The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy

Authors: Tan, Lay Shuen ^{1, 2}, Lau, Hwee Hui ¹, Abdelalim, Essam M. ^{3, 4}, Khoo, Chin Meng ^{5, 6}, O’Brien, Richard M. ⁷, Tai, E. Shyong ^{5, 6}, Teo, Adrian Kee Keong ^{1, 5, 6, 8, ⁎}

Source: In Trends in Molecular Medicine February 2025 31(2):152-164

Tissue engineering of decellularized pancreas scaffolds for regenerative medicine in diabetes

Authors: Lim, Lillian Yuxian, Ding, Shirley Suet Lee, Muthukumaran, Padmalosini, Teoh, Swee Hin, Koh, Yexin, Teo, Adrian Kee Keong

Source: Acta biomaterialia. 157:49-66

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179843294.0x000001&indx=1&recIds=ETOCvdc_100179843294.0x000001

FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro

Authors: Lau, Hwee Hui, Amirruddin, Nur Shabrina, Loo, Larry Sai Weng, Chan, Jun Wei, Iich, Elhadi, Krishnan, Vidhya Gomathi, Hoon, Shawn, Teo, Adrian Kee Keong

Source: In iScience 18 August 2023 26(8)

Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease

Authors: Tay, Kai Yi, Wu, Kan Xing, Chioh, Florence Wen Jing, Autio, Matias Ilmari, Pek, Nicole Min Qian, Narmada, Balakrishnan Chakrapani, Tan, Sock-Hwee, Low, Adrian Fatt-Hoe, Lian, Michelle Mulan, Chew, Elaine Guo Yan, Lau, Hwee Hui, Kao, Shih Ling, Teo, Adrian Kee Keong, Foo, Jia Nee, Foo, Roger Sik Yin, Heng, Chew Kiat, Chan, Mark Yan Yee, Cheung, Christine

Source: In Atherosclerosis December 2022 362:11-22

Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells

Authors: Pistollato, Francesca, Bal-Price, Anna, Coecke, Sandra, Parvatam, Surat, Pamies, David, Czysz, Katherine, Hao, Jie, Kee, Kehkooi, Teo, Adrian Kee Keong, Niu, Shuaishuai, Wilmes, Anja, Smirnova, Lena, Freund, Christian, Mummery, Christine, Stacey, Glyn

Source: REPRODUCTIVE TOXICOLOGY -NEW YORK. 112:36-50

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Chromatin Immunoprecipitation in Human Pluripotent Stem Cell-Derived 3D Organoids to Analyze DNA—Protein Interactions

Authors: Tan, Wei Xuan, Bok, Chek Mei, Ng, Natasha Hui Jin, Teo, Adrian Kee Keong

Source: Methods in molecular biology. 2429:215-232

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629324018&indx=1&recIds=ETOCRN629324018

Charting the next century of insulin replacement with cell and gene therapies

Authors: Lau, Hwee Hui, Gan, Shu Uin, Lickert, Heiko, Shapiro, Andrew Mark James, Lee, Kok Onn, Teo, Adrian Kee Keong

Source: In Med 8 October 2021 2(10):1138-1162

Tissue engineering and 3D printing of bioartificial pancreas for regenerative medicine in diabetes

Authors: Soetedjo, Andreas Alvin Purnomo, Lee, Jia Min, Lau, Hwee Hui, Goh, Guo Liang, An, Jia, Koh, Yexin, Yeong, Wai Yee, Teo, Adrian Kee Keong

Source: In Trends in Endocrinology & Metabolism August 2021 32(8):609-622

Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

Authors: Teo, Adrian Kee Keong, Nguyen, Linh, Gupta, Manoj K., Lau, Hwee Hui, Loo, Larry Sai Weng, Jackson, Nicholas, Lim, Chang Siang, Mallard, William, Gritsenko, Marina A., Rinn, John L., Smith, Richard D., Qian, Wei-Jun, Kulkarni, Rohit N.

Source: In Journal of Biological Chemistry January-June 2021 296

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

Authors: Carrat, Gaelle R., Haythorne, Elizabeth, Tomas, Alejandra, Haataja, Leena, Müller, Andreas, Arvan, Peter, Piunti, Alexandra, Cheng, Kaiying, Huang, Mutian, Pullen, Timothy J., Georgiadou, Eleni, Stylianides, Theodoros, Amirruddin, Nur Shabrina, Salem, Victoria, Distaso, Walter, Cakebread, Andrew, Heesom, Kate J., Lewis, Philip A., Hodson, David J., Briant, Linford J., Fung, Annie C.H., Sessions, Richard B., Alpy, Fabien, Kong, Alice P.S., Benke, Peter I., Torta, Federico, Teo, Adrian Kee Keong, Leclerc, Isabelle, Solimena, Michele, Wigley, Dale B., Rutter, Guy A.

