Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors

Authors: Tarfah Al-Warhi, Ahmed A. Al-Karmalawy, Ayman Abo Elmaaty, Maha A. Alshubramy, Marwa Abdel-Motaal, Taghreed A. Majrashi, Medhat Asem, Ahmed Nabil, Wagdy M. Eldehna, Marwa Sharaky

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 176-191 (2023)

Subject Terms: Pyridine/pyrimidine derivatives, EGFR, in vitro, in silico, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/adf517f35b1249309f2559b7c318ae10

Phytochemical profiling and mechanistic evaluation of black garlic extract on multiple sclerosis rat model

Authors: Yasmin A. Elkhawas, Mae Seleem, Marwa I. Shabayek, Taghreed A. Majrashi, Tarfah Al-Warhi, Wagdy M. Eldehna, Nada M. Mostafa

Source: Journal of Functional Foods, Vol 111, Iss , Pp 105900- (2023)

Subject Terms: Black garlic, Multiple sclerosis, Antioxidant, Anti-inflammatory, Allium sativum, Molecular docking, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464623005005; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/6c773b52bdd4445b88d8a24c5f08c65c

Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in Egypt

Authors: Omyma Rabie, Heba A. S. El-Nashar, Taghreed A. Majrashi, Tarfah Al‐Warhi, Mahmoud A. El Hassab, Wagdy M. Eldehna, Nada M. Mostafa

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: Callistemon subulatus, seasonal variation, Elastase, acetylcholinesterase, molecular docking, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/c3d021e721f34daeaa358c1291e31adc

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators

Authors: Mohammed Farrag El-Behairy, Walaa Hamada Abd-Allah, Mohamed M. Khalifa, Mohamed S. Nafie, Mohamed A. Saleh, Mohammed S. Abdel-Maksoud, Tarfah Al-Warhi, Wagdy M. Eldehna, Ahmed A. Al‐Karmalawy

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: Dibenzo[bf]azepines, rigidification, ring closure, topoisomerase II, in vivo, SAR, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/c4fb055b92c24a3eb4000d2f73075561

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

Authors: Wagdy M. Eldehna, Mohammed S. Taghour, Tarfah Al-Warhi, Alessio Nocentini, Mostafa M. Elbadawi, Hazem A. Mahdy, Mohamed A. Abdelrahman, Ohoud J. Alotaibi, Nada Aljaeed, Diaaeldin M. Elimam, Kamyar Afarinkia, Hatem A. Abdel-Aziz, Claudiu T. Supuran

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 531-541 (2022)

Subject Terms: carbonic anhydrase inhibitors, 3-acetylcoumarin, apoptosis induction, anticancer agents, hypoxic tumours, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/5d3bb60069d24463bf9eed48b8baeff9

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment

Authors: Mahmoud F. Abo-Ashour, Hadia Almahli, Alessandro Bonardia, Amira Khalil, Tarfah Al-Warhi, Sara T. Al-Rashood, Hatem A. Abdel-Aziz, Alessio Nocentini, Claudiu T. Supuran, Wagdy M. Eldehna

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2256-2264 (2022)

Subject Terms: Carbonic anhydrase, H-NMR, enaminone, stopped-flow assay, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/36287e74dd30418bb742055917f5a846

GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights

Authors: Dina M. El-Kersh, Nada M. Mostafa, Shaimaa Fayez, Tarfah Al-Warhi, Mohammed A. S. Abourehab, Wagdy M. Eldehna, Mohamed A. Salem

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1974-1986 (2022)

Subject Terms: Essential oils, GC-MS profiling, in-silico study, metabolomics, antioxidant, cytotoxicity activity, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/dacf8eddf21743c5824645b5f4cbdd12

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

Authors: Wagdy M. Eldehna, Raed M. Maklad, Hadia Almahli, Tarfah Al-Warhi, Eslam B. Elkaeed, Mohammed A. S. Abourehab, Hatem A. Abdel-Aziz, Ahmed M. El Kerdawy

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1227-1240 (2022)

Subject Terms: Kinase inhibitors, pancreatic cancer, molecular docking, benzofuran synthesis, apoptotic agents, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/65dfd93fede44ce9a1e2edd26cc78138

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

Authors: Tarfah Al-Warhi, Mostafa M. Elbadawi, Alessandro Bonardi, Alessio Nocentini, Ahmed A. Al-Karmalawy, Nada Aljaeed, Ohoud J. Alotaibi, Hatem A. Abdel-Aziz, Claudiu T. Supuran, Wagdy M. Eldehna

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2635-2643 (2022)

Subject Terms: Metalloenzymes, sulphonamides, anticancer agents, hypoxic tumours, ureido derivatives, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/6e3271a462794868b6ff9a0a598fdbf4

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

Authors: Wagdy M. Eldehna, Mahmoud A. El Hassab, Zainab M. Elsayed, Tarfah Al-Warhi, Hazem Elkady, Mahmoud F. Abo-Ashour, Mohammed A. S. Abourehab, Ibrahim H. Eissa, Hatem A. Abdel-Aziz

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2992c2f159244be99dafe591d062191e

1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking

Authors: Ahmed E. Elsawi, Mai I. Shahin, Hager A. Elbendary, Tarfah Al-Warhi, Fatma E. Hassan, Wagdy M. Eldehna

