Brain age mediates gut microbiome dysbiosis-related cognition in older adults

Authors: Sang Joon Son, Dong Yun Lee, Hyun Woong Roh, Maria Ly, Antonija Kolobaric, Howard Aizenstein, Carmen Andreescu, Eldin Jašarević, Tharick A. Pascoal, Pamela C. L Ferreira, Bruna Bellaver, Yong Hyuk Cho, Sunhwa Hong, You Jin Nam, Bumhee Park, Narae Kim, Jin Wook Choi, Jae Youn Cheong, Yoon-Keun Kim, Tae-Seop Shin, Chil-Sung Kang, Cheol-O Kwon, Seo-Yoon Yoon, Chang Hyung Hong, Helmet T. Karim

Source: Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-13 (2025)

Subject Terms: Brain age, Gut microbiome, Cognition, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/c399ffcf0668450982ae42de07acf9f0

Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer’s disease

Authors: Xuemei Zeng, Tara K. Lafferty, Anuradha Sehrawat, Yijun Chen, Pamela C. L. Ferreira, Bruna Bellaver, Guilherme Povala, M. Ilyas Kamboh, William E. Klunk, Ann D. Cohen, Oscar L. Lopez, Milos D. Ikonomovic, Tharick A. Pascoal, Mary Ganguli, Victor L. Villemagne, Beth E. Snitz, Thomas K. Karikari

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)

Subject Terms: Preclinical Alzheimer’s disease, Plasma biomarkers, Proteomics, Amyloid pathology, Tau pathology, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/c51e1a14802e4f3799358b5410df0e5b

Hormone therapy is associated with lower Alzheimer’s disease tau biomarkers in post-menopausal females -evidence from two independent cohorts

Authors: Yi-Ting Wang, Joseph Therriault, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S. Mathotaarachchi, Jenna Stevenson, Firoza Z. Lussier, Andréa L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/daf9534a01764ab599de980ae7f154aa

Identification of late-stage tau accumulation using plasma phospho-tau217Research in context

Authors: Marcel S. Woo, Joseph Therriault, Erin M. Jonaitis, Rachael Wilson, Rebecca E. Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J. Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J. Betthauser, Firoza Z. Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C. Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Jesse Klostranec, Paolo Vilali, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C. Johnson, Pedro Rosa-Neto

Source: EBioMedicine, Vol 109, Iss , Pp 105413- (2024)

Subject Terms: Alzheimer's disease, p-tau217, Prognosis, Blood biomarker, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004493; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/fb10423af32b4438978a55cda015eda3

Insights into the use of biomarkers in clinical trials in Alzheimer's disease

Authors: Tharick A. Pascoal, Cristiano S. Aguzzoli, Firoza Z. Lussier, Lucía Crivelli, Claudia K. Suemoto, Juan Fortea, Pedro Rosa-Neto, Eduardo R. Zimmer, Pamela C.L. Ferreira, Bruna Bellaver

Source: EBioMedicine, Vol 108, Iss , Pp 105322- (2024)

Subject Terms: Alzheimer's disease, Clinical trials, Biomarkers, Disease-modifying therapies, BEST glossary, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235239642400358X; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/92d7c3ec7c0941b7b85c9899db6986c9

Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease

Authors: Julie Ottoy, Min Su Kang, Jazlynn Xiu Min Tan, Lyndon Boone, Reinder Vos de Wael, Bo-yong Park, Gleb Bezgin, Firoza Z. Lussier, Tharick A. Pascoal, Nesrine Rahmouni, Jenna Stevenson, Jaime Fernandez Arias, Joseph Therriault, Seok-Jun Hong, Bojana Stefanovic, JoAnne McLaurin, Jean-Paul Soucy, Serge Gauthier, Boris C. Bernhardt, Sandra E. Black, Pedro Rosa-Neto, Maged Goubran

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fde529232e944d638ac5830511c20cef

Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting

Authors: Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K. Lafferty, Julia Kofler, Sarah B. Berman, Robert A. Sweet, Dana L. Tudorascu, William E. Klunk, Milos D. Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E. Snitz, Anne D. Cohen, Victor L. Villemagne, Tharick A. Pascoal, M. llyas Kamboh, Oscar I. Lopez, Kaj Blennow, Thomas K. Karikari

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)

Subject Terms: Blood biomarker, Standardization, Preanalytical factors, Alzheimer’s disease, Biobanking, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/64c9dbe829a54f7ea0148397b7f5ae86

The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer’s disease

Authors: Yi-Ting Wang, Nicholas J. Ashton, Stijn Servaes, Johanna Nilsson, Marcel S. Woo, Tharick A. Pascoal, Cécile Tissot, Nesrine Rahmouni, Joseph Therriault, Firoza Lussier, Mira Chamoun, Serge Gauthier, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Andréa L. Benedet

Source: Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/892a82c42fb84ac6a6a98d8ee15c62b9

Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Authors: Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/b47ea600285b4aea8f46ab3e27b0c3b2

14-3-3 $$\upzeta /\updelta$$ ζ / δ -reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2

Authors: Marcel S. Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L. Benedet, Nicholas J. Ashton, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z. Lussier, Thomas K. Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-12 (2023)

