Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition

Authors: Lee, Christine M., Zane, Nicole R., Veal, Gareth, Thakker, Dhiren R.

Source: CPT: pharmacometrics & systems pharmacology. 8(10):759-768

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Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours

Authors: Cai, Hao, Everett, Ruth S., Thakker, Dhiren R.

Source: British journal of pharmacology. 176(15):2724-2735

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Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny

Authors: Chen, Yao, Zane, Nicole R, Thakker, Dhiren R, Wang, Michael Zhuo ^*

Source: In Drug Metabolism and Disposition July 2016 44(7):975-983

Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis

Authors: Proctor, William R., Ming, Xin, Bourdet, David, Han, Tianxiang (Kevin), Everett, Ruth S., Thakker, Dhiren R.

Source: In Journal of Pharmaceutical Sciences February 2016 105(2):484-496

A Tribute to Ronald T. Borchardt—Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Authors: Schowen, Katharine Barbara, Schowen, Richard L., Borchardt, Susan E., Borchardt, Paul M., Artursson, Per, Audus, Kenneth L., Augustijns, Patrick, Nicolazzo, Joseph A., Raub, Thomas J., Schöneich, Christian, Siahaan, Teruna J., Takakura, Yoshi, Thakker, Dhiren R., Wolfe, Michael S.

Source: In Journal of Pharmaceutical Sciences February 2016 105(2):370-385

Four Cation-Selective Transporters Contribute to Apical Uptake and Accumulation of Metformin in Caco-2 Cell Monolayers

Authors: Han, Tianxiang (Kevin) ¹, Proctor, William R. ², Costales, Chester L. ³, Cai, Hao, Everett, Ruth S., Thakker, Dhiren R. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics March 2015 352(3):519-528

Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit

Authors: Watt, Kevin M., Cohen-Wolkowiez, Michael, Williams, Duane C., Bonadonna, Desiree K., Cheifetz, Ira M., Thakker, Dhiren, Benjamin, Daniel K., Brouwer, Kim L. R.

Source: Journal of extra-corporeal technology. 49(3):150-159

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Intestinal First-Pass Metabolism by Cytochrome P450 and Not P-Glycoprotein Is the Major Barrier to Amprenavir Absorption

Authors: Dufek, Matthew B., Bridges, Arlene S., Thakker, Dhiren R. ^*

Source: In Drug Metabolism and Disposition September 2013 41(9):1695-1702

Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes

Authors: Han, Tianxiang (Kevin), Everett, Ruth S., Proctor, William R. ¹, Ng, Chee M. ², Costales, Chester L., Brouwer, Kim L.R., Thakker, Dhiren R. ^*

Source: In Molecular Pharmacology August 2013 84(2):182-189

Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites

Authors: Swift, Brandon, Nebot, Noelia, Lee, Jin Kyung, Han, Tianxiang, Proctor, William R, Thakker, Dhiren R, Lang, Dieter, Radtke, Martin, Gnoth, Mark J, Brouwer, Kim L. R ^*

Source: In Drug Metabolism and Disposition June 2013 41(6):1179-1186

P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism

Authors: Dufek, Matthew B. ¹, Knight, Beverly M., Bridges, Arlene S., Thakker, Dhiren R. ^*

Source: In Drug Metabolism and Disposition March 2013 41(3):642-650

Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug

Authors: Generaux, Claudia N., Ainslie, Garrett R., Bridges, Arlene S., Ismail, Mohamed A., Boykin, David W., Tidwell, Richard R., Thakker, Dhiren R., Paine, Mary F. ^*

Source: In Drug Metabolism and Disposition February 2013 41(2):518-528

Determination of the Androgen Receptor Inhibitor Enzalutamide and its Metabolites in Animal Plasma and Brain Homogenates Using LC-MS/MS and its Application to Pharmacokinetic Studies

Authors: Ohtsu, Yoshiaki, Thakker, Dhiren R., Gibbons, Jacqueline A., Tsubota, Kenjiro, Otsuka, Shohei, Arai, Hiroshi

Source: Chromatography. 36(3):115-122

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Method for enhancing catalytic activity of a lipase

Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122

Authors: Klein, Ryan R., Bourdon, David M., Costales, Chester L., Wagner, Craig D., White, Wendy L., Williams, Jon D., Hicks, Stephanie N., Sondek, John, Thakker, Dhiren R.

Source: In Journal of Biological Chemistry 8 April 2011 286(14):12407-12416

Exploring the role of the pharmacist in global health

Authors: Steeb, David R., Joyner, Pamela U., Thakker, Dhiren R.

Source: Journal of the American Pharmacists Association. 54(5):552-555

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In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

Authors: Yanni, Souzan B., Augustijns, Patrick F., Benjamin, Daniel K., Jr., Brouwer, Kim L.R., Thakker, Dhiren R., Annaert, Pieter P. ^*

Source: In Drug Metabolism and Disposition October 2010 38(10):1848-1856

Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil

Authors: Ming, Xin, Thakker, Dhiren R.

Source: In Biochemical Pharmacology 1 February 2010 79(3):455-462

In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3

Authors: Yanni, Souzan B., Annaert, Pieter P., Augustijns, Patrick, Ibrahim, Joseph G., Benjamin, Daniel K., Jr., Thakker, Dhiren R. ^*

Source: In Drug Metabolism and Disposition January 2010 38(1):25-31

Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

Authors: Ming, Xin, Ju, Wujian, Wu, Huali, Tidwell, Richard R., Hall, James E., Thakker, Dhiren R. ^*

Source: In Drug Metabolism and Disposition February 2009 37(2):424-430