RNA is a pro-apoptotic target of cisplatin in cancer cell lines and C. elegans

Authors: Rose, Fabian, Köberle, Beate, Honnen, Sebastian, Bay, Cindy, Burhenne, Jürgen, Weiss, Johanna, Haefeli, Walter E., Theile, Dirk

Source: In Biomedicine & Pharmacotherapy April 2024 173

Molecular prediction of clinical response to anti‐PD‐1/anti‐PD‐L1 immune checkpoint inhibitors: New perspectives for precision medicine and mass spectrometry‐based investigations

Authors: Longuespée, Rémi, Theile, Dirk, Zörnig, Inka, Hassel, Jessica C., Lindner, Joshua Raoul, Haefeli, Walter E., Fresnais, Margaux

Source: International journal of cancer. 153(2):252-264

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182474624.0x000001&indx=1&recIds=ETOCvdc_100182474624.0x000001

Wechselwirkung zwischen Protonenpumpen-Inhibitoren und Checkpoint-Inhibitoren

Authors: Jost, Franziska, Theile, Dirk

Source: Medizinische Monatsschrift für Pharmazeuten. 45(9):344-350

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630039549&indx=1&recIds=ETOCRN630039549

Physiology‐based pharmacokinetic modelling and experimental data suggest that rifabutin alters dolutegravir kinetics by both P‐glycoprotein induction and concurrent inhibition

Authors: Theile, Dirk, Nilles, Julie, Meid, Andreas D.

Source: British journal of clinical pharmacology. 89(7):2329-2331

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185440141.0x000001&indx=1&recIds=ETOCvdc_100185440141.0x000001

In vitro evidence suggesting that the toll-like receptor 7 and 8 agonist resiquimod (R-848) unlikely affects drug levels of co-administered compounds

Authors: Theile, Dirk, Wagner, Lelia, Haefeli, Walter E., Weiss, Johanna

Source: In European Journal of Pharmaceutical Sciences 1 July 2021 162

A nuclear factor kappa B reporter cell line used to evaluate ex vivo the net inflammatory effect of plasma samples from patients with rheumatoid arthritis, psoriasis, or COVID-19

Authors: Wagner, Lelia, Haefeli, Walter E., Merle, Uta, Lorenz, Hanns-Martin, Hohmann, Nicolas, Weiss, Johanna, Theile, Dirk

Source: In Cytokine February 2021 138

Approaching sites of action of drugs in clinical pharmacology: New analytical options and their challenges

Authors: Longuespée, Rémi, Theile, Dirk, Fresnais, Margaux, Burhenne, Jürgen, Weiss, Johanna, Haefeli, Walter E.

Source: British journal of clinical pharmacology. 87(3):858-874

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116577318.0x000001&indx=1&recIds=ETOCvdc_100116577318.0x000001

Reporter cell assay-based functional quantification of TNF-α-antagonists in serum – a proof-of-principle study for adalimumab

Authors: Schuster, Lukas, Sauter, Max, Uhl, Philipp, Meid, Andreas, Haefeli, Walter E., Weiss, Johanna, Theile, Dirk

Source: In Analytical Biochemistry 1 May 2020 596

Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo.

Authors: Nilles, Julie^1,2 (AUTHOR), Theile, Dirk¹ (AUTHOR), Weiss, Johanna¹ (AUTHOR), Haefeli, Walter E.¹ (AUTHOR), Ruez, Stephanie² (AUTHOR) stephanie.ruez@boehringer-ingelheim.com

Source: Archives of Toxicology. Aug2024, Vol. 98 Issue 8, p2541-2556. 16p.

