Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques

Authors: Saunders, Kevin O., Counts, James, Thakur, Bhishem, Stalls, Victoria, Edwards, Robert, Manne, Kartik, Lu, Xiaozhi, Mansouri, Katayoun, Chen, Yue, Parks, Rob, Barr, Maggie, Sutherland, Laura, Bal, Joena, Havill, Nicholas, Chen, Haiyan, Machiele, Emily, Jamieson, Nolan, Hora, Bhavna, Kopp, Megan, Janowska, Katarzyna, Anasti, Kara, Jiang, Chuancang, Van Itallie, Elizabeth, Venkatayogi, Sravani, Eaton, Amanda, Henderson, Rory, Barbosa, Christopher, Alam, S. Munir, Santra, Sampa, Weissman, Drew, Moody, M. Anthony, Cain, Derek W., Tam, Ying K., Lewis, Mark, Williams, Wilton B., Wiehe, Kevin, Montefiori, David C., Acharya, Priyamvada, Haynes, Barton F.

Source: In Cell 4 January 2024 187(1):79-94

Biosynthesis of silver nanoparticles using nitrate reductase from Aspergillus terreus N4 and their potential use as a non-alcoholic disinfectant

Authors: Rose, Gaurav Kumar, Thakur, Bhishem, Soni, Raman, Soni, Sanjeev Kumar

Source: Journal of biotechnology. 373:49-62

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195571256.0x000001&indx=1&recIds=ETOCvdc_100195571256.0x000001

Counter‐intuitive enhancement of degradation of polyethylene terephthalate through engineering of lowered enzyme binding to solid plastic

Authors: Mrigwani, Arpita, Thakur, Bhishem, Guptasarma, Purnananda

Source: Proteins. 91(6):807-821

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182201160.0x000001&indx=1&recIds=ETOCvdc_100182201160.0x000001

Rational mutagenesis of Thermobifida fusca cutinase to modulate the enzymatic degradation of polyethylene terephthalate

Authors: Mrigwani, Arpita, Pitaliya, Madhav, Kaur, Harman, Kasilingam, Bharathraj, Thakur, Bhishem, Guptasarma, Purnananda

Source: Biotechnology and bioengineering. 120(3):674-686

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176195171.0x000001&indx=1&recIds=ETOCvdc_100176195171.0x000001

Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor

Authors: Pilewski, Kelsey A., Wall, Steven, Richardson, Simone I., Manamela, Nelia P., Clark, Kaitlyn, Hermanus, Tandile, Binshtein, Elad, Venkat, Rohit, Sautto, Giuseppe A., Kramer, Kevin J., Shiakolas, Andrea R., Setliff, Ian, Salas, Jordan, Mapengo, Rutendo E., Suryadevara, Naveen, Brannon, John R., Beebout, Connor J., Parks, Rob, Raju, Nagarajan, Frumento, Nicole, Walker, Lauren M., Fechter, Emilee Friedman, Qin, Juliana S., Murji, Amyn A., Janowska, Katarzyna, Thakur, Bhishem, Lindenberger, Jared, May, Aaron J., Huang, Xiao, Sammour, Salam, Acharya, Priyamvada, Carnahan, Robert H., Ross, Ted M., Haynes, Barton F., Hadjifrangiskou, Maria, Crowe, James E., Jr., Bailey, Justin R., Kalams, Spyros, Morris, Lynn, Georgiev, Ivelin S.

Source: In Cell Reports 28 February 2023 42(2)

Conversion of polyethylene terephthalate into pure terephthalic acid through synergy between a solid-degrading cutinase and a reaction intermediate-hydrolysing carboxylesteraseElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2gc01965e

Authors: Mrigwani, Arpita, Thakur, Bhishem, Guptasarma, Purnananda

Source: Green chemistry. 24(17):6707-6719

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159007079.0x000001&indx=1&recIds=ETOCvdc_100159007079.0x000001

The DNA-binding protein HU is a molecular glue that attaches bacteria to extracellular DNA in biofilms

Authors: Thakur, Bhishem, Arora, Kanika, Gupta, Archit, Guptasarma, Purnananda

Source: In Journal of Biological Chemistry January-June 2021 296

N-Terminal Extensions Appear to Frustrate HU Heterodimer Formation by Strengthening Intersubunit Contacts and Blocking the Formation of a Heterotetrameric Intermediate

Authors: Arora, Kanika, Thakur, Bhishem, Mrigwani, Arpita, Guptasarma, Purnananda

Source: Biochemistry. 60(23):1836-1852

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626837942&indx=1&recIds=ETOCRN626837942

A novel protein-engineered dsDNA-binding protein (HU-Simulacrum) inspired by HU, a nucleoid-associated DNABII protein

Authors: Thakur, Bhishem, Gupta, Archit, Guptasarma, Purnananda

Source: Biochemical and biophysical research communications. 534:47-52

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120430386.0x000001&indx=1&recIds=ETOCvdc_100120430386.0x000001

The Impact of SARS-CoV-2 Omicron Mutations on the Conformational Landscape of the Spike Protein.

