Effect of globin peptide on female fertility in aging granulosa cell-specific Nrg1 knockout mice

Authors: Takashi UMEHARA, Marino OGASAHARA, D.M.V. Supun PREMARATHNE, Yuka SASAKAWA, Yasuo SUMIDA, Masayuki SHIMADA

Source: The Journal of Reproduction and Development, Vol 70, Iss 3, Pp 202-206 (2024)

Subject Terms: fertility, metabolism, mitochondria, ovary, Reproduction, QH471-489, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://www.jstage.jst.go.jp/article/jrd/70/3/70_2023-076/_pdf/-char/en; https://doaj.org/toc/0916-8818; https://doaj.org/toc/1348-4400

Access URL: https://doaj.org/article/c0aa709f0e764b44aa30ac28870be3a3

Efficiency of transcription and translation of cell-free protein synthesis systems in cell-sized lipid vesicles with changing lipid composition determined by fluorescence measurements

Authors: Akari Miwa, Masatoshi Wakamori, Tetsuro Ariyoshi, Yasushi Okada, Mikako Shirouzu, Takashi Umehara, Koki Kamiya

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e556d5036f8846bba93418939d59267e

Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties

Authors: Nando D. Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, Haruhiko Koseki, Yutaka Kondo, Aki Minoda, Takashi Umehara

Source: BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)

Subject Terms: Epigenetics, Histone acetylation, Inhibitor, Nucleosome, Tumorigenesis, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/5b74b7e87b6c485084dc2c0220e913a3

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

Authors: Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/acaf383597024ad590d456fce9a48fc8

Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle

Authors: Ihshan Akthar, Yejin Kim, Takashi Umehara, Chihiro Kanno, Motoki Sasaki, Mohamed Ali Marey, Mohamed Samy Yousef, Shingo Haneda, Masayuki Shimada, Akio Miyamoto

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: cattle, hyperactivation, immune response, mucus, sperm, Toll-like receptor 2, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1319572/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/42edfaa6c48d42a2b5823995e9ebc606

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

Authors: Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/854cca959e544001b639a7418e25c89f

#252 : Granulosa Cell Metabolism is Differentially Impacted by Obesity and Aging and Correlated With Oocyte Competence

Authors: Atsushi Morimoto, Ryan Rose, Kirsten Smith, Doan ‘Thao’ Dinh, Takashi Umehara, Yasmyn Winstanley, Yoshiharu Morimoto, Darryl Russell, Rebecca Robker

Source: Fertility & Reproduction, Vol 05, Iss 04, Pp 323-323 (2023)

Subject Terms: Reproduction, QH471-489

File Description: electronic resource

Relation: https://doaj.org/toc/2661-3182; https://doaj.org/toc/2661-3174

Access URL: https://doaj.org/article/19b1cefba8b6488eb8b4fea759ebbc1c

Characteristic H3 N-tail dynamics in the nucleosome core particle, nucleosome, and chromatosome

Authors: Ayako Furukawa, Masatoshi Wakamori, Yasuhiro Arimura, Hideaki Ohtomo, Yasuo Tsunaka, Hitoshi Kurumizaka, Takashi Umehara, Yoshifumi Nishimura

Source: iScience, Vol 25, Iss 11, Pp 105408- (2022)

Subject Terms: Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222016807; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/4c08afbc89814082b417b06881f3110d

Saturated fatty acids accelerate linear motility through mitochondrial ATP production in bull sperm

Authors: Md. Mazharul Islam, Takashi Umehara, Natsumi Tsujita, Masayuki Shimada

Source: Reproductive Medicine and Biology, Vol 20, Iss 3, Pp 289-298 (2021)

Subject Terms: fatty acid transporter, frozen sperm, mitochondria oxygen consumption, mitochondrial β‐oxidation, sperm motility pattern, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Reproduction, QH471-489

File Description: electronic resource

Relation: https://doaj.org/toc/1445-5781; https://doaj.org/toc/1447-0578

Access URL: https://doaj.org/article/1e11fe75818d4c979a3e57ab55b16a84

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

Authors: Erna Davydova, Tadahiro Shimazu, Maren Kirstin Schuhmacher, Magnus E. Jakobsson, Hanneke L. D. M. Willemen, Tongri Liu, Anders Moen, Angela Y. Y. Ho, Jędrzej Małecki, Lisa Schroer, Rita Pinto, Takehiro Suzuki, Ida A. Grønsberg, Yoshihiro Sohtome, Mai Akakabe, Sara Weirich, Masaki Kikuchi, Jesper V. Olsen, Naoshi Dohmae, Takashi Umehara, Mikiko Sodeoka, Valentina Siino, Michael A. McDonough, Niels Eijkelkamp, Christopher J. Schofield, Albert Jeltsch, Yoichi Shinkai, Pål Ø. Falnes