Source: Pharmaceuticals, Vol 17, Iss 1, p 81 (2024)

Subject Terms: angiogenesis, anti-cancer agents, synthesis, molecular modeling, tail approach, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/1/81; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/b0471381783149de825651e3784432e9

Development of 2-oxindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

Authors: Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Tarfah Al-Warhi, Sara T. Al-Rashood, Amal Alharbi, Rezk R. Ayyad, Khayal Al-Khayal, Maha Abdulla, Hatem A. Abdel-Aziz, Rehan Ahmad, Radwan El-Haggar

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 320-329 (2021)

Subject Terms: anti-proliferative indoles, apoptosis, isatin-indole, bcl2/bclxl inhibitors, colorectal cancer, western blotting, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/ae0ff9bf7af7424389e31b9650cd019c

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

Authors: Wagdy M. Eldehna, Sara T. Al-Rashood, Tarfah Al-Warhi, Razan O. Eskandrani, Amal Alharbi, Ahmed M. El Kerdawy

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 271-286 (2021)

Subject Terms: dual kinase inhibitors, cdk2/gsk-3β inhibitors, benzofuran-2-carbohydrazide, isatin, anticancer agents, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/c871d6c232b4418db9c7d9dceea43754

Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria

Authors: Zainab M. Elsayed, Wagdy M. Eldehna, Marwa M. Abdel-Aziz, Mahmoud A. El Hassab, Eslam B. Elkaeed, Tarfah Al-Warhi, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Eman R. Mohammed

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 384-392 (2021)

Subject Terms: anti-tubercular activity, dpre1 inhibitors, resistant tb, nicotinohydrazide, isatin derivatives, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/9a41c567d6f34b458504f67509a0e1aa

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

Authors: Wagdy M. Eldehna, Rofaida Salem, Zainab M. Elsayed, Tarfah Al-Warhi, Hamada R. Knany, Rezk R. Ayyad, Thamer Bin Traiki, Maha-Hamadien Abdulla, Rehan Ahmad, Hatem A. Abdel-Aziz, Radwan El-Haggar

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1423-1434 (2021)

Subject Terms: benzofuran hydrazide, isatin, cleaved parp, bcl2 inhibitors, colon cancer, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/3772b97f90654613a38cd0678b5d84ab

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Authors: Tarfah Al-Warhi, Ola A. Abu Ali, Leena S. Alqahtani, Eman Abo-Elabass, Mohammed El Behery, Atef E. Abd El-Baky, Mohamed Samir A. Zaki, Eman Fayad, Eman M. Radwan

Source: Crystals, Vol 13, Iss 7, p 1037 (2023)

Subject Terms: apoptosis, aromatase, cell cycle analysis, methoxycoumarin, MCF-7, sulfatase, Crystallography, QD901-999

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4352/13/7/1037; https://doaj.org/toc/2073-4352

Access URL: https://doaj.org/article/a97d05ad100042a6a7db527a4cc29ab0

1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights

Authors: Tarfah Al-Warhi, Hadia Almahli, Raed M. Maklad, Zainab M. Elsayed, Mahmoud A. El Hassab, Ohoud J. Alotaibi, Nada Aljaeed, Rezk R. Ayyad, Hazem A. Ghabour, Wagdy M. Eldehna, Mohamed K. El-Ashrey

Source: Molecules, Vol 28, Iss 7, p 3203 (2023)

Subject Terms: thiazole, anti-proliferative, isatin, MCF-7 cells, A-549 cells, VEGFR-2 inhibitor, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/7/3203; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/c712b5ee74854ecf8d52c4fdee007d41

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights

Authors: Ahmed Sabt, Wagdy M. Eldehna, Tarfah Al-Warhi, Ohoud J. Alotaibi, Mahmoud M. Elaasser, Howayda Suliman, Hatem A. Abdel-Aziz

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1616-1630 (2020)

Subject Terms: breast cancer, aminopyridazines, cdk2 inhibitors, apoptosis inducers, molecular docking, cell cycle arrest, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/cc1dac3e3489492eba1857ac6cde2e2d

Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

Authors: Tarfah Al-Warhi, Mahmoud F. Abo-Ashour, Hadia Almahli, Ohoud J. Alotaibi, Mohammad M. Al-Sanea, Ghada H. Al-Ansary, Hanaa Y. Ahmed, Mahmoud M. Elaasser, Wagdy M. Eldehna, Hatem A. Abdel-Aziz

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1300-1309 (2020)

Subject Terms: isatin, n-alkylindole, hybridisation, anticancer, bcl-2 inhibitor, cdk2 inhibitor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/a7e62eb9296f40d3b752213c6be30565

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

Authors: Mohamed A. Abdelrahman, Hadia Almahli, Tarfah Al-Warhi, Taghreed A. Majrashi, Marwa M. Abdel-Aziz, Wagdy M. Eldehna, Mohamed A. Said

Source: Molecules, Vol 27, Iss 24, p 8807 (2022)

Subject Terms: quinolone, hydrazone, anti-mycobacterial activity, Mycobacterium resistance, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/24/8807; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/dd46c9f0ee8546ed9232a7481f76b477