapy: Oncology, Vol 32, Iss 1, Pp 200781- (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924000237; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/bd5e41f52ec741b3a0f05ae33db7ed3b

Progress in sarcomas: Highlights from the 2023 annual meeting of the Connective Tissue Oncology Society

Authors: Timothy P. Cripe, Ryan D. Roberts, Dawn S. Chandler, Bhuvana A. Setty, Sonja Chen, Archana Shenoy, Akila S. Venkataramany, Emily M. Ringwalt, Thomas Scharschmidt, Thomas Utset-Ward, David J. Konieczkowski, Valerie P. Grignol, Joel D. Beane, Samantha M. Ruff, Raphael E. Pollock

Source: Molecular Therapy: Oncology, Vol 32, Iss 1, Pp 200779- (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924000213; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/3dbdb33110894eb38fffb4588ffea8fd

Opportunities and challenges of combining adoptive cellular therapy with oncolytic virotherapy

Authors: Joseph A. Mamola, Chun-Yu Chen, Mark A. Currier, Kevin Cassady, Dean A. Lee, Timothy P. Cripe

Source: Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 118-124 (2023)

Subject Terms: oncolytic virotherapy, adoptive cellular therapy, CAR-T, NK, CAR NK, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770523000335; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/6e5e3ef423954cc8a6709b96845317d9

Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironment

Authors: Alessandro Canella, Matthew Nazzaro, Sakthi Rajendran, Claire Schmitt, Abigail Haffey, Giovanni Nigita, Diana Thomas, Justin M. Lyberger, Gregory K. Behbehani, Nduka M. Amankulor, Elaine R. Mardis, Timothy P. Cripe, Prajwal Rajappa

Source: Cell Reports, Vol 42, Iss 8, Pp 112891- (2023)

Subject Terms: CP: Cancer, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723009026; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/30306653fadb443a81cc1ac3965bc482

An open-label multi-center phase 1 safety study of BXQ-350 in children and young adults with relapsed solid tumors, including recurrent malignant brain tumors

Authors: Mohamed S. Abdelbaki, Mariko Dawn DeWire Schottmiller, Timothy P. Cripe, Richard C. Curry, Charles A. Cruze, Leah Her, Suzanne Demko, Denise Casey, Bhuvana Setty

Source: Heliyon, Vol 8, Iss 12, Pp e12450- (2022)

Subject Terms: Pediatric oncology, Tumors, Brain, Phase I clinical Trials, Rare tumors, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844022037380; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/8548165f27c04ab687a6cbd2a4192cf7

Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations

Authors: Payal Aggarwal, Wen Luo, Katherine C. Pehlivan, Hai Hoang, Prajwal Rajappa, Timothy P. Cripe, Kevin A. Cassady, Dean A. Lee, Mitchell S. Cairo

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: high grade glioma, glioblastoma, pediatric, adult, immunotherapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1038096/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/59aa2ba0d016490c89b1120c5578edcc

Immunotherapeutic Challenges for Pediatric Cancers

Authors: Brian Hutzen, Mohammed Ghonime, Joel Lee, Elaine R. Mardis, Ruoning Wang, Dean A. Lee, Mitchell S. Cairo, Ryan D. Roberts, Timothy P. Cripe, Kevin A. Cassady

Source: Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 38-48 (2019)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770519300762; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/36af620670ea4aae9d7d981fa9e79e75

GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival

Authors: Paola Sette, Nduka Amankulor, Aofei Li, Marco Marzulli, Daniela Leronni, Mingdi Zhang, William F. Goins, Balveen Kaur, Chelsea Bolyard, Timothy P. Cripe, Jianhua Yu, E. Antonio Chiocca, Joseph C. Glorioso, Paola Grandi

Source: Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 214-222 (2019)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770519300956; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/5f4315ec1f9e411f9c37060adda0a50a

Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma

Authors: Mary Frances Wedekind, Katherine E. Miller, Chun-Yu Chen, Pin-Yi Wang, Brian J. Hutzen, Mark A. Currier, Brooke Nartker, Ryan D. Roberts, Louis Boon, Joe Conner, Stephanie LaHaye, Benjamin J. Kelly, David Gordon, Peter White, Elaine R. Mardis, Timothy P. Cripe

Source: iScience, Vol 24, Iss 7, Pp 102759- (2021)

Subject Terms: cancer, immunology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221007276; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/42684aaa1ef54305b26e4df761b4bd3f

A Novel Pathogenic Variant in CARMIL2 (RLTPR) Causing CARMIL2 Deficiency and EBV-Associated Smooth Muscle Tumors

Authors: Jennifer R. Yonkof, Ajay Gupta, Cesar M. Rueda, Shamlal Mangray, Benjamin T. Prince, Hemalatha G. Rangarajan, Mohammad Alshahrani, Elizabeth Varga, Timothy P. Cripe, Roshini S. Abraham

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: primary immunodeficiencies, immune dysregulation, CARMIL2 deficiency, RLTPR, DOCK8 deficiency, EBV-associated smooth muscle tumor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00884/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/87b4ac74073b41caa02885e1d944b91c