A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

Authors: Anne T. Schneider, Christiane Koppe, Emilie Crouchet, Aristeidis Papargyriou, Michael T. Singer, Veronika Büttner, Leonie Keysberg, Marta Szydlowska, Frank Jühling, Julien Moehlin, Min-Chun Chen, Valentina Leone, Sebastian Mueller, Thorsten Neuß, Mirco Castoldi, Marina Lesina, Frank Bergmann, Thilo Hackert, Katja Steiger, Wolfram T. Knoefel, Alex Zaufel, Jakob N. Kather, Irene Esposito, Matthias M. Gaida, Ahmed Ghallab, Jan G. Hengstler, Henrik Einwächter, Kristian Unger, Hana Algül, Nikolaus Gassler, Roland M. Schmid, Roland Rad, Thomas F. Baumert, Maximilian Reichert, Mathias Heikenwalder, Vangelis Kondylis, Mihael Vucur, Tom Luedde

Source: Nature Communications, Vol 16, Iss 1, Pp 1-18 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cb506106dd654faf9d0210e32eb7a145

A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response

Authors: Emilie Crouchet, Nuno Almeida, Sarah C. Durand, Marie Parnot, Marine A. Oudot, Fabio Giannone, Cloé Gadenne, Natascha Roehlen, Antonio Saviano, Emanuele Felli, Patrick Pessaux, Hong Tuan Duong, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Thomas F. Baumert, Catherine Schuster

Source: JHEP Reports, Vol 7, Iss 2, Pp 101252- (2025)

Subject Terms: Liver cancer, 3D model, Tumor spheroids, Drug discovery and development, Immuno-oncology, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924002568; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/cdff5a0b71e44a159c27b202d782ffd0

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Authors: Atish Mukherji, Frank Jühling, Yogy Simanjuntak, Emilie Crouchet, Fabio Del Zompo, Yuji Teraoka, Alexandre Haller, Philippe Baltzinger, Soumith Paritala, Fahmida Rasha, Naoto Fujiwara, Cloé Gadenne, Nevena Slovic, Marine A. Oudot, Sarah C. Durand, Clara Ponsolles, Catherine Schuster, Xiaodong Zhuang, Jacinta Holmes, Ming-Lun Yeh, Hiromi Abe-Chayama, Mathias Heikenwälder, Angelo Sangiovanni, Massimo Iavarone, Massimo Colombo, Steven K. H. Foung, Jane A. McKeating, Irwin Davidson, Ming-Lung Yu, Raymond T. Chung, Yujin Hoshida, Kazuaki Chayama, Joachim Lupberger, Thomas F. Baumert

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/faee0116ddb14568af297762b93cc7d2

CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1

Authors: Valerio Taverniti, Laura Meiss-Heydmann, Cloé Gadenne, Hannah Vanrusselt, Dieudonné Buh Kum, Fabio Giannone, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert, Yannick Debing, Eloi R. Verrier

Source: JHEP Reports, Vol 6, Iss 10, Pp 101134- (2024)

Subject Terms: Hepatitis B virus, Capsid assembly modulators, Apoptosis, ANXA1, Annexin A1, Lipocortin I, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924001381; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/6a35f09c18f042008a06b7ebb33fb53d

Single-cell RNA-sequencing of virus-specific cellular immune responses in chronic hepatitis B patients

Authors: Klas Hatje, Tony Kam-Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo-Noumbissie, Nadine Kumpesa, Tobias Nilsson, François Habersetzer, Thomas F. Baumert, Nadege Pelletier, Marianne Forkel

Source: Scientific Data, Vol 11, Iss 1, Pp 1-12 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/c9c49586d0034ecf8069324ee36f3f71

Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

Authors: Oleksandr Petrenko, Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S. Hofer, Katharina Bareiner, Benedikt Simbrunner, Frank Jühling, Thomas F. Baumert, Joachim Lupberger, Michael Trauner, Stefan G. Kauschke, Larissa Pfisterer, Eric Simon, André F. Rendeiro, Laura P.M.H. de Rooij, Philipp Schwabl, Thomas Reiberger

