A new potent and selective peroxisome proliferator-activated receptor alpha partial agonist displays anti-steatotic effects In vitro and behaves as a safe hypolipidemic and hypoglycemic agent in a diabetic mouse model

Authors: Laghezza, Antonio ^{a, 1}, Falbo, Emanuele ^{b, 1}, Gilardi, Federica ^{c, d}, Thomas, Aurélien ^{c, d}, Brunetti, Leonardo ^a, Leuci, Rosalba ^a, Piemontese, Luca ^a, Tortorella, Paolo ^a, Biswas, Abanish ^e, Singh, Ravi Pratap ^e, Pattnaik, Ashok Kumar ^e, Jayaprakash, Venkatesan ^e, Tambe, Suhas ^f, Ca, Sudeep ^g, Wackerlig-Damle, Judith ^h, Paoli, Paolo ⁱ, Loiodice, Fulvio ^{a, ⁎}, Lavecchia, Antonio ^{b, ⁎⁎}

Source: In European Journal of Medicinal Chemistry 5 May 2025 289

Arsenic induces metabolome remodeling in mature human adipocytes

Authors: Gasser, Marie, Lenglet, Sébastien, Bararpour, Nasim, Sajic, Tatjana, Vaucher, Julien, Wiskott, Kim, Augsburger, Marc, Fracasso, Tony, Gilardi, Federica, Thomas, Aurélien

Source: In Toxicology December 2023 500

Toxicity and Metabolomic Impact of Cobalt, Chromium, and Nickel Exposure on HepaRG Hepatocytes

Authors: Bellouard, Marie, Gasser, Marie, Lenglet, Sébastien, Gilardi, Federica, Bararpour, Nasim, Augsburger, Marc, Thomas, Aurélien, Alvarez, Jean-Claude

Source: Chemical research in toxicology. 35(5):807-816

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631524577&indx=1&recIds=ETOCRN631524577

Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6‐hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots

Authors: Magliocco, Gaëlle, Desmeules, Jules, Samer, Caroline Flora, Thomas, Aurélien, Daali, Youssef

Source: Clinical and translational science. 15(6):1482-1491

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153673890.0x000001&indx=1&recIds=ETOCvdc_100153673890.0x000001

An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat

Authors: Nunes, Carolina, Singh, Pranika, Mazidi, Zahra, Murphy, Cormac, Bourguignon, Aurore, Wellens, Sara, Chandrasekaran, Vidya, Ghosh, Sreya, Zana, Melinda, Pamies, David, Thomas, Aurélien, Verfaillie, Catherine, Culot, Maxime, Dinnyes, Andras, Hardy, Barry, Wilmes, Anja, Jennings, Paul, Grillari, Regina, Grillari, Johannes, Zurich, Marie-Gabrielle, Exner, Thomas

Source: In Toxicology in Vitro June 2022 81

A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity

Authors: Sblano, Sabina, Cerchia, Carmen, Laghezza, Antonio, Piemontese, Luca, Brunetti, Leonardo, Leuci, Rosalba, Gilardi, Federica, Thomas, Aurelien, Genovese, Massimo, Santi, Alice, Tortorella, Paolo, Paoli, Paolo, Lavecchia, Antonio, Loiodice, Fulvio

Source: In European Journal of Medicinal Chemistry 5 May 2022 235

Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes

Authors: Gasser, Marie, Lenglet, Sébastien, Bararpour, Nasim, Sajic, Tatjana, Wiskott, Kim, Augsburger, Marc, Fracasso, Tony, Gilardi, Federica, Thomas, Aurélien

Source: In Toxicology 30 March 2022 470

Vascular-targeted micelles as a specific MRI contrast agent for molecular imaging of fibrin clots and cancer cells

Authors: Vorobiev, Vassily, Adriouach, Souad, Crowe, Lindsey A., Lenglet, Sébastien, Thomas, Aurélien, Chauvin, Anne-Sophie, Allémann, Eric

Source: In European Journal of Pharmaceutics and Biopharmaceutics January 2021 158:347-358

Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity

Authors: Magliocco, Gaëlle, Desmeules, Jules, Matthey, Alain, Quirós‐Guerrero, Luis M., Bararpour, Nasim, Joye, Timothée, Marcourt, Laurence, Queiroz, Emerson F., Wolfender, Jean‐Luc, Gloor, Yvonne, Thomas, Aurélien, Daali, Youssef

Source: British journal of pharmacology. 178(23):4708-4725

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134517361.0x000001&indx=1&recIds=ETOCvdc_100134517361.0x000001

Investigation of the impact of exposure to trace elements on health and disease from the ToxiLaus study.

