On the Significance of the Terminal Location of Prion-Forming Regions of Yeast Proteins.

Authors: Galliamov, Arthur A.¹ (AUTHOR), Urakov, Valery N.¹ (AUTHOR), Dergalev, Alexander A.¹ (AUTHOR), Kushnirov, Vitaly V.¹ (AUTHOR) vkushnirov@inbi.ras.ru

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1637. 20p.

Subject Terms: *N-terminal residues, *PROTEIN structure, *PROTEINASES, *AMYLOID, *YEAST, *PRIONS

Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformation yield.

Authors: Spencer, Garrick W. K.^1,2 (AUTHOR), Li, Xu¹ (AUTHOR), Lam, Kenny W. L.¹ (AUTHOR), Mutch, George² (AUTHOR), Fry, Fiona H.² (AUTHOR), Gras, Sally L.¹ (AUTHOR) sgras@unimelb.edu.au

Source: Journal of Biological Engineering. 1/19/2025, Vol. 19 Issue 1, p1-12. 12p.

Subject Terms: *ENZYME stability, *C-terminal residues, *GIBBS' free energy, *OPIUM poppy, *BIOCONVERSION

Mode of Metal Ligation Governs Inhibition of Carboxypeptidase A.

Authors: Amador Balderas, Jorge Antonio¹ (AUTHOR) jorge.ab.amador@fau.de, Beierlein, Frank^1,2 (AUTHOR) anselm.horn@fau.de, Horn, Anselm H. C.^2,3 (AUTHOR), Volkenandt, Senta¹ (AUTHOR) senta.volkenandt@fau.de, Völcker, Leon¹ (AUTHOR) leon.voelcker@fau.de, Mokhtari, Nikoo¹ (AUTHOR) nikoo.mokhtari@fau.de, Ndongue, Jules Cesar Epee¹ (AUTHOR) jules.cn.epee@fau.de, Imhof, Petra¹ (AUTHOR) petra.imhof@fau.de

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13725. 19p.

Subject Terms: *C-terminal residues, *MOLECULAR dynamics, *PEPTIDES, *SMALL molecules, *AMINO acids

Monkeypox virus A29L protein as the target for specific diagnosis and serological analysis.

Authors: Liang, Chia-Yu¹, Chao, Tai-Ling², Chao, Chong‐Syun¹, Liu, Wang-Da^3,4, Cheng, Yu-Chen², Chang, Sui-Yuan^2,5, sychang@ntu.edu.tw, Chang, Shih-Chung^1,6, shihchung@ntu.edu.tw

Source: Applied Microbiology & Biotechnology; 11/21/2024, Vol. 108 Issue 1, p1-13, 13p

Engineering the C-Terminal Region to Enhance the Thermal Stability of Streptomyces hygroscopicus Transglutaminase.

Authors: Wang, Zhaoxiang^1,2 (AUTHOR) jnckkang@126.com, Chen, Kangkang^2,3 (AUTHOR), Liu, Song^1,2 (AUTHOR) liusong@jiangnan.edu.cn, Li, Jianghua^1,3 (AUTHOR) lijianghua@jiangnan.edu.cn, Du, Guocheng^1,2 (AUTHOR) lijianghua@jiangnan.edu.cn

Source: Catalysts (2073-4344). Oct2024, Vol. 14 Issue 10, p706. 11p.

Subject Terms: *C-terminal residues, *N-terminal residues, *THERMAL stability, *TERTIARY structure, *HYDROGEN bonding

Lysine 473 Regulates the Progression of SLC7A11, the Cystine/Glutamate Exchanger, through the Secretory Pathway.

Authors: Koppin, Anna¹ (AUTHOR) koppi033@umn.edu, Chase, Leah² (AUTHOR) chase@hope.edu

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10271. 23p.

Subject Terms: *MEMBRANE transport proteins, *C-terminal residues, *ENDOPLASMIC reticulum, *GLUTAMATE transporters, *SITE-specific mutagenesis

Aromatic residues in N-terminal domain of archaeal trehalase affect the folding and activity of catalytic domain.

