CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13

Authors: Tien, Jean Ching-Yi, Luo, Jie, Chang, Yu, Zhang, Yuping, Cheng, Yunhui, Wang, Xiaoju, Yang, Jianzhang, Mannan, Rahul, Mahapatra, Somnath, Shah, Palak, Wang, Xiao-Ming, Todd, Abigail J., Eyunni, Sanjana, Cheng, Caleb, Rebernick, Ryan J., Xiao, Lanbo, Bao, Yi, Neiswender, James, Brough, Rachel, Pettitt, Stephen J., Cao, Xuhong, Miner, Stephanie J., Zhou, Licheng, Wu, Yi-Mi, Labanca, Estefania, Wang, Yuzhuo, Parolia, Abhijit, Cieslik, Marcin, Robinson, Dan R., Wang, Zhen, Feng, Felix Y., Chou, Jonathan, Lord, Christopher J., Ding, Ke, Chinnaiyan, Arul M.

Source: In Cell Reports Medicine 15 October 2024 5(10)

Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

Authors: Chang, Yu, Wang, Xiaoju, Yang, Jianzhang, Tien, Jean Ching-Yi, Mannan, Rahul, Cruz, Gabriel, Zhang, Yuping, Vo, Josh N., Magnuson, Brian, Mahapatra, Somnath, Cho, Hanbyul, Dhanasekaran, Saravana Mohan, Wang, Cynthia, Wang, Zhen, Zhou, Licheng, Zhou, Kaijie, Zhou, Yang, Zhang, Pujuan, Huang, Weixue, Xiao, Lanbo, Liu, Weihuang Raymond, Hamadeh, Rudana, Su, Fengyun, Wang, Rui, Miner, Stephanie J., Cao, Xuhong, Cheng, Yunhui, Mehra, Rohit, Ding, Ke, Chinnaiyan, Arul M.

Source: In Cell Reports Medicine 15 October 2024 5(10)

Discovery of YJZ5118: A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition.

Authors: Yang, Jianzhang^1,2 (AUTHOR), Chang, Yu³ (AUTHOR), Zhou, Kaijie¹ (AUTHOR), Huang, Weixue¹ (AUTHOR), Tien, Jean Ching-Yi^3,4 (AUTHOR), Zhang, Pujuan¹ (AUTHOR), Liu, Wenyan^1,3 (AUTHOR), Zhou, Licheng² (AUTHOR), Zhou, Yang² (AUTHOR), Ren, Xiaomei¹ (AUTHOR), Mannan, Rahul³ (AUTHOR), Mahapatra, Somnath³ (AUTHOR), Zhang, Yuping³ (AUTHOR), Hamadeh, Rudana³ (AUTHOR), Ervine, Grafton³ (AUTHOR), Wang, Zhen¹ (AUTHOR) wangz@sioc.ac.cn, Wang, George Xiaoju^3,4 (AUTHOR) xiaojuw@med.umich.edu, Chinnaiyan, Arul M.^3,4,5,6,7 (AUTHOR) arul@med.umich.edu, Ding, Ke¹ (AUTHOR) dingk@sioc.ac.cn

Source: Journal of Medicinal Chemistry. 3/27/2025, Vol. 68 Issue 6, p6718-6734. 17p.

AGO2 promotes tumor progression in KRAS-driven mouse models of non–small cell lung cancer

Authors: Tien, Jean Ching-Yi, Chugh, Seema, Goodrum, Andrew E., Cheng, Yunhui, Mannan, Rahul, Zhang, Yuping, Wang, Lisha, Dommeti, Vijaya L., Wang, Xiaoming, Xu, Alice, Hon, Jennifer, Kenum, Carson, Su, Fengyun, Wang, Rui, Cao, Xuhong, Shankar, Sunita, Chinnaiyan, Arul M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 May . 118(20), 1-8.

Access URL: https://www.jstor.org/stable/27040431

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

Authors: Qiao, Yuanyuan, Wang, Xiao-Ming, Mannan, Rahul, Pitchiaya, Sethuramasundaram, Zhang, Yuping, Wotring, Jesse W., Xiao, Lanbo, Robinson, Dan R., Wu, Yi-Mi, Tien, Jean Ching-Yi, Cao, Xuhong, Simko, Stephanie A., Apel, Ingrid J., Bawa, Pushpinder, Kregel, Steven, Narayanan, Sathiya P., Raskind, Gregory, Ellison, Stephanie J., Parolia, Abhijit, Zelenka-Wang, Sylvia, McMurry, Lisa, Su, Fengyun, Wang, Rui, Cheng, Yunhui, Delekta, Andrew D., Mei, Zejie, Pretto, Carla D., Wang, Shaomeng, Mehra, Rohit, Sexton, Jonathan Z., Chinnaiyan, Arul M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jan 01. 118(1), 1-12.