Authors: Mouti, Idriss, Perrais, Maïwenn, Marques-Vidal, Pedro, Thomas, Aurélien, Vaucher, Julien

Source: Scientific Reports; 11/29/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: INDUCTIVELY coupled plasma mass spectrometry, CARDIOVASCULAR diseases risk factors, BODY mass index, METABOLIC syndrome, COPPER

Reference values for plasma and urine trace elements in a Swiss population-based cohort.

Authors: Perrais, Maïwenn, Trächsel, Bastien, Lenglet, Sébastien, Pruijm, Menno, Ponte, Belen, Vogt, Bruno, Augsburger, Marc, Rousson, Valentin, Bochud, Murielle, Thomas, Aurélien

Source: Clinical Chemistry & Laboratory Medicine; Oct2024, Vol. 62 Issue 11, p2242-2255, 14p

Subject Terms: INDUCTIVELY coupled plasma mass spectrometry, TRACE elements, REFERENCE values, COPPER, TRACE elements in water, BIOLOGICAL monitoring, URINE

Differentiating individuals through the chemical composition of their fingermarks

Authors: Gorka, Marie, Thomas, Aurélien, Bécue, Andy

Source: Forensic science international. 346

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193890708.0x000001&indx=1&recIds=ETOCvdc_100193890708.0x000001

Liquid chromatography-high resolution mass spectrometry for broad-spectrum drug screening of dried blood spot as microsampling procedure

Authors: Joye, Timothée, Sidibé, Jonathan, Déglon, Julien, Karmime, Abderrahim, Sporkert, Frank, Widmer, Christèle, Favrat, Bernard, Lescuyer, Pierre, Augsburger, Marc, Thomas, Aurélien

Source: In Analytica Chimica Acta 31 July 2019 1063:110-116

In situ metabolomic changes in rat hippocampus after acute cocaine administration

Authors: Joye, Timothée, Bararpour, Nasim, Augsburger, Marc, Boutrel, Benjamin, Thomas, Aurélien

Source: In International Journal of Mass Spectrometry March 2019 437:87-91

Trace element intakes should be revisited in burn nutrition protocols: A cohort study

Authors: Jafari, Paris, Thomas, Aurelien, Haselbach, Daniel, Watfa, William, Pantet, Olivier, Michetti, Murielle, Raffoul, Wassim, Applegate, Lee Ann, Augsburger, Marc, Berger, Mette M.

Source: In Clinical Nutrition June 2018 37(3):958-964

δppfor, Clostridium_ASF356 mutants prevent perivascular adipose tissue and endothelial senescence

Authors: Pugin, Benoit, Constancias, Florentin, Thomas, Aurélien, Le Gludic, Sylvain, Menni, Cristina, Beer, Jürg H., Paneni, Francesco, Ruschitzka, Frank, Saeedi Saravi, Seyed Soheil

Source: In Atherosclerosis August 2024 395 Supplement 1

Geospatial clustering of auto-antibodies against apolipoprotein A-1, heavy metals, cardiovascular and liver diseases in the general population

Authors: Joost, Stéphane, Fellay, Noe, Pagano, Sabrina, Marques-Vidal, Pedro, Vollenweider, Peter, Stringhini, Silvia, De Ridder, David, Vaucher, Julien, Perrais, Maïwenn, Thomas, Aurélien, Somm, Emmanuel, Jornayvaz, François, Guessous, Idris, Vuilleumier, Nicolas

Source: In Atherosclerosis August 2024 395 Supplement 1

Phenotyping of Human CYP450 Enzymes by Endobiotics: Current Knowledge and Methodological Approaches

Authors: Magliocco, Gaëlle, Thomas, Aurélien, Desmeules, Jules, Daali, Youssef

Source: Clinical pharmacokinetics. 58(11):1373-1391

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130227821.0x000001&indx=1&recIds=ETOCvdc_100130227821.0x000001

Chemical composition of the fingermark residue: Assessment of the intravariability over one year using MALDI-MSI

Authors: Gorka, Marie, Thomas, Aurélien, Bécue, Andy

Source: Forensic science international. 338

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169445404.0x000001&indx=1&recIds=ETOCvdc_100169445404.0x000001

Interactions between physical exercise, associative memory, and genetic risk for Alzheimer's disease.

Authors: Igloi, Kinga, Bosch, Blanca Marin, Kuenzi, Noémie, Thomas, Aurélien, Lauer, Estelle, Bringard, Aurélien, Schwartz, Sophie

Source: Cerebral Cortex; May2024, Vol. 34 Issue 5, p1-11, 11p