MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans

Authors: Leonie Mayer, Leonie M. Weskamm, Anahita Fathi, Maya Kono, Jasmin Heidepriem, Verena Krähling, Sibylle C. Mellinghoff, My Linh Ly, Monika Friedrich, Svenja Hardtke, Saskia Borregaard, Thomas Hesterkamp, Felix F. Loeffler, Asisa Volz, Gerd Sutter, Stephan Becker, Christine Dahlke, Marylyn M. Addo

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/5b1fea1ceb2340e395b1e673ec685d27

Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models

Authors: Katharina Rox, Rolf Jansen, Tadeja Lukežič, Marina Greweling-Pils, Jennifer Herrmann, Marcus Miethke, Stephan Hüttel, Fabienne Hennessen, Antoine Abou Fayad, Cornelia Holzhausen, Carina Vingsbo Lundberg, Joanne Teague, Enge Sudarman, Lisa Bülter, Thomas Hesterkamp, Marc Stadler, Mark Brönstrup, Rolf Müller

Source: Microbiology Spectrum, Vol 12, Iss 1 (2024)

Subject Terms: tetracycline, urinary tract infection, Klebsiella pneumoniae, Escherichia coli, PK/PD, chelocardin, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/820d30d4e9e141c286291b4710977660

Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome

Authors: Anahita Fathi, Christine Dahlke, Verena Krähling, Alexandra Kupke, Nisreen M. A. Okba, Matthijs P. Raadsen, Jasmin Heidepriem, Marcel A. Müller, Grigori Paris, Susan Lassen, Michael Klüver, Asisa Volz, Till Koch, My L. Ly, Monika Friedrich, Robert Fux, Alina Tscherne, Georgia Kalodimou, Stefan Schmiedel, Victor M. Corman, Thomas Hesterkamp, Christian Drosten, Felix F. Loeffler, Bart L. Haagmans, Gerd Sutter, Stephan Becker, Marylyn M. Addo

Source: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9c0741a645df4990aa04ffff02338df4

Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A

Authors: Jennifer L. Edwards, Jacqueline T. Balthazar, Danillo L. A. Esposito, Julio C. Ayala, Andrea Schiefer, Kenneth Pfarr, Achim Hoerauf, Silke Alt, Thomas Hesterkamp, Miriam Grosse, Marc Stadler, Daniel Golparian, Magnus Unemo, Timothy D. Read, William M. Shafer

Source: mSphere, Vol 7, Iss 5 (2022)

Subject Terms: Neisseria gonorrhoeae, gonorrhea, corallopyronin A, anti-gonococcal, ex vivo model, biofilm, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/961e129f07f64b2fb61e13b4c0e7ef00

In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A

Authors: Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Gabriele M. König, Achim Hoerauf, Karl G. Wagner

Source: Pharmaceutics, Vol 14, Iss 8, p 1657 (2022)

Subject Terms: absorption, amorphous solid dispersion, anti-infective, bioavailability, corallopyronin A, dissolution, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/8/1657; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/d722c35fa6af4f79a653c16ff534728b

The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus

Authors: Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Miriam Grosse, Rolf Jansen, Thomas Hesterkamp, Andrea Schiefer, Gabriele M. König, Marc Stadler, Achim Hoerauf, Gabriele Bierbaum

Source: Antibiotics, Vol 11, Iss 7, p 920 (2022)

Subject Terms: Corallopyronin A, Staphylococcus aureus, rifampicin, mutation frequency, mutation rate, natural product, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/11/7/920; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/f755728120db4450ac61d370364e0082

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.

Authors: Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Tilman Aden, Marianne Koschel, Helene Neufeld, Lillibeth Chaverra-Muñoz, Rolf Jansen, Stefan Kehraus, Gabriele M König, Domen Pogorevc, Rolf Müller, Marc Stadler, Stephan Hüttel, Thomas Hesterkamp, Karl Wagner, Kenneth Pfarr, Achim Hoerauf

Source: PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

Access URL: https://doaj.org/article/d4370a71cad149209e66761eb918df85

Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

Authors: Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J. Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P. Hübner, Kenneth Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M. König, Achim Hoerauf, Karl G. Wagner

Source: Pharmaceutics, Vol 12, Iss 11, p 1105 (2020)

Subject Terms: corallopyronin A (CorA), antibiotic, anthelmintic, povidone (PVP), copovidone (PVP/VA), solubility enhanced formulation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/12/11/1105; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/e03acd88b74a4c9d8c536584505e42ed

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

Authors: Fabienne Hennessen, Marcus Miethke, Nestor Zaburannyi, Maria Loose, Tadeja Lukežič, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Judith Schmiedel, Moritz Fritzenwanker, Can Imirzalioglu, Jörg Vogel, Alexander J. Westermann, Thomas Hesterkamp, Marc Stadler, Florian Wagenlehner, Hrvoje Petković, Jennifer Herrmann, Rolf Müller

Source: Antibiotics, Vol 9, Iss 9, p 619 (2020)

Subject Terms: chelocardins, atypical tetracyclines, broad-spectrum antibiotics, clinical isolates, uropathogens, urinary tract infection (UTI), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/9/9/619; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/fc36e4f89345465b87aaee08472535e8