Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus

Authors: Valentin Greigert, Iti Saraav, Juhee Son, Yinxing Zhu, Denise Dayao, Avan Antia, Saul Tzipori, William H. Witola, Thaddeus S. Stappenbeck, Siyuan Ding, L. David Sibley

Source: Gut Microbes, Vol 16, Iss 1 (2024)

Subject Terms: Vaccine, mucosal immunity, interferon, antiviral, co-infection, enteric infection, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/423709fcf24243cba0cbfe768d74d5db

Development of a deep learning algorithm for Paneth cell density quantification for inflammatory bowel diseaseResearch in context

Authors: Liang-I Kang, Kathryn Sarullo, Jon N. Marsh, Liang Lu, Pooja Khonde, Changqing Ma, Talin Haritunians, Angela Mujukian, Emebet Mengesha, Dermot P.B. McGovern, Thaddeus S. Stappenbeck, S. Joshua Swamidass, Ta-Chiang Liu

Source: EBioMedicine, Vol 110, Iss , Pp 105440- (2024)

Subject Terms: Whole slide images, Crohn's disease, Pathology, Prognosis, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004766; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/d6ee7e60df3d40798b221a94e04d6610

Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort

Authors: Tzipi Braun, Rui Feng, Amnon Amir, Nina Levhar, Hila Shacham, Ren Mao, Rotem Hadar, Itamar Toren, Yadid Algavi, Kathleen Abu-Saad, Shuoyu Zhuo, Gilat Efroni, Alona Malik, Orit Picard, Miri Yavzori, Bella Agranovich, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Lee Denson, Ofra Kalter-Leibovici, Eyal Gottlieb, Elhanan Borenstein, Eran Elinav, Minhu Chen, Shomron Ben-Horin, Yael Haberman

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d3ff1aa1ed9f41528d8b98fa27c06fe5

Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth

Authors: Lisa J. Funkhouser-Jones, Rui Xu, Georgia Wilke, Yong Fu, Lawrence A. Schriefer, Heyde Makimaa, Rachel Rodgers, Elizabeth A. Kennedy, Kelli L. VanDussen, Thaddeus S. Stappenbeck, Megan T. Baldridge, L. David Sibley

Source: Cell Reports, Vol 42, Iss 7, Pp 112680- (2023)

Subject Terms: CP: Microbiology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723006915; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/59e6a266f8ee48cab18b8af576086baf

HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal EpitheliumSummary

Authors: Elisa Murray, Xiaoqing Cheng, Anagha Krishna, Xiaohua Jin, Takahiro E. Ohara, Thaddeus S. Stappenbeck, Ron Bose

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1105-1120 (2021)

Subject Terms: Colorectal Cancer, Intestinal Organoids, Intermediate Cells, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X21000837; https://doaj.org/toc/2352-345X

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Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1

Authors: Gerco den Hartog, Lindsay D. Butcher, Amber L. Ablack, Laura A. Pace, Jailal N. G. Ablack, Richard Xiong, Soumita Das, Thaddeus S. Stappenbeck, Lars Eckmann, Peter B. Ernst, Sheila E. Crowe

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: intestinal epithelial barrier, invasion, internalization, Rac1, Salmonella Typhimurium, AIEC LF82 strain, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.553994/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/909a51ee968d491cb7336a83d534599b

Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells

Authors: Kelli L. VanDussen, Lisa J. Funkhouser-Jones, Marianna E. Akey, Deborah A. Schaefer, Kevin Ackman, Michael W. Riggs, Thaddeus S. Stappenbeck, L. David Sibley

Source: mBio, Vol 11, Iss 6 (2020)

Subject Terms: 16S rRNA, Cryptosporidium parvum, enteric infection, essential nutrient, fatty acid, metabolite, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/15ba3df73dfa42048c217995bef69455

L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams

Authors: Kelli L. VanDussen, Naomi M. Sonnek, Thaddeus S. Stappenbeck

Source: Stem Cell Research, Vol 37, Iss , Pp - (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506119300601; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/cd982d5c2add4c858de91995d0755b4e

Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In Vitro

Authors: Georgia Wilke, Soumya Ravindran, Lisa Funkhouser-Jones, Jennifer Barks, Qiuling Wang, Kelli L. VanDussen, Thaddeus S. Stappenbeck, Theresa B. Kuhlenschmidt, Mark S. Kuhlenschmidt, L. David Sibley

Source: mSphere, Vol 3, Iss 3 (2018)

Subject Terms: Cryptosporidium, cytoskeleton, intracellular parasites, membrane proteins, monoclonal antibodies, sexual development, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/c3910f6574d3407b9f6a61d337be9bea

Cellular differentiation: Potential insight into butyrate paradox?

Authors: Stacy H. Ryu, Gerard E. Kaiko, Thaddeus S. Stappenbeck

Source: Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)

Subject Terms: butyrate, colonocyte, differentiation, foxo3, hdac, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2372-3556

Access URL: https://doaj.org/article/8da40894e1564d72ad0f5aa6711b7e68

Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis

Authors: Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren

Source: EBioMedicine, Vol 1, Iss 1, Pp 46-57 (2014)

Subject Terms: Immunomodulatory therapy, Mucosal immunology, Immunopathology, Uropathogenic E. coli, UPEC, COX-2, Urinary tract infection, UTI, recurrent infection, Chronic infection, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396414000139; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/06a88a77574746e8a4a2cabcd13ca808

IL-6 stimulates intestinal epithelial proliferation and repair after injury.

Authors: Kristine A Kuhn, Nicholas A Manieri, Ta-Chiang Liu, Thaddeus S Stappenbeck

Source: PLoS ONE, Vol 9, Iss 12, p e114195 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4257684?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8cd8d8f86a5344dbb0de774a65aa763a

A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.

Authors: Haytham Aly, Nidhi Rohatgi, Connie A Marshall, Tiffani C Grossenheider, Hiroyuki Miyoshi, Thaddeus S Stappenbeck, Scot J Matkovich, Michael L McDaniel

Source: PLoS ONE, Vol 8, Iss 6, p e66131 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3680388?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5fd82f224eb0466dbcad8713a11f8da7

Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells.

Authors: Gwanghee Lee, Sofia Origanti, Lynn S White, Jinwu Sun, Thaddeus S Stappenbeck, Helen Piwnica-Worms

Source: PLoS ONE, Vol 6, Iss 1, p e15561 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3026785?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5c6aecf6497b4e68a1896cfc7b85e9e6

An antibiotic-responsive mouse model of fulminant ulcerative colitis.

Authors: Silvia S Kang, Seth M Bloom, Lyse A Norian, Michael J Geske, Richard A Flavell, Thaddeus S Stappenbeck, Paul M Allen

Source: PLoS Medicine, Vol 5, Iss 3, p e41 (2008)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2270287?pdf=render; https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

Access URL: https://doaj.org/article/e4fd673cf64a4154b11d3f6b5b81563b