Small-molecule inhibitor BAY synergizes with gemcitabine through AHR inhibition in pancreatic cancer cells

Authors: Stukas, Darius ^{a, ⁎}, Zievyte, Inga ^a, Ivanauskiene, Sandra ^a, Karvelyte, Gabriele ^a, Jasukaitiene, Aldona ^a, Bartkeviciene, Arenida ^a, Matthews, Jason ^{b, c}, Maimets, Toivo ^d, Teino, Indrek ^d, Jaudzems, Kristaps ^e, Gulbinas, Antanas ^a, Dambrauskas, Zilvinas ^a

Source: In Biochemical Pharmacology March 2025 233

Loss of aryl hydrocarbon receptor reduces pancreatic tumor growth by increasing immune cell infiltration

Authors: Kannen, Vinicius ^a, Olafsen, Ninni E. ^b, Das, Siddhartha ^b, Giuliana, Paolo ^a, Izzati, Fauzia N. ^a, Choksi, Hani ^a, Åhrling, Samaneh S. ^b, Cappello, Paola ^c, Teino, Indrek ^d, Maimets, Toivo ^d, Jaudzems, Kristaps ^e, Gulbinas, Antanas ^f, Dambrauskas, Zilvinas ^f, Edgar, Landon J. ^a, Grant, Denis M. ^a, Matthews, Jason ^{a, b, ⁎}

Source: In Biochemical Pharmacology June 2025 236

Loss of Parp7 increases type I interferon signalling and reduces pancreatic tumour growth by enhancing immune cell infiltration.

Authors: Kannen, Vinicius, Rasmussen, Marit, Das, Siddhartha, Giuliana, Paolo, Izzati, Fauzia N., Choksi, Hani, Erlingsson, Linnea A. M., Olafsen, Ninni E., Åhrling, Samaneh S., Cappello, Paola, Teino, Indrek, Maimets, Toivo, Jaudzems, Kristaps, Gulbinas, Antanas, Dambrauskas, Zilvinas, Edgar, Landon J., Grant, Denis M., Matthews, Jason

Source: Frontiers in Immunology; 2025, p1-18, 18p

Subject Terms: TYPE I interferons, KILLER cells, PANCREATIC duct, CELLULAR signal transduction, CANCER cells

Discovery and optimisation of pyrazolo[1,5-a] pyrimidines as aryl hydrocarbon receptor antagonists.

Authors: Bobrovs, Raitis, Terentjeva, Svetlana, Olafsen, Ninni Elise, Dambrauskas, Zilvinas, Gulbinas, Antanas, Maimets, Toivo, Teino, Indrek, Jirgensons, Aigars, Matthews, Jason, Jaudzems, Kristaps

Source: RSC Medicinal Chemistry; Oct2024, Vol. 15 Issue 10, p3477-3484, 8p

2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells

Authors: Ounpuu, Lyudmila, Klepinin, Aleksandr, Pook, Martin, Teino, Indrek, Peet, Nadezda, Paju, Kalju, Tepp, Kersti, Chekulayev, Vladimir, Shevchuk, Igor, Koks, Sulev, Maimets, Toivo, Kaambre, Tuuli

Source: In BBA - General Subjects August 2017 1861(8):2146-2154

Transcriptional repression of the Ahr gene by LHCGR signaling in preovulatory granulosa cells is controlled by chromatin accessibility

Authors: Teino, Indrek, Matvere, Antti, Kuuse, Sulev, Ingerpuu, Sulev, Maimets, Toivo, Kristjuhan, Arnold, Tiido, Tarmo

Source: In Molecular and Cellular Endocrinology 25 January 2014 382(1):292-301

Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway.

Authors: Stukas, Darius, Jasukaitiene, Aldona, Bartkeviciene, Arenida, Matthews, Jason, Maimets, Toivo, Teino, Indrek, Jaudzems, Kristaps, Gulbinas, Antanas, Dambrauskas, Zilvinas

Source: International Journal of Molecular Sciences; Sep2023, Vol. 24 Issue 17, p13155, 18p

Subject Terms: PANCREATIC cancer, ARYL hydrocarbon receptors, GENE expression, CANCER cells, GEMCITABINE, IMMUNOPRECIPITATION

Changes in Laminin Expression Pattern during Early Differentiation of Human Embryonic Stem Cells.

