Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans

Authors: Kehdy, Fernanda S.G., Pita-Oliveira, Murilo, Scudeler, Mariana M., Torres-Loureiro, Sabrina, Zolini, Camila, Moreira, Rennan, Michelin, Lucas A., Alvim, Isabela, Silva-Carvalho, Carolina, Furlan, Vinicius C., Aquino, Marla M., Santolalla, Meddly L., Borda, Victor, Soares-Souza, Giordano B., Jaramillo-Valverde, Luis, Vasquez-Dominguez, Andres, Neira, Cesar Sanchez, Aguiar, Renato S., Verdugo, Ricardo A., O`Connor, Timothy D., Guio, Heinner, Tarazona-Santos, Eduardo, Leal, Thiago P., Rodrigues-Soares, Fernanda

Source: Genetics and Molecular Biology. January 2021 44(1)

Subject Terms: TMPRSS2, ACE2, Native Americans, SARS-CoV-2, population genomics

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200315

Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas

Authors: Borda, Victor ^{1, 2, 64, ∗}, Loesch, Douglas P. ^{1, 64}, Guo, Bing ^{1, 64}, Laboulaye, Roland ^{1, 64}, Veliz-Otani, Diego ¹, French, Jennifer N. ¹, Leal, Thiago Peixoto ³, Gogarten, Stephanie M. ⁴, Ikpe, Sunday ¹, Gouveia, Mateus H. ⁵, Mendes, Marla ⁶, Abecasis, Gonçalo R. ⁷, Alvim, Isabela ⁶, Arboleda-Bustos, Carlos E. ⁸, Arboleda, Gonzalo ⁸, Arboleda, Humberto ⁸, Barreto, Mauricio L. ⁹, Barwick, Lucas ¹⁰, Bezzera, Marcos A. ¹¹, Blangero, John ¹², Borges, Vanderci ¹³, Caceres, Omar ^{14, 15}, Cai, Jianwen ¹⁶, Chana-Cuevas, Pedro ¹⁷, Chen, Zhanghua ¹⁸, Custer, Brian ¹⁹, Dean, Michael ²⁰, Dinardo, Carla ²¹, Domingos, Igor ¹¹, Duggirala, Ravindranath ¹², Dieguez, Elena ²², Fernandez, Willian ⁸, Ferraz, Henrique B. ¹³, Gilliland, Frank ¹⁸, Guio, Heinner ^{14, 23, 24}, Horta, Bernardo ²⁵, Curran, Joanne E. ¹², Johnsen, Jill M. ²⁶, Kaplan, Robert C. ^{27, 28}, Kelly, Shannon ^{19, 29}, Kenny, Eimear E. ³⁰, Konkle, Barbara A. ³¹, Kooperberg, Charles ²⁸, Lescano, Andres ²², Lima-Costa, M. Fernanda ³², Loos, Ruth J.F. ³³, Manichaikul, Ani ³⁴, Meyers, Deborah A. ³⁵, Naslavsky, Michel S. ³⁶, Nickerson, Deborah A. ^{37, 63}, North, Kari E. ³⁸, Padilla, Carlos ¹⁴, Preuss, Michael ³⁰, Raggio, Victor ³⁹, Reiner, Alexander P. ^{28, 40}, Rich, Stephen S. ³⁴, Rieder, Carlos R. ⁴¹, Rienstra, Michiel ⁴², Rotter, Jerome I. ⁴³, Rundek, Tatjana ⁴⁴, Sacco, Ralph L. ⁴⁴, Sanchez, Cesar ¹⁴, Sankaran, Vijay G. ^{45, 46, 47}, Santos-Lobato, Bruno Lopes ⁴⁸, Schumacher-Schuh, Artur Francisco ^{49, 50}, Scliar, Marilia O. ³⁶, Silverman, Edwin K. ⁵¹, Sofer, Tamar ⁵², Lasky-Su, Jessica ⁵¹, Tumas, Vitor ⁵³, Weiss, Scott T. ⁵¹, Mata, Ignacio F. ³, Hernandez, Ryan D. ^{54, 55, 56, 57}, Tarazona-Santos, Eduardo ^{6, 58}, O’Connor, Timothy D. ^{1, 59, 60, 61, 65, ∗∗}

Source: In Cell Genomics 13 November 2024 4(11)

Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas

Authors: Hughes, Odessica, Bentley, Amy R., Breeze, Charles E., Aguet, Francois, Xu, Xiaoguang, Nadkarni, Girish, Sun, Quan, Lin, Bridget M., Gilliland, Thomas, Meyer, Mariah C., Du, Jiawen, Raffield, Laura M., Kramer, Holly, Morton, Robert W., Gouveia, Mateus H., Atkinson, Elizabeth G., Valladares-Salgado, Adan, Wacher-Rodarte, Niels, Dueker, Nicole D., Guo, Xiuqing, Hai, Yang, Adeyemo, Adebowale, Best, Lyle G., Cai, Jianwen, Chen, Guanjie, Chong, Michael, Doumatey, Ayo, Eales, James, Goodarzi, Mark O., Ipp, Eli, Irvin, Marguerite Ryan, Jiang, Minzhi, Jones, Alana C., Kooperberg, Charles, Krieger, Jose E., Lange, Ethan M., Lanktree, Matthew B., Lash, James P., Lotufo, Paulo A., Loos, Ruth J.F., Ha My, Vy Thi, Peralta-Romero, Jesús, Qi, Lihong, Raffel, Leslie J., Rich, Stephen S., Rodriquez, Erik J., Tarazona-Santos, Eduardo, Taylor, Kent D., Umans, Jason G., Wen, Jia, Young, Bessie A., Yu, Zhi, Zhang, Ying, Ida Chen, Yii-Der, Rundek, Tanja, Rotter, Jerome I., Cruz, Miguel, Fornage, Myriam, Lima-Costa, Maria Fernanda, Pereira, Alexandre C., Paré, Guillaume, Natarajan, Pradeep, Cole, Shelley A., Carson, April P., Lange, Leslie A., Li, Yun, Perez-Stable, Eliseo J., Do, Ron, Charchar, Fadi J., Tomaszewski, Maciej, Mychaleckyj, Josyf C., Rotimi, Charles, Morris, Andrew P., Franceschini, Nora

Source: In Cell Genomics 10 January 2024 4(1)

NAToRA, a relatedness-pruning method to minimize the loss of dataset size in genetic and omics analyses

Authors: Leal, Thiago Peixoto, Furlan, Vinicius C, Gouveia, Mateus Henrique, Saraiva Duarte, Julia Maria, Fonseca, Pablo AS, Tou, Rafael, Scliar, Marilia de Oliveira, Araujo, Gilderlanio Santana de, Costa, Lucas F., Zolini, Camila, Peixoto, Maria Gabriela Campolina Diniz, Carvalho, Maria Raquel Santos, Lima-Costa, Maria Fernanda, Gilman, Robert H, Tarazona-Santos, Eduardo, Rodrigues, Maíra Ribeiro

Source: In Computational and Structural Biotechnology Journal 2022 20:1821-1828

HLA-G 3’UTR haplotype frequencies in highland and lowland South Native American populations

Authors: Jacovas, Vanessa Cristina, Michita, Rafael Tomoya, Bisso-Machado, Rafael, Reales, Guillermo, Tarazona-Santos, Eduardo M., Sandoval, José Raul, Salazar-Granara, Alberto, Chies, José Artur Bogo, Bortolini, Maria Cátira

Source: In Human Immunology January 2022 83(1):27-38

The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture

Authors: Borda, Víctor, Alvim, Isabela, Mendes, Marla, Silva-Carvalho, Carolina, Soares-Souza, Giordano B., Leal, Thiago P., Furlan, Vinicius, Scliar, Marilia O., Zamudio, Roxana, Zolini, Camila, Araújo, Gilderlanio S., Luizon, Marcelo R., Padilla, Carlos, Cáceres, Omar, Levano, Kelly, Sánchez, César, Trujillo, Omar, Flores-Villanueva, Pedro O., Dean, Michael, Fuselli, Silvia, Machado, Moara, Romero, Pedro E., Tassi, Francesca, Yeager, Meredith, O’Connor, Timothy D., Gilman, Robert H., Tarazona-Santos, Eduardo, Guio, Heinner

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Dec . 117(51), 32557-32565.

Access URL: https://www.jstor.org/stable/27005826

Genome-Wide Insights into Internalizing Symptoms in Admixed Latin American Children.

Authors: Britto, Gabriela de Sales Guerreiro, Moreira, Alberto O., Bispo Amaral, Edson Henrique, Santos, Daniel Evangelista, São Pedro, Raquel B., Barreto, Thaís M. M., Feitosa, Caroline Alves, Neves dos Santos, Darci, Tarazona-Santos, Eduardo, Barreto, Maurício Lima, Figueiredo, Camila Alexandrina Viana de, Costa, Ryan dos Santos, Godard, Ana Lúcia Brunialti, Oliveira, Pablo Rafael Silveira

Source: Genes; Jan2025, Vol. 16 Issue 1, p63, 16p

Subject Terms: INTERNALIZING behavior, CHILD Behavior Checklist, LATIN Americans, GLOBAL burden of disease, BRAZILIANS

Rare Genetic Variants of NLRP12 in Admixed Latino-American Children With SARS-CoV-2–Related Multisystem Inflammatory Syndrome.