Source: iScience, Vol 27, Iss 3, Pp 109301- (2024)

Subject Terms: Disease, Fibrosis, Integrative aspects of cell biology, Model organism, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224005224; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/86925cb6106c40e38d57b9872bca512c

Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers

Authors: Magda Rybicka, Eloi R. Verrier, Thomas F. Baumert, Krzysztof Piotr Bielawski

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/cab850d967bc4f398999ca44affecbe3

Inflammation-related prognostic markers in resected hepatocellular carcinoma

Authors: Fabio Giannone, Nevena Slovic, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert, Joachim Lupberger

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: HCC, biomarkers, genetic signatures, inflammation, patient outcome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1267870/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/3da65f9bf57d4dee8f93e38e26ed7434

Atorvastatin favorably modulates a clinical hepatocellular carcinoma risk gene signature

Authors: Myung‐Ho Kim, Mi‐Young Kim, Shadi Salloum, Tongqi Qian, Lai Ping Wong, Min Xu, Yoojin Lee, Stuti G. Shroff, Ruslan I. Sadreyev, Kathleen E. Corey, Thomas F. Baumert, Yujin Hoshida, Raymond T. Chung

Source: Hepatology Communications, Vol 6, Iss 9, Pp 2581-2593 (2022)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/40cf497b78c3424da7b5b2059d8f1041

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Authors: Emilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire, Mirian Fernández-Vaquero, Tobias Riedl, Xiaochen Sun, Hadassa Hirschfield, Frank Jühling, Shijia Zhu, Natascha Roehlen, Clara Ponsolles, Laura Heydmann, Antonio Saviano, Tongqi Qian, Anu Venkatesh, Joachim Lupberger, Eloi R. Verrier, Mozhdeh Sojoodi, Marine A. Oudot, François H. T. Duong, Ricard Masia, Lan Wei, Christine Thumann, Sarah C. Durand, Victor González-Motos, Danijela Heide, Jenny Hetzer, Shigeki Nakagawa, Atsushi Ono, Won-Min Song, Takaaki Higashi, Roberto Sanchez, Rosa S. Kim, C. Billie Bian, Karun Kiani, Tom Croonenborghs, Aravind Subramanian, Raymond T. Chung, Beate K. Straub, Detlef Schuppan, Maliki Ankavay, Laurence Cocquerel, Evelyne Schaeffer, Nicolas Goossens, Anna P. Koh, Milind Mahajan, Venugopalan D. Nair, Ganesh Gunasekaran, Myron E. Schwartz, Nabeel Bardeesy, Alex K. Shalek, Orit Rozenblatt-Rosen, Aviv Regev, Emanuele Felli, Patrick Pessaux, Kenneth K. Tanabe, Mathias Heikenwälder, Catherine Schuster, Nathalie Pochet, Mirjam B. Zeisel, Bryan C. Fuchs, Yujin Hoshida, Thomas F. Baumert

Source: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/454d7d31ae1e40b7812cd73b90a2e7e3

Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation

Authors: Emilie Crouchet, Shen Li, Mozhdeh Sojoodi, Simonetta Bandiera, Naoto Fujiwara, Hussein El Saghire, Shijia Zhu, Tongqi Qian, Fahmida Akter Rasha, Fabio Del Zompo, Stephen C. Barrett, Eugénie Schaeffer, Marine A. Oudot, Clara Ponsolles, Sarah C. Durand, Sarani Ghoshal, Gunisha Arora, Fabio Giannone, Raymond T. Chung, Nevena Slovic, Nicolaas Van Renne, Emanuele Felli, Patrick Pessaux, Joachim Lupberger, Nathalie Pochet, Catherine Schuster, Kenneth K. Tanabe, Yujin Hoshida, Bryan C. Fuchs, Thomas F. Baumert

Source: JCI Insight, Vol 7, Iss 13 (2022)

Subject Terms: Hepatology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/d091965ffda14d4aaba85c9d24b3a727

