Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy

Authors: Wolf, Cordula M. ^{a, b, c, ∗}, Zenker, Martin ^{d, ∗}, Boleti, Olga ^e, Norrish, Gabrielle ^e, Russell, Mark ^f, Meisner, Joshua K. ^f, Peng, David M. ^f, Prendiville, Terence ^g, Kleinmahon, Jake ^h, Kantor, Paul F. ⁱ, Gottlieb Sen, Danielle ^j, Human, Derek G. ^k, Ewert, Peter ^{a, b, c}, Krueger, Marcus ^l, Reber, Daniela ^l, Donner, Birgit ^m, Hart, Christopher ⁿ, Odri Komazec, Irena ^o, Rupp, Stefan ^p, Hahn, Andreas ^q, Hanser, Anja ^r, Hofbeck, Michael ^r, Draaisma, Jos M.T. ^s, Udink ten Cate, Floris E.A. ^s, Mussa, Alessandro ^t, Ferrero, Giovanni B. ^u, Vaujois, Laurence ^v, Raboisson, Marie-Josée ^w, Delrue, Marie-Ange ^w, Marquis, Christopher ^w, Théoret, Yves ^w, Bogarapu, Soujanya ^x, Dancea, Adrian ^y, Handrup, Mette Moller ^{c, z}, Kemna, Mariska ^aa, Ojala, Tiina ^{c, bb}, Dham, Niti ^cc, Dicke, Frank ^dd, Friede, Tim ^{ee, ff, gg}, Kaski, Juan Pablo ^e, Gelb, Bruce D. ^{hh, †}, Andelfinger, Gregor ^{w, ∗, †}

Source: In JACC: Basic to Translational Science February 2025 10(2):152-166

Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity

Authors: Bognàr, Tim, Garcia-Rosa, Moises, Lalmohamed, Arief, Güngör, Tayfun, Hauri-Hohl, Mathias, Prockop, Susan, Oram, Layne, Pai, Sung-Yun, Brooks, Jordan, Savic, Rada M., Dvorak, Christopher C., Long-Boyle, Janel R., Krajinovic, Maja, Bittencourt, Henrique, Teyssier, Anne-Charlotte, Théorêt, Yves, Martinez, Cary, Egberts, Toine C. G., Morales, Erin, Slatter, Mary, Cuvelier, Geoffrey D. E., Chiesa, Robert, Wynn, Robert F., Coussons, Mary, Cicalese, Maria P., Ansari, Marc, Long, Susan E., Ebens, Christen L., Lust, Hannah, Chaudhury, Sonali, Nath, Christa E., Shaw, Peter J., Keogh, Steven J., van der Stoep, M. Y. Eileen C., Bredius, Robbert, Lindemans, Caroline A., Boelens, Jaap-Jan, Bartelink, Imke H.

Source: In Blood Advances 8 October 2024 8(19):5137-5145

Combined IFN-γ and JAK inhibition to treat hemophagocytic lymphohistiocytosis in mice

Authors: Joly, Josée-Anne, Vallée, Alexis, Bourdin, Benoîte, Bourbonnais, Sara, Patey, Natalie, Gaboury, Louis, Théorêt, Yves, Decaluwe, Hélène

Source: In The Journal of Allergy and Clinical Immunology January 2023 151(1):247-259

Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation

Authors: Bognàr, Tim, Bartelink, Imke H., Egberts, Toine C.G., Rademaker, Carin M.A., Versluys, A. Birgitta, Slatter, Mary A., Kletzel, Morris, Nath, Christa E., Cuvelier, Geoffrey D.E, Savic, Rada M., Dvorak, Christopher, Long-Boyle, Janel R., Cowan, Morton J., Bittencourt, Henrique, Bredius, Robbert G.M., Güngör, Tayfun, Shaw, Peter J., Ansari, Marc, Hassan, Moustapha, Krajinovic, Maja, Hempel, Georg, Marktel, Sarah, Chiesa, Robert, Théoret, Yves, Lund, Troy, Orchard, Paul J., Wynn, Robert F., Boelens, Jaap Jan, Lalmohamed, Arief

