CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches

Authors: Tang, Jiajia, Zheng, Quan, Wang, Qi, Zhao, Yaru, Ananthanarayanan, Preeta, Reina, Chiara, Šabanović, Berina, Jiang, Ke, Yang, Ming-Hsin, Meny, Clara Csilla, Wang, Huimin, Agerbaek, Mette Ø., Clausen, Thomas Mandel, Gustavsson, Tobias, Wen, Chenlei, Borghi, Felice, Mellano, Alfredo, Fenocchio, Elisabetta, Gregorc, Vanesa, Sapino, Anna, Theander, Thor G., Fu, Da, Aicher, Alexandra, Salanti, Ali, Shen, Baiyong, Heeschen, Christopher

Source: In Cell Reports Medicine 17 September 2024 5(9)

Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Authors: Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Spinello, Antinori, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, de Jongh, Willem A., Salanti, Ali, Theander, Thor G., McCall, Matthew B.B., Esen, Meral, Van Coillie, Julie ^{1, 2, 12}, Pongracz, Tamas ^{3, 12}, Šuštić, Tonći ^{1, 2}, Wang, Wenjun ³, Nouta, Jan ³, Le Gars, Mathieu ⁴, Keijzer, Sofie ⁵, Linty, Federica ^{1, 2}, Cristianawati, Olvi ⁵, Keijser, Jim B.D. ⁵, Visser, Remco ^{1, 2}, Smit, Merel J. ⁸, Sander, Adam ^{9, 10}, Schmidt, David E. ¹, Steenhuis, Maurice ⁵, Rispens, Theo ⁵, Nielsen, Morten A. ⁹, Mordmüller, Benjamin G. ⁸, Ellen van der Schoot, C. ¹, Roozendaal, Ramon ⁴, Wuhrer, Manfred ³, Vidarsson, Gestur ^{1, 2, 13, ∗}

Source: In iScience 15 September 2023 26(9)

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

Authors: Smit, Merel J, Sander, Adam F, Ariaans, Maud B P A, Fougeroux, Cyrielle, Heinzel, Constanze, Fendel, Rolf, Esen, Meral, Kremsner, Peter G, ter Heine, Rob, Wertheim, Heiman F, Idorn, Manja, Riis Paludan, Søren, Underwood, Alexander P, Binderup, Alekxander, Ramirez, Santseharay, Bukh, Jens, Soegaard, Max, Erdogan, Sayit M, Gustavsson, Tobias, Clemmensen, Stine, Theander, Thor G, Salanti, Ali, Hamborg, Mette, de Jongh, Willem A, McCall, Matthew B B, Nielsen, Morten A, Mordmüller, Benjamin G, Dagil, Robert, Goksøyr, Louise, Hulen, Thomas M, Janitzek, Christoph, Jensen, Daniel S, Justesen, Sune, Khalifé, Paul K, Kreidenweiss, Andrea, Lança, Telma, Lie-Andersen, Olivia, Teelen, Karina, Vidal-Calvo, Elena, Paludan, Søren Riis

Source: In The Lancet Microbe March 2023 4(3):e140-e148

Changing Plasmodium falciparum malaria prevalence in two villages of northeastern Tanzania between 2003 and 2021 in relation to vectors, interventions and climatic factors.

Authors: Lyimo, Eric, Kulaya, Neema B., Njotto, Lembris, Kassam, Nancy A., Gesase, Samwel, Malabeja, Anangisye, Liheluka, Edwin A., Mbwana, Joyce R., Baraka, Vito, Alifrangis, Michael, Kavishe, Reginald A., Lavstsen, Thomas, Mmbando, Bruno P., Theander, Thor G., Minja, Daniel T. R., Lusingu, John P. A., Wang, Christian W.

Source: Malaria Journal; 3/3/2025, Vol. 24 Issue 1, p1-14, 14p

Subject Terms: GENERALIZED estimating equations, HUMIDITY, CLIMATE change, MALARIA, CHI-squared test

The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

Authors: Spliid, Charlotte B., Toledo, Alejandro Gomez, Sanderson, Patience, Mao, Yang, Gatto, Francesco, Gustavsson, Tobias, Choudhary, Swati, Saldanha, Ana L., Vogelsang, Rasmus P., Gögenur, Ismail, Theander, Thor G., Leach, Franklin E., 3rd, Amster, I. Jonathan, Esko, Jeffrey D., Salanti, Ali, Clausen, Thomas Mandel

Source: In Journal of Biological Chemistry December 2021 297(6)

First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria

Authors: Mordmüller, Benjamin, Sulyok, Mihály, Egger-Adam, Diane, Resende, Mafalda, de Jongh, Willem A., Jensen, Mette H., Smedegaard, Helle Holm, Ditlev, Sisse B., Soegaard, Max, Poulsen, Lars, Dyring, Charlotte, Calle, Carlos Lamsfus, Knoblich, Annette, Ibáñez, Javier, Esen, Meral, Deloron, Philippe, Ndam, Nicaise, Issifou, Saadou, Houard, Sophie, Howard, Randall F., Reed, Steven G., Leroy, Odile, Luty, Adrian J. F., Theander, Thor G., Kremsner, Peter G., Salanti, Ali, Nielsen, Morten A.

