Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report

Authors: Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

Source: Journal of Cancer Research and Clinical Oncology, Vol 151, Iss 1, Pp 1-12 (2025)

Subject Terms: Molecular tumor board - Li-Fraumeni syndrome, Precision oncology, Targeted therapy, Case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-1335

Access URL: https://doaj.org/article/db6bdf601f6042f699d37e22a6e012a9

Iron metabolism in a mouse model of hepatocellular carcinoma

Authors: Dilay Yilmaz, Umesh Tharehalli, Rossana Paganoni, Paul Knoop, Andreas Gruber, Yuexin Chen, Rui Dong, Frank Leithäuser, Thomas Seufferlein, Kerstin Leopold, André Lechel, Maja Vujić Spasić

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: Iron metabolism, Trace elements, Liver cancer, Hepcidin, Transferrin receptor, p53, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4b7d30e219e04022bcf086bbe19e39e5

Prognostic value of the CRM-status in pancreatic ductal adenocarcinoma - data from a regional cancer registry

Authors: Jasmin Schuhbaur, Irina Surovtsova, Thomas Seufferlein, Daria Kokh, Gertrud Szotyori-Artz, Claudia Winzler, Juliane Schütz, Waldemar Uhl, Andrea Tannapfel, Philipp Morakis

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: Pancreatic cancer, Resection margin, R0 resection, Prognostic factors, CRM, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/892df4435c1943a2846450bd879e651e

Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines

Authors: Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

Source: Journal for ImmunoTherapy of Cancer, Vol 13, Iss 1 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/13/1/e010579.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/46814f0277344ba583bfcdf7b292bfd3

Correction: Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic

Authors: Volker Arndt, Daniela Doege, Stefan Fröhling, Peter Albers, Hana Algül, Ralf Bargou, Carsten Bokemeyer, Martin Bornhäuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Brümmendorf, Hartmut Döhner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann

Source: Journal of Cancer Research and Clinical Oncology, Vol 151, Iss 1, Pp 1-2 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-1335

Access URL: https://doaj.org/article/47324f7e68db49f0855695fda6b0e871

A pancreatic cancer organoid-in-matrix platform shows distinct sensitivities to T cell killing

Authors: Anton Lahusen, Jierui Cai, Reinhold Schirmbeck, Anton Wellstein, Alexander Kleger, Thomas Seufferlein, Tim Eiseler, Yuan-Na Lin

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b0d5b32d19104b149b1be3d870bb0c11

Protocol of the IntenSify‐Trial: An open‐label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab‐paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination's pharmacokinetics, safety, and efficacy

Authors: Nicolas Hohmann, Martin Ronald Sprick, Moritz Pohl, Azaz Ahmed, Jürgen Burhenne, Marietta Kirchner, Lucian Le Cornet, Markus Kratzmann, Jacek Hajda, Albrecht Stenzinger, Karen Steindorf, Stefan Delorme, Heinz‐Peter Schlemmer, Sabine Riethdorf, Ron vanSchaik, Klaus Pantel, Jens Siveke, Thomas Seufferlein, Dirk Jäger, Walter E. Haefeli, Andreas Trumpp, Christoph Springfeld

Source: Clinical and Translational Science, Vol 16, Iss 12, Pp 2483-2493 (2023)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/c68c01273a54478990c71f106d610b42

Risks and benefits of TIPS in HCC and other liver malignancies: a literature review

Authors: Anna Fichtl, Thomas Seufferlein, Eugen Zizer

Source: BMC Gastroenterology, Vol 23, Iss 1, Pp 1-10 (2023)

Subject Terms: Transjugular intrahepatic portosystemic shunt (TIPS), Clinically significant portal Hypertension (CSPH), Hepatocellular carcinoma (HCC), Liver metastases, Liver Cirrhosis, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1471-230X

