Navigating the complexity of Polycomb repression: Enzymatic cores and regulatory modules

Authors: Tamburri, Simone ^{1, 2, ∗}, Rustichelli, Samantha ¹, Amato, Simona ¹, Pasini, Diego ^{1, 2, ∗∗}

Source: In Molecular Cell 19 September 2024 84(18):3381-3405

PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression

Authors: Del Vecchio, Annachiara ^{1, 5}, Mulé, Patrizia ^{1, 5}, Fernández-Pérez, Daniel ¹, Amato, Simona ¹, Lattanzi, Georgia ¹, Zanotti, Marika ¹, Rustichelli, Samantha ¹, Pivetti, Silvia ¹, Oldani, Paola ¹, Mariani, Andrea ¹, Iommazzo, Fabiola ¹, Koseki, Haruhiko ⁴, Facciotti, Federica ^{1, 3}, Tamburri, Simone ^{1, 2}, Ferrari, Karin J. ¹, Pasini, Diego ^{1, 2, 6, ∗}

Source: In Developmental Cell 5 February 2024 59(3):368-383

Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer

Authors: Tamburri, Simone, Conway, Eric, Pasini, Diego

Source: Trends in genetics. 38(4):333-352

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157520245.0x000001&indx=1&recIds=ETOCvdc_100157520245.0x000001

SP140 represses specific loci by recruiting polycomb repressive complex 2 and NuRD complex.

Authors: Tamburri, Simone, Zucchelli, Chiara, Matafora, Vittoria, Zapparoli, Ettore, Jevtic, Zivojin, Farris, Francesco, Iannelli, Fabio, Musco, Giovanna, Bachi, Angela

Source: Nucleic Acids Research; 2/28/2025, Vol. 53 Issue 4, p1-17, 17p

BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

Authors: Conway, Eric, Rossi, Federico, Fernandez-Perez, Daniel, Ponzo, Eleonora, Ferrari, Karin Johanna, Zanotti, Marika, Manganaro, Daria, Rodighiero, Simona, Tamburri, Simone, Pasini, Diego

Source: In Molecular Cell 2 September 2021 81(17):3526-3541

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

Authors: Tamburri, Simone, Lavarone, Elisa, Fernández-Pérez, Daniel, Conway, Eric, Zanotti, Marika, Manganaro, Daria, Pasini, Diego

Source: In Molecular Cell 20 February 2020 77(4):840-856

Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities

Authors: Scelfo, Andrea, Fernández-Pérez, Daniel, Tamburri, Simone, Zanotti, Marika, Lavarone, Elisa, Soldi, Monica, Bonaldi, Tiziana, Ferrari, Karin Johanna, Pasini, Diego

Source: In Molecular Cell 6 June 2019 74(5):1037-1052

Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain

Authors: Zucchelli, Chiara, Tamburri, Simone, Filosa, Giuseppe, Ghitti, Michela, Quilici, Giacomo, Bachi, Angela, Musco, Giovanna

Source: In BBA - General Subjects February 2019 1863(2):456-465

Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity

Authors: Matafora, Vittoria, Farris, Francesco, Restuccia, Umberto, Tamburri, Simone, Martano, Giuseppe, Bernardelli, Clara, Sofia, Andrea, Pisati, Federica, Casagrande, Francesca, Lazzari, Luca, Marsoni, Silvia, Bonoldi, Emanuela, Bachi, Angela

Source: EMBO reports. 21(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115438555.0x000001&indx=1&recIds=ETOCvdc_100115438555.0x000001

Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis

Authors: Bruckmann, Chiara, Tamburri, Simone, De Lorenzi, Valentina, Doti, Nunzianna, Monti, Alessandra, Mathiasen, Lisa, Cattaneo, Angela, Ruvo, Menotti, Bachi, Angela, Blasi, Francesco

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174681659.0x000001&indx=1&recIds=ETOCvdc_100174681659.0x000001

Editorial: Polycomb group (PcG) proteins in development and disease.

Authors: Pethe, Prasad, Rao, Satyanarayana M. R., Tamburri, Simone, Tomar, Raghuvir Singh

Source: Frontiers in Cell & Developmental Biology; 2024, p1-2, 2p

Subject Terms: POLYCOMB group proteins, PROTEINS

Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1.

Authors: Zucchelli, Chiara¹, Tamburri, Simone^1,2,3, Quilici, Giacomo¹, Palagano, Eleonora², Berardi, Andrea¹, Saare, Mario⁴, Peterson, Pärt⁴, Bachi, Angela², Musco, Giovanna¹

Source: FEBS Journal. Jan2014, Vol. 281 Issue 1, p216-231. 16p.

Subject Terms: *CHRONIC lymphocytic leukemia, *LEUKOCYTES, *CIRRHOSIS of the liver, *PEPTIDYLPROLYL isomerase, *GENE expression, *HOMEOBOX proteins, *CHROMATIN, *PROTEIN folding, *CANCER risk factors

Intestinal differentiation involves cleavage of histone H3 N-terminal tails by multiple proteases.

Authors: Ferrari, Karin Johanna, Amato, Simona, Noberini, Roberta, Toscani, Cecilia, Fernández-Pérez, Daniel, Rossi, Alessandra, Conforti, Pasquale, Zanotti, Marika, Bonaldi, Tiziana, Tamburri, Simone, Pasini, Diego

Source: Nucleic Acids Research; 1/25/2021, Vol. 49 Issue 2, p791-804, 14p

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1.

Authors: Thomas, Jonathan F.¹, Igor Valencia-Sánchez, Marco¹, Tamburri, Simone^2,3, Gloor, Susan L.⁴, Rustichelli, Samantha², Godínez-López, Victoria¹, De Ioannes, Pablo¹, Lee, Rachel¹, Abini-Agbomson, Stephen¹, Gretarsson, Kristjan⁵, Burg, Jonathan M.⁴, Hickman, Allison R.⁴, Lu Sun⁴, Gopinath, Saarang⁴, Taylor, Hailey F.⁴, Zu-Wen Sun⁴, Ezell, Ryan J.⁴, Vaidya, Anup⁴, Meiners, Matthew J.⁴, Cheek, Marcus A.⁴

Source: Science Advances. 8/11/2023, Vol. 9 Issue 32, p1-15. 15p.

Subject Terms: *GENE expression, *GENETIC regulation, *HYDROXAMIC acids, *LINEAR velocity