Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells

Authors: Haas, Andrew R., Golden, Ryan J., Litzky, Leslie A., Engels, Boris, Zhao, Linlin, Xu, Fangmin, Taraszka, John A., Ramones, Melissa, Granda, Brian, Chang, Wan-Jung, Jadlowsky, Julie, Shea, Kim-Marie, Runkle, Adam, Chew, Anne, Dowd, Emily, Gonzalez, Vanessa, Chen, Fang, Liu, Xiaojun, Fang, Chongyun, Jiang, Shuguang, Davis, Megan M., Sheppard, Neil C., Zhao, Yangbing, Fraietta, Joseph A., Lacey, Simon F., Plesa, Gabriela, Melenhorst, J. Joseph, Mansfield, Keith, Brogdon, Jennifer L., Young, Regina M., Albelda, Steven M., June, Carl H., Tanyi, Janos L.

Source: Molecular therapy. 31(8):2309-2325

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194917364.0x000001&indx=1&recIds=ETOCvdc_100194917364.0x000001

A retrospective case series of Mohs micrographic surgery and interdisciplinary management of female genital skin cancers: Local recurrence rates and patient-reported outcomes

Authors: Nugent, Shannon T., Raj, Leela K., Latif, Nawar A., Cory, Lori, Tanyi, Janos L., Kovach, Stephen J., Fischer, John P., Fosnot, Joshua, Lin, Ines C., Etzkorn, Jeremy R., Shin, Thuzar M., Giordano, Cerrene N., Higgins, H. William, Walker, Joanna L., Miller, Christopher J.

Source: Journal of the American Academy of Dermatology. 89(2):301-308

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194202443.0x000001&indx=1&recIds=ETOCvdc_100194202443.0x000001

A Phase III Study of Pafolacianine Injection (OTL38) for Intraoperative Imaging of Folate Receptor–Positive Ovarian Cancer (Study 006)

Authors: Tanyi, Janos L., Randall, Leslie M., Chambers, Setsuko K., Butler, Kristina A., Winer, Ira S., Langstraat, Carrie L., Han, Ernest S., Vahrmeijer, Alexander L., Chon, Hye Sook, Morgan, Mark A., Powell, Matthew A., Tseng, Jill H., Lopez, Alexis S., Wenham, Robert M.

Source: Journal of clinical oncology. 41(2):276-284

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179829902.0x000001&indx=1&recIds=ETOCvdc_100179829902.0x000001

Systematic illumination of druggable genes in cancer genomes

Authors: Jiang, Junjie, Yuan, Jiao, Hu, Zhongyi, Zhang, Youyou, Zhang, Tianli, Xu, Mu, Long, Meixiao, Fan, Yi, Tanyi, Janos L., Montone, Kathleen T., Tavana, Omid, Vonderheide, Robert H., Chan, Ho Man, Hu, Xiaowen, Zhang, Lin

Source: In Cell Reports 22 February 2022 38(8)

Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

Authors: Duraiswamy, Jaikumar, Turrini, Riccardo, Minasyan, Aspram, Barras, David, Crespo, Isaac, Grimm, Alizée J., Casado, Julia, Genolet, Raphael, Benedetti, Fabrizio, Wicky, Alexandre, Ioannidou, Kalliopi, Castro, Wilson, Neal, Christopher, Moriot, Amandine, Renaud-Tissot, Stéphanie, Anstett, Victor, Fahr, Noémie, Tanyi, Janos L., Eiva, Monika A., Jacobson, Connor A., Montone, Kathleen T., Westergaard, Marie Christine Wulff, Svane, Inge Marie, Kandalaft, Lana E., Delorenzi, Mauro, Sorger, Peter K., Färkkilä, Anniina, Michielin, Olivier, Zoete, Vincent, Carmona, Santiago J., Foukas, Periklis G., Powell, Daniel J., Jr., Rusakiewicz, Sylvie, Doucey, Marie-Agnès, Dangaj Laniti, Denarda, Coukos, George

Source: In Cancer Cell 13 December 2021 39(12):1623-1642

An NK-like CAR T cell transition in CAR T cell dysfunction

Authors: Good, Charly R., Aznar, M. Angela, Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

