Targeting PARP-1 and DNA Damage Response Defects in Colorectal Cancer Chemotherapy with Established and Novel PARP Inhibitors.

Authors: Demuth, Philipp¹ (AUTHOR) pdemuth@rptu.de, Thibol, Lea¹ (AUTHOR) thibol@rptu.de, Lemsch, Anna¹ (AUTHOR) anna.lemsch@gmx.de, Potlitz, Felix² (AUTHOR) felix.potlitz@gmail.com, Schulig, Lukas² (AUTHOR) lukas.schulig@uni-greifswald.de, Grathwol, Christoph³ (AUTHOR) christoph.grathwol@kit.edu, Manolikakes, Georg⁴ (AUTHOR) manolikakes@chemie.uni-kl.de, Schade, Dennis⁵ (AUTHOR) schade@pharmazie.uni-kiel.de, Roukos, Vassilis⁶ (AUTHOR) v.roukos@imb-mainz.de, Link, Andreas² (AUTHOR) link@uni-greifswald.de, Fahrer, Jörg¹ (AUTHOR) fahrer@chemie.uni-kl.de

Source: Cancers. Oct2024, Vol. 16 Issue 20, p3441. 25p.

Subject Terms: *THERAPEUTIC use of antineoplastic agents, *COMPUTER-assisted molecular modeling, *IN vitro studies, *NUCLEAR magnetic resonance spectroscopy, *T-test (Statistics), *RESEARCH funding, *ENZYME inhibitors, *COLORECTAL cancer, *IMMUNODIAGNOSIS, *FLUORESCENT antibody technique, *DESCRIPTIVE statistics, *CANCER chemotherapy, *CELL culture, *DNA repair, *DRUG efficacy, *MOLECULAR structure, *MASS spectrometry, *WESTERN immunoblotting, *CELL death, *DATA analysis software, *CELL survival, *DRUG synergism, *REGRESSION analysis, *CELL surface antigens

Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery.

Authors: Haas, Manuel, Wirachowski, Karina, Thibol, Lea, Küpper, Jan-Heiner, Schrenk, Dieter, Fahrer, Jörg

Source: Archives of Toxicology; May2023, Vol. 97 Issue 5, p1413-1428, 16p

Subject Terms: LIVER cells, LIVER cancer, CANCER cells, GENETIC toxicology, BIOTRANSFORMATION (Metabolism), PYRROLIZIDINES, ALKALOIDS