Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy

Authors: Ediriweera, Gayathri R. ^{a, 1}, Sivaram, Amal J. ^{a, 1}, Cowin, Gary ^{a, b}, Brown, Mikayla L. ^c, McAlary, Luke ^c, Lum, Jeremy S. ^{c, d}, Fletcher, Nicholas L. ^a, Robinson, Liam ^c, Simpson, Joshua D. ^e, Chen, Liyu ^f, Wasielewska, Joanna M. ^{g, h}, Byrne, Ella ^c, Finnie, John W. ⁱ, Manavis, Jim ⁱ, White, Anthony R. ^{g, h}, Yerbury, Justin J. ^c, Thurecht, Kristofer J. ^a, Vine, Kara L. ^{c, ⁎}

Source: In Journal of Controlled Release 10 February 2025 378:221-235

Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer

Authors: Liu, Feifei ^{a, b, c}, Howard, Christopher B. ^a, Huda, Pie ^{a, b}, Fletcher, Nicholas L. ^{a, b}, Bell, Craig A. ^{a, b}, Blakey, Idriss ^{a, b}, Agrez, Michael ^{c, d}, Thurecht, Kristofer J. ^{a, b, c, ⁎}

Source: In Biomaterials June 2025 317

Influence of chirality on protein corona formation of low-fouling chiral poly(2-oxazoline) coated nanoparticles

Authors: Pizzi, David, Nandakumar, Aparna, Morrow, Joshua P., Humphries, James, Siddiqui, Ghizal, Creek, Darren J., Quinn, John.F., Yin, Jialiang, Shi, Qianqian, Cheng, Wenlong, Thurecht, Kristofer J., Kempe, Kristian

Source: In European Polymer Journal 24 April 2024 210

Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma.

Authors: Logan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest, Kavallaris, Maria

Source: In Journal of Controlled Release March 2024 367:806-820

Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers

Authors: Balaji, Arunpandian, Bell, Craig A., Houston, Zachary H., Bridle, Kim R., Genz, Berit, Fletcher, Nicholas L., Ramm, Grant A., Thurecht, Kristofer J.

Source: In Biomaterials November 2023 302

Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma

Authors: Janjua, Taskeen Iqbal, Cao, Yuxue, Ahmed-Cox, Aria, Raza, Aun, Moniruzzaman, Md, Akhter, Dewan Taslima, Fletcher, Nicholas L., Kavallaris, Maria, Thurecht, Kristofer J., Popat, Amirali

Source: Journal of controlled release. 357:161-174

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195222576.0x000001&indx=1&recIds=ETOCvdc_100195222576.0x000001

Development and Validation of a Targeted Treatment for Brain Tumors Using a Multi-Drug Loaded, Relapse-Resistant Polymeric Theranostic

Authors: Chu, Weijing, Houston, Zachary H., Fletcher, Nicholas L., Huda, Pie, Ahamed, Muneer, Lim, Ting Xiang, Day, Bryan W., Pinkham, Mark, Thurecht, Kristofer J.

Source: Biomacromolecules. 24(6):2674-2690

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633027297&indx=1&recIds=ETOCRN633027297

RAFT Polymer—Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo

Authors: Ardana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J., Williams, Charlotte C.

Source: Molecular pharmaceutics. 20(6):3073-3087

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632826095&indx=1&recIds=ETOCRN632826095

Probing the Biocompatibility and Immune Cell Association of Chiral, Water-Soluble, Bottlebrush Poly(2-oxazoline)s

Authors: Pizzi, David, Humphries, James, Morrow, Joshua P., Mahmoud, Ayaat M., Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Thurecht, Kristofer J., Kempe, Kristian

Source: Biomacromolecules. 24(1):246-257

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632342262&indx=1&recIds=ETOCRN632342262

Pharmacokinetics and Biodistribution of ^8^9Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma

Authors: Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J., Thurecht, Kristofer J.

Source: Molecular pharmaceutics. 20(3):1549-1563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631919593&indx=1&recIds=ETOCRN631919593

Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platformElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2bm01626e

Authors: Arno, Maria C., Simpson, Joshua D., Blackman, Lewis D., Brannigan, Ruairí P., Thurecht, Kristofer J., Dove, Andrew P.

