Structural and Dynamic Features of Acinetobacter baumannii OXA-66 β-Lactamase Explain Its Stability and Evolution of Novel Variants

Authors: Klamer, Zachary L., June, Cynthia M., Wawrzak, Zdzislaw, Taracila, Magdalena A., Grey, Joshua A., Benn, Alyssa M.I., Russell, Christopher P., Bonomo, Robert A., Powers, Rachel A., Leonard, David A., Szarecka, Agnieszka

Source: In Journal of Molecular Biology 15 June 2024 436(12)

Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum

Authors: Powers, Rachel A., June, Cynthia M., Fernando, Micah C., Fish, Erin R., Maurer, Olivia L., Baumann, Rachelle M., Beardsley, Trevor J., Taracila, Magdalena A., Rudin, Susan D., Hujer, Kristine M.

Source: Journal of medicinal chemistry. 66(13):8510-8525

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Resistance to Novel β-Lactam–β-Lactamase Inhibitor Combinations: The “Price of Progress”

Authors: Papp-Wallace, Krisztina M., Mack, Andrew R., Taracila, Magdalena A., Bonomo, Robert A.

Source: In Infectious Disease Clinics of North America December 2020 34(4):773-819

Α‐Triazolylboronic Acids: A Promising Scaffold for Effective Inhibitors of KPCs

Authors: Introvigne, Maria Luisa, Taracila, Magdalena A., Prati, Fabio, Caselli, Emilia, Bonomo, Robert A.

Source: ChemMedChem. 15(14):1283-1288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107440729.0x000001&indx=1&recIds=ETOCvdc_100107440729.0x000001

A comprehensive and contemporary 'snapshot' of β-lactamases in carbapenem resistant Acinetobacter baumannii

Authors: Hujer, Andrea M., Hujer, Kristine M., Leonard, David A., Powers, Rachel A., Wallar, Bradley J., Mack, Andrew R., Taracila, Magdalena A., Rather, Philip N., Higgins, Paul G., Prati, Fabio, Caselli, Emilia, Marshall, Steven H., Clarke, Thomas, Greco, Christopher, Venepally, Pratap, Brinkac, Lauren, Kreiswirth, Barry N., Fouts, Derrick E., Bonomo, Robert A.

Source: Diagnostic microbiology and infectious disease. 99(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132782648.0x000001&indx=1&recIds=ETOCvdc_100132782648.0x000001

Exploring a novel Class A β‐Lactamase Inhibitor against the Class C β‐Lactamase Pseudomonas‐Derived Cephalosporinase (PDC)

Authors: Mack, Andrew, Kumar, Vijay, Taracila, Magdalena, Page, Malcolm, Bonomo, Robert, Akker, Focco

Source: FASEB journal. 35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123850778.0x000001&indx=1&recIds=ETOCvdc_100123850778.0x000001

Insights into β-Lactamases from Burkholderia Species, Two Phylogenetically Related yet Distinct Resistance Determinants

Authors: Papp-Wallace, Krisztina M., Taracila, Magdalena A., Gatta, Julian A., Ohuchi, Nozomi, Bonomo, Robert A. ^**, Nukaga, Michiyoshi

Source: In Journal of Biological Chemistry 28 June 2013 288(26):19090-19102

Predicting β-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of β-lactamase inhibitors

Authors: Hujer, Andrea M., Long, S. Wesley, Olsen, Randall J., Taracila, Magdalena A., Rojas, Laura J., Musser, James M., Bonomo, Robert A.

Source: Diagnostic microbiology and infectious disease. 98(3)

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Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes

Authors: Lin, Lin, Tan, Brandon, Pantapalangkoor, Paul, Ho, Tiffany, Hujer, Andrea M., Taracila, Magdalena A., Bonomo, Robert A., Spellberg, Brad

Source: In Vaccine 2 January 2013 31(2):313-318

Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases

Authors: Mojica, Maria F., Mahler, S. Graciela, Bethel, Christopher R., Taracila, Magdalena A., Kosmopoulou, Magda, Papp-Wallace, Krisztina M., Llarrull, Leticia I., Wilson, Brigid M., Marshall, Steven H., Wallace, Christopher J.

Source: Biochemistry. 54(20):3183-3196

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601297508&indx=1&recIds=ETOCRN601297508

Exploring the Role of a Conserved Class A Residue in the Ω-Loop of KPC-2 β-Lactamase: A MECHANISM FOR CEFTAZIDIME HYDROLYSIS

Authors: Levitt, Peter S., Papp-Wallace, Krisztina M., Taracila, Magdalena A., Hujer, Andrea M., Winkler, Marisa L., Smith, Kerri M. ^**, Xu, Yan ^**, Harris, Michael E., Bonomo, Robert A.

