Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer

Authors: Xue Yang, Xiuquan Ma, Tianyue Zhao, David R. Croucher, Elizabeth V. Nguyen, Kimberley C. Clark, Changyuan Hu, Sharissa L. Latham, Charles Bayly-Jones, Bao V. Nguyen, Srikanth Budnar, Sung-Young Shin, Lan K. Nguyen, Thomas R. Cotton, Anderly C. Chüeh, Terry C. C. Lim Kam Sian, Margaret M. Stratton, Andrew M. Ellisdon, Roger J. Daly

Source: Nature Communications, Vol 16, Iss 1, Pp 1-19 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b8d9cec2dd1a43ff98ed16c22fa99db2

Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling

Authors: Michael J. Roy, Minglyanna G. Surudoi, Ashleigh Kropp, Jianmei Hou, Weiwen Dai, Joshua M. Hardy, Lung-Yu Liang, Thomas R. Cotton, Bernhard C. Lechtenberg, Toby A. Dite, Xiuquan Ma, Roger J. Daly, Onisha Patel, Isabelle S. Lucet

Source: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5b2aa666db0e4b438310eae34e24f33b

The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family

Authors: Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6df400b1fdfd4a3a9df0102e30295f9d