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f285ea6c5c6e4717b078c180ed9b6cd5

Cutting the ovarian surface improves the responsiveness to exogenous hormonal treatment in aged mice

Authors: Takashi Umehara, Nao Urabe, Toshiki Obata, Takashi Yamaguchi, Atsushi Tanaka, Masayuki Shimada

Source: Reproductive Medicine and Biology, Vol 19, Iss 4, Pp 415-424 (2020)

Subject Terms: angiogenesis, control ovarian stimulation, cutting the ovarian surface, low responder, ovarian fibrosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Reproduction, QH471-489

File Description: electronic resource

Relation: https://doaj.org/toc/1445-5781; https://doaj.org/toc/1447-0578

Access URL: https://doaj.org/article/b0b48e57839f408ebe79d9e040948f5e

Epidrugs: Toward Understanding and Treating Diverse Diseases

Authors: Takashi Umehara

Source: Epigenomes, Vol 6, Iss 3, p 18 (2022)

Subject Terms: chromatin, DNA, epigenetics, histone, nucleosome, post-translational modification, Genetics, QH426-470, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4655/6/3/18; https://doaj.org/toc/2075-4655

Access URL: https://doaj.org/article/c9e7a913c4674a79a397fd18438931fb

Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8

Authors: Takeshi Tsusaka, Masaki Kikuchi, Tadahiro Shimazu, Takehiro Suzuki, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takashi Umehara, Yoichi Shinkai

Source: Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-16 (2018)

Subject Terms: G9a/Ehmt2, GLP/Ehmt1, ATF7IP, MPP8, Non-histone methylation, Transgene silencing, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13072-018-0231-z; https://doaj.org/toc/1756-8935

Access URL: https://doaj.org/article/1cc73731d93540978a8329f7d39f5860

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

Authors: Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hiroshi Kimura, Aki Minoda, Takashi Umehara

Source: Epigenetics, Vol 13, Iss 4, Pp 410-431 (2018)

Subject Terms: bet, brd2, cage, h4 hyperacetylation, jq1, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/a5a3e24b8e2b44a8ae4456359d3ec093

Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases

Authors: Hideaki Niwa, Takashi Umehara

Source: Epigenetics, Vol 12, Iss 5, Pp 340-352 (2017)

Subject Terms: chromatin, crystal structure, epigenetics, fad, histone, lsd1, lsd2, nucleosome, transcription, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/579491c57f574614a496f2ba49e8c47b

Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm.

Authors: Takashi Umehara, Natsumi Tsujita, Masayuki Shimada

Source: PLoS Biology, Vol 17, Iss 8, p e3000398 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/b39e68f475b7454bb0b0536af26d446f

Gene Expression and Protein Synthesis in Mitochondria Enhance the Duration of High-Speed Linear Motility in Boar Sperm

Authors: Zhendong Zhu, Takashi Umehara, Tetsuji Okazaki, Masaaki Goto, Yoko Fujita, S. A. Masudul Hoque, Tomoko Kawai, Wenxian Zeng, Masayuki Shimada

Source: Frontiers in Physiology, Vol 10 (2019)

Subject Terms: metabolic activity, glycolysis, mitochondrial oxidative phosphorylation, sperm motility pattern, energy source, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2019.00252/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/4404b514550e4e2ba650d6aa6a5e6907

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

Authors: Yosuke Yoneyama, Peter Lanzerstorfer, Hideaki Niwa, Takashi Umehara, Takashi Shibano, Shigeyuki Yokoyama, Kazuhiro Chida, Julian Weghuber, Fumihiko Hakuno, Shin-Ichiro Takahashi

Source: eLife, Vol 7 (2018)

Subject Terms: IGF, IGF-I receptor, IRS, clathrin, AP2, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/32893; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/388bab19741b4c1cb10063dd56c18698

Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice.

Authors: Hiroya Kitasaka, Tomoko Kawai, S A Masudul Hoque, Takashi Umehara, Youko Fujita, Masayuki Shimada

Source: PLoS ONE, Vol 13, Iss 2, p e0192458 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5805282?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c60347316a3344dd81b9dbcb029a679d

Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile

Authors: Hideaki Niwa, Shin Sato, Tomoko Hashimoto, Kenji Matsuno, Takashi Umehara

Source: Molecules, Vol 23, Iss 7, p 1538 (2018)

Subject Terms: chromatin, epigenetics, histone demethylase, protein-inhibitor complex, crystal structure, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/7/1538; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/fba19d46a0294e14bd1a164799f102cd