Source: In Cell 9 December 2021 184(25):6081-6100

Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

Authors: Jadlowsky, Julie K., Hexner, Elizabeth O., Marshall, Amy, Grupp, Stephan A., Frey, Noelle V., Riley, James L., Veloso, Elizabeth, McConville, Holly, Rogal, Walter, Czuczman, Cory, Hwang, Wei-Ting, Li, Yimei, Leskowitz, Rachel M., Farrelly, Olivia, Karar, Jayashree, Christensen, Shannon, Barber-Rotenberg, Julie, Gaymon, Avery, Aronson, Naomi, Bernstein, Wendy, Melenhorst, Jan Joseph, Roche, Aoife M., Everett, John K., Zolnoski, Sonja A., McFarland, Alexander G., Reddy, Shantan, Petrichenko, Angelina, Cook, Emma J., Lee, Carole, Gonzalez, Vanessa E., Alexander, Kathleen, Kulikovskaya, Irina, Ramírez-Fernández, Ángel, Minehart, Janna C., Ruella, Marco, Gill, Saar I., Schuster, Stephen J., Cohen, Adam D., Garfall, Alfred L., Shah, Payal D., Porter, David L., Maude, Shannon L., Levine, Bruce L., Siegel, Donald L., Chew, Anne, McKenna, Stephen, Lledo, Lester, Davis, Megan M., Plesa, Gabriela, Herbst, Friederike, Stadtmauer, Edward A., Tebas, Pablo, DiNofia, Amanda, Haas, Andrew, Haas, Naomi B., Myers, Regina, O’Rourke, Donald M., Svoboda, Jakub, Tanyi, Janos L., Aplenc, Richard, Jacobson, Jeffrey M., Ko, Andrew H., Cohen, Roger B., June, Carl H., Bushman, Frederic D., Fraietta, Joseph A.

Source: Nature Medicine; 20250101, Issue: Preprints p1-11, 11p

Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment

Authors: Shan, Weiwei, Yuan, Jiao, Hu, Zhongyi, Jiang, Junjie, Wang, Yueying, Loo, Nicki, Fan, Lingling, Tang, Zhaoqing, Zhang, Tianli, Xu, Mu, Pan, Yutian, Lu, Jiaqi, Long, Meixiao, Tanyi, Janos L., Montone, Kathleen T., Fan, Yi, Hu, Xiaowen, Zhang, Youyou, Zhang, Lin

Source: In Cell Reports 14 July 2020 32(2)

Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers

Authors: Haas, Andrew R., Tanyi, Janos L., O’Hara, Mark H., Gladney, Whitney L., Lacey, Simon F., Torigian, Drew A., Soulen, Michael C., Tian, Lifeng, McGarvey, Maureen, Nelson, Anne Marie, Farabaugh, Caitlin S., Moon, Edmund, Levine, Bruce L., Melenhorst, J. Joseph, Plesa, Gabriela, June, Carl H., Albelda, Steven M., Beatty, Gregory L.

Source: In Molecular Therapy 6 November 2019 27(11):1919-1929

A phase II, multicenter, open-label trial of OTL38 injection for the intra-operative imaging of folate receptor-alpha positive ovarian cancer

Authors: Randall, Leslie M., Wenham, Robert M., Low, Philip S., Dowdy, Sean C., Tanyi, Janos L.

Source: In Gynecologic Oncology October 2019 155(1):63-68

Identification of Novel Pathogenic Sequence Variants of the Mismatch Repair Genes During Screening for Lynch Syndrome in a Single Centre of Eastern Hungary

Authors: Kóder, Gergely, Olasz, Judit, Tanyi, Janos L., George, Erin, Tóth, László, Antal-Szalmás, Péter, Nagy, Béla, Bubán, Tamás, András, Csilla, Urbancsek, Hilda, Laczik, Miklós, Csuka, Orsolya, Damjanovich, László, Tanyi, Miklós

Source: Journal of gastrointestinal cancer. 51(3):1007-1015

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172110703.0x000001&indx=1&recIds=ETOCvdc_100172110703.0x000001

Detection of Residual Peritoneal Metastases Following Cytoreductive Surgery Using Pegsitacianine, a pH-Sensitive Imaging Agent: Final Results from a Phase II Study.

