AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies

Authors: Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek

Source: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/bfa18d4f4cb54bf398d1a6ddf489f5be

Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes

Authors: Kolja Becker, Carina M. Weigelt, Holger Fuchs, Coralie Viollet, Werner Rust, Hannah Wyatt, Jochen Huber, Thorsten Lamla, Francesc Fernandez-Albert, Eric Simon, Nina Zippel, Remko A. Bakker, Holger Klein, Norbert H. Redemann

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-20 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6aaa2e0a328d459892cb845548a66e42

Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery

Authors: Dalia Pakalniškytė, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, Martin Lenter

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/5f71560143154c38951bffbfbcaeeb5e

GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1

Authors: Lucia Balazova, Miroslav Balaz, Carla Horvath, Áron Horváth, Caroline Moser, Zuzana Kovanicova, Adhideb Ghosh, Umesh Ghoshdastider, Vissarion Efthymiou, Elke Kiehlmann, Wenfei Sun, Hua Dong, Lianggong Ding, Ez-Zoubir Amri, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Barbara Ukropcova, Jozef Ukropec, Pawel Pelczar, Thorsten Lamla, Bradford Hamilton, Heike Neubauer, Christian Wolfrum

Source: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/88ee4530cad64964a1bb8fbac9b2b659

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Authors: Jonas Weinmann, Sabrina Weis, Josefine Sippel, Warut Tulalamba, Anca Remes, Jihad El Andari, Anne-Kathrin Herrmann, Quang H. Pham, Christopher Borowski, Susanne Hille, Tanja Schönberger, Norbert Frey, Martin Lenter, Thierry VandenDriessche, Oliver J. Müller, Marinee K. Chuah, Thorsten Lamla, Dirk Grimm

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fcda7a44d2044540880d0f383706efd9

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