Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension

Authors: Kelly, Tanika N., Sun, Xiao, He, Karen Y., Brown, Michael R., Taliun, Sarah A. Gagliano, Hellwege, Jacklyn N., Irvin, Marguerite R., Mi, Xuenan, Brody, Jennifer A., Franceschini, Nora, Guo, Xiuqing, Hwang, Shih-Jen, de Vries, Paul S., Gao, Yan, Moscati, Arden, Nadkarni, Girish N., Yanek, Lisa R., Elfassy, Tali, Smith, Jennifer A., Chung, Ren-Hua, Beitelshees, Amber L., Patki, Amit, Aslibekyan, Stella, Blobner, Brandon M., Peralta, Juan M., Assimes, Themistocles L., Palmas, Walter R., Liu, Chunyu, Bress, Adam P., Huang, Zhijie, Becker, Lewis C., Hwa, Chii-Min, O'Connell, Jeffrey R., Carlson, Jenna C., Warren, Helen R., Das, Sayantan, Giri, Ayush, Martin, Lisa W., Craig Johnson, W., Fox, Ervin R., Bottinger, Erwin P., Razavi, Alexander C., Vaidya, Dhananjay, Chuang, Lee-Ming, Chang, Yen-Pei C., Naseri, Take, Jain, Deepti, Kang, Hyun Min, Hung, Adriana M., Srinivasasainagendra, Vinodh, Snively, Beverly M., Gu, Dongfeng, Montasser, May E., Reupena, Muagututi'a Sefuiva, Heavner, Benjamin D., LeFaive, Jonathon, Hixson, James E., Rice, Kenneth M., Wang, Fei Fei, Nielsen, Jonas B., Huang, Jianfeng, Khan, Alyna T., Zhou, Wei, Nierenberg, Jovia L., Laurie, Cathy C., Armstrong, Nicole D., Shi, Mengyao, Pan, Yang, Stilp, Adrienne M., Emery, Leslie, Wong, Quenna, Hawley, Nicola L., Minster, Ryan L., Curran, Joanne E., Munroe, Patricia B., Weeks, Daniel E., North, Kari E., Tracy, Russell P., Kenny, Eimear E., Shimbo, Daichi, Chakravarti, Aravinda, Rich, Stephen S., Reiner, Alex P., Blangero, John, Redline, Susan, Mitchell, Braxton D., Rao, Dabeeru C., Ida Chen, Yii-Der, Kardia, Sharon L.R., Kaplan, Robert C., Mathias, Rasika A., He, Jiang, Psaty, Bruce M., Fornage, Myriam, Loos, Ruth J.F., Correa, Adolfo, Boerwinkle, Eric, Rotter, Jerome I., Kooperberg, Charles, Edwards, Todd L., Abecasis, Gonçalo R., Zhu, Xiaofeng, Levy, Daniel, Arnett, Donna K., Morrison, Alanna C.

Source: Hypertension. 79(8):1656-1667

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172924223.0x000001&indx=1&recIds=ETOCvdc_100172924223.0x000001

GWAS of Hematuria

Authors: Taliun, Sarah A. Gagliano, Sulem, Patrick, Sveinbjornsson, Gardar, Gudbjartsson, Daniel F., Stefansson, Kari, Paterson, Andrew D., Barua, Moumita

Source: Clinical journal of the American Society of Nephrology. 17(5):672-683

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629177461&indx=1&recIds=ETOCRN629177461

Leveraging sex-genetic interactions to understand brain disorders: recent advances and current gaps.

Authors: Neale, Nikita, Lona-Durazo, Frida, Ryten, Mina, Taliun, Sarah A Gagliano

Source: Brain Communications; 2024, Vol. 6 Issue 3, p1-16, 16p

Whole genome sequence analysis of pulmonary function and COPD in 19, 996 multi-ethnic participants

Authors: Zhao, Xutong, Qiao, Dandi, Yang, Chaojie, Kasela, Silva, Kim, Wonji, Ma, Yanlin, Shrine, Nick, Batini, Chiara, Sofer, Tamar, Taliun, Sarah A. Gagliano, Sakornsakolpat, Phuwanat, Balte, Pallavi P., Prokopenko, Dmitry, Yu, Bing, Lange, Leslie A., Dupuis, Josée, Cade, Brian E., Lee, Jiwon, Gharib, Sina A., Daya, Michelle, Laurie, Cecelia A., Ruczinski, Ingo, Cupples, L. Adrienne, Loehr, Laura R., Bartz, Traci M., Morrison, Alanna C., Psaty, Bruce M., Vasan, Ramachandran S., Wilson, James G., Taylor, Kent D., Durda, Peter, Johnson, W. Craig, Cornell, Elaine, Guo, Xiuqing, Liu, Yongmei, Tracy, Russell P., Ardlie, Kristin G., Aguet, François, VanDenBerg, David J., Papanicolaou, George J., Rotter, Jerome I., Barnes, Kathleen C., Jain, Deepti, Nickerson, Deborah A., Muzny, Donna M., Metcalf, Ginger A., Doddapaneni, Harshavardhan, Dugan-Perez, Shannon, Gupta, Namrata, Gabriel, Stacey, Rich, Stephen S., O'Connor, George T., Redline, Susan, Reed, Robert M., Laurie, Cathy C., Daviglus, Martha L., Preudhomme, Liana K., Burkart, Kristin M., Kaplan, Robert C., Wain, Louise V., Tobin, Martin D., London, Stephanie J., Lappalainen, Tuuli, Oelsner, Elizabeth C., Abecasis, Goncalo R., Silverman, Edwin K., Barr, R. Graham, Cho, Michael H., Manichaikul, Ani

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174512915.0x000001&indx=1&recIds=ETOCvdc_100174512915.0x000001

Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally.