Authors: Sakoh, Takumi¹, Satoh, Nagisa¹, Domon, Yumeka¹, Nakamura, Maho¹, Kawakita, Masao¹, Sakaguchi, Masayoshi¹, bt11532@ns.kogakuin.ac.jp

Source: Applied Microbiology & Biotechnology; 8/15/2024, Vol. 108 Issue 1, p1-11, 11p

Unveiling the importance of the C-terminus in the sugar acid dehydratase of the IlvD/EDD superfamily.

Authors: Ren, Yaxin¹ (AUTHOR), Vettenranta, Elias¹ (AUTHOR), Penttinen, Leena¹ (AUTHOR), Blomster Andberg, Martina² (AUTHOR), Koivula, Anu² (AUTHOR), Rouvinen, Juha¹ (AUTHOR), Hakulinen, Nina¹ (AUTHOR) nina.hakulinen@uef.fi

Source: Applied Microbiology & Biotechnology. 8/10/2024, Vol. 108 Issue 1, p1-12. 12p.

Subject Terms: *RHIZOBIUM leguminosarum, *C-terminal residues, *DEHYDRATION reactions, *BIOCHEMICAL substrates, *MONOMERS

HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration.

Authors: Li, Min¹ (AUTHOR) lmin@niddk.nih.gov, Li, Zhen² (AUTHOR) zhen_li@dfci.harvard.edu, Chen, Xuemin³ (AUTHOR) 21037@ahu.edu.cn, Cui, Yanxiang⁴ (AUTHOR) yanxiang.cui@nih.gov, Engelman, Alan N.^2,5 (AUTHOR) alan_engelman@dfci.harvard.edu, Craigie, Robert¹ (AUTHOR) lmin@niddk.nih.gov

Source: Viruses (1999-4915). Jul2024, Vol. 16 Issue 7, p1166. 16p.

Subject Terms: *C-terminal residues, *VIRAL DNA, *PROTEIN domains, *HIV, *VIRAL replication

Bioinformatic Analysis of Topoisomerase IIα Reveals Interdomain Interdependencies and Critical C-Terminal Domain Residues.

Authors: Endsley, Clark E.¹ (AUTHOR), Moore, Kori A.¹ (AUTHOR), Townsley, Thomas D.² (AUTHOR), Durston, Kirk K.³ (AUTHOR), Deweese, Joseph E.^1,4 (AUTHOR) jdeweese@fhu.edu

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5674. 19p.

Subject Terms: *C-terminal residues, *DNA topoisomerase I, *UNCERTAINTY (Information theory), *DNA topoisomerase II, *DRUG target, *AMINO acids

Deletion of 82–85 N-Terminal Residues in SARS-CoV-2 Nsp1 Restricts Virus Replication.

Authors: Gori Savellini, Gianni¹ (AUTHOR) gabriele.anichini2@unisi.it, Anichini, Gabriele¹ (AUTHOR), Manetti, Fabrizio² (AUTHOR) claudia.trivisani2@unisi.it, Trivisani, Claudia Immacolata² (AUTHOR), Cusi, Maria Grazia¹ (AUTHOR) gianni.gori@unisi.it

Source: Viruses (1999-4915). May2024, Vol. 16 Issue 5, p689. 18p.

Subject Terms: *N-terminal residues, *SARS-CoV-2, *VIRAL replication, *VIRAL proteins, *GENE expression, *DRUG development, *MESSENGER RNA

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein.

Authors: Carnec, Xavier^1,2, Borges-Cardoso, Virginie^1,2, Reynard, Stéphanie^1,2, Kowalski, Heinrich³, Gaillard, Jean-Charles⁴, Mateo, Mathieu^1,2, Armengaud, Jean⁴, Baize, Sylvain^1,2, sylvain.baize@pasteur.fr

Source: PLoS Pathogens; 12/3/2024, Vol. 20 Issue 12, p1-28, 28p

Mapping of Prion Structures in the Yeast Rnq1.

Authors: Galliamov, Arthur A.¹ (AUTHOR) arturens96@gmail.com, Malukhina, Alena D.^1,2 (AUTHOR), Kushnirov, Vitaly V.¹ (AUTHOR) vkushnirov@inbi.ras.ru

Source: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3397. 15p.