Source: In Journal of Biological Chemistry 14 September 2012 287(38):31783-31793

The Effectiveness of Imipenem–Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase.

Authors: Papp-Wallace, Krisztina M., Barnes, Melissa D., Taracila, Magdalena A., Bethel, Christopher R., Rutter, Joseph D., Zeiser, Elise T., Young, Katherine, Bonomo, Robert A.

Source: Antibiotics (2079-6382); May2023, Vol. 12 Issue 5, p892, 11p

Subject Terms: MOLECULAR models, DEACYLATION, IMIPENEM, CEFTAZIDIME, AMINO acids

Company/Entity: UNITED States. Food & Drug Administration

Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii.

Authors: Introvigne, Maria Luisa, Beardsley, Trevor J., Fernando, Micah C., Leonard, David A., Wallar, Bradley J., Rudin, Susan D., Taracila, Magdalena A., Rather, Philip N., Colquhoun, Jennifer M., Song, Shaina, Fini, Francesco, Hujer, Kristine M., Hujer, Andrea M., Prati, Fabio, Powers, Rachel A., Bonomo, Robert A., Caselli, Emilia

Source: Antibiotics (2079-6382); Apr2023, Vol. 12 Issue 4, p644, 19p

Subject Terms: ACINETOBACTER baumannii, BETA lactamases, CEFTAZIDIME, CARBAPENEMASE, STRUCTURE-activity relationships, GRAM-negative bacteria

Company/Entity: WORLD Health Organization

Strategic Design of an Effective β-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2′-SUBSTITUTED PENICILLIN SULFONE

Authors: Pattanaik, Priyaranjan, Bethel, Christopher R., Hujer, Andrea M., Hujer, Kristine M., Distler, Anne M., Taracila, Magdalena, Anderson, Vernon E., Fritsche, Thomas R., Jones, Ronald N., Pagadala, Sundar Ram Reddy, van den Akker, Focco, Buynak, John D., Bonomo, Robert A.

Source: In Journal of Biological Chemistry 9 January 2009 284(2):945-953

Raman Crystallographic Studies of the Intermediates Formed by Ser130Gly SHV, a β-Lactamase that Confers Resistance to Clinical Inhibitors.

Authors: Helfand, Marion S., Taracila, Magdalena A., Totir, Monica A.

Source: Biochemistry; July 24 2007, Vol. 46 Issue 29, p8689-8699, 11p

698. Nacubactam Inhibits Class A β-lactamases

Authors: Barnes, Melissa D, Good, Caryn E, Bajaksouzian, Saralee, Taracila, Magdalena A, Duin, David Van, Kreiswirth, Barry N, Jacobs, Michael R, Papp-Wallace, Krisztina M, Bonomo, Robert A

Source: Open forum infectious diseases. 5(suppl 1):S251-S252

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091765972.0x000001&indx=1&recIds=ETOCvdc_100091765972.0x000001

Insights Into the Inhibition of MOX-1 β-Lactamase by S02030, a Boronic Acid Transition State Inhibitor.

Authors: Ishikawa, Tatsuya, Furukawa, Nayuta, Caselli, Emilia, Prati, Fabio, Taracila, Magdalena A., Bethel, Christopher R., Ishii, Yoshikazu, Shimizu-Ibuka, Akiko, Bonomo, Robert A.

Source: Frontiers in Microbiology; 12/14/2021, Vol. 12, p1-7, 7p

Subject Terms: CEFTAZIDIME, BORONIC acids, CLAVULANIC acid, AUTOMATED teller machines, GRAM-negative bacteria, AZTREONAM, PROOF of concept, ESCHERICHIA coli

1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase.

Authors: Caselli, Emilia, Fini, Francesco, Introvigne, Maria Luisa, Stucchi, Mattia, Taracila, Magdalena A., Fish, Erin R., Smolen, Kali A., Rather, Philip N., Powers, Rachel A., Wallar, Bradley J., Bonomo, Robert A., Prati, Fabio

Source: ACS Infectious Diseases; 7/10/2020, Vol. 6 Issue 7, p1965-1975, 11p

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol.

Authors: Dagher, Michael, Ruffin, Felicia, Marshall, Steven, Taracila, Magdalena, Bonomo, Robert A, Reilly, Rachel, Fowler, Vance G, Thaden, Joshua T

Source: Open Forum Infectious Diseases; May2020, Vol. 7 Issue 5, p1-5, 5p

Subject Terms: ACINETOBACTER baumannii, DRUG resistance in bacteria, DRUG resistance in microorganisms, OSTEOMYELITIS, RESCUES, ANTIBIOTICS

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