Subject Terms: *CYTOCHROME P-450 CYP3A, *CYTOCHROME P-450, *LIVER cells, *SUICIDE, *PROTEIN expression, *P-glycoprotein, *DRUG interactions, *GENE expression, *CYTOCHROME c

Pharmacodynamic monitoring using biomarkers to individualize pharmacotherapy

Authors: Theile, Dirk, Cho, William C

Source: Biomarkers in medicine. 13(05):393-408

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191744778.0x000001&indx=1&recIds=ETOCvdc_100191744778.0x000001

t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit

Authors: Theile, Dirk, Geng, Shuhui, Denny, Erin C., Momand, Jamil, Kane, Susan E.

Source: In Cellular Signalling December 2017 40:53-61

Clementine juice has the potential for drug interactions – In vitro comparison with grapefruit and mandarin juice

Authors: Theile, Dirk, Hohmann, Nicolas, Kiemel, Dominik, Gattuso, Giuseppe, Barreca, Davide, Mikus, Gerd, Haefeli, Walter Emil, Schwenger, Vedat, Weiss, Johanna

Source: In European Journal of Pharmaceutical Sciences 15 January 2017 97:247-256

Elucidating the beneficial effects of melphalan, adriamycin, and corticoids in combination with bortezomib against multiple myeloma in vitro

Authors: Schäfer, Julia, Burhenne, Jürgen, Weiss, Johanna, Theile, Dirk

Source: Naunyn-Schmiedeberg's archives of pharmacology. 392(4):461-466

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100126864943.0x000001&indx=1&recIds=ETOCvdc_100126864943.0x000001

Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays

Authors: Becker, Jonas Philipp, Clemens, Jannick Robert, Theile, Dirk, Weiss, Johanna

Source: In Analytical Biochemistry 15 September 2016 509:124-129

The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters

Authors: Rigalli, Juan Pablo, Tocchetti, Guillermo Nicolás, Arana, Maite Rocío, Villanueva, Silvina Stella Maris, Catania, Viviana Alicia, Theile, Dirk, Ruiz, María Laura, Weiss, Johanna ^*

Source: In Cancer Letters 28 June 2016 376(1):165-172

The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants.

Authors: Nilles, Julie, Weiss, Johanna, Masin, Martin, Tuffs, Christopher, Strowitzki, Moritz J., Haefeli, Walter E., Ruez, Stephanie, Theile, Dirk

Source: Naunyn-Schmiedeberg's Archives of Pharmacology; Apr2024, Vol. 397 Issue 4, p2485-2496, 12p

Subject Terms: PREGNANE X receptor, RIFAMPIN, GENE expression, DRUG metabolism, REPORTER genes, POLYMERASE chain reaction

Desmethyl bosentan displays a similar in vitro interaction profile as bosentan

Authors: Weiss, Johanna, Baumann, Sybille, Theile, Dirk, Haefeli, Walter Emil

Source: In Pulmonary Pharmacology & Therapeutics February 2015 30:80-86

What, if all alerts were specific – Estimating the potential impact on drug interaction alert burden

Authors: Seidling, Hanna M., Klein, Ulrike, Schaier, Matthias, Czock, David, Theile, Dirk, Pruszydlo, Markus G., Kaltschmidt, Jens, Mikus, Gerd, Haefeli, Walter E.

Source: In International Journal of Medical Informatics April 2014 83(4):285-291

Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site.

Authors: Phondeth, Lottida, Kamaraj, Rajamanikkam, Nilles, Julie, Weiss, Johanna, Haefeli, Walter E., Pávek, Petr, Theile, Dirk

Source: Archives of Toxicology; Jan2024, Vol. 98 Issue 1, p223-231, 9p

Subject Terms: P-glycoprotein, BINDING sites, RIFAMPIN, MOLECULAR docking, GENE expression, FLOW cytometry

Interaction profile of macitentan, a new non-selective endothelin-1 receptor antagonist, in vitro

Authors: Weiss, Johanna, Theile, Dirk, Rüppell, Maximilian Alexander, Speck, Tobias, Spalwisz, Adriana, Haefeli, Walter Emil

Source: In European Journal of Pharmacology 15 February 2013 701(1-3):168-175