Letter to the Editor regarding Response to 'Letter to Editor: 'Real-World Effectiveness of Ensitrelvir in Reducing Severe Outcomes in Outpatients at High Risk for COVID-19'

Authors: Takahiro Takazono, Satoki Fujita, Takuji Komeda, Shogo Miyazawa, Yuki Yoshida, Yoshitake Kitanishi, Masahiro Kinoshita, Satoshi Kojima, Huilian Shen, Takeki Uehara, Naoki Hosogaya, Naoki Iwanaga, Hiroshi Mukae

Source: Infectious Diseases and Therapy, Vol 13, Iss 11, Pp 2463-2467 (2024)

Subject Terms: Ensitrelvir, Hospitalization, COVID-19, Japanese nationwide database, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8229; https://doaj.org/toc/2193-6382

Access URL: https://doaj.org/article/d330b484c3574a8db9aa58b61448ddbc

Real-World Effectiveness of Ensitrelvir in Reducing Severe Outcomes in Outpatients at High Risk for COVID-19

Authors: Takahiro Takazono, Satoki Fujita, Takuji Komeda, Shogo Miyazawa, Yuki Yoshida, Yoshitake Kitanishi, Masahiro Kinoshita, Satoshi Kojima, Huilian Shen, Takeki Uehara, Naoki Hosogaya, Naoki Iwanaga, Hiroshi Mukae

Source: Infectious Diseases and Therapy, Vol 13, Iss 8, Pp 1821-1833 (2024)

Subject Terms: Ensitrelvir, Hospitalization, COVID-19, Japanese nationwide database, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8229; https://doaj.org/toc/2193-6382

Access URL: https://doaj.org/article/7413e1399c5245c6a312d602e8452527

Baloxavir safety and clinical and virologic outcomes in influenza virus-infected pediatric patients by age group: age-based pooled analysis of two pediatric studies conducted in Japan

Authors: Nobuo Hirotsu, Hiroki Sakaguchi, Keita Fukao, Satoshi Kojima, Pedro A. Piedra, Kenji Tsuchiya, Takeki Uehara

Source: BMC Pediatrics, Vol 23, Iss 1, Pp 1-11 (2023)

Subject Terms: Age group, Baloxavir marboxil, Influenza, Children, Pooled analysis, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2431

Access URL: https://doaj.org/article/fccdb9e60eed412cbeabf0846587041f

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model.

Authors: Leo Y Lee, Jie Zhou, Paulina Koszalka, Rebecca Frise, Rubaiyea Farrukee, Keiko Baba, Shahjahan Miah, Takao Shishido, Monica Galiano, Takashi Hashimoto, Shinya Omoto, Takeki Uehara, Edin J Mifsud, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Steffen Wildum, Wendy S Barclay, Aeron C Hurt

Source: PLoS Pathogens, Vol 17, Iss 5, p e1009527 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/6a080755b2e74791b2fa666dd6d94232

Mechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats

Authors: Harsh Dweep, Yuji Morikawa, Binsheng Gong, Jian Yan, Zhichao Liu, Tao Chen, Halil Bisgin, Wen Zou, Huixiao Hong, Tieliu Shi, Ping Gong, Christina Castro, Takeki Uehara, Yuping Wang, Weida Tong

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/fbe8d2ed9b374448a100bb4a54a29912

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission.

Authors: Leo Yi Yang Lee, Jie Zhou, Rebecca Frise, Daniel H Goldhill, Paulina Koszalka, Edin J Mifsud, Kaoru Baba, Takahiro Noda, Yoshinori Ando, Kenji Sato, Aoe-Ishikawa Yuki, Takao Shishido, Takeki Uehara, Steffen Wildum, Elke Zwanziger, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Aeron C Hurt, Wendy S Barclay

Source: PLoS Pathogens, Vol 16, Iss 4, p e1008395 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/61b97708882143f882083c1fe0a052d6

The DEN and CCl4-Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

Authors: Takeki Uehara, Pogribny, Igor P., Rusyn, Ivan

Source: Current Protocols; Aug2021, Vol. 1 Issue 8, p1-11, 11p

Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.

Authors: Ko Omura^1,2, Takeki Uehara^2,3, Yuji Morikawa^2,3, Hitomi Hayashi^4,5, Kunitoshi Mitsumori⁴, Keiichi Minami^2,6, Masayuki Kanki^1,2, Hiroshi Yamada², Atsushi Ono^2,7, Tetsuro Urushidani^2,8

Source: Journal of Toxicological Sciences. Dec2014, Vol. 39 Issue 6, p837-848. 12p.

