Different dynamics of soluble inflammatory mediators after clearance of respiratory SARS-CoV-2 versus blood-borne hepatitis C virus infections

Authors: Antonia Zeuzem, Saumya Dileep Kumar, Carlos Oltmanns, Moana Witte, Jasmin Mischke, Nora Drick, Jan Fuge, Isabell Pink, Jan Tauwaldt, Jennifer Debarry, Thomas Illig, Heiner Wedemeyer, Benjamin Maasoumy, Yang Li, Anke R. M. Kraft, Markus Cornberg

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: SARS-CoV-2 infection, COVID-19, Long-COVID, Hepatitis C virus, Proteomics, Direct-acting antiviral, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/265b33f0351f4a819efaf65475043c57

Systematic assessment of COVID-19 host genetics using whole genome sequencing data.

Authors: Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, DeCOI host genetics group, T Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V Schmidt, Philipp Schommers, Christoph D Spinner, Maria J G T Vehreschild, Thirumalaisamy P Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J Brent Richards, DeCOI, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L Schultze, Peter Nürnberg, Markus M Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C Schulte, Kerstin U Ludwig

Source: PLoS Pathogens, Vol 20, Iss 12, p e1012786 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/1e791f568ea0417a9070a1420ba5cbc7

A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients

Authors: Juliane Hannemann, Anne Zink, Yoana Mileva, Paul Balfanz, Edgar Dahl, Sonja Volland, Thomas Illig, Edzard Schwedhelm, Florian Kurth, Alexandra Stege, Martin Aepfelbacher, Armin Hoffmann, Rainer Böger

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Infectious diseases, Nitric oxide, Intensive care, Biomarker, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/fd19c5f66dfd4915bcc8f54205a52bc6

A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation

Authors: Katharina S. Appel, Chin Huang Lee, Susana M. Nunes de Miranda, Daniel Maier, Jens-Peter Reese, Gabriele Anton, Thomas Bahmer, Sabrina Ballhausen, Beate Balzuweit, Carla Bellinghausen, Arne Blumentritt, Markus Brechtel, Irina Chaplinskaya-Sobol, Johanna Erber, Karin Fiedler, Ramsia Geisler, Ralf Heyder, Thomas Illig, Mirjam Kohls, Jenny Kollek, Lilian Krist, Roberto Lorbeer, Olga Miljukov, Lazar Mitrov, Carolin Nürnberger, Christian Pape, Christina Pley, Christian Schäfer, Jens Schaller, Mario Schattschneider, Margarete Scherer, Nick Schulze, Dana Stahl, Hans Christian Stubbe, Thalea Tamminga, Johannes Josef Tebbe, Maria J. G. T. Vehreschild, Silke Wiedmann, Jörg Janne Vehreschild

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Performance-based reimbursement, Funding allocation, Clinical studies, COVID-19, Research infrastructure, Germany, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/fedd46ae850b48ea83969adf79fa50df

Author Correction: A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients

Authors: Juliane Hannemann, Anne Zink, Yoana Mileva, Paul Balfanz, Edgar Dahl, Sonja Volland, Thomas Illig, Edzard Schwedhelm, Florian Kurth, Alexandra Stege, Martin Aepfelbacher, Armin Hofmann, Rainer Böger

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-1 (2025)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/cce6084d3a6e43069b31dab2f5c5eb76

Validation of the predictive value of BDNF -87 methylation for antidepressant treatment success in severely depressed patients—a randomized rater-blinded trial

Authors: Hannah Benedictine Maier, Alexandra Neyazi, Gabriel L. Bundies, Fiona Meyer-Bockenkamp, Stefan Bleich, Hansi Pathak, Yvonne Ziert, Barbara Neuhaus, Franz-Josef Müller, Iris Pollmann, Thomas Illig, Stefanie Mücke, Meike Müller, Brinja Kira Möller, Steffen Oeltze-Jafra, Tim Kacprowski, Jan Voges, Fabian Müntefering, Josef Scheiber, Andreas Reif, Mareike Aichholzer, Christine Reif-Leonhard, Maren Schmidt-Kassow, Ulrich Hegerl, Hanna Reich, Stefan Unterecker, Heike Weber, Jürgen Deckert, Nicole Bössel-Debbert, Hans J. Grabe, Michael Lucht, Helge Frieling

Source: Trials, Vol 25, Iss 1, Pp 1-12 (2024)

Subject Terms: BDNF, Biomarker, RCT, Major depressive disorder, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/55ea2c6790ba48b2a005ed3270692acc

Vaccination Schedule and Age Influence Impaired Responsiveness to Hepatitis B Vaccination: A Randomized Trial in Central Asia

Authors: Janyn Heisig, Zuridin Sh. Nurmatov, Peggy Riese, Stephanie Trittel, Gulsunai J. Sattarova, Saikal N. Temirbekova, Gulnara Zh. Zhumagulova, Zhanylai N. Nuridinova, Aisuluu A. Derkenbaeva, Bubuzhan K. Arykbaeva, Bakyt I. Dzhangaziev, Jana Prokein, Norman Klopp, Thomas Illig, Carlos A. Guzmán, Omor T. Kasymov, Manas K. Akmatov, Frank Pessler

Source: Pathogens, Vol 13, Iss 12, p 1082 (2024)

Subject Terms: aging, Central Asia, compliance, hepatitis B, immune response, Kyrgyzstan, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/13/12/1082; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/0d789d5d71204e849a027684f0276d76

A variational autoencoder trained with priors from canonical pathways increases the interpretability of transcriptome data.