Source: In Molecular Metabolism October 2020 40

A new perspective of probe development for imaging pancreatic beta cell in vivo

Authors: Neo, Claire Wen Ying, Ciaramicoli, Larissa Miasiro, Soetedjo, Andreas Alvin Purnomo, Teo, Adrian Kee Keong ^**, Kang, Nam-Young ^*

Source: In Seminars in Cell and Developmental Biology July 2020 103:3-13

New insights into human beta cell biology using human pluripotent stem cells

Authors: Amirruddin, Nur Shabrina, Low, Blaise Su Jun, Lee, Kok Onn, Tai, E Shyong ^*, Teo, Adrian Kee Keong ^*

Source: In Seminars in Cell and Developmental Biology July 2020 103:31-40

Tools for Bioimaging Pancreatic β Cells in Diabetes

Authors: Kang, Nam-Young, Soetedjo, Andreas Alvin Purnomo, Amirruddin, Nur Shabrina, Chang, Young-Tae, Eriksson, Olof, Teo, Adrian Kee Keong

Source: In Trends in Molecular Medicine August 2019 25(8):708-722

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Authors: Ng, Natasha Hui Jin, Jasmen, Joanita Binte, Lim, Chang Siang, Lau, Hwee Hui, Krishnan, Vidhya Gomathi, Kadiwala, Juned, Kulkarni, Rohit N., Ræder, Helge, Vallier, Ludovic, Hoon, Shawn, Teo, Adrian Kee Keong

Source: In iScience 28 June 2019 16:192-205

Dynamic proteome profiling of human pluripotent stem cell‐derived pancreatic progenitors

Authors: Loo, Larry Sai Weng, Vethe, Heidrun, Soetedjo, Andreas Alvin Purnomo, Paulo, Joao A., Jasmen, Joanita, Jackson, Nicholas, Bjørlykke, Yngvild, Valdez, Ivan A., Vaudel, Marc, Barsnes, Harald, Gygi, Steven P., Ræder, Helge, Teo, Adrian Kee Keong, Kulkarni, Rohit N.

Source: Stem cells. 38(4):542-555

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The molecular functions of hepatocyte nuclear factors – In and beyond the liver

Authors: Lau, Hwee Hui, Ng, Natasha Hui Jin, Loo, Larry Sai Weng, Jasmen, Joanita Binte, Teo, Adrian Kee Keong

Source: In Journal of Hepatology May 2018 68(5):1033-1048

Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes

Authors: Dirice, Ercument, Kahraman, Sevim, De Jesus, Dario F., El Ouaamari, Abdelfattah, Basile, Giorgio, Baker, Rocky L., Yigit, Burcu, Piehowski, Paul D., Kim, Mi-Jeong, Dwyer, Alexander J., Ng, Raymond W. S., Schuster, Cornelia, Vethe, Heidrun, Martinov, Tijana, Ishikawa, Yuki, Teo, Adrian Kee Keong, Smith, Richard D., Hu, Jiang, Haskins, Kathryn, Serwold, Thomas, Qian, Wei-Jun, Fife, Brian T., Kissler, Stephan, Kulkarni, Rohit N.

Source: Nature metabolism. 1(5):509-518

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Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment

Authors: Tan, Lay Shuen, Chen, Juin Ting, Lim, Lillian Yuxian, Teo, Adrian Kee Keong

Source: Cell proliferation. 55(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157761647.0x000001&indx=1&recIds=ETOCvdc_100157761647.0x000001

Featured Cover

Authors: Tan, Lay Shuen, Chen, Juin Ting, Lim, Lillian Yuxian, Teo, Adrian Kee Keong

Source: Cell proliferation. 55(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157761582.0x000001&indx=1&recIds=ETOCvdc_100157761582.0x000001

HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes.

Authors: Ng, Natasha Hui Jin, Ghosh, Soumita, Bok, Chek Mei, Ching, Carmen, Low, Blaise Su Jun, Chen, Juin Ting, Lim, Euodia, Miserendino, María Clara, Tan, Yaw Sing, Hoon, Shawn, Teo, Adrian Kee Keong

Source: Nature Communications; 6/22/2024, Vol. 15 Issue 1, p1-21, 21p

Subject Terms: PANCREATIC beta cells, MATURITY onset diabetes of the young, GENETIC regulation, LIVER cells, TYPE 2 diabetes, GENE expression