Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity.

Authors: Dai, Quanhui^1,2, Preusse, Kristina², Yu, Danni¹, Kovall, Rhett A.³, Thorner, Konrad², Lin, Xinhua¹, xlin@fudan.edu.cn, Kopan, Raphael², Rafi.kopan@gmail.com

Source: PLoS Genetics; 12/12/2024, Vol. 20 Issue 12, p1-27, 27p

The unique functions of Runx1 in skeletal muscle maintenance and regeneration are facilitated by an ETS interaction domain.

Authors: Meng Yu¹, Thorner, Konrad², Parameswaran, Sreeja³, Wei Wei¹, Chuyue Yu¹, Xinhua Lin¹ xlin@fudan.edu.cn, Kopan, Raphael² Rafi.kopan@gmail.com, Hass, Matthew R.^2,3 Matthew.Hass@cchmc.org

Source: Development (09501991). Dec2024, Vol. 151 Issue 24, p1-13. 13p.

Subject Terms: *TRANSCRIPTION factors, *MUSCLE regeneration, *SKELETAL muscle, *MUSCLE cells, *T cells, *SATELLITE cells

CAR-T Engineering: Optimizing Signal Transduction and Effector Mechanisms

Authors: Roselli, Emiliano, Frieling, Jeremy S., Thorner, Konrad, Ramello, María C., Lynch, Conor C., Abate-Daga, Daniel

Source: BioDrugs. 33(6):647-659

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130229416.0x000001&indx=1&recIds=ETOCvdc_100130229416.0x000001

Transplanted human intestinal organoids: a resource for modeling human intestinal development.

Authors: Singh, Akaljot, Poling, Holly M., Chaturvedi, Praneet, Thorner, Konrad, Sundaram, Nambirajan, Kechele, Daniel O., Childs, Charlie J., McCauley, Heather A., Fisher, Garrett W., Brown, Nicole E., Spence, Jason R., Wells, James M., Helmrath, Michael A.

Source: Development (09501991); May2023, Vol. 150 Issue 9, p1-11, 11p

Subject Terms: PLURIPOTENT stem cells, INTESTINES, HUMAN stem cells, HUMAN resources departments, ORGANOIDS

Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation.

Authors: Elliott, Kelsey H., Balchand, Sai K., Paese, Christian Louis Bonatto, Ching-Fang Chang, Yanfen Yang, Brown, Kari M., Rasicci, Daniel T., Hao He, Thorner, Konrad, Chaturvedi, Praneet, Murray, Stephen A., Jing Chen, Porollo, Aleksey, Peterson, Kevin A., Brugmann, Samantha A.

Source: Development (09501991); Apr2023, Vol. 150 Issue 8, p1-12, 12p

Subject Terms: EMBRYOLOGY, CELL differentiation, GENE expression profiling, NEURAL crest

Use of phage display biopanning as a tool to design CAR-T cells against glioma stem cells.

Authors: Potez, Marine, Snedal, Sebastian, Chunhua She, Jongmyung Kim, Thorner, Konrad, Tran, Timothy H., Ramello, Maria Cecilia, Abate-Daga, Daniel, Liu, James K. C.

Source: Frontiers in Oncology; 3/24/2023, Vol. 13, p1-12, 12p

Subject Terms: BRAIN tumors, STEM cells, GLIOMAS, CANCER stem cells, PEPTIDES, SURFACE plasmon resonance

Bridging the Gap of Late-Gestation Human Nephrogenesis Using a Nonhuman Primate Model

Authors: Thakkar, Kairavee, Yarlagadda, Sunitha, Alkhudairy, Lyan, Potter, Andrew, Thorner, Konrad, Salomonis, Nathan, Kopan, Raphael, Schuh, Meredith Posner

Source: Journal of the American Society of Nephrology; October 2024, Vol. 35 Issue: 10, Number 10 Supplement 10