Authors: Barreto, Thaís M M, Souza, Roberta S, Pedro, Raquel B São, Paiva, Isadora M, Silva, Andréia S, Nogueira, Ana L, Bellinat, Ana P N, Dias, Nathália L S, Nunes, Sara, Britto, Gabriela S G, Amaral, Edson H B, Rocha, Gabriela D, Silva-Carvalho, Carolina, Lyra, Ricardo, Kehdy, Fernanda S G, Campos, Túlio L, Moura, Patrícia M M F, Tarazona-Santos, Eduardo, Cunha, Thiago M, Tavares, Natália M

Source: Journal of Infectious Diseases; 12/15/2024, Vol. 230 Issue 6, p1400-1409, 10p

Subject Terms: MULTISYSTEM inflammatory syndrome in children, MUTANT proteins, GENETIC variation, SARS-CoV-2, GENETICS

The history behind the mosaic of the Americas

Authors: Mendes, Marla, Alvim, Isabela, Borda, Victor, Tarazona-Santos, Eduardo

Source: In Current Opinion in Genetics & Development June 2020 62:72-77

The Genomic Impact of European Colonization of the Americas

Authors: Ongaro, Linda, Scliar, Marilia O., Flores, Rodrigo, Raveane, Alessandro, Marnetto, Davide, Sarno, Stefania, Gnecchi-Ruscone, Guido A., Alarcón-Riquelme, Marta E., Patin, Etienne, Wangkumhang, Pongsakorn, Hellenthal, Garrett, Gonzalez-Santos, Miguel, King, Roy J., Kouvatsi, Anastasia, Balanovsky, Oleg, Balanovska, Elena, Atramentova, Lubov, Turdikulova, Shahlo, Mastana, Sarabjit, Marjanovic, Damir, Mulahasanovic, Lejla, Leskovac, Andreja, Lima-Costa, Maria F., Pereira, Alexandre C., Barreto, Mauricio L., Horta, Bernardo L., Mabunda, Nédio, May, Celia A., Moreno-Estrada, Andrés, Achilli, Alessandro, Olivieri, Anna, Semino, Ornella, Tambets, Kristiina, Kivisild, Toomas, Luiselli, Donata, Torroni, Antonio, Capelli, Cristian, Tarazona-Santos, Eduardo, Metspalu, Mait, Pagani, Luca, Montinaro, Francesco

Source: In Current Biology 2 December 2019 29(23):3974-3986

The need to diversify genomic studies: Insights from Andean highlanders and Amazonians.

Authors: Alvim, Isabela^1,2,3,4, Silva-Carvalho, Carolina¹, Mendes de Aquino, Marla^1,5, Borda, Victor^1,6,7, Sanchez, Cesar⁸, Padilla, Carlos⁸, Cáceres, Omar⁸, Rezende-Diniz, Isabela¹, Saraiva-Duarte, Julia¹, Faria-Costa, Lucas¹, Santolalla, Meddly L.^1,9, Rodrigues-Soares, Fernanda¹⁰, Zolini, Camila¹, Llerena, Adrián¹¹, O'Connor, Timothy D.^6,12,13,14, Gilman, Robert H.¹⁵, Guio, Heinner^8,16,17, Tarazona-Santos, Eduardo^1,9, edutars@gmail.com

Source: Cell (0092-8674); Sep2024, Vol. 187 Issue 18, p4819-4823, 5p

Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire

Authors: Harris, Daniel N., Song, Wei, Shetty, Amol C., Levano, Kelly S., Cáceres, Omar, Padilla, Carlos, Borda, Víctor, Tarazona, David, Trujillo, Omar, Sanchez, Cesar, Kessler, Michael D., Galarza, Marco, Capristano, Silvia, Montejo, Harrison, Flores-Villanueva, Pedro O., Tarazona-Santos, Eduardo, O’Connor, Timothy D., Guio, Heinner

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Jul 01. 115(28), E6526-E6535.

Access URL: https://www.jstor.org/stable/26510934

Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population

Authors: da Silva, Thiago Magalhães, Fiaccone, Rosemeire L., Kehdy, Fernanda S.G., Tarazona-Santos, Eduardo, Rodrigues, Laura C., Costa, Gustavo N.O., Figueiredo, Camila A., Alcantara-Neves, Neuza Maria, Barreto, Maurício L.