Source: Clinical Infectious Diseases, 2019 Nov 01. 69(9), 1509-1516.

Access URL: https://www.jstor.org/stable/26819202

Malaria in Early Pregnancy and the Development of the Placental Vasculature

Authors: Moeller, Sofie L., Nyengaard, Jens R., Larsen, Lise G., Nielsen, Karsten, Bygbjerg, Ib C., Msemo, Omari A., Lusingu, John P. A., Minja, Daniel T. R., Theander, Thor G., Schmiegelow, Christentze

Source: The Journal of Infectious Diseases, 2019 Nov 01. 220(9), 1425-1434.

Access URL: https://www.jstor.org/stable/26801957

Anemia in late pregnancy induces an adaptive response in fetoplacental vascularization

Authors: Moeller, Sofie L., Schmiegelow, Christentze, Larsen, Lise G., Nielsen, Karsten, Msemo, Omari Abdul, Lusingu, John P.A., Minja, Daniel T.R., Theander, Thor G., Bygbjerg, Ib C., Nyengaard, Jens R.

Source: In Placenta May 2019 80:49-58

Acquisition of Antibodies Against Endothelial Protein C Receptor–Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria

Authors: Rambhatla, Janavi S., Turner, Louise, Manning, Laurens, Laman, Moses, Davis, Timothy M. E., Beeson, James G., Mueller, Ivo, Warrel, Jonathan, Theander, Thor G., Lavstsen, Thomas, Rogerson, Stephen J.

Source: The Journal of Infectious Diseases, 2019 Mar 01. 219(5), 808-818.

Access URL: https://www.jstor.org/stable/26748996

Mosaic and cocktail capsid-virus-like particle vaccines for induction of antibodies against the EPCR-binding CIDRα1 domain of PfEMP1.

Authors: Riedmiller, Ilary, Fougeroux, Cyrielle, Jensen, Rasmus W., Kana, Ikhlaq H., Sander, Adam F., Theander, Thor G., Lavstsen, Thomas, Turner, Louise

Source: PLoS ONE; 7/24/2024, Vol. 19 Issue 7, p1-13, 13p

Subject Terms: ERYTHROCYTE membranes, PROTEIN C, MEMBRANE proteins, VACCINES, IMMUNOGLOBULINS, PROTEIN receptors, MOSAIC viruses

Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

Authors: Derkach, Andriy, Otim, Isaac, Pfeiffer, Ruth M., Onabajo, Olusegun O., Legason, Ismail D., Nabalende, Hadijah, Ogwang, Martin D., Kerchan, Patrick, Talisuna, Ambrose O., Ayers, Leona W., Reynolds, Steven J., Nkrumah, Francis, Neequaye, Janet, Bhatia, Kishor, Theander, Thor G., Prokunina-Olsson, Ludmila, Turner, Louise, Goedert, James J., Lavstsen, Thomas, Mbulaiteye, Sam M.

Source: In EBioMedicine January 2019 39:358-368

Plasmodium falciparum Infection Early in Pregnancy has Profound Consequences for Fetal Growth

Authors: Schmiegelow, Christentze, Matondo, Sungwa, Minja, Daniel T. R., Resende, Mafalda, Pehrson, Caroline, Nielsen, Birgitte Bruun, Olomi, Raimos, Nielsen, Morten A., Deloron, Philippe, Salanti, Ali, Lusingu, John, Theander, Thor G.

Source: The Journal of Infectious Diseases, 2017 Dec . 216(12), 1601-1610.

Access URL: https://www.jstor.org/stable/26491739

Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1

Authors: Ndam, Nicaise Tuikue, Moussiliou, Azizath, Lavstsen, Thomas, Kamaliddin, Claire, Jensen, Anja T. R., Mama, Atikatou, Tahar, Rachida, Wang, Christian W., Jespersen, Jakob S., Alao, Jules M., Gamain, Benoit, Theander, Thor G., Deloron, Philippe

Source: The Journal of Infectious Diseases, 2017 Jun . 215(12), 1918-1925.