Authors: Pook, Martin¹ pookm@ut.ee, Teino, Indrek¹, Kallas, Ade¹, Maimets, Toivo¹, Ingerpuu, Sulev¹, Jaks, Viljar^1,2

Source: PLoS ONE. 9/17/2015, Vol. 10 Issue 9, p1-16. 16p.

Subject Terms: *LAMININS, *PROTEIN expression, *EMBRYONIC stem cells, *CELL differentiation, *CELL culture, *TRETINOIN

Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network.

Authors: Klepinina, Ljudmila, Klepinin, Aleksandr, Truu, Laura, Chekulayev, Vladimir, Vija, Heiki, Kuus, Kaisa, Teino, Indrek, Pook, Martin, Maimets, Toivo, Kaambre, Tuuli

Source: PLoS ONE; 1/20/2021, Vol. 16 Issue 1, p1-23, 23p

Subject Terms: CANCER cell differentiation, SODIUM butyrate, COLON cancer, BUTYRATES, GLUTAMINE, CELL differentiation, CELLS

Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14.

Authors: Ervin, Egle-Helene, Pook, Martin, Teino, Indrek, Kasuk, Valmar, Trei, Annika, Pooga, Margus, Maimets, Toivo

Source: Stem Cell Research & Therapy; 1/24/2019, Vol. 10 Issue 1, p1-14, 14p

Subject Terms: EMBRYONIC stem cells, PEPTIDES, RNA, CYTOLOGY, GENE silencing

Impact of AHR Ligand TCDD on Human Embryonic Stem Cells and Early Differentiation.

Authors: Teino, Indrek¹ (AUTHOR) antti.matvere@ut.ee, Matvere, Antti¹ (AUTHOR) martin.pook@ut.ee, Pook, Martin¹ (AUTHOR) inge.varik@gmail.com, Varik, Inge¹ (AUTHOR) laura.pajusaar@gmail.com, Pajusaar, Laura¹ (AUTHOR) keyt.uudekyll@gmail.com, Uudeküll, Keyt¹ (AUTHOR) helen.vaher@ut.ee, Vaher, Helen¹ (AUTHOR) annika.trei@ut.ee, Trei, Annika¹ (AUTHOR) arnold.kristjuhan@ut.ee, Kristjuhan, Arnold¹ (AUTHOR) toivo.maimets@ut.ee, Org, Tõnis^2,3 (AUTHOR) tonis.org@ut.ee, Maimets, Toivo¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Dec2020, Vol. 21 Issue 23, p9052. 1p.

Subject Terms: *HUMAN embryonic stem cells, *CELL differentiation, *MESODERM, *ARYL hydrocarbon receptors, *PLURIPOTENT stem cells, *GENE expression profiling

FSH/LH-Dependent Upregulation of Ahr in Murine Granulosa Cells Is Controlled by PKA Signaling and Involves Epigenetic Regulation.

Authors: Matvere, Antti¹ (AUTHOR) antti.matvere@gmail.com, Teino, Indrek¹ (AUTHOR) inge.varik@gmail.com, Varik, Inge¹ (AUTHOR) skuuse@ebc.ee, Kuuse, Sulev¹ (AUTHOR) arnold.kristjuhan@ut.ee, Tiido, Tarmo² (AUTHOR) tarmo.tiido@ut.ee, Kristjuhan, Arnold¹ (AUTHOR) toivo.maimets@ut.ee, Maimets, Toivo¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Jun2019, Vol. 20 Issue 12, p3068. 1p. 1 Diagram, 1 Chart, 4 Graphs.

Subject Terms: *GRANULOSA cells, *ARYL hydrocarbon receptors, *OVARIAN follicle, *GONADOTROPIN, *TRANSCRIPTION factors, *PROTEIN kinases, *LUTEINIZING hormone

This result is not displayed to guests.
Login for full access.