Source: Biomaterials science. 11(3):908-915

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178311815.0x000001&indx=1&recIds=ETOCvdc_100178311815.0x000001

Multiplexing Label-Free Polymeric Nanocarriers via Antipolymer Antibodies.

Authors: Humphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian, Thurecht, Kristofer J.

Source: ACS Sensors; 2/28/2025, Vol. 10 Issue 2, p1280-1288, 9p

Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption

Authors: Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J., Thurecht, Kristofer J.

Source: In Biomaterials April 2022 283

Template-Assisted Antibody Assembly: A Versatile Approach for Engineering Functional Antibody Nanoparticles

Authors: Hu, Yingjie, Li, Jianhua, Ju, Yi, Houston, Zachary H., Fletcher, Nicholas L., De Rose, Robert, Fernandes, Soraia, Hagemeyer, Christoph E., Alt, Karen, Thurecht, Kristofer J.

Source: Chemistry of materials. 34(8):3694-3704

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632544350&indx=1&recIds=ETOCRN632544350

Modulating Macrophage Clearance of Nanoparticles: Comparison of Small-Molecule and Biologic Drugs as Pharmacokinetic Modifiers of Soft Nanomaterials

Authors: Mills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J., Fletcher, Nicholas L.

Source: Molecular pharmaceutics. 19(11):4080-4097

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630683050&indx=1&recIds=ETOCRN630683050

Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted deliveryElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2cc01874h

Authors: Gao, Zhiliang, Li, Xiaoyu, Zhao, Kaijie, Geng, Huimin, Zhang, Peiyu, Ju, Yi, Huda, Pie, Howard, Christopher B., Thurecht, Kristofer J., Ashokkumar, Muthupandian, Hao, Jingcheng, Cui, Jiwei

Source: Chemical communications. 58(56):7777-7780

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155217415.0x000001&indx=1&recIds=ETOCvdc_100155217415.0x000001

Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeuticsElectronic supplementary information (ESI) available: Characterisation method and in vivo assays; additional characterisation data of synthesised polymers and their precursors; cmc calculations; additional in vitro characterisation; minimum information reporting in Bio–Nano experimental literature checklist. See DOI: https://doi.org/10.1039/d2py00257d

Authors: Ahmed, Salma E., Fletcher, Nicholas L., Prior, Amber R., Huda, Pie, Bell, Craig A., Thurecht, Kristofer J.

Source: Polymer chemistry. 13(27):4004-4017

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155127250.0x000001&indx=1&recIds=ETOCvdc_100155127250.0x000001

Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation

Authors: Mills, Jessica A., Liu, Feifei, Jarrett, Thomas R., Fletcher, Nicholas L., Thurecht, Kristofer J.

Source: Biomaterials science. 10(12):3029-3053

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152743475.0x000001&indx=1&recIds=ETOCvdc_100152743475.0x000001

Antibody-Based Formats to Target Glioblastoma: Overcoming Barriers to Protein Drug Delivery

Authors: Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Howard, Christopher B., Walsh, Bradley, Campbell, Douglas, Pinkham, Mark B., Thurecht, Kristofer J.

Source: Molecular pharmaceutics. 19(5):1233-1247

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629244541&indx=1&recIds=ETOCRN629244541

Synthesis, characterisation and evaluation of hyperbranched N-(2-hydroxypropyl) methacrylamides for transport and delivery in pancreatic cell lines in vitro and in vivoElectronic supplementary information (ESI) available. See DOI: 10.1039/d1bm01548f

Authors: Anane-Adjei, Akosua B., Fletcher, Nicholas L., Cavanagh, Robert J., Houston, Zachary H., Crawford, Theodore, Pearce, Amanda K., Taresco, Vincenzo, Ritchie, Alison A., Clarke, Phillip, Grabowska, Anna M., Gellert, Paul R., Ashford, Marianne B., Kellam, Barrie, Thurecht, Kristofer J., Alexander, Cameron

Source: Biomaterials science. 10(9):2328-2344

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148662674.0x000001&indx=1&recIds=ETOCvdc_100148662674.0x000001