Access URL: https://www.jstor.org/stable/27006456

Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer

Authors: Wang, Xiaoju, Qiao, Yuanyuan, Asangani, Irfan A., Ateeq, Bushra, Poliakov, Anton, Cieślik, Marcin, Pitchiaya, Sethuramasundaram, Chakravarthi, Balabhadrapatruni V.S.K., Cao, Xuhong, Jing, Xiaojun, Wang, Cynthia X., Apel, Ingrid J., Wang, Rui, Tien, Jean Ching-Yi, Juckette, Kristin M., Yan, Wei, Jiang, Hui, Wang, Shaomeng, Varambally, Sooryanarayana, Chinnaiyan, Arul M.

Source: In Cancer Cell 10 April 2017 31(4):532-548

Nkx3.1 Functions as Para-transcription Factor to Regulate Gene Expression and Cell Proliferation in Non-cell Autonomous Manner

Authors: Zhou, Jian, Qin, Li, Tien, Jean Ching-Yi, Gao, Li, Chen, Xian, Wang, Fen, Hsieh, Jer-Tsong, Xu, Jianming ^**

Source: In Journal of Biological Chemistry 18 May 2012 287(21):17248-17256

Disruption of the SRC-1 Gene in Mice Suppresses Breast Cancer Metastasis without Affecting Primary Tumor Formation

Authors: Wang, Shu, Yuan, Yuhui, Liao, Lan, Kuang, Shao-Qing, Tien, Jean Ching-Yi, O'Malley, Bert W., Xu, Jianming

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Jan 01. 106(1), 151-156.

Access URL: https://www.jstor.org/stable/40272332

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13.

Authors: Yang, Jianzhang¹ (AUTHOR), Chang, Yu^1,2 (AUTHOR), Tien, Jean Ching-Yi^2,3 (AUTHOR), Wang, Zhen⁴ (AUTHOR), Zhou, Yang¹ (AUTHOR), Zhang, Pujuan⁴ (AUTHOR), Huang, Weixue⁴ (AUTHOR), Vo, Josh² (AUTHOR), Apel, Ingrid J.² (AUTHOR), Wang, Cynthia² (AUTHOR), Zeng, Victoria Zhixuan² (AUTHOR), Cheng, Yunhui² (AUTHOR), Li, Shuqin² (AUTHOR), Wang, George Xiaoju^2,3,5 (AUTHOR) xiaojuw@med.umich.edu, Chinnaiyan, Arul M.^2,3,5,6,7 (AUTHOR) arul@med.umich.edu, Ding, Ke^1,4,8,9 (AUTHOR) dingke@jnu.edu.cn

Source: Journal of Medicinal Chemistry. 8/25/2023, Vol. 65 Issue 16, p11066-11083. 18p.

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13.

Authors: Yang, Jianzhang¹ (AUTHOR), Chang, Yu^1,2 (AUTHOR), Tien, Jean Ching-Yi^2,3 (AUTHOR), Wang, Zhen⁴ (AUTHOR), Zhou, Yang¹ (AUTHOR), Zhang, Pujuan⁴ (AUTHOR), Huang, Weixue⁴ (AUTHOR), Vo, Josh² (AUTHOR), Apel, Ingrid J.² (AUTHOR), Wang, Cynthia² (AUTHOR), Zeng, Victoria Zhixuan² (AUTHOR), Cheng, Yunhui² (AUTHOR), Li, Shuqin² (AUTHOR), Wang, George Xiaoju^2,3,5 (AUTHOR) xiaojuw@med.umich.edu, Chinnaiyan, Arul M.^2,3,5,6,7 (AUTHOR) arul@med.umich.edu, Ding, Ke^1,4,8,9 (AUTHOR) dingke@jnu.edu.cn

Source: Journal of Medicinal Chemistry. 8/5/2022, Vol. 65 Issue 16, p11066-11083. 18p.

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.

Authors: Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Chugh, Seema, Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Wang, Xiao-Ming, Apel, Ingrid J., Waninger, Jessica, Eyunni, Sanjana, Xu, Alice, Mody, Malay, Goodrum, Andrew, Zhang, Yuping, Tesmer, John J., Mannan, Rahul, Cao, Xuhong, Vats, Pankaj, Pitchiaya, Sethuramasundaram, Ellison, Stephanie J.

Source: Nature Communications; 6/4/2020, Vol. 11 Issue 1, p1-17, 17p

Subject Terms: PANCREATIC cancer, CELL membranes, SOLAR plexus, CELL transformation

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