Access URL: https://www.jstor.org/stable/26364738

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

Authors: Lennartz, Frank, Adams, Yvonne, Bengtsson, Anja, Olsen, Rebecca W., Turner, Louise, Ndam, Nicaise T., Ecklu-Mensah, Gertrude, Moussiliou, Azizath, Ofori, Michael F., Gamain, Benoit, Lusingu, John P., Petersen, Jens E.V., Wang, Christian W., Nunes-Silva, Sofia, Jespersen, Jakob S., Lau, Clinton K.Y., Theander, Thor G., Lavstsen, Thomas, Hviid, Lars, Higgins, Matthew K., Jensen, Anja T.R.

Source: In Cell Host & Microbe 8 March 2017 21(3):403-414

Comparison of functional assays used in the clinical development of a placental malaria vaccine

Authors: Pehrson, Caroline, Heno, Kristine K., Adams, Yvonne, Resende, Mafalda, Mathiesen, Line, Soegaard, Max, de Jongh, Willem A., Theander, Thor G., Salanti, Ali, Nielsen, Morten A.

Source: In Vaccine 23 January 2017 35(4):610-618

Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting

Authors: Clausen, Thomas Mandel, Pereira, Marina Ayres, Oo, Htoo Zarni, Resende, Mafalda, Gustavson, Tobias, Mao, Yang, Sugiura, Nobuo, Liew, Janet, Fazli, Ladan, Theander, Thor G., Daugaard, Mads, Salanti, Ali

Source: In Sensing and Bio-Sensing Research July 2016 9:23-30

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

Authors: Salanti, Ali, Clausen, Thomas M., Agerbæk, Mette Ø., Al Nakouzi, Nader, Dahlbäck, Madeleine, Oo, Htoo Z., Lee, Sherry, Gustavsson, Tobias, Rich, Jamie R., Hedberg, Bradley J., Mao, Yang, Barington, Line, Pereira, Marina A., LoBello, Janine, Endo, Makoto, Fazli, Ladan, Soden, Jo, Wang, Chris K., Sander, Adam F., Dagil, Robert, Thrane, Susan, Holst, Peter J., Meng, Le, Favero, Francesco, Weiss, Glen J., Nielsen, Morten A., Freeth, Jim, Nielsen, Torsten O., Zaia, Joseph, Tran, Nhan L., Trent, Jeff, Babcook, John S., Theander, Thor G., Sorensen, Poul H., Daugaard, Mads

Source: In Cancer Cell 12 October 2015 28(4):500-514

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

Authors: Fougeroux, Cyrielle, Goksøyr, Louise, Idorn, Manja, Soroka, Vladislav, Myeni, Sebenzile K., Dagil, Robert, Janitzek, Christoph M., Søgaard, Max, Aves, Kara-Lee, Horsted, Emma W., Erdoğan, Sayit Mahmut, Gustavsson, Tobias, Dorosz, Jerzy, Clemmensen, Stine, Fredsgaard, Laurits, Thrane, Susan, Vidal-Calvo, Elena E., Khalifé, Paul, Hulen, Thomas M., Choudhary, Swati, Theisen, Michael, Singh, Susheel K., Garcia-Senosiain, Asier, Van Oosten, Linda, Pijlman, Gorben, Hierzberger, Bettina, Domeyer, Tanja, Nalewajek, Blanka W., Strøbæk, Anette, Skrzypczak, Magdalena, Andersson, Laura F., Buus, Søren, Buus, Anette Stryhn, Christensen, Jan Pravsgaard, Dalebout, Tim J., Iversen, Kasper, Harritshøj, Lene H., Mordmüller, Benjamin, Ullum, Henrik, Reinert, Line S., de Jongh, Willem Adriaan, Kikkert, Marjolein, Paludan, Søren R., Theander, Thor G., Nielsen, Morten A., Salanti, Ali, Sander, Adam F.

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191414194.0x000001&indx=1&recIds=ETOCvdc_100191414194.0x000001

Pre-clinical and clinical development of the first placental malaria vaccine

Authors: Pehrson, Caroline, Salanti, Ali, Theander, Thor G., Nielsen, Morten A.

Source: Expert review of vaccines. 16(6):613-624

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103219298.0x000001&indx=1&recIds=ETOCvdc_100103219298.0x000001

Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display

Authors: Singh, Susheel K., Thrane, Susan, Janitzek, Christoph M., Nielsen, Morten A., Theander, Thor G., Theisen, Michael, Salanti, Ali, Sander, Adam F.

Source: Vaccine. 35(30):3726-3732

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100044972080.0x000001&indx=1&recIds=ETOCvdc_100044972080.0x000001