Access URL: https://doaj.org/article/e00a08a490174827a3bf99dd21df3db3

Efficiency and safety of nasal positive airway pressure systems during endoscopic procedures in high-risk patients: Endo-Breath study

Authors: Alexander Kalner, Friedrich Küchler, Ellen Kavallari, Martin Müller, Thomas Seufferlein, Benjamin M Walter

Source: Endoscopy International Open, Vol 12, Iss 05, Pp E704-E714 (2024)

Subject Terms: Quality and logistical aspects, Sedation and monitoring, Quality management, Performance and complications, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2364-3722; https://doaj.org/toc/2196-9736

Access URL: https://doaj.org/article/b21c072bfa164ae68c6665610d0d3eb9

Treatment sequences and prognostic/predictive factors in metastatic pancreatic ductal adenocarcinoma: univariate and multivariate analyses of a real-world study in Europe

Authors: Julien Taieb, Thomas Seufferlein, Michele Reni, Daniel H. Palmer, John A. Bridgewater, Antonio Cubillo, Gerald W. Prager, Alice Vermeire, Fabienne Hédouin-Biville, Zhaoyang Teng, Teresa Macarulla

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)

Subject Terms: Pancreatic cancer, Metastatic, Survival, Prognostic factors, Real-world data, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/b704e34c886c4af38f6083a309fd66cd

Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial.

Authors: Thomas Seufferlein, Ludwig Lausser, Alexander Stein, Dirk Arnold, Gerald Prager, Stefan Kasper-Virchow, Michael Niedermeier, Lothar Müller, Stefan Kubicka, Alexander König, Petra Büchner-Steudel, Kai Wille, Andreas W Berger, Angelika M R Kestler, Johann M Kraus, Silke D Werle, Lukas Perkhofer, Thomas J Ettrich, Hans A Kestler

Source: PLoS ONE, Vol 19, Iss 6, p e0304324 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/70304decadfc447c8eecb19ea70285b5

TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration

Authors: Michael Karl Melzer, Silvia Schirge, Johann Gout, Frank Arnold, Dharini Srinivasan, Ingo Burtscher, Chantal Allgöwer, Medhanie Mulaw, Friedemann Zengerling, Cagatay Günes, Heiko Lickert, Vincent M. Christoffels, Stefan Liebau, Martin Wagner, Thomas Seufferlein, Christian Bolenz, Anne M. Moon, Lukas Perkhofer, Alexander Kleger

Source: BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)

Subject Terms: Pancreatic development, TBX3, Acute pancreatitis, Organ regeneration, Embryonic development, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/d01ac3b5e56244e18b99989bd1a98642

RBPJ Deficiency Sensitizes Pancreatic Acinar Cells to KRAS-Mediated Pancreatic Intraepithelial Neoplasia InitiationSummary

Authors: Leiling Pan, Medhanie A. Mulaw, Johann Gout, Min Guo, Hina Zarrin, Peggy Schwarz, Bernd Baumann, Thomas Seufferlein, Martin Wagner, Franz Oswald

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 5, Pp 783-807 (2023)

Subject Terms: Acinar Cells, ADM, PDAC, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X23001455; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/04e3fa24650a4a80b4d92d4f238b50c0

CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants

Authors: Na Qiu, Akshaya Srikanth, Medhanie Mulaw, Umesh Tharehalli, Shanthiya Selvachandran, Martin Wagner, Thomas Seufferlein, Katja Stifter, André Lechel, Reinhold Schirmbeck

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: CD8 T cells, ER-stress, HBV surface antigen, immune escape variants, liver carcinoma, tg mice, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/43a5928ae6104fa09f96ae7fb1b43fc2

Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic

Authors: Volker Arndt, Daniela Doege, Stefan Fröhling, Peter Albers, Hana Algül, Ralf Bargou, Carsten Bokemeyer, Martin Bornhäuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Brümmendorf, Hartmut Döhner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann

Source: Journal of Cancer Research and Clinical Oncology, Vol 149, Iss 2, Pp 913-919 (2022)

Subject Terms: SARS-CoV-2 infection, Early diagnosis of cancer, Treatment delays, Aftercare, Comprehensive cancer centers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/0171-5216; https://doaj.org/toc/1432-1335

Access URL: https://doaj.org/article/4ab718b28c7241eaa5a6b9e9c207ba81

Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types

Authors: Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ourailidis, Michael Allgäuer, Michael Menzel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger

Source: The Journal of Pathology: Clinical Research, Vol 8, Iss 4, Pp 371-382 (2022)

Subject Terms: homologous recombination deficiency, HRD, microsatellite instability, MSI, PARP inhibitors, immune cell populations, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/2056-4538

Access URL: https://doaj.org/article/ff3298d8c2e9487488e839624f250057

Treating hepatitis D with bulevirtide – Real-world experience from 114 patients

Authors: Christopher Dietz-Fricke, Frank Tacke, Caroline Zöllner, Münevver Demir, Hartmut H. Schmidt, Christoph Schramm, Katharina Willuweit, Christian M. Lange, Sabine Weber, Gerald Denk, Christoph P. Berg, Julia M. Grottenthaler, Uta Merle, Alexander Olkus, Stefan Zeuzem, Kathrin Sprinzl, Thomas Berg, Florian van Bömmel, Johannes Wiegand, Toni Herta, Thomas Seufferlein, Eugen Zizer, Nektarios Dikopoulos, Robert Thimme, Christoph Neumann-Haefelin, Peter R. Galle, Martin Sprinzl, Ansgar W. Lohse, Julian Schulze zur Wiesch, Jan Kempski, Andreas Geier, Florian P. Reiter, Bernhard Schlevogt, Juliana Gödiker, Wolf Peter Hofmann, Peter Buggisch, Julia Kahlhöfer, Kerstin Port, Benjamin Maasoumy, Markus Cornberg, Heiner Wedemeyer, Katja Deterding

Source: JHEP Reports, Vol 5, Iss 4, Pp 100686- (2023)

Subject Terms: Hepatitis D, Viral hepatitis, Bulevirtide, Real world experience, Antiviral treatment, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923000174; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/25235c3dba9540059b007583dc50c8da

Endothelial Protein kinase D1 is a major regulator of post-traumatic hyperinflammation

Authors: Jonathan Schönfelder, Tanja Seibold, Mareen Morawe, Robert Sroka, Nora Schneider, Jierui Cai, Josip Golomejic, Lena Schütte, Milena Armacki, Markus Huber-Lang, Miriam Kalbitz, Thomas Seufferlein, Tim Eiseler

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: trauma, hyperinflammation, sEVs, protein kinase D, leukotriene B4, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093022/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c79b3984f7a240d8a78aa509466db241

Local control and patient reported outcomes after online MR guided stereotactic body radiotherapy of liver metastases

Authors: Laura Uder, Marcel Nachbar, Sarah Butzer, Jessica Boldt, Sabrina Baumeister, Michael Bitzer, Alfred Königsrainer, Thomas Seufferlein, Rüdiger Hoffmann, Sergios Gatidis, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth, Cihan Gani, Simon Boeke

Source: Frontiers in Oncology, Vol 12 (2023)

Subject Terms: magnetic resonance guided radiotherapy, stereotactic body radiation therapy, image guided radiation therapy, liver metastases, online adaptive radiation therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.1095633/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/4fc3cd3391a1466bbc058b6ad6e5d756

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation

Authors: Sandra Heller, Zhijian Li, Qiong Lin, Ryan Geusz, Markus Breunig, Meike Hohwieler, Xi Zhang, Gopika G. Nair, Thomas Seufferlein, Matthias Hebrok, Maike Sander, Cécile Julier, Alexander Kleger, Ivan G. Costa

Source: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/4622ff7d00c840df9df59d2628589a8c