Circadian control of hepatitis B virus replication

Authors: Xiaodong Zhuang, Donall Forde, Senko Tsukuda, Valentina D’Arienzo, Laurent Mailly, James M. Harris, Peter A. C. Wing, Helene Borrmann, Mirjam Schilling, Andrea Magri, Claudia Orbegozo Rubio, Robert J. Maidstone, Mudassar Iqbal, Miguel Garzon, Rosalba Minisini, Mario Pirisi, Sam Butterworth, Peter Balfe, David W. Ray, Koichi Watashi, Thomas F. Baumert, Jane A. McKeating

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f8

Genetic variation in IL-10 influences the progression of hepatitis B infection

Authors: Magda Rybicka, Anna Woziwodzka, Alicja Sznarkowska, Tomasz Romanowski, Piotr Stalke, Marcin Dręczewski, Eloi R. Verrier, Thomas F. Baumert, Krzysztof Piotr Bielawski

Source: International Journal of Infectious Diseases, Vol 96, Iss , Pp 260-265 (2020)

Subject Terms: HBV, Cirrhosis, Fibrosis, IL10, Single-nucleotide polymorphism, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971220302976; https://doaj.org/toc/1201-9712

Access URL: https://doaj.org/article/1c66a0150547457aac1af0b0cd251b49

Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes

Authors: Vaclav Janovec, Jan Hodek, Kamila Clarova, Tomas Hofman, Pavel Dostalik, Jiri Fronek, Jaroslav Chlupac, Laurence Chaperot, Sarah Durand, Thomas F. Baumert, Iva Pichova, Barbora Lubyova, Ivan Hirsch, Jan Weber

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d66559148ab3479e9a9a72c1b20bba42

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Authors: Carla Eller, Laura Heydmann, Che C. Colpitts, Houssein El Saghire, Federica Piccioni, Frank Jühling, Karim Majzoub, Caroline Pons, Charlotte Bach, Julie Lucifora, Joachim Lupberger, Michael Nassal, Glenn S. Cowley, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, Emanuele Felli, Patrick Pessaux, Camille Sureau, Catherine Schuster, David E. Root, Eloi R. Verrier, Thomas F. Baumert

Source: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0742f94d66504c4986045226266777a1

Tight Junction Protein Signaling and Cancer Biology

Authors: Zeina Nehme, Natascha Roehlen, Punita Dhawan, Thomas F. Baumert

Source: Cells, Vol 12, Iss 2, p 243 (2023)

Subject Terms: tight junctions, carcinogenesis, signaling pathways, therapeutic targets, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/2/243; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/626ccabd20cb4b2ab20c982e9482f2f8

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

Authors: Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A.C. Wing, Mirjam Schilling, James M. Harris, Helene Borrmann, Sophie B. Morgan, Jennifer L. Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, Charlotte Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy S.C. Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating

Source: iScience, Vol 24, Iss 10, Pp 103144- (2021)

Subject Terms: Molecular biology, Microbiology, Virology, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221011123; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/9e863295d0ed4df8a498ce0d3e971ee4

Interleukin‐32 Contributes to Human Nonalcoholic Fatty Liver Disease and Insulin Resistance

Authors: Nassim Dali‐Youcef, Michel Vix, Federico Costantino, Houssein El‐Saghire, Benoit Lhermitte, Cosimo Callari, Jacopo D’Agostino, Silvana Perretta, Stefan Paveliu, Monica Gualtierotti, Edith Dumeny, Marine A. Oudot, Amélie Jaulin, Doulaye Dembélé, Mirjam B. Zeisel, Catherine Tomasetto, Thomas F. Baumert, Michel Doffoël

Source: Hepatology Communications, Vol 3, Iss 9, Pp 1205-1220 (2019)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/5c47567d5a5f4bdea27e87f48d9dd20c

Nucleic Acid-Induced Signaling in Chronic Viral Liver Disease

Authors: Armando Andres Roca Suarez, Barbara Testoni, Thomas F. Baumert, Joachim Lupberger

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: hepatitis B virus, hepatitis C virus, hepatocellular carcinoma, viral sensing, signaling, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.624034/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ea6ac6485b0b4f6f98445660fef0db15

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Authors: Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Jane A. McKeating

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d57b7a19acc942b6a61940c29a11b307