Authors: D'Sa, Karishma, Guelfi, Sebastian, Vandrovcova, Jana, Reynolds, Regina H., Zhang, David, Hardy, John, Botía, Juan A., Weale, Michael E., Taliun, Sarah A. Gagliano, Small, Kerrin S., Ryten, Mina

Source: Scientific Reports; 8/24/2023, Vol. 13 Issue 1, p1-13, 13p

Subject Terms: GENETIC regulation, RNA analysis, GENE expression, RNA regulation, GENOMICS, POSTMORTEM changes, BRAIN physiology

Dissociable influences of maternal vs paternal Alzheimer's risk on neurocognitive and cardiovascular health in men and women.

Authors: Savignac, Chloé, St‐Onge, Frederic, Villeneuve, Sylvia, Badhwar, AmanPreet, Taliun, Sarah A Gagliano, Farhan, Sali, Geddes, Maiya R., Medina, Yasser Iturria, Poirier, Judes, Spreng, R. Nathan, Bzdok, Danilo

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 15, Vol. 19, p1-3, 3p

Lipid-lowering drug targets and Parkinson's disease: A sex-specific Mendelian randomization study.

Authors: Yangfan Zhao, Taliun, Sarah A. Gagliano

Source: Frontiers in Neurology; 9/1/2022, Vol. 13, p1-12, 12p

Subject Terms: PARKINSON'S disease, DRUG target, ANTILIPEMIC agents, MOVEMENT disorders, LDL cholesterol, CIS-regulatory elements (Genetics), CAUSAL inference

Genome-wide association study of cardiac troponin I in the general population.

Authors: Moksnes, Marta R, Røsjø, Helge, Richmond, Anne, Lyngbakken, Magnus N, Graham, Sarah E, Hansen, Ailin Falkmo, Wolford, Brooke N, Taliun, Sarah A Gagliano, LeFaive, Jonathon, Rasheed, Humaira, Thomas, Laurent F, Zhou, Wei, Aung, Nay, Surakka, Ida, Douville, Nicholas J, Campbell, Archie, Porteous, David J, Petersen, Steffen E, Munroe, Patricia B, Welsh, Paul

Source: Human Molecular Genetics; Nov2021, Vol. 30 Issue 21, p2027-2039, 13p

Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases.

Authors: Feleke, Rahel, Reynolds, Regina H., Smith, Amy M., Tilley, Bension, Taliun, Sarah A. Gagliano, Hardy, John, Matthews, Paul M., Gentleman, Steve, Owen, David R., Johnson, Michael R., Srivastava, Prashant K., Ryten, Mina

Source: Acta Neuropathologica; Sep2021, Vol. 142 Issue 3, p449-474, 26p

Subject Terms: LEWY body dementia, PARKINSON'S disease, NEURODEGENERATION, RNA splicing, DEMENTIA, MOLECULAR pathology

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

Authors: Taliun, Daniel, Harris, Daniel N., Kessler, Michael D., Carlson, Jedidiah, Szpiech, Zachary A., Torres, Raul, Taliun, Sarah A. Gagliano, Corvelo, André, Gogarten, Stephanie M., Kang, Hyun Min, Pitsillides, Achilleas N., LeFaive, Jonathon, Lee, Seung-been, Tian, Xiaowen, Browning, Brian L., Das, Sayantan, Emde, Anne-Katrin, Clarke, Wayne E., Loesch, Douglas P., Shetty, Amol C.

Source: Nature; 2/11/2021, Vol. 590 Issue 7845, p290-299, 10p

Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.

Authors: Zhao, Xutong, Qiao, Dandi, Yang, Chaojie, Kasela, Silva, Kim, Wonji, Ma, Yanlin, Shrine, Nick, Batini, Chiara, Sofer, Tamar, Taliun, Sarah A. Gagliano, Sakornsakolpat, Phuwanat, Balte, Pallavi P., Prokopenko, Dmitry, Yu, Bing, Lange, Leslie A., Dupuis, Josée, Cade, Brian E., Lee, Jiwon, Gharib, Sina A., Daya, Michelle

Source: Nature Communications; 10/14/2020, Vol. 11 Issue 1, p1-12, 12p

Subject Terms: OBSTRUCTIVE lung diseases, NUCLEOTIDE sequencing, SEQUENCE analysis

Geographic Terms: UNITED Kingdom

Informing disease modelling with brain-relevant functional genomic annotations.

Authors: Reynolds, Regina H¹, Hardy, John^1,2, Ryten, Mina¹, mina.ryten@ucl.ac.uk, Taliun, Sarah A Gagliano³, Gagliano Taliun, Sarah A³

Source: Brain: A Journal of Neurology; Dec2019, Vol. 142 Issue 12, p3694-3712, 19p

Ancestry-agnostic estimation of DNA sample contamination from sequence reads

Authors: Zhang, Fan, Flickinger, Matthew, Taliun, Sarah A. Gagliano, Abecasis, Goncalo R., Scott, Laura J., McCaroll, Steven A., Pato, Carlos N., Boehnke, Michael, Kang, Hyun Min

Source: Genome Research; 2020, Vol. 30 Issue: 2 p185-194, 10p

Common Genetically Predicted Skipping of COL4A4 Exon 27 Is Associated with Hematuria and Albuminuria

Authors: Barua, Moumita, Durazo, Frida Lona, Omachi, Kohei, Fermin, Damian, Eichinger, Felix H., Troost, Jonathan P., Miner, Jeffrey H., Paterson, Andrew, Taliun, Sarah A. Gagliano

Source: Journal of the American Society of Nephrology; November 2023, Vol. 34 Issue: 11, Number 11 Supplement 11 p662-662, 1p

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