Subject Terms: Alzheimer’s disease, sTREM2, Microglia, Neuroinflammation, Synaptic loss, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/8072bbc5673044c19bd12aa939e0a997

Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health Study

Authors: Caterina Rosano, Thomas K. Karikari, Ryan Cvejkus, Bruna Bellaver, Pamela C. L. Ferreira, Joseph Zmuda, Victor Wheeler, Tharick A. Pascoal, Iva Miljkovic

Source: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 2, Pp n/a-n/a (2024)

Subject Terms: ADRD, African Ancestry, blood biomarkers of Alzheimer's Pathology, cardiometabolic diseases, Caribbean, early and late life exposure, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8737

Access URL: https://doaj.org/article/c4436e9e5c31420db7a705bafce096b2

Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease

Authors: Marco Antônio De Bastiani, Bruna Bellaver, Giovanna Carello-Collar, Maria Zimmermann, Peter Kunach, Ricardo A.S. Lima-Filho, Stefania Forner, Alessandra Cadete Martini, Tharick A. Pascoal, Mychael V. Lourenco, Pedro Rosa-Neto, Eduardo R. Zimmer

Source: iScience, Vol 27, Iss 1, Pp 108671- (2024)

Subject Terms: Neuroscience, Molecular neuroscience, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223027487; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/e4b444db5ed14a0b8880174f4ad5e107

Glymphatic system waste clearance and Alzheimer’s disease

Authors: João Luis Barichello de Quevedo, Douglas Teixeira Leffa, Tharick A. Pascoal

Source: Brazilian Journal of Psychiatry (2023)

Subject Terms: Psychiatry, RC435-571

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462023005007201&tlng=en; https://doaj.org/toc/1809-452X

Access URL: https://doaj.org/article/c9bed359031c4e01814d25dfe56b54eb

Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer’s disease continuum

Authors: Johan Gobom, Andréa L. Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow

Source: Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-14 (2022)

Subject Terms: Tau, Phosphorylation, Alzheimer’s disease, LC–MS, Cerebrospinal fluid, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/aa784c8a491a4687aa6cd3d9eff70b92

CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals

Authors: Joel Simrén, Wagner S. Brum, Nicholas J. Ashton, Andrea L. Benedet, Thomas K. Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z. Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A. Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow

Source: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/696a39d2f58b4396bc056504a06b2bf9

Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET

Authors: Joseph Therriault, Firoza Z. Lussier, Cécile Tissot, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Gleb Bezgin, Stijn Servaes, Peter Kunach, Yi‐Ting Wang, Jaime Fernandez‐Arias, Marie Vermeiren, Tharick A. Pascoal, Gassan Massarweh, Paolo Vitali, Jean‐Paul Soucy, Paramita Saha‐Chaudhuri, Serge Gauthie, Pedro Rosa‐Neto

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023)

Subject Terms: Alzheimer's disease, amyloid beta, positron emission tomography, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/0743f6a4d88b477e9305928c3c9f2449

[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Authors: Tharick A. Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L. Benedet, Joseph Therriault, Firoza Z. Lussier, Frederick A. Schroeder, Jonathan M. DuBois, Baileigh G. Hightower, Tonya M. Gilbert, Nicole R. Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A. Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T. Hyman, Bradford C. Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M. Hooker, Pedro Rosa-Neto

Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fa6fec43d93b4296b1333a2f0ecd7e12

Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer’s disease

Authors: Johanna Nilsson, Nicholas J. Ashton, Andrea L. Benedet, Laia Montoliu-Gaya, Johan Gobom, Tharick A. Pascoal, Mira Chamoun, Erik Portelius, Andreas Jeromin, Muriel Mendes, Henrik Zetterberg, Pedro Rosa-Neto, Ann Brinkmalm, Kaj Blennow

Source: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)

Subject Terms: Alzheimer’s disease, Synaptic pathology, Mass spectrometry, Biomarkers, SNAP-25, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/78ce5c4096dd44a496a006e1150f5ee5

Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease

Authors: Tharick A. Pascoal, Antoine Leuzy, Joseph Therriault, Mira Chamoun, Firoza Lussier, Cecile Tissot, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pamela C. L. Ferreira, João Pedro Ferrari‐Souza, Ruben Smith, Andrea Lessa Benedet, Serge Gauthier, Oskar Hansson, Pedro Rosa‐Neto

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 1, Pp n/a-n/a (2023)

Subject Terms: Alzheimer's disease, A/T/N system, biomarker, diagnose, PET, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/2164d28cba23488f90d144831f9de21f

Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology

Authors: Guilherme Povala, Bruna Bellaver, Marco Antônio De Bastiani, Wagner S. Brum, Pamela C. L. Ferreira, Andrei Bieger, Tharick A. Pascoal, Andrea L. Benedet, Diogo O. Souza, Ricardo M. Araujo, Bruno Zatt, Pedro Rosa-Neto, Eduardo R. Zimmer, for the Alzheimer’s Disease Neuroimaging Initiative

Source: Cell & Bioscience, Vol 11, Iss 1, Pp 1-13 (2021)

Subject Terms: Alzheimer’s disease, Amyloid-beta, Tau pathology, Neurodegeneration, Machine learning, Proteomics, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/2d34afcff2224b4f905cbb59816241fa