Authors: Parsons, Ruth J, Calloway, Alexandria, Zhang, Ellie, Thakur, Bhishem, Janowska, Katarzyna, Acharya, Priyamvada

Source: Microscopy & Microanalysis; 2024 Supplement, Vol. 30, p1-6, 6p

BPS2025 - Rational engineering of HIV-1 Env to enhance recognition of fusion peptide in a glycan-dependent manner

Authors: Thakur, Bhishem, Lella, Muralikrishna, Huang, Xiao, Devkota, Priyanka, Ilevbare, Victor, Adhikari, Radha D., Janowska, Katarzyna, Acharya, Priyamvada

Source: In Biophysical Journal 13 February 2025 124(3) Supplement 1:386a-386a

Synergistic action of different thermostable esterases in pet degradation: improvement of activity against intermediate degradation products by protein engineering

Authors: Mrigwani, Arpita, Thakur, Bhishem, Kaur, Harman, Guptasarma, Purnananda

Source: Biophysical journal. 121(S1):347a-348a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155585296.0x000001&indx=1&recIds=ETOCvdc_100155585296.0x000001

Newly-discovered behaviour in the bacterial histone-like protein, HU.

Authors: Gupta, Archit¹, Thakur, Bhishem¹, Arora, Kanika¹, Guptasarma, Purnananda¹ guptasarma@iisermohali.ac.in

Source: Indian Journal of Biochemistry & Biophysics. Sep2023, Vol. 60 Issue 9, p666-672. 7p.

Subject Terms: *BACTERIAL proteins, *DNA-binding proteins, *BINDING sites, *BIOFILMS, *LIPOPOLYSACCHARIDES

Fusion peptide dynamics during receptor-induced conformational changes in the HIV-1 envelope

Authors: Thakur, Bhishem, Janowska, Katarzyna, Acharya, Priyamvada

Source: In Biophysical Journal 8 February 2024 123(3) Supplement 1:158a-158a

Structures and stability of SARS-CoV-2 spike S2 subunit mutants targeting inter-subunit interactions

Authors: Parsons, Ruth J., Calloway, Alexandria, Zhang, Ellie, Thakur, Bhishem, Janowska, Katarzyna, Acharya, Priyamvada

Source: In Biophysical Journal 8 February 2024 123(3) Supplement 1:352a-352a

HU-AB simulacrum: Fusion of HU-B and HU-A into HU-B-A, a functional analog of the Escherichia coli HU-AB heterodimer

Authors: Arora, Kanika, Thakur, Bhishem, Gupta, Archit, Guptasarma, Purnananda

Source: In Biochemical and Biophysical Research Communications 30 June 2021 560:27-31

Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield.

Authors: Wrapp, Daniel¹ daniel.wrapp@duke.edu, Mu, Zekun^1,2, Thakur, Bhishem¹, Janowska, Katarzyna¹, Ajayi, Oluwatobi¹, Barr, Maggie^1,3, Parks, Robert^1,3, Mansouri, Katayoun¹, Edwards, Robert J.¹, Hahn, Beatrice H.^4,5, Acharya, Priyamvada^1,6, Saunders, Kevin O.^1,2,6,7 kevin.saunders@duke.edu, Haynes, Barton F.^1,2,3 barton.haynes@duke.edu

Source: Journal of Virology. Jan2023, Vol. 97 Issue 1, p1-13. 13p.

Subject Terms: *HIV, *VIRAL envelope proteins, *VACCINE development, *PROTEIN engineering, *VACCINE effectiveness, *DURABILITY, *FOOD of animal origin

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.

Authors: Zhang, Qianyi E.^1,2 (AUTHOR), Lindenberger, Jared¹ (AUTHOR), Parsons, Ruth J.^1,2 (AUTHOR), Thakur, Bhishem¹ (AUTHOR), Parks, Rob¹ (AUTHOR), Park, Chan Soo¹ (AUTHOR), Huang, Xiao¹ (AUTHOR), Sammour, Salam¹ (AUTHOR), Janowska, Katarzyna¹ (AUTHOR), Spence, Taylor N.¹ (AUTHOR), Edwards, Robert J.^1,3 (AUTHOR), Martin, Mitchell¹ (AUTHOR), Williams, Wilton B.^1,4,5 (AUTHOR), Gobeil, Sophie^1,6 (AUTHOR), Montefiori, David C.^1,4 (AUTHOR), Korber, Bette^7,8 (AUTHOR), Saunders, Kevin O.^1,4,5,9 (AUTHOR), Haynes, Barton F.^1,3,5 (AUTHOR), Henderson, Rory^1,3 (AUTHOR), Acharya, Priyamvada^1,2,4 (AUTHOR) priyamvada.acharya@duke.edu

Source: Molecular Cell. Jul2024, Vol. 84 Issue 14, p2747-2747. 1p.

Subject Terms: *SARS-CoV-2, *SARS-CoV-2 Omicron variant