Subject Terms: *DNA methylation, *LIVER cancer, *PHENOBARBITAL, *GENE expression, *DISEASE progression, *GLUTATHIONE synthase, *IMMUNE response, *LABORATORY rats, *GENETICS

Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.

Authors: Ko Omura^1,2,3 kou.omura@astellas.com, Takeki Uehara^3,4, Yuji Morikawa^3,4, Hitomi Hayashi^5,6, Kunitoshi Mitsumori⁵, Keiichi Minami^3,7, Masayuki Kanki^1,3, Hiroshi Yamada³, Atsushi Ono^3,8, Tetsuro Urushidani^3,9

Source: Journal of Toxicological Sciences. Oct2014, Vol. 39 Issue 5, p785-794. 10p.

Subject Terms: *GENETIC toxicology, *CARCINOGENS, *LABORATORY rats, *PREDICTION models, *DIETHYLAMINE, *LIVER cancer

Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts.

Authors: Hideyuki Ikematsu¹, Hayden, Frederick G.², fgh@virginia.edu, Keiko Kawaguchi³, Masahiro Kinoshita³, de Jong, Menno D.⁴, Lee, Nelson⁵, Satoru Takashima³, Takeshi Noshi³, Kenji Tsuchiya³, Takeki Uehara³, Ikematsu, Hideyuki⁶, Kawaguchi, Keiko⁶, Kinoshita, Masahiro⁶, Takashima, Satoru⁶, Noshi, Takeshi⁶, Tsuchiya, Kenji⁶, Uehara, Takeki⁶

Source: New England Journal of Medicine; 7/23/2020, Vol. 383 Issue 4, p309-320, 12p

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Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.

Authors: Baloxavir Marboxil Investigators Group, Hayden, Frederick G.¹, Kota Yamada², Portsmouth, Simon³, Keiko Kawaguchi⁴, Takao Shishido⁴, Masatsugu Arai⁴, Kenji Tsuchiya⁴, Takeki Uehara⁴, Akira Watanabe⁵, Sugaya, Norio⁶, Hirotsu, Nobuo⁶, Ishida, Tadashi⁶, Sekino, Hisakuni⁶, Yamada, Kota⁶, Kawaguchi, Keiko⁶, Shishido, Takao⁶, Arai, Masatsugu⁶, Tsuchiya, Kenji⁶, Uehara, Takeki⁶

Source: New England Journal of Medicine; 9/6/2018, Vol. 379 Issue 10, p913-923, 11p

ENSITRELVIR FOR MILD-TO-MODERATE COVID-19: PHASE 3 PART OF PHASE 2/3 STUDY.

Authors: Genki Ichihashi, Hiroshi Yotsuyanagi, Norio Ohmagari, Yohei Doi, Masaya Yamato, Takumi Imamura, Takuhiro Sonoyama, Takao Sanaki, Yuko Tsuge, Takeki Uehara, Hiroshi Mukae

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p68-69, 2p

Combinatorial Measurement of CDKN1A/p21 and KIF20A Expression for Discrimination of DNA Damage-Induced Clastogenicity.

Authors: Rina Sakai, Yuji Morikawa, Chiaki Kondo, Hiroyuki Oka, Hirofumi Miyajima, Kihei Kubo, Takeki Uehara

Source: International Journal of Molecular Sciences; Oct2014, Vol. 15 Issue 10, p17256-17269, 54p, 2 Diagrams, 4 Charts, 2 Graphs

Subject Terms: GENE expression in mammals, DNA damage, CYTOGENETICS, CHROMOSOME abnormalities, MAMMAL cytology, GENETIC markers, CELLULAR signal transduction, DIAGNOSIS, MAMMALS

Predictive genomic biomarkers for drug-induced nephrotoxicity in mice.

Authors: Chiaki Kondo¹, Miwa Aoki², Emi Yamamoto¹, Yutaka Tonomura¹, Minoru Ikeda³, Masako Kaneto¹, Jyoji Yamate³, Mikinori Torii¹, Takeki Uehara^1,3 takeki.uehara@shionogi.co.jp

Source: Journal of Toxicological Sciences. Aug2012, Vol. 37 Issue 4, p723-737. 15p.

Subject Terms: *GENETIC markers, *NEPHROTOXICOLOGY, *POLYENES, *MACROLIDE antibiotics, *GENE expression, *MICROARRAY technology, *LABORATORY mice