Source: In SSM - Population Health April 2018 4:301-306

Multiple inflammatory markers and 15-year incident ADL disability in admixed older adults: The Bambui-Epigen Study

Authors: Lima-Costa, Maria Fernanda, Mambrini, Juliana V.M., Torres, Karen C.L., Peixoto, Sérgio V., Andrade, Fabíola B., De Oliveira, Cesar, Tarazona-Santos, Eduardo, Teixeira-Carvalho, Andrea, Martins-Filho, Olindo A.

Source: In Archives of Gerontology and Geriatrics September-October 2017 72:103-107

Pharmacogenetic variability of tuberculosis biomarkers in native and mestizo Peruvian populations.

Authors: Jaramillo‐Valverde, Luis, Levano, Kelly S., Tarazona, David D., Capristano, Silvia, Sanchez, Cesar, Poterico, Julio A., Tarazona‐Santos, Eduardo, Guio, Heinner

Source: Pharmacology Research & Perspectives; Jun2024, Vol. 12 Issue 3, p1-10, 10p

Subject Terms: TUBERCULOSIS, CYTOCHROME P-450 CYP2E1, SINGLE nucleotide polymorphisms, DRUG side effects, BIOMARKERS, ANTITUBERCULAR agents

Geographic Terms: PERU, LIMA (Peru)

Surnames and genetic structure of a high-altitude Quechua community from the Ichu River Valley, Peruvian Central Andes, 1825-1914.

Authors: Pettener, Davide, Pastor, Santiago, Tarazona-Santos, Eduardo

Source: Human Biology; October 1998, Vol. 70 Issue 5, p865-887, 23p

Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations

Authors: The Brazilian EPIGEN Project Consortium, Kehdy, Fernanda S. G., Gouveia, Mateus H., Machado, Moara, Magalhães, Wagner C. S., Horimoto, Andrea R., Horta, Bernardo L., Moreira, Rennan G., Leal, Thiago P., Scliar, Marilia O., Soares-Souza, Giordano B., Rodrigues-Soares, Fernanda, Araújo, Gilderlanio S., Zamudio, Roxana, Anna, Hanaisa P. Sant, Santos, Hadassa C., Duarte, Nubia E., Fiaccone, Rosemeire L., Figueiredo, Camila A., Silva, Thiago M., Costa, Gustavo N. O., Beleza, Sandra, Berg, Douglas E., Cabrera, Lilia, Debortoli, Guilherme, Duarte, Denise, Ghirotto, Silvia, Gilman, Robert H., Gonçalves, Vanessa F., Marrero, Andrea R., Muniz, Yara C., Weissensteiner, Hansi, Yeager, Meredith, Rodrigues, Laura C., Barreto, Mauricio L., Lima-Costa, M. Fernanda, Pereira, Alexandre C., Rodrigues, Maíra R., Tarazona-Santos, Eduardo

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Jul . 112(28), 8696-8701.

Access URL: https://www.jstor.org/stable/26466024

Unappreciated subcontinental admixture in Europeans and European Americans and implications for genetic epidemiology studies.

Authors: Gouveia, Mateus H., Bentley, Amy R., Leal, Thiago P., Tarazona-Santos, Eduardo, Bustamante, Carlos D., Adeyemo, Adebowale A., Rotimi, Charles N., Shriner, Daniel

Source: Nature Communications; 11/7/2023, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: GENETIC epidemiology, DISEASE risk factors, BODY mass index, MONOGENIC & polygenic inheritance (Genetics), HUMAN genome

The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma.

Authors: Ribeiro Vieira, Mariana Isadora, Nunes Pinheiro de Queiroz, Mônica Versiani, Rabelo de Santana, Maria Borges, dos Santos Silva, Hatilla, Oliveira, Almirane, Viana Figueiredo, Camila Alexandrina, Tarazona Santos, Eduardo Martín, dos Santos Costa, Ryan, Belizário Facury Lasmar, Laura Maria de Lima

Source: Brazilian Journal of Pulmonology / Jornal Brasileiro de Pneumologia; Nov/Dec2023, Vol. 49 Issue 6, p1-7, 7p

Subject Terms: GENETIC polymorphisms, SINGLE nucleotide polymorphisms, ASTHMATICS, CHILD patients, WHEEZE, ASTHMA, GENETIC models

81. CHARACTERIZING THE GENETIC ARCHITECTURE OF AUTISM FROM A MULTI-ANCESTRY PERSPECTIVE

Authors: de Aquino, Marla Mendes, Xu, Chen Yang, Engchuan, Worrawat, Trost, Brett, Thiruvahindrapuram, Bhooma, de Paiva, Thales Henrique, Zhou, Xiaopu, Tarazona-Santos, Eduardo, Pua, Victor Borda, Scherer, Stephen W.

Source: In European Neuropsychopharmacology October 2024 87 Supplement 1:93-94