Subject Terms: *PRIONS, *C-terminal residues, *ALGORITHMS, *YEAST, *PROTEINASES

Rab10 function in tubular endosome formation requires the N-terminal K3 residue and is disrupted by N-terminal tagging.

Authors: Rinka Hata¹, Akira Sugawara¹, Mitsunori Fukuda¹ nori@tohoku.ac.jp

Source: Journal of Cell Science. Feb2025, Vol. 138 Issue 3, p1-8. 8p.

Subject Terms: *AMINO acid residues, *N-terminal residues, *HELA cells, *GUANOSINE triphosphatase, *MELANOCYTES

Effect of trypsin digestion on the integrity and antigenic epitopes of GII.6 norovirus virus-like particles: Effect of trypsin digestion on the integrity: J. Ma et al.

Authors: Ma, Jie¹ (AUTHOR), Liu, Jinjin¹ (AUTHOR), Liu, Xinyi² (AUTHOR), Wang, Chao¹ (AUTHOR), Huo, Yuqi¹ (AUTHOR) 1246105971@qq.com

Source: Archives of Virology. Feb2025, Vol. 170 Issue 2, p1-8. 8p.

Subject Terms: *PEPTIDE mass fingerprinting, *C-terminal residues, *VIRUS-like particles, *HYBRIDOMAS, *DIGESTION, *MONOCLONAL antibodies, *TRYPSIN

Wnt target gene activation requires β-catenin separation into biomolecular condensates.

Authors: Stewart, Richard A.¹, Ding, Zhihao¹, Jeon, Ung Seop¹, Goodman, Lauren B.¹, Tran, Jeannine J.¹, Zientko, John P.¹, Sabu, Malavika¹, Cadigan, Ken M.¹, cadigan@umich.edu

Source: PLoS Biology; 9/24/2024, Vol. 22 Issue 9, p1-36, 36p

Effects of truncations in the N‐ and C‐terminal domains of filensin on filament formation with phakinin in cell‐free conditions and cultured cells.

Authors: Tashiro, Moe¹, Nakamura, Akari¹, Kuratani, Yamato¹, Takada, Miyako¹, Iwamoto, Satoshi¹, Oka, Mikako², Ando, Shoji¹, andosho@bio.sojo-u.ac.jp

Source: FEBS Open Bio; Nov2023, Vol. 13 Issue 11, p1990-2004, 15p

Phosphoregulation of the yeast Pma1 H⁺-ATPase autoinhibitory domain involves the Ptk1/2 kinases and the Glc7 PP1 phosphatase and is under TORC1 control.

Authors: Guarini, Nadia¹ (AUTHOR), Saliba, Elie¹ (AUTHOR), André, Bruno¹ (AUTHOR) bruno.andre@ulb.be

Source: PLoS Genetics. 1/16/2024, Vol. 20 Issue 1, p1-28. 28p.

Subject Terms: *KINASES, *C-terminal residues, *EUKARYOTIC cells, *YEAST, *CELL membranes, *PROTEIN kinases, *ADENOSINE triphosphatase, *ACTIVE aging

Association of Radical Chemistry with LanD Flavoprotein Activity for C‐Terminal Macrocyclization of a Ribosomal Peptide by Formation of an Unsaturated Thioether Residue.

Authors: Cheng, Botao¹, Huang, Jiwu¹, Duan, Yuting¹, Liu, Wen¹, wliu@sioc.ac.cn

Source: Angewandte Chemie International Edition; 8/28/2023, Vol. 62 Issue 35, p1-7, 7p

Conserved signalling functions for Mps1, Mad1 and Mad2 in the Cryptococcus neoformans spindle checkpoint.

Authors: Aktar, Koly¹, Davies, Thomas¹, Leontiou, Ioanna¹, Clark, Ivan¹, Spanos, Christos¹, Wallace, Edward¹, Tuck, Laura¹, Jeyaprakash, A. Arockia^1,2, Hardwick, Kevin G.¹, Kevin.Hardwick@ed.ac.uk

Source: PLoS Genetics; 6/3/2024, Vol. 20 Issue 6, p1-29, 29p