Authors: Wagner, Patrick, Levine, Edward A., Kim, Alex C., Shen, Perry, Fleming, Nicole D., Westin, Shannon N., Berry, Laurel K., Karakousis, Giorgos C., Tanyi, Janos L., Olson, Madeline T., Madajewski, Brian, Ostrander, Brian, Krishnan, Kartik, Balch, Charles M., Bartlett, David L.

Source: Annals of Surgical Oncology: An Oncology Journal for Surgeons; Jul2024, Vol. 31 Issue 7, p4726-4734, 9p

A Phase III Study of Pafolacianine Injection (OTL38) for Intraoperative Imaging of Folate Receptor–Positive Ovarian Cancer (Study 006)

Authors: Tanyi, Janos L., Randall, Leslie M., Chambers, Setsuko K., Butler, Kristina A., Winer, Ira S., Langstraat, Carrie L., Han, Ernest S., Vahrmeijer, Alexander L., Chon, Hye Sook, Morgan, Mark A., Powell, Matthew A., Tseng, Jill H., Lopez, Alexis S., Wenham, Robert M.

Source: Obstetrical & gynecological survey. 78(6):341-342

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191494029.0x000001&indx=1&recIds=ETOCvdc_100191494029.0x000001

CAR-T Cell Therapy in Ovarian Cancer: Where Are We Now?

Authors: Cutri-French, Clare, Nasioudis, Dimitrios, George, Erin, Tanyi, Janos L.

Source: Diagnostics (2075-4418); Apr2024, Vol. 14 Issue 8, p819, 17p

Subject Terms: OVARIAN cancer, CELLULAR therapy, CYTOKINE release syndrome, CANCER treatment, CHIMERIC antigen receptors

Preoperative predictors that impact the survival and outcome of patients undergoing secondary cytoreduction for ovarian cancer

Authors: Katsnelson, Marina, Hwang, Wei-Ting, Tahirovic, Emin, Rubin, Stephen C., Tanyi, Janos L.

Source: Journal of obstetrics and gynaecology. 38(3):395-401

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063044148.0x000001&indx=1&recIds=ETOCvdc_100063044148.0x000001

Personalized vaccination against ovarian cancer: what are the possibilities?

Authors: Tanyi, Janos L., George, Erin

Source: Expert review of vaccines. 17(11):955-958

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103221450.0x000001&indx=1&recIds=ETOCvdc_100103221450.0x000001

Systematic evaluation of multiple immune markers reveals prognostic factors in ovarian cancer

Authors: Santoiemma, Phillip P., Reyes, Carolina, Wang, Li-Ping, McLane, Mike W., Feldman, Michael D., Tanyi, Janos L., Powell, Daniel J., Jr.

Source: In Gynecologic Oncology October 2016 143(1):120-127

Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers

Authors: Yan, Xiaohui, Hu, Zhongyi, Feng, Yi, Hu, Xiaowen, Yuan, Jiao, Zhao, Sihai D., Zhang, Youyou, Yang, Lu, Shan, Weiwei, He, Qun, Fan, Lingling, Kandalaft, Lana E., Tanyi, Janos L., Li, Chunsheng, Yuan, Chao-Xing, Zhang, Dongmei, Yuan, Huiqing, Hua, Keqin, Lu, Yiling, Katsaros, Dionyssios, Huang, Qihong, Montone, Kathleen, Fan, Yi, Coukos, George, Boyd, Jeff, Sood, Anil K., Rebbeck, Timothy, Mills, Gordon B., Dang, Chi V., Zhang, Lin

Source: In Cancer Cell 12 October 2015 28(4):529-540

Overcoming barriers of car T-cell therapy in patients with mesothelin-expressing cancers

Authors: O'Hara, Mark H, Stashwick, Caitlin, Plesa, Gabriela, Tanyi, Janos L

Source: Immunotherapy. 9(9):767-780

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159249035.0x000001&indx=1&recIds=ETOCvdc_100159249035.0x000001

Possible Compartmental Cytokine Release Syndrome in a Patient With Recurrent Ovarian Cancer After Treatment With Mesothelin-targeted CAR-T Cells

Authors: Tanyi, Janos L., Stashwick, Caitlin, Plesa, Gabriela, Morgan, Mark A., Porter, David, Maus, Marcela V., June, Carl H.

Source: Journal of immunotherapy. 40(3):104-107

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042411163.0x000001&indx=1&recIds=ETOCvdc_100042411163.0x000001