Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

Authors: Grigory Ryzhakov, Hannah Almuttaqi, Alastair L. Corbin, Dorothée L. Berthold, Tariq Khoyratty, Hayley L. Eames, Samuel Bullers, Claire Pearson, Zhichao Ai, Kristina Zec, Sarah Bonham, Roman Fischer, Luke Jostins-Dean, Simon P. L. Travis, Benedikt M. Kessler, Irina A. Udalova

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/083b7a2470054dbf911ff4a0bab0a0ba

ROS-producing immature neutrophils in giant cell arteritis are linked to vascular pathologies

Authors: Lihui Wang, Zhichao Ai, Tariq Khoyratty, Kristina Zec, Hayley L. Eames, Erinke van Grinsven, Alison Hudak, Susan Morris, David Ahern, Claudia Monaco, Evgeniy B. Eruslanov, Raashid Luqmani, Irina A. Udalova

Source: JCI Insight, Vol 5, Iss 20 (2020)

Subject Terms: Vascular biology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/9479450c622941bc9ee438a4e6c35b4b