Authors: Bin Liu, Bodo Rosenhahn, Thomas Illig, David S DeLuca

Source: PLoS Computational Biology, Vol 20, Iss 7, p e1011198 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/84a8f7f25f1b40699bdf6ac214c68554

An artificial intelligence-assisted clinical framework to facilitate diagnostics and translational discovery in hematologic neoplasiaResearch in context

Authors: Ming Tang, Željko Antić, Pedram Fardzadeh, Stefan Pietzsch, Charlotte Schröder, Adrian Eberhardt, Alena van Bömmel, Gabriele Escherich, Winfried Hofmann, Martin A. Horstmann, Thomas Illig, J. Matt McCrary, Jana Lentes, Markus Metzler, Wolfgang Nejdl, Brigitte Schlegelberger, Martin Schrappe, Martin Zimmermann, Karolina Miarka-Walczyk, Agata Patsorczak, Gunnar Cario, Bernhard Y. Renard, Martin Stanulla, Anke Katharina Bergmann

Source: EBioMedicine, Vol 104, Iss , Pp 105171- (2024)

Subject Terms: Clinical framework, Data integration, Machine learning, Leukaemia, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424002068; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/73ab5d4f744341ce91b017ca5e0c00a9

Ethical and coordinative challenges in setting up a national cohort study during the COVID-19 pandemic in Germany

Authors: Katharina Tilch, Sina M. Hopff, Katharina Appel, Monika Kraus, Bettina Lorenz-Depiereux, Lisa Pilgram, Gabi Anton, Sarah Berger, Ramsia Geisler, Kirsten Haas, Thomas Illig, Dagmar Krefting, Roberto Lorbeer, Lazar Mitrov, Maximilian Muenchhoff, Matthias Nauck, Christina Pley, Jens-Peter Reese, Siegbert Rieg, Margarete Scherer, Melanie Stecher, Christoph Stellbrink, Heike Valentin, Christof Winter, Martin Witzenrath, J. Janne Vehreschild

Source: BMC Medical Ethics, Vol 24, Iss 1, Pp 1-16 (2023)

Subject Terms: Pandemic preparedness, Ethical approval, COVID-19, Multicenter study, Study initiation, Ethics committee, Medical philosophy. Medical ethics, R723-726

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6939

Access URL: https://doaj.org/article/4edf526535364b018d9c6b0891af0e66

Metabolomics analysis reveals novel serum metabolite alterations in cancer cachexia

Authors: Tushar H. More, Karsten Hiller, Martin Seifert, Thomas Illig, Rudi Schmidt, Raphael Gronauer, Thomas von Hahn, Hauke Weilert, Axel Stang

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: cancer cachexia, GC-MS metabolomics, erythronic acid, glucuronic acid, serum metabolites, metabolic pathways, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1286896/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/877b087badc74524b315595bfa9f72aa

FUNCTIONAL ANALYSES OF RUNX1 VARIANTS IN THE CONTEXT OF FAMILIAL PLATELET DISORDER WIT PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES

Authors: Melanie Decker, Förster Alisa, Prüne Alina, Anne Seebacher, Alena Wittstock, Thomas Illig, Brigitte Schlegelberger, Tim Ripperger

Source: EJC Paediatric Oncology, Vol 2, Iss , Pp 100050- (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772610X2300048X; https://doaj.org/toc/2772-610X

Access URL: https://doaj.org/article/7eebe0d059644cdbbe62b390ace55a4e

Plasma markers of COVID-19 severity: a pilot study

Authors: Julia Beimdiek, Sabina Janciauskiene, Sabine Wrenger, Sonja Volland, Adriana Rozy, Jan Fuge, Beata Olejnicka, Isabell Pink, Thomas Illig, Alexander Popov, Joanna Chorostowska, Falk F. R. Buettner, Tobias Welte

Source: Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)

Subject Terms: COVID-9 severity, Acute phase proteins, Cell death, Inflammation, N-glycosylation, Trombosis, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/15e691f1a242452fa7cc0b2bc025ec12

Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Authors: Peggy Riese, Stephanie Trittel, Manas K. Akmatov, Marcus May, Jana Prokein, Thomas Illig, Christoph Schindler, Birgit Sawitzki, Yassin Elfaki, Stefan Floess, Jochen Huehn, Adrian J. Błażejewski, Till Strowig, Esteban A. Hernandez-Vargas, Robert Geffers, Bowen Zhang, Yang Li, Frank Pessler, Carlos A. Guzmán

Source: Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9417193549c440fd81f568927dc6de4e

MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functions in hepatocellular carcinoma by directly targeting hepatoma-derived growth factor HDGF

Authors: Nicole Huge, Thea Reinkens, Reena Buurman, Maria Sandbothe, Anke Bergmann, Hannah Wallaschek, Beate Vajen, Amelie Stalke, Melanie Decker, Marlies Eilers, Vera Schäffer, Oliver Dittrich-Breiholz, Engin Gürlevik, Florian Kühnel, Brigitte Schlegelberger, Thomas Illig, Britta Skawran

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-16 (2022)

Subject Terms: HCC, HDAC inhibitors, miRNA sequencing, ERK signaling, Wnt signaling, miRNA replacement therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/3da413d23a3548bfa6c3093759f16cd4

Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia

Authors: Martin Wetzke, Katharina Schütz, Matthias Volkmar Kopp, Jürgen Seidenberg, Christian Vogelberg, Tobias Ankermann, Christine Happle, Gesche Voigt, Holger Köster, Thomas Illig, Christiane Lex, Antje Schuster, Ralph Maier, Marcus Panning, Grit Barten, Gernot Rohde, Tobias Welte, Gesine Hansen

Source: ERJ Open Research, Vol 9, Iss 2 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/9/2/00286-2022.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/9fa7d83f75914a4f84d8717ae3504d9b

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Authors: Bowen Zhang, Zhenhua Zhang, Valerie A.C.M. Koeken, Saumya Kumar, Michelle Aillaud, Hsin-Chieh Tsay, Zhaoli Liu, Anke R.M. Kraft, Chai Fen Soon, Ivan Odak, Berislav Bošnjak, Anna Vlot, Morris A. Swertz, Uwe Ohler, Robert Geffers, Thomas Illig, Jochen Huehn, Antoine-Emmanuel Saliba, Leif Erik Sander, Reinhold Förster, Cheng-Jian Xu, Markus Cornberg, Leon N. Schulte, Yang Li

Source: Cell Genomics, Vol 3, Iss 2, Pp 100232- (2023)

Subject Terms: COVID-19, genetic regulation, epigenetic regulation, scATAC-seq, scRNA-seq, allele-specific open chromatin, Genetics, QH426-470, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666979X22001902; https://doaj.org/toc/2666-979X

Access URL: https://doaj.org/article/1d8a821dff98448fb35c91743f5b812b

Canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event

Authors: Holger Andreas Volk, Tobias Welte, Claudia Schulz, Andreas Nitsche, Thomas Illig, Lothar Kreienbrock, Maren von Köckritz-Blickwede, Michael Peter Manns, Nele Alexandra ten Hagen, Friederike Twele, Sebastian Meller, Lisa Wijnen, Clara Schoneberg, Albert Osterhaus, Anna-Lena Boeck, Konstantin Boeck, Viktoria Bonda, Veronika Pilchová, Franziska Karola Kaiser, Mariana Gonzalez Hernandez, Hans Ebbers, Julia Hinsenkamp, Isabell Pink, Nora Drick, Andreas Puyskens, Christiane Ernst, Michael Engels, Esther Schalke

Source: BMJ Global Health, Vol 7, Iss 11 (2022)

Subject Terms: Medicine (General), R5-920, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://gh.bmj.com/content/7/11/e010276.full; https://doaj.org/toc/2059-7908

Access URL: https://doaj.org/article/3c6da634b23f4f49811e9512da3361d3

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

Authors: Maximilian Ackermann, Jan C. Kamp, Christopher Werlein, Claire L. Walsh, Helge Stark, Verena Prade, Rambabu Surabattula, Willi L. Wagner, Catherine Disney, Andrew J. Bodey, Thomas Illig, Diana J. Leeming, Morten A. Karsdal, Alexandar Tzankov, Peter Boor, Mark P. Kühnel, Florian P. Länger, Stijn E. Verleden, Hans M. Kvasnicka, Hans H. Kreipe, Axel Haverich, Stephen M. Black, Axel Walch, Paul Tafforeau, Peter D. Lee, Marius M. Hoeper, Tobias Welte, Benjamin Seeliger, Sascha David, Detlef Schuppan, Steven J. Mentzer, Danny D. Jonigk

Source: EBioMedicine, Vol 85, Iss , Pp 104296- (2022)

Subject Terms: COVID-19, Intussusceptive angiogenesis, Fibrogenesis, Biomarkers, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422004789; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/b4f5f451eaf04dc4b18d8490c6c059a3

Candidate genes and sequence variants for susceptibility to mycobacterial infection identified by whole-exome sequencing

Authors: Alexander Varzari, Igor V. Deyneko, Gitte Hoffmann Bruun, Maja Dembic, Winfried Hofmann, Victor M. Cebotari, Sergei S. Ginda, Brage S. Andresen, Thomas Illig

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: disseminated tuberculosis, BCG-itis, primary immunodeficiency (PID) disorders, whole-exome sequencing (WES), trio analysis, pre-mRNA splicing, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.969895/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/45a80c359357407798df86e0a462fdeb