Source: In Transplantation and Cellular Therapy April 2022 28(4):196-202

Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

Authors: Ben Hassine, Khalil, Nava, Tiago, Théoret, Yves, Nath, Christa E., Daali, Youssef, Kassir, Nastya, Lewis, Victor, Bredius, Robbert G. M., Shaw, Peter J., Bittencourt, Henrique, Krajinovic, Maja, Uppugunduri, Chakradhara Rao Satyanarayana, Ansari, Marc

Source: CPT: pharmacometrics & systems pharmacology. 10(9):1043-1056

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131136392.0x000001&indx=1&recIds=ETOCvdc_100131136392.0x000001

Genetic Susceptibility to Hepatic Sinusoidal Obstruction Syndrome in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

Authors: Ansari, Marc, Petrykey, Kateryna, Rezgui, Mohamed Aziz, Del Vecchio, Veronica, Cortyl, Jacques, Ralph, Reginald-Olivier, Nava, Tiago, Beaulieu, Patrick, St-Onge, Pascal, Jurkovic Mlakar, Simona, Huezo-Diaz Curtis, Patricia, Uppugunduri, Chakradhara Rao S., Lesne, Laurence, Théoret, Yves, Chalandon, Yves, Bartelink, Imke H., Boelens, Jaap-Jan, Bredius, Robbert G.M., Dalle, Jean-Hugues, Lewis, Victor, Kangarloo, Bill S., Peters, Christina, Sinnett, Daniel, Bittencourt, Henrique, Krajinovic, Maja

Source: In Biology of Blood and Marrow Transplantation May 2020 26(5):920-927

Pharmacokinetics and Pharmacodynamics of Nebulized and Intratracheal Milrinone in a Swine Model of Hypercapnia Pulmonary Hypertension

Authors: Gavra, Paul ^⁎, Denault, André Y. ^†, Théoret, Yves ^‡, Perrault, Louis P. ^§, Varin, France ^{*, 1}

Source: In Journal of Cardiothoracic and Vascular Anesthesia October 2018 32(5):2130-2138

GSTA1 Genetic Variants and Conditioning Regimen: Missing Key Factors in Dosing Guidelines of Busulfan in Pediatric Hematopoietic Stem Cell Transplantation

Authors: Nava, Tiago ^*, Rezgui, Mohamed A., Uppugunduri, Chakradhara R.S., Curtis, Patricia Huezo-Diaz, Théoret, Yves, Duval, Michel, Daudt, Liane E., Ansari, Marc, Krajinovic, Maja, Bittencourt, Henrique

Source: In Biology of Blood and Marrow Transplantation November 2017 23(11):1918-1924

Use of nebulized milrinone in cardiac surgery; Comparison of vibrating mesh and simple jet nebulizers

Authors: Gavra, Paul, Laflamme, Maxime, Denault, André Y., Théoret, Yves, Perrault, Louis P., Varin, France

Source: In Pulmonary Pharmacology & Therapeutics October 2017 46:20-29

Impact of trametinib on the neuropsychological profile of NF1 patients.

Authors: Lalancette, Eve, Cantin, Édith, Routhier, Marie-Ève, Mailloux, Chantal, Bertrand, Marie-Claude, Kiaei, Dorsa Sadat, Larouche, Valérie, Tabori, Uri, Hawkins, Cynthia, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, McKeown, Tara, Ospina, Luis H., Vairy, Stéphanie, Ramaswamy, Vijay, Coltin, Hallie, Sultan, Serge, Legault, Geneviève

Source: Journal of Neuro-Oncology; May2024, Vol. 167 Issue 3, p447-454, 8p

Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis

Authors: Bartelink, Imke H, Lalmohamed, Arief, van Reij, Elisabeth M L, Dvorak, Christopher C, Savic, Rada M, Zwaveling, Juliette, Bredius, Robbert G M, Egberts, Antoine C G, Bierings, Marc, Kletzel, Morris, Shaw, Peter J, Nath, Christa E, Hempel, George, Ansari, Marc, Krajinovic, Maja, Théorêt, Yves, Duval, Michel, Keizer, Ron J, Bittencourt, Henrique, Hassan, Moustapha, Güngör, Tayfun, Wynn, Robert F, Veys, Paul, Cuvelier, Geoff D E, Marktel, Sarah, Chiesa, Robert, Cowan, Morton J, Slatter, Mary A, Stricherz, Melisa K, Jennissen, Cathryn, Long-Boyle, Janel R, Boelens, Jaap Jan

Source: In The Lancet Haematology November 2016 3(11):e526-e536

Hypertrophic Cardiomyopathy in Noonan Syndrome Treated by MEK-Inhibition

Authors: Andelfinger, Gregor, Marquis, Christopher, Raboisson, Marie-Josée, Théoret, Yves, Waldmüller, Stephan, Wiegand, Gesa, Gelb, Bruce D., Zenker, Martin, Delrue, Marie-Ange, Hofbeck, Michael

Source: Journal of the American College of Cardiology. 73(17):2237-2239

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081891231.0x000001&indx=1&recIds=ETOCvdc_100081891231.0x000001

Inhaled milrinone in cardiac surgical patients: a pilot randomized controlled trial of jet vs. mesh nebulization

Authors: Nguyen, Anne Quynh-Nhu, Denault, André Y., Théoret, Yves, Perrault, Louis P., Varin, France

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161863522.0x000001&indx=1&recIds=ETOCvdc_100161863522.0x000001

A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01

Authors: Perreault, Sébastien, Larouche, Valérie, Tabori, Uri, Hawkin, Cynthia, Lippé, Sarah, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, Sultan, Serge, Cantin, Édith, Routhier, Marie-Ève, Caru, Maxime, Legault, Geneviève, Bouffet, Éric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Jabado, Nada

Source: BMC cancer. 19(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193709205.0x000001&indx=1&recIds=ETOCvdc_100193709205.0x000001

Levetiracetam in children with refractory epilepsy: Lack of correlation between plasma concentration and efficacy

Authors: Giroux, Patricia C., Salas-Prato, Milagros, Théorêt, Yves, Carmant, Lionel

Source: In Seizure: European Journal of Epilepsy 2009 18(8):559-563

Inhaled milrinone in cardiac surgical patients: pharmacokinetic and pharmacodynamic exploration.

Authors: Nguyen, Anne Quynh-Nhu, Denault, André Y., Théoret, Yves, Varin, France

Source: Scientific Reports; 3/2/2023, Vol. 13 Issue 1, p1-11, 11p

Subject Terms: MILRINONE, CARDIAC patients, PHARMACOKINETICS, CARDIOPULMONARY bypass, SURGICAL complications

IV Busulfan Dose Individualization in Children undergoing Hematopoietic Stem Cell Transplant: Limited Sampling Strategies

Authors: Dupuis, L. Lee, Sibbald, Cathryn, Schechter, Tal, Ansari, Marc, Gassas, Adam, Théorêt, Yves, Kassir, Nastya, Champagne, Martin A., Doyle, John

Source: In Biology of Blood and Marrow Transplantation 2008 14(5):576-582

Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia

Authors: Krajinovic, Maja, Lamothe, Stéphanie, Labuda, Damian, Lemieux-Blanchard, Émilie, Théorêt, Yves, Moghrabi, Albert, Sinnett, Daniel ^*

Source: In Blood 1 January 2004 103(1):252-257

LGG-25. A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY. TRAM-01

Authors: Perreault, Sébastien, Larouche, Valérie, Tabori, Uri, Hawkins, Cynthia, Lippé, Sarah, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, Sultan, Serge, Cantin, Édith, Routhier, Marie-Ève, Caru, Maxime, Legault, Geneviève, Bouffet, Eric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Jabado, Nada

Source: Neuro-oncology. 22(Supplement 3):iii371-iii371

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112160813.0x000001&indx=1&recIds=ETOCvdc_100112160813.0x000001

Stability of total plasma homocysteine in perinatology

Authors: Théorêt, Yves, Rivard, Georges-Etienne, Infante-Rivard, Claire, Yotov, Wagner V. ^*

Source: In Clinica